FOR A PEACEFUL PREGNANCY...

Becoming a parent is one of the most beautiful and life-changing

experiences, but at the same time this period is full of responsibilities,

questions and the desire to do everything right.

ovo prenatal offers you professional services to reassure and guide

you throughout this beautiful experience.

Its professional team is specialized in the field of women’s health, more

specifically, obstetrics, gynecology, cytogenetics, ultrasound imaging,

osteopathy, and laboratory analyses.

THE MULTIDISCIPLINARY TEAM

OF SPECIALISTS AT OVO PRENATAL

OFFERS YOU RELIABLE TESTS

AND PROFESSIONAL ASSISTANCE

TO RESPOND TO YOUR NEEDS

THROUGHOUT YOUR PREGNANCY

EXTENDED BUSINESS HOURS,

FOR OPTIMAL APPOINTMENT FLEXIBILITY

SPACIOUS AND WELCOMING OFFICES

FOR MAXIMUM COMFORT AND PRIVACY

EQUIPMENTS AND TECHNICS AT THE CUTTING

EDGE OF TECHNOLOGY

FASTER AND MOST ACCURATE RESULTS

A HOME COLLECTION SERVICE

FOR OUR LABORATORY TESTS (ANA-LYSE)

During your pregnancy, one of the first steps is to assess your baby’s risk ofsuffering from a genetic disorder.

The prenatal screening tests ovolution rely on the analysis of differentparameters, or risk markers as determined by an ultrasound (nuchaltranslucency, nasal bone, etc) and blood test at the 1st trimester. In 20% ofcases, a blood test is required in the 2nd trimester (From 15 weeks and 2 days).

The prenatal screening test ovolution is a sequiential contigented screeningtest to detect trsiomy 21, 18, and 13.

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HIGH RATE OF DETECTIONGENETIC ANOMALIES Done in 45 minutes (ultrasound and the blood test). he detection rate forgenetic anomalies is evaluated at 95 %

Ultrasound done between 11 weeks 4 days and 13 weeks 6 days. At theend of the examination you will receive a full report, pictures and a DVD.

Blood test done the same day to evaluate the levels of certain hormones.

Many screening and diagnostic tests are available to meet your needs.

Each trimester is characterized by specific markers. The gestational ageindicates which type of test is required in order to fully asses the risk ofyour baby to have a genetic abnormality such as trisomy 18 and 21.

Based on the recommendations of your doctor, it is possible to do aprenatal screening test ovolution, a prenatal screening test nukleo, aprenatal diagnostic test such as amniocentesis or ultrasounds.

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1 EARLY REASSURANCE done during pregnancy’s 1st trimester 11th week + 4 days to 13th week + 6 days

2 A NON-INVASIVE TESTsafe test for both mother and baby

3 RELIABILITYdetection rate up to 95%

4 RESULTS REPORTED IN 2-3 BUSINESS DAYSa copy of the report will be sent to your doctor

FOR FASTER AND PERSONALIZEDAPPROACH

4 RESULTS IN 2 HOURSavailable on site or by phone

5 PERSONALIZED GENETIC COUNSELINGour genetic team will explain the results of the test to youand the recommended follow-up

OUR PRENATALSCREENING TEST

OVOLUTION RESULTS MAY INDICATEA low risk means that no further test are needed.

A medium risk means that you will need the ovolution 2nd trimester, afterwhich your risk will be recalculated.

A high risk means that you will need a diagnostic test such as amniocentesisor chorionic villous sampling.

No further test AmniocentesisCVS

1ST TRIMESTER - 11 W. 4 DAYS TO 13 W. 6 DAYS

LOW RISK<1:1000

MEDIUM RISK1:1000 - 1:100

HIGH RISK>1:100

2ND TRIMESTER - 15 W. TO 20 W. 6 DAYS

LOW RISK<1:200

HIGH RISK>1:200

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A PERSONALIZED FOLLOW-UPOF THE WELL-BEING OF YOUR CHILD

SCREENING FOR NEURAL TUBE ANOMALIES (SPINA BIFIDA)Recommended to patients with risk factors such as family history or previousabnormal screening.

The screening includes a blood test done between the 15th and 20th weeks todetermine the AFP level and a detailed morphologic 2nd trimester ultrasoundbetween 18 and 22 weeks.

