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INDEX

443

Volume 164, November-December 1968

17u.Acetoxy-6-dimethylaminomethyl-21-fiuoro -3-ethoxypregna-3,5-dien-20-one hydrochloride

(SC-17599), a steroid, analgetic activity andother pharmacologic properties of, 371

Acetylcholine, cholinergic inhibition of self.

stimulation behavior, 202effect on catecholamine release from perfused

cat adrenal gland, 115sensitivity of the isolated nictitating membrane

of the cat to, after various procedures andagents, 146

stimulation of prostatic secretion by, 312

Acids, barbiturate, and barbiturate salts, orallyadministered, a comparison of the effects onhuman psychomotor performance, 433

Adenosine triphosphate, complex formation ofprocaine and procaine amide with, 239

Adrenal gland, cat, perfused, effect of potassium,nicotine, pilocarpine and acetylcholine ondifferential secretion of epinephrine andnorepinephrine from, 115

Adrenergic receptor(s), alpha, effect of pro-pranolol on blockade of, 82

alpha, nature of, and the preferred conforma-tions of ephedrine isomers, 75

Aiion, J., see Bliss, E. L., 122

Albuquerque, E. X., Whitsel, B. L. and Smith,C. M., 191

Alkylammonium compounds, patterns of musclespindle afferent stimulation by, 191

Aminopyrine demethylase activity, after pheno-barbital treatment in adult male rats, livergrowth associated with induction of, 405

Analgetic activity, and other pharmacologicproperties of a steroid, 17a-acetoxy-6-dimethylaminomethyl - 21 - fluoro - 3 - ethoxy -

pregna-3,5-dien-20-one hydrochloride (SC-

17599), 371Anaphylaxis, accompanied by bronchospasm,

reduced by dexamethasone or hydrocortisone,302

Anderson, E. G., see Shibuya, T., 185

Antiarrhythmic activity, of the dextro- and levo-rotatory isomers of 4-(2-isopropylamino-1-hydroxyethyl) methanesulfonanilide (MJ

1999), 317Antimalarial effect, of chioroquine and dihydro-

quinine upon Plasmodium knowlesi, in vitrostudies of, 380

Antonio, A., see Corrado, A. P., 253Aqueous humor, increased outflow of, from the

eyes of rabbits twenty-four hours after

cervical sympathetic ganglionectomy, furtherstudies on the mechanism of, 280

Aramendla, P., see Kaumann, A. J., 326Argyris, T. S., 405Arnold, K., see Gerber, N., 232Aviado, D. M., see Carrillo, L. R., 302

see Dungan, K. W., 290Azcurra, J. M., see Sellinger, 0. Z., 212

Barbiturate salts, and barbiturate acids, orallyadministered, a comparison of the effects onhuman psychomotor performance, 433

Barr, C. F., see Polet, H., 380Behavior, self-stimulation, cholinergic inhibition

of, 202Belej , M. A., Papacostas, C. A., Sevy, R. W. and

Jackson, A. F., 342Benzothiadiazide, effect on the isolated toad

bladder, 348Benzothiadiazine compounds, as hyperglycemic

agents, structure-activity relationships of,421

Berndt, W. 0. and Grote, D., 223Biiary excretion, of probenecid and its glucuro-

nide, 387a,a’-Bis-(dimethylammoniumacetaldehyde dieth-

ylacetal) - p,p’ - diacetylbiphenyl bromide

(DMAE), antagonism of ganglionic stimu-lants by, 176

Bladder, toad, isolated, effect of a benzothiadia-zide on, 348

toad, isolated, effect of chlormerodrin on, 362Bliss, E. L., Aiion, J. and Zwanziger, J., 122Blockade, ganglionic, and gangliomo hyper-

polarization, by dimethyiphenylpiperazinium,effects of lithium on, 166

neuromuscular, in the cat, vasodilatation ofbrainstem origin suppressed by, 333

of alpha adrenergic receptors, effect of pro-

pranolol on, 82Borison, H. L., see Miranda, P. M. S., 333Brain, cat, circadian rhythm of norepinephrine

regionally in, relationship to environmental

lighting and regional diurnal variations inbrain serotonin, 135

rat, kinetics of H’-norepinephrine accumulationinto slices from different regions of, 90

rat, with stress, metabolism of norepinephrine,serotonin and dopamine in, 122

Brainstem, origin, vasodilatation of, suppressedby neuromuscular blockade in the cat, 333

