fMRI BASIC LOGIC OF NEUROIMAGING (functional magnetic ...
Transcript of fMRI BASIC LOGIC OF NEUROIMAGING (functional magnetic ...
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BASIC LOGIC OF NEUROIMAGINGfMRI
(functional magnetic resonance imaging)
Bottom line on how it works:
Adapts MRI to register the magnetic properties of oxygenated and deoxygenated hemoglobin, allowing real-time blood flow to be imaged.
Neuroimaging vs. other methods Hemoglobin
Brilliant Insight! From Stimulus to BOLD
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BOLD Time CoursefMRI Setup
Subtraction Method Let’s be a bit more specific
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Slice Thicknesse.g., 6 mm
Number of Slicese.g., 10
SAGITTAL SLICE IN-PLANE SLICE
Field of View (FOV)e.g., 19.2 cm
VOXEL(Volumetric Pixel)
3 mm
3 mm6 mm
Slice Terminology
Matrix Sizee.g., 64 x 64
In-plane resolutione.g., 192 mm / 64
= 3 mm
Statistical Mapsuperimposed on
anatomical MRI image
~2s
Functional images
Time
~ 5 min
Time
fMRISignal
(% change)
ROI Time Course
Condition
Activation Statistics
Region of interest (ROI)
Example
Knutson, B., Wimmer, G. E., Kuhnen, C. M., & Winkielman, P. (2008). Nucleus accumbensactivation mediates the influence of reward cues on financial risk taking. NeuroReport, 19, 509-513.
Sex Sells Risk
Emotional Influence in Nevada Of course, sex works!
But how does it work?
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“Cold and dry” view: Influence via activation of evaluative concepts
“success, risk,
fun, play”, etc
Gamble?YES!
“Hot and juicy” view:
Influence via activation of core-reward processes Gamble?
YES!
Sexy Gambles
All males, Paid $20 per hour
$10.00 cash endowment. Plus their earnings (positive or negative) from gambling during the task.
54 trials
Task learned well before the scanner
Fully informