Functional Physiology of the G.I. & Biliary System · 2018-08-16 · of the G.I. & Biliary System...

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Functional Physiology of the GI Dicken Weatherby, N.D. © Weatherby & Associates, LLC https://OptimalDX.com 1 Functional Physiology, Dysfunctions, and Assessments of the G.I. and Gallbladder – a 3-part Webinar Series The Functional Diagnosis Webinars With DR. DICKEN WEATHERBY Creator of the Blood Chemistry Software Functional Physiology of the G.I. & Biliary System Digestion, Absorption, and Excretion

Transcript of Functional Physiology of the G.I. & Biliary System · 2018-08-16 · of the G.I. & Biliary System...

Page 1: Functional Physiology of the G.I. & Biliary System · 2018-08-16 · of the G.I. & Biliary System Digestion, Absorption, and Excretion. Functional Physiology of the GI ... Excretion

Functional Physiology of the GIDicken Weatherby, N.D.

© Weatherby & Associates, LLChttps://OptimalDX.com 1

Functional Physiology, Dysfunctions, and Assessments

of the G.I. and Gallbladder –a 3-part Webinar Series

The Functional Diagnosis Webinars With

DR. DICKEN WEATHERBYCreator of the Blood Chemistry Software

Functional Physiologyof the G.I. & Biliary System

Digestion, Absorption,

and Excretion

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Functional Physiology of the GIDicken Weatherby, N.D.

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Digestion

Organs of the Digestive System

and Related Structures

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Functional Physiology of the GIDicken Weatherby, N.D.

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Layers of G.I.

G.I. TerminologyDigestion – breakdown of macronutrients

Absorption – movement of digested particles across

intestinal mucosa

Transportation/Assimilation – assimilated into blood

stream and distributed around the body

Utilization – movement from blood into the cell

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Functional Physiology of the GIDicken Weatherby, N.D.

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External and Interior Anatomy of the Stomach

Histology of the Stomach

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Functional Physiology of the GIDicken Weatherby, N.D.

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The Small Intestine-Digestion Continues

Pancreatic Enzyme SecretionProteolytic Enzymes

Carbohydrate digestion

Fat digestion

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Functional Physiology of the GIDicken Weatherby, N.D.

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Regulation of Pancreatic SecretionsSecretin

Bicarbonate

Cholecystokinin

The Hepato-Biliary System – Fat

Emulsification & Digestion

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Functional Physiology of the GIDicken Weatherby, N.D.

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Functions of Bile1.Fat digestion and emulsification

2.Excretion

3.Regulation of bile secretion

The Role of CCKInhibits gastric emptyingStimulates secretion of pancreatic juicesInduces a feeling of satietyCauses the gallbladder to ejecting bile into the

small intestine

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Functional Physiology of the GIDicken Weatherby, N.D.

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Absorption

Small Intestine & Absorption

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Functional Physiology of the GIDicken Weatherby, N.D.

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The Physiology of Gut Flora

Functions of GI FloraTypes of flora: Lactobacillus acidophilus and

bifidobacteriaThe origin of floraBeneficial effects

Anatomy of the Large Intestine

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Summary


Introduction to PBPK · Biliary excretion Distribution Predicted tissue partitioning Perfusion limited Measured tissue partitioning (rat) Permeability limited tissue model with active

Introduction to PBPK · Biliary excretion Distribution Predicted tissue partitioning Perfusion limited Measured tissue partitioning (rat) Permeability limited tissue model with active

Chylomicrons EnhanceEndotoxin Excretion Bile · Biliary excretion ofendotoxin. After3 h, rats injectedwith 125I-endotoxin-chylomicron complexes had a 67% increase in total biliary

Chylomicrons EnhanceEndotoxin Excretion Bile · Biliary excretion ofendotoxin. After3 h, rats injectedwith 125I-endotoxin-chylomicron complexes had a 67% increase in total biliary

Excretion in Rats - D-Scholarship@Pittd-scholarship.pitt.edu/4650/1/31735062118157.pdf · FK 506 ON HEPATIC EXCRETION IN RATS OJ E I ... The BSP biliary excretion rate for the animals

Excretion in Rats - [email protected]/4650/1/31735062118157.pdf · FK 506 ON HEPATIC EXCRETION IN RATS OJ E I ... The BSP biliary excretion rate for the animals

Excretion of Drugs By the end of this lecture, students should be able to Identify main and minor routes of Excretion including renal elimination and biliary.

Excretion of Drugs By the end of this lecture, students should be able to Identify main and minor routes of Excretion including renal elimination and biliary.

G.I. Joe (2005)

G.I. Joe (2005)

Clinical Practice Guidelines JOURNAL OF CLINICAL ANDthrough bile and 80% is transported to the periphery, bound to ceruloplasmin. The biliary excretion is approxi-mately 2.5 mg/d.

Clinical Practice Guidelines JOURNAL OF CLINICAL ANDthrough bile and 80% is transported to the periphery, bound to ceruloplasmin. The biliary excretion is approxi-mately 2.5 mg/d.

Digestion, Absorption, Transport, and Excretion of Nutrients...the release of CCK (which stimulates biliary and pancreatic secretions) and enterogastrone, which inhibit gastric secretions

Digestion, Absorption, Transport, and Excretion of Nutrients...the release of CCK (which stimulates biliary and pancreatic secretions) and enterogastrone, which inhibit gastric secretions

Review Article ...downloads.hindawi.com/journals/ppar/2009/501739.pdfcholesterol uptake, biliary cholesterol excretion, lipoprotein synthesis, and reverse cholesterol transport. Defects

Review Article ...downloads.hindawi.com/journals/ppar/2009/501739.pdfcholesterol uptake, biliary cholesterol excretion, lipoprotein synthesis, and reverse cholesterol transport. Defects

Wilson’s disease: trientine dihydrochloride...Wilson’s disease is a rare inherited genetic disorder in which biliary excretion of copper is impaired. Copper accumulates in the

Wilson’s disease: trientine dihydrochloride...Wilson’s disease is a rare inherited genetic disorder in which biliary excretion of copper is impaired. Copper accumulates in the

Control G.I

Control G.I

Visualization of hepatobiliary excretory function by intravital … · ßuids such as blood or urine. 2 Real-time imaging of hepato- biliary excretion has been approached on ex-vivo

Visualization of hepatobiliary excretory function by intravital … · ßuids such as blood or urine. 2 Real-time imaging of hepato- biliary excretion has been approached on ex-vivo

Press Release - Daiichi Sankyo...*Telmisartan Tablets 20mg “DSEP” Biliary excretion sustained release AT1 receptor antagonist . MicardisⓇ Tablets : 20mg/40mg/80mg *Telmisartan

Press Release - Daiichi Sankyo...*Telmisartan Tablets 20mg “DSEP” Biliary excretion sustained release AT1 receptor antagonist . MicardisⓇ Tablets : 20mg/40mg/80mg *Telmisartan

GI Tract - OTC · 2016. 8. 20. · components in the GI tract • Half life – bismuth 21-72 days, salicylic acid 2-5 hours • Excretion – bismuth = urine & biliary, salicylic

GI Tract - OTC · 2016. 8. 20. · components in the GI tract • Half life – bismuth 21-72 days, salicylic acid 2-5 hours • Excretion – bismuth = urine & biliary, salicylic

P2.::’...norepinephrine from, 115 Glucocorticoid-deficient animals, circulatory ef-fects ofcatecholamines andouabain in,31 Glucuronide, ofprobenecid, biliary excretion of, 387 Glutamine

P2.::’...norepinephrine from, 115 Glucocorticoid-deficient animals, circulatory ef-fects ofcatecholamines andouabain in,31 Glucuronide, ofprobenecid, biliary excretion of, 387 Glutamine

An In Vitro Assay to Assess Transporter-Based Cholestatic ...dmd.aspetjournals.org/content/dmd/early/2009/11/12/dmd...2009/11/12  · biliary excretion. Because sandwich-cultured hepatocytes

An In Vitro Assay to Assess Transporter-Based Cholestatic ...dmd.aspetjournals.org/content/dmd/early/2009/11/12/dmd...2009/11/12  · biliary excretion. Because sandwich-cultured hepatocytes

To report SUSPECTED ADVERSE REACTIONS, contact OSI … · 2012-06-21 · Erlotinib is eliminated by hepatic metabolism and biliary excretion. Although erlotinib exposure was similar

To report SUSPECTED ADVERSE REACTIONS, contact OSI … · 2012-06-21 · Erlotinib is eliminated by hepatic metabolism and biliary excretion. Although erlotinib exposure was similar

Target Journal: Drug Metabolism and Disposition · 7/14/2020  · mainly by metabolism and subsequent biliary/fecal and renal excretion. Excretion of radioactivity was complete after

Target Journal: Drug Metabolism and Disposition · 7/14/2020  · mainly by metabolism and subsequent biliary/fecal and renal excretion. Excretion of radioactivity was complete after

Biliary Excretion Mechanism of CPT-11 and Its …...Because biliary excretion is one of the important pathways involved in the detoxification of xenobiotics, many transport studies

Biliary Excretion Mechanism of CPT-11 and Its …...Because biliary excretion is one of the important pathways involved in the detoxification of xenobiotics, many transport studies

of excretion - Journal of Lipid Research · excretion of micelle-forming bile salts and associated phos- ... (3) and the recently ... in the form of biliary vesicles or micelles,

of excretion - Journal of Lipid Research · excretion of micelle-forming bile salts and associated phos- ... (3) and the recently ... in the form of biliary vesicles or micelles,

NST110: Advanced Toxicology Lecture 3: ExcretionExcreon Toxicants are eliminated from the body by several routes: 1.Kidney is the most important route (urine) 2.Feces (biliary excretion)

NST110: Advanced Toxicology Lecture 3: ExcretionExcreon Toxicants are eliminated from the body by several routes: 1.Kidney is the most important route (urine) 2.Feces (biliary excretion)