Brazilian scorpion venom (Tityus serrulatus),

444 INDEX

an unusual sympathetic postganglionic stimu-lant, 253

Bronchodilator, agent, new, soterenol (MJ 1992),pharmacologic potency and selectivity of, 290

effects, of corticosteroids in the sensitized rabbit,mechanisms for, 302

Bronchospasm, accompanying anaphylaxis, re-duced by dexamethasone or hydrocortisone,302

Calcium, and norepinephrine, sensitivity of theguinea-pig pacemaker to, after pretreatment

with reserpine, 259ion, effect on frequency-force relationship in

cardiac muscle, 1

Canine prostatic secretion, stimulation of, byparasympathomimetic agents, 312

Cardiac changes, in acute tolerance to norepineph-rine infusions, 270

Cardiac glycosides, interaction with catechol-amines, effects on glycolysis and glycogenoly-sis in skeletal muscle, 22

six radiolabeled, uptake and binding by guinea-pig hearts and isolated sarcoplasmic reticu-mm, 10

Cardiac muscle, effect of calcium and sodium ionon frequency-force relationship in, 1

Carrillo, L. R. and Aviado, D. M., 302Catapres (ST 155), hypotensive drug, effect on

heart and peripheral circulation, 45Catecholamines, circulatory effects in gluco-

corticoid-deficient animals, 31effect of potassium, nicotine, piocarpine and

acetyicholine on release from perfused catadrenal gland, 115

interaction with cardiac glycosides, effects onglycolysis and glycogenolysis in skeletalmuscle, 22

Cells, mast, rat peritoneal, histamine releasefrom, inhibition by coichicine and potentia-tion by deuterium oxide, 158

Central nervous system, of the cat, distribution

of C14-sucrose and 1126-iodide in, after variousroutes of injection into the cerebrospinalfluid, 412

Cerebrospinal fluid, distribution of C’4-sucroseand I”5-iodide in the central nervous systemof the cat after various routes of injection into,412

Cervical sympathetic ganglionectomy, furtherstudies on the mechanism of the increasedoutflow of aqueous humor from the eyes ofrabbits twenty-four hours after, 280

Chiormerodrin, effect on the isolated toad bladder,362

Chloroquine, and dihydroquinine, in vitro studiesof their antimalarial effect upon Plasmodium

knotvtesi, 380

Cho, Y. W., see Dungan, K. W., 290Cholinergic inhibition, of self-stimulation be-

havior, 202Circadian rhythm, of norepinephrine regionally

in cat brain, relationship to environmentallighting and regional diurnal variations inbrain serotonin, 135

Circulation, effects of catecholamines and ouabainin glucocorticoid-deficient animals, 31

peripheral, effect of the hypotensive drug ST155 (Catapres) on, 45

Coichicine, inhibition of histamine release fromrat peritoneal mast cells, 158#{149}

Compound 48/80, inhibition by coichicine ofhistamine release induced by, 158

Conn, H. L., Jr., see Thyrum, P. T., 239Cord transection, chronic, influence on effects of

5-hydroxytryptophan, 1-tryptophan and par-gyline on spinal neuronal activity, 185

Coronary ligation, prevention of ventricularfibrillation induced by, 326

Corrado, A. P., Antonio, A. and Diniz, C. R., 253Cortex, rabbit kidney, accumulation of Cu.

dinitrophenol by slices of, 223Corticosteroids, in the sensitized rabbit, mecha-

nisms for the bronchodilator effects of, 302Corvelli, A., see Reis, D. J., 135Craig, C. R., 371Cueto, C., Jr. and Moran, N. C., 31Cutler, R. W. P., see Korobkin, R. K., 412

Datta, D. K., see Dutta, S., 10Denham, S., see Tsai, T. H., 146Deuterium oxide, potentiation of histamine

release from rat peritoneal mast cells, 158Dexamethasone, reducing bronchospasm as-

companying anaphylaxis, 302Dihydroquinine, and chloroquine, in vitro studies

of their antimalarial effect upon Plasmodiu,n

knowlesi, 380Dimethyiphenylpiperazinium, ganglionic hyper-

polarization and blockade by, effects oflithium on, 166

C’4-Dinitrophenol, accumulation of, by slices ofrabbit kidney cortex, 223

Diniz, C. R., see Corrado, A. P., 253

Diphenylliydantoin, metabolism, effect of di-phenyl-piperazine compounds and other

agents on, 232Diphenyl-piperazine compounds, and other

agents, effect on diphenylhydantoin, zoxazola.mine and hexobarbital metabolism, 232