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PRENATAL SCREENING BY FETAL DNA IN MATERNAL BLOOD

NON-INVASIVE TEST

ORIGINAL TECHNIQUE

HIGHER DETECTION RATE

RESULTS IN 72 HOURS

WHAT IS NUKLEO ? nukleo is a non-invasive prenatal test used to screen for trisomy 21 (Downsyndrome) and other fetal chromosomal abnormalities.

nukleo is performed on a simple maternal blood sample. As early as the ninthweek of pregnancy, it can accurately determine the probability of the fetushaving Down syndrome or another chromosomal abnormality such as trisomy13 or 18. nukleo can also be used to determine the sex of the fetus at yourdoctor’s request. The detection rate for trisomy 13, 18 and 21 is higher than99%.

nukleo considerably reduces the need for invasive procedures, such asamniocentesis and chorionic villus sampling, which are responsible formiscarriages in approximately 0.5 to 1% of cases.

If the nukleo test result is positive (indicating a high risk for a trisomy), aninvasive diagnostic test will be recommended to confirm the result.

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NATURE AND PRINCIPLE OF THE TESTnukleo analyzes fragments of fetal DNA present in the maternal blood duringpregnancy. Note that fetal DNA accounts for only about 10% of the DNApresent in maternal blood, as of the ninth week of pregnancy.

While nukleo is a genetic test, its purpose is not to analyze the fetus’sgenome, but rather to evaluate the proportion of fragments from chromosomes13, 18, and 21. A fetus with trisomy 13, 18 or 21 will have extra geneticmaterial.

nukleo is a powerful and patented test developed by the scientists at cliniqueovo.

TEST PROCEDUREBlood sample from the motherFrom the ninth week of pregnancy, thepregnant woman can do the prenatal testnukleo, with a prescription from her doctor.A simple blood test (2 tubes of 10mL each)will be required.

AnalysisThe fetal DNA in maternal blood will be analyzed by our geneticists in a recordtime, because of an advanced technology and a specific process.

Report sent to your doctorThe results will be sent to the referring physician, who will contact the patientwithin three to five days.

A DOCTOR'S PRESCRIPTION IS REQUIRED TO ACCESS THE NUKLEO TEST. THE SEX

OF THE FETUS IS NOT REVEALED EXCEPT UPON WRITTEN REQUEST OF THE

PRESCRIBING PHYSICIAN..

nukleotest.com

OBSTETRICAL ULTRASOUNDS

At clinique ovo the ultrasounds are done using the latestultrasound equipment. At the end of the examination you willbe given an ultrasound report and a DVD with your baby’spictures (no additional fees).

FIRST TRIMESTER ULTRASOUND is done between 11 weeks + 4 days and 13 weeks + 6 days toquantify the risk of genetic abnormalities by measuring the nuchaltranslucency (NT) and other markers such as nasal bone.

SECOND TRIMESTER ULTRASOUND also called morphologic ultrasound. It is done between 18 and 22 weeksto asses the fetal anatomy by examining the head, thorax, abdomen, spineand limbs. It can also detect the sex of the baby if the baby is in a goodposition.

THIRD TRIMESTER ULTRASOUND is done to monitor the well-being of the baby by doing the fetalbiophysical profile. We will examine baby’s body movements,breathing movements, tone, amniotic fluid and heart rate. Theevaluation of the estimated weight will also be done.

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An amniocentesis consists of obtaining a small amount of amniotic fluid thatsurrounds the baby. The conventional genetic analysis is available in 8 days.This test is used for the detection of chromosomal anomalies.

The FISH analysis offers results within 24h. This test detects majorchromosomal anomalies such as trisomy 13, 18, 21, anomalies ofchromosome X and Y.

The risk of miscarriage associated with this test is 0.5%.

This diagnostic test is suggested to all the patients who have risk factors or ahigh risk during the first or second trimester screening test.

It is usually done after 15 weeks.

AMNIOCENTESIS

CHORIONIC VILLOUS SAMPLING

Chorionic villous sampling consists of obtaining a sample from the exteriorsurface of the placenta (chorionic villous). The test can be performed throughthe cervix or through the abdomen. The sample is then analysed in our lab todiagnose genetic disorders in the foetus.

Offered to patients between 10-12 weeks, the procedure generates a 1 to2% risk of miscarriage.2)

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FREQUENTLY ASKED QUESTIONS

What is the difference between trisomy 21 and 18?

Trisomy 21, also known as Down syndrome, is a genetic disorder that affects one in

every 700 babies born in Canada. The condition is associated with various degrees of

cognitive impairments as well as other health conditions such as congenital heart

defects.

Trisomy 18 or Edwards Syndrome is another genetic disorder associated with sever

malformations.

What does a positive result in the prenatal screening test for trisomy 18 or

trisomy 21 indicate?

A positive result indicates an elevated risk of giving birth to a baby who may suffer from

one of these genetic disorders. The presence or absence of such a disorder can be

confirm by prenatal diagnosis.

