3526 patients
description
Transcript of 3526 patients
Funding: Health Foundation, ESVS
3526 patients
24 countries
95 centres
GALA
Funding: Health Foundation, ESVS
Countries & Centres
AustriaAustralia
BelarusChina
CroatiaCzech
RepublicEstonia
GeorgiaGermany
GreeceHungary
Israel
ItalyLatvia
NetherlandsPoland
PortugalSaudi Arabia
SlovakiaSpain
SwedenTurkey
UKUkraine
Funding: Health Foundation, ESVS
Is it time for a randomized trial of local versus generalanaesthesia for carotid endarterectomy?M. J. Gough, T. A. J. Calvey, A. J. McCleary, S. Whitely, A.Bodenham Leeds, UK
Non-randomized, patients had a free choice of the type of anaesthetic.
LA GAN=89 N=101*
30-day stroke rate 0 (0) 4 (4)Perioperative MI 1 (1) 3 (3)Death 1 (1) 2 (2)*P=0·057 versus LAP=0·046 versus LA for combined stroke/MI
These results reinforce the need for a prospective, randomized trial.
Background
Funding: Health Foundation, ESVS
Eur J Vasc Endovasc Surg 13, 491-499 (1997)Local Versus General Anaesthesia in Carotid Endarterectomy:a Systematic Review of the EvidenceC. Tangkanakul, C. E. Counsell and C. P. WarlowNeurosciences Trials Unit, Department of Clinical Neurosciences, Western General Hospital, Edinburgh, U.K.
Eur J Vasc Endovasc Surg 12, 173-181 (1996)The Differing Effects of Regional and General Anaesthesia onCerebral Metabolism During Carotid Endarterectomy*A.J. McCleary, N. M. Dearden, D. H. Dickson, A. Watson M. J. GoughDepartments of Vascular Surgery and Anaesthetics, The General Infirmary, Leeds, U.K.
Introduction
Funding: Health Foundation, ESVS
What Happened Next?
CPW, MJG
Steering Committee
Protocol
MREC
Trial Co-ordinator
Funding
Pilot: 20 UK Centres
Funding: Health Foundation, ESVS
GALA - continued
• Pilot study completed
• MREC approval for main trial
• Funding: Health Foundation
ESVS
• Centre recruitment:Journal advertsVascular SocietyCharing CrossEuropean Meetings
• Trial Office:Bridget ColamAnne FraserSteff LewisMary PatersonVera SoosayAdam Young
• Trial Steering Committee
• Data Monitoring Committee