Diurnal variations, in brain serotonin, relation-ship to circadian rhythm of norepinephrineregionally in cat brain, 135

DMAE (a,a’ - bis - (dimethylammoniumacetalde -

hyde diethylacetal) - p,p’ - diacetylbiphenyl

INDEX 445.

bromide), antagonism of ganglionic stimu-lants by, 176

Domino, E. F. and Olds, M. E., 202Dopamine, metabolism of, in rat brain with

stress, 122

Drug, hypotensive, ST 155 (Catapres), effect on

heart and peripheral circulation, 45metabolism, in hypothermia, uptake, excretion

and, of C14-procaine by the isolated, perfusedrat liver, 396

Dungan, K. W., Cho, Y. W., Gomoll, A. W.,Aviado, D. M. and Lish, P. M., 290

Dutta, S., Goswami, S., Datta, D. K., Lindower,J. 0. and Marks, B. H., 10

Ephedrine isomers, preferred conformations andthe nature of the alpha adrenergic receptor,75

Epinephrine, differential secretion of, from per-fused cat adrenal gland, effect of potassium,nicotine, pilocarpine and acetyicholine on, 115

Epstein, L. C. and Lasagna, L., 433Eyes, of rabbits, further studies on the mechanism

of the increased outflow of aqueous humorfrom, twenty-four hours after cervical sympa-thetic ganglionectomy, 280

Farah, A., see Teiger, D. G., 1

Fibrillation, ventricular, induced by coronaryligation, prevention of, 326

Fleming, W. W., see Westfall, D. P., 259

Ganglionectomy, cervical sympathetic, further

studies on the mechanism of the increasedoutflow of aqueous humor from the eyes ofrabbits twenty-four hours after, 280

Ganglionic blockade and hyperpolarization, bydimethyiphenylpiperazinium, effects of lith-ium on, 166

Ganglionic stimulants, antagonism of, by a,a’-

bis-(dimethylammoniumacetaldehyde dieth-

ylacetal) - p,p’ - diacetylbiphenyl bromide(DMAE), 176

Gerber, N. and Arnold, K., 232Gillespie, E., Levine, R. J. and Malawista, S. E.,

158Gland, perfused cat adrenal, effect of potassium,

nicotine, piocarpine and acetylcholine ondifferential secretion of epinephrine andnorepinephrine from, 115

Glucocorticoid-deficient animals, circulatory ef-fects of catecholamines and ouabain in, 31

Glucuronide, of probenecid, biliary excretion of,387

Glutamine synthetase, inhibitory effects, dis-sociation of the convulsant and, methioninesulfoximine seizures, 212

Glycogenolysis, in skeletal muscle, effects of

cardiac glycosides and their interaction withcatecholamines on, 22

Glycolysis, in skeletal muscle, effects of cardiac-glycosides and their interaction with cate-cholamines on, 22

Glycosides, cardiac, interaction with catechol-

amines, effects on glycolysis and glycogenoly-sis in skeletal muscle, 22

81X radiolabeled cardiac, uptake and bindingby guinea-pighearts and isolated sarcoplasmie

reticulum, 10G#{243}mez,B., see Miranda, P. M. S., 333

Gomez, H. J. and Yard, A. C., 270Gomoll, A. W., see Dungan, K. W., 290

Goswam�i, S., see Dutta, S., 10

Grant, A. M., 8ee Wales, J. K., 421Green, A. I., see Snyder, S. H., 90Grote, D., see Berndt, W. 0., 223Guarino, A. M. and Schanker, L. S., 387Guinea-pig hearts, uptake and binding . of six

radiolabeled cardiac glycosides by, 10pacemaker, sensitivity to norepinephrine and

calcium after pretreatment with reserpine,

259

Heart(s), effect of the hypotensive drug ST l5�

(Catapres) on, 45guinea-pig, uptake and binding of six radio-

labeled cardiac glycosides by, 10Hemicholinium analog, DMAE, and ganglionic

transmission, 176

Hendley, E. D., see Snyder, S. H., 90Hexobarbital, metabolism, effect of diphenyl-

piperazine compounds and other agents on,232

Histamine, release from rat peritoneal mast cells,inhibition by colchicine and potentiation bydeuterium oxide, 158

Horita, A., see Yamamura, H. I., 82Humor, aqueous, increased outflow of, from the

eyes of rabbits twenty-four hours after

cervical sympathetic ganglionectomy, further

studies on the mechanism of, 280

Hydrocortisone, reducing bronchospasm as-companying anaphylaxis, 302

5-Hydroxytryptophan, effects on spinal neuronat

activity, influence of chronic cord transectiom

on, 185Hyperglycemic agents, structure-activity rela-

tionships of benzothiadiazine compounds as,421

Hyperpolarization, ganglionic, and ganglionie

blockade, by dimethyiphenylpiperasinium,

effects of lithium on, 166Hypothermia, drug metabolism in, and uptake

and excretion of C’4-procaine by the isolated,

perfused rat liver, 396

446 INDEX

i�.iodide, and C14-sucrose, distribution of, in the

central nervous system of the cat after various� - ..� � routes of injection into the cerebrospinal� . fluid,412

Ion, calcium and sodium, effect on frequency-� . � fos�ce relationship in cardiac muscle, 1

Isomers, dextro- and levo-rotatory, 4-(2-isopropyl-amino-1-hydroxyethyl) methanesulfonaniide

� .� � � ��MJ 1999), antiarrhythmic activity of, 317� � .ephedrine, preferred conformations and the

nature of the alpha adrenergic receptor, 754-(2-Isopropylamino-1-hydroxyethyl) methane-

sulfonaniide (MJ 1999), antiarrhythmicactivity of the dextro- and levo-rotatoryisomers of, 317

Jackson, A. F., see Belej, M. A., 342Jaramillo, J. and Volle, R. L., 166

Kals#{232}t-,S. C., Kelvington, E. J., Kunig, R. andRandolph, M. M., 396

1�, �. �., �ee Lipsius, M. R., 60

1<autnann, A. J. and Aramendfa, P., 326Kelvington, E. J., see Kaiser, S. C., 396�i�dney cortex, rabbit, accumulation of C’4-

dinitrophenol by slices of, 223Ki#{231}r,L.B., 75

Kinetics, of fl.norepinep�ine accumulation intoslices from different regions of rat brain, 90

Korobkin, It. K., Lorenzo, A. V. and Cutler, R.W. P., 412

Krees, �. V.., see Wales, J. K., 421� see.Kalser, S. C., 396

KSrpson, �:, Triner, L. and Nahas, G. G., 22

Lasagna, L., see Epstein, L. C., 433Levine, R. J., see Gillespie, E., 158

Ligation, coronary, prevention of ventricular:. �flbrillation induced by, 326

Lighting, environmental, in brain serotonin, re-

�. � Lat,io�iahip to circadian rhythm of norepineph-rine regionally in cat brain, 135

Ljndower., J.. 0., see Dutta, S., 10Lipsius, M. R., Siegman, M. J. and Kao, C. Y., 60jA�h,1�.M.,see Dungan, K. W., 290�ithi�n, #{149}effects on ganglionic hyperpolarization

and blockade by dimethyiphenylpiperazinium,

166Li�v�r, �#{149}growth associated with induction of

. aminbpyrine demethylase activity after

phenobarbital treatment in adult male rats,. � � �405#{149}’���#{149}

�rat, is#{246}l#{225}ted,perfused, uptake, metabolism andexcretion of C’4-procaine by, in hypothermia,

. .. -P396 � �Long, J� P.,see Wong, S., 176Lorenzo, A. V., see Korobkin, R. K., 412

Lowe, T. E., see Nayler, W. G., 45Luchi, R. J., see Thyrum, P. T., 239

Malawista, S. E., see Gillespie, E., 158Marks, B. H., see Dutta, S., 10Mast cells, rat peritoneal, histamine release from,

inhibition by coichicine and potentiation bydeuterium oxide, 158

McGrath, W. R., see Thai, T. H., 146Mclnnes, I., see Nayler, W. G., 45Membrane, isolated nictitating, of the cat,

sensitivity to norepinephrine and acetyl-choline after various procedures and agents,146