What is the significance of the nuchal translucency measurement?

An ultrasound can measure the nuchal translucency. This test will assess the amount

of fluid behind the neck of the fetus. Babies at risk for a genetic disorder have a

tendency of having a higher amount of fluid around the neck.

Can I do the ovolution if I am having twins?

Yes, you can. ovolution is now available for twin pregnancies. A complete ultrasound

is performed on both of the babies

Can I do ovolution, if my ultrasound is done somewhere else?

We can calculate the risk even if your ultrasound was done outside than our clinic,

please bring the ultrasound report with you (results from the ultrasound may change

the detection rate of the test).

What is FISH?

FISH is a very useful technique used for identifying the most frequent chromosomal

abnormalities seen at birth, such as trisomy 21, 18 and 13. As well as the abnormalities

found in the X and Y chromosomes. F.I.S.H. is 99% reliable and can provide results in

24 hours. In order to perform this diagnostic test, 2 to 5ml of extra amniotic fluid is

taken during an amniocentesis

1. Cuckle et al. Down syndrome screening in the first and/or second trimester: model predicted performance using meta-analysisparameters. Semin. Perinatol. 2005 Aug ; 29(4): 252-7.

2. Faris et al. Procedure-Related. Complications of amniocentesis and chorionic villus sampling: A systemic review. Obst-gyn2007; 110: 687-94.

A SUPPORT THROUGHOUTYOUR PREGNANCY

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PREGNANCY FOLLOW-UP

PSYCHOLOGICAL SUPPORT

OSTEOPATHY

PRENATAL SESSIONS& SUPPORT AT BIRTH

In collaboration with Professor Howard Cuckle, Emeritus at University of Leedsand perkin elmer company, the scientific team at ovo r&d is conducting aclinical study over a 5 years period, enrolling 2 000 pregnant women in orderto evaluate the benefits of measuring first trimester risk marker such asPlacental Growth Factor (PlGF) and Progesterone-Induced Blocking Factor(PIBF) for the detection of early onset preeclampsia, as well as their use as apotential marker for Trisomy 21 and other aneuploidy That study is a noninterventional study and our goal is to better understand the onset ofpreeclampsia and how it may be treated.

FIRST TRIMESTER EVALUATION OF A NEW POTENTIAL SERUM MARKER INDETECTING EARLY ONSET PREECLAMPSIA

ADDITIONAL INFORMATIONSUR CE PROJET DE RECHERCHETo have more information about this research project you can contact theproject manager at (514) 798-2000 extension 755 or at r-d@cliniqueovo.comor cliniqueovo.com section r&d

ABOUT OVO R&DSince 2008, the ovo r&d department coordinates clinical researchactivities to translate scientific findings into medical advances.Based on the expertise of a multidisciplinary research teamcomposed of medical specialists, renowned scientists, nurses andresearch assistants, ovo r&d is dedicated to improve knowledgein the fields of obstetrics, gynecology, fertility and genetics ofreproduction.

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MultiplePregnancy

PRENATAL SCREENING TESTS

OVOLUTION *

Ultrasound + blood test $ 395 $ 495

Blood test only** $ 265 -

OVOLUTION EXPRESS (2 hours results) *

Ultrasound + blood test $ 450 -

Blood test only** $ 325 -

OVOLUTION 2nd trimester

4 markers $ 300

NUKLEO

Prenatal screening for fetal DNA in maternal blood $ 625

SCREENING FOR NEURAL TUBE ANOMALIES (Spina Bifida)

Blood test + 2nd trimester ultrasound $ 320

OBSTETRICAL ULTRASOUNDS (2D + 3D) *

Échographie de datation $ 125

1st trimester $ 155 $ 250

2nd ou 3rd trimester $ 215 $ 270

* Ultrasound report, pictures and DVD included. ** If the ultrasound has been performed at your doctor is office. Please bring the ultrasound report.

DIAGNOSTIC TESTS

AMNIOCENTESIS

Collection of fluid (caryotype) $ 265

Conventional genetic analysis $ 252

Genetic analysis by F.I.S.H. $ 370

CHORIONIC VILLUS SAMPLING

Biopsy $ 250

Genetic analysis $ 750

PREGNANCY FOLLOW UP

For more information on our services, call us 514-798-2000 ext. 2

All applicable taxes are extra. Prices are subject to change without notice.

OUR PRICES THE MAJORITY OF PRIVATE INSURANCE COMPANIES MAY COVER THE

FEES PAID. PLEASE ASK YOUR INSURANCE COMPANY.

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