Metabolism, diphenylhydantoin, zoxazolamineand hexobarbital, effect of diphenyl-pipera-zinc compounds and other agents on, 232

muscle, effects of cardiac glycosides and theirinteraction with catecholamines on glycolysis

and glycogenolysis in, 22norepinephrine, serotonin and dopamine in rat

brain with stress, 122uptake and excretion, of C’4-procaine by the

isolated, perfused rat liver, in hypothermia,396

Methacholine, stimulation of prostatic secretionby, 312

i�-Methionine, antagonism of methionine sulfoxi-mine seizures, 212

Methionine sulfoximine, seizures, dissociation ofthe convulsant and glutamine synthetaseinhibitory effects, 212

Miele, E., see Rubin, R. P., 115Miranda, P. M. S., G#{243}mez,B. and Borison, H. L.,

333MJ 1992 (soterenol), a new bronchodilator agent,

pharmacologic potency and selectivity of,290

MJ 1999 [4-(2. isopropylamino - 1 -hydroxyethyl)methanesulfonaniide], antiarrhythmic as-tivity of the dextro- and levo-rotatory isomersof, 317

Molecular conformations, preferred, of ephedrine

isomers, and the nature of the alpha adrenergic

receptor, 75Moran, N. C., see Cueto, C., Jr., 31Muscle, cardiac, effect of calcium and sodium ion

on frequencg-force relationship in, 1patterns from spindle afferent stimulation by

alkylammonium compounds, 191skeletal, glycolysis and glycogenolysis in, effects

of cardiac glycosides and their interactionwith catecholamises on, 22

vascular smooth, direct relaxant actions ofprocaine and tetrodotoxin on, 60

Musculoskeletal system, effects of cardiac gly-cosides and their interaction with catechol-amines on glycolysis and glycogenolysis in, 22

INDEX 447

Nahas, G. G., see Kypson, J., 22Nayler, W. G., Price, J. M., Swann, J. B., Mclnnes,

I.,Race,D.andLowe,T.E.,45

Neostigmine, stimulation of prostatic secretionby, 312

Nerve stimulation, regulatory effect of puromycinon accelerated norepinephrine synthesis

associated with, 103Nervous system, central, of the cat, distribution

of C’4.sucrose and 1125-iodide in, after variousroutes of injection into the cerebrospinal

fluid, 412

Neuromuscular blockade, in the cat, vasodiata-tion of brainstem origin suppressed by, 333

Neuronal activity, spinal, influence of chroniccord transection on effects of 5-hydroxy-tryptophan, 1-tryptophan and pargyline on,

185

Nicotine, effect on catecholamine release fromperfused cat adrenal gland, 115

ganglionic stimulation and blockade by DMAE,176

reversal, in phenoxybenzamine-treatcd dogs,mechanism of, 342

Nictitating membrane, isolated, of the cat,sensitivity to norepinephrine and acetyl-choline after various procedures and agents,146

Norepinephrine, and calcium, sensitivity of theguinea-pig pacemaker to, after pretreatmentwith reserpine, 259

circadian rhythm of, regionally in cat brain,relationship to environmental lighting andregional diurnal variations in brain serotonin,135

differential secretion of, from perfused catadrenal gland, effect of potassium, nicotine,

piocarpine and acetyicholine on, 115infusions, cardiac and vascular changes in

acute tolerance to, 270metabolism of, in rat brain with stress, 122sensitivity of the isolated nictitating membrane

of the cat to, after various procedures andagents, 146

synthesis, accelerated, associated with nervestimulation, regulation of, effect of puromycinon, 103

H5-Norepinephrine, kinetics of, accumulation into

slices from different regions of rat brain,

90

Ohisson, W. G., see Sellinger, 0. Z., 212

Olds, M. E., see Domino, E. F., 202Ouabain, circulatory effects in glucocorticoid-

deficient animals, 31Outflow, increased, of aqueous humor from the

eyes of rabbits twenty-four hours after

cervical sympathetic ganglionectomy, furtherstudies on the mechanism of, 280

Oxotremorine, stimulation of prostatic secruti�mby, 312 . � .:

Pacemaker, guinea-pig, sensitivity to. norepineph-rine and calcium after. pretreatment � withreserpine, 259

Papacostas, C. A., see Belej, M. A., 342Parasympathomimetic agents, stimulation of

canine prostatic secretion by, 312 � -.

Pargyline, effects on spinal neuronal activity,influence of chronic cord transection on, 18&#{149}

Pendleton, R. G., Sullivan, L. P. and Tucker, J.M.,362 �

Sullivan, L. P., Tucker, J. M. and Stephenaon,R. E., III, 348

Peritoneal mast cells, rat, histamine release from,inhibition by colchicine and potentiation bydeuterium oxide, 158

Phenobarbital, a comparison of the effects ofbarbiturate salts and barbiturate acids onhuman psychomotor performance, 433

treatment in adult male rats, liver growthassociated with induction of aminopyrine

demethylase activity after, 405 .

Phenoxybenzamine-treated dogs, mechanisni ofnicotine reversal in, 342 . . � �:

Physostigmine, stimulation of prostatic secretionby,312

Piocarpine, effect on catecholamine release fromperfused cat adrenal gland, 115

stimulation of prostatic secretion by, 312Placebo, a comparison of the effects of barbiturate

salts and barbiturate acids on human psycho-motor performance, 433 :

Plasmodium knowlesi, in vitro studies of theantimalarial effect of chioroquine and di-hydroquinine upon, 380 .

Polet, H. and Barr, C. F., 380

Postganglionic stimulant, an unusual sym-pathetic, Brazilian scorpion venom (Tityus

serrulatus) , 253Potassium, effect on catecholamine release from

perfused cat adrenal gland, 115 �Price, J. M., see Nayler, W. G., 45Probenecid, and its glucuronide, biiary excretion

of,387 .

Procaine, and procaine amide, complex formationof, with adenosine triphosphate, 239

direct relaxant actions on vascular smoothmuscle, 60 . -

C’4-Procaine, uptake, metabolism and excretion of,by the isolated, perfused rat liver, in hy-pothermia, 396

Procaine amide, and procaine, complex formation

of, with adenosine triphosphate, 239 : -

448 INDEX

Propranolol, effect on blockade of alpha adrenergic

receptors, 82

Prostatic secretion, canine, stimulation of, byparasympathomimetic agents, 312

Psychomotor performance, human, a comparisonof the effects of orally administered bar-biturate salts and barbiturate acids on, 433

Puromycin, regulatory effect on acceleratednorepinephrine synthesis associated withnerve stimulation, 103

Itabadjija, M., see Weiner, N., 103Race, D., 885 Nayler, W. G., 45

Randolph, M. M., see Kalser, S. C., 396

Receptor(s), alpha adrenergic, effect of pro-pranolol on blockade of, 82

alpha adrenergic, nature of, and the preferredconformations of ephedrine isomers, 75

Reis, D. J., Weinbren, M. and Corvelli, A., 135Reserpine, sensitivity of the guinea-pig pace-

maker to norepinephrine and calcium afterpretreatment with, 259

Reticulum, isolated sarcoplasmic, uptake andbinding of six radiolabeled cardiac glycosidesby, 10

Reversal, nicotine, in phenoxybenzamine-treateddogs, mechanism of, 342

Rosser,M.J.andSears,M.L., 280

Rotatory isomers, dextro- and levo-, 4-(2-isopropyl-amino-1-hydroxyethyl) methanesulfonaniide(MJ 1999), antiarrhythmic activity of, 317

Rubin, R. P. and Miele, E., 115

Salts, barbiturate, and barbiturate acids, orallyadministered, a comparison of the effects on

human psychomotor performance, 433Sarcoplasinic reticulum, isolated, uptake and

binding of six radiolabeled cardiac glycosidesby, 10

SC-17599 (17a-acetoxy-6-dimethylazninomethyl-21-fluoro-3-ethoxypregna-3,5-dien-20-one hy-drochloride), a steroid, analgetic activity andother pharmacologic properties of, 371

Schanker, L. S., see Guarino, A. M., 387Sears, M. L., see Rosser, M. J., 280Secobarbital, a comparison of the effects of bar-

biturate salts and barbiturate acids on human. psychomotor performance, 433

Secretion, differential, of epinephrine and nor-

epinephrine from perfused cat adrenal gland,effect of potassium, nicotine, piocarpine andacetylcholine on, 115

Seizures, methionine sulfoximine, dissociation ofthe convulsant and glutamine synthetase in-hibitory effects, 212

Sellinger, 0. Z., Azcurra, J. M. and Ohisson, W.G., 212

Serotonin, brain, regional diurnal variations in,

effect of circadian rhythm of norepinephrine

regionally, relationship to environmentallighting and to, 135

metabolism of, in rat brain with stress, 122Sexy, R. W., See Belej, M. A., 342

Shibuya, T. and Anderson, E. G., 185

Siegman, M. J., 865 Lipsius, M. R., 60

Skeletal muscle, glycolysis and glytogenolysis in,effects of cardiac glycosidea and their inter-action with catecholamines on, 22

Smith, C. M., see Albuquerque, E. X., 191Smith, E. R., 312Smooth muscle, vascular, direct relaxant actions

of procaine and tetrodotoxin on, 60Snyder, S. H., Green, A. I. and Hendley, E. D., 90Sodium ion, effect on frequency-force relationship

in cardiac muscle, 1Somani, P. and Watson, D. L., 317Soterenol (MJ 1992), a new bronchodilator agent,

pharmacologic potency and selectivity of, 290Spinal cord, influence of chronic transection on

effects of 5-hydroxytryptophan, t-tryptophanand pargyline on spinal neuronal activity, 185

ST 155 (Catapres), hypotensive drug, effect onheart and peripheral circulation, 45

Stephenson, R. E., III, see Pendleton, R. G., 348Steroid, 17a-acetoxy-6-dimethylaminomethyl-21-

fluoro-3-ethoxypregna-3,5-dien-20.one hydro-

chloride (SC-17599), analgetic activity and

other pharmacologic properties of, 371Stimulant, an unusual sympathetic poetgangli-

onic, Brazilian scorpion venom (T#{252}yus aerru-

Lotus), 253

C14-Sucrose, and 1111-iodide, distribution of, in thecentral nervous system of the cat after variousroutes of injection into the cerebrospinalfluid, 412

Sullivan, L. P., see Pendleton, R. G., 348, 362Swarm, J. B., 865 Nayler, W. G., 45Sympathetic ganglionectomy, cervical, further

studies on the mechanism of the increased out-flow of aqueous humor from the eyes of rabbitstwenty-four hours after, 280

Sympathetic postganglionic stimulant, an un.usual, Brazilian scorpion venom (Tityus serru-talus), 253

Synthesis, norepinephrine, accelerated, associatedwith nerve stimulation, regulation of, effect

of puromycin on, 103

Synthetase, glutamine, inhibitoryeffects, dissocia-tion of the convulsant and, methionine sul-foximine seizures, 212

Teiger, D. G. and Farah, A., 1Tetrodotoxin, direct relaxant actions on vascular

smooth muscle, 60Thyrum, P. T., Luchi, R. J. and Conn, H. L., Jr.,

239

INDEX

Tityus serr-uiatus (Brazilian scorpion venom), anunusual sympathetic postganglionic stimu-lant, 253

Toad bladder, isolated, effect of a benzothiadia-zide on, 348

isolated, effect of chiormerodrin on, 362Triner, L., see Kypson, J., 22l-Tryptophan, effects on spinal neuronal activity,

influence of chronic cord transection on, 185Tsai, T. H., Denham, S. and McGrath, W. R., 146Tucker, J. M., see Pendleton, R. G., 348, 362

Vascular changes, in acute tolerance to norepi-nephrine infusions, 270

Vascular smooth muscle, direct relaxant actionsof procaine and tetrodotoxin on, 60

Vasodilatation, of brainstem origin, suppressedby neuromuscular blockade in the cat, 333

Venom, Brazilian scorpion (Tityus serrutatus), anunusual sympathetic postganglionic stimu-

lant, 253

449

Ventricular fibrillation, induced by coronaryligation, prevention of, 326

Viktora, J. K., see Wales, J. K., 421Voile, R. L., see Jaramillo, J., 166

Wales, J. K., Krees, S. V., Grant, A. M., Viktora,J. K. and Wolff, F. W., 421

Watson, D. L., see Somani, P., 317Weinbren, M., see Reis, D. J., 135

Weiner, N. and Rabadjija, M., 103Westfall, D. P. and Fleming, W. W., 259Whited, B. L., see Albuquerque, E. X., 191Wolff, F. W., see Wales, J. K., 421

Wong, S. and Long, J. P., 176

Yamamura, H. I. and Horita, A., 82Yard, A. C., see Gomez, H. J., 270

Zoxazolamine, metabolism, effect of diphenyl-

piperazine compounds and other agents on, 232Zwanziger, J., see Bliss, E. L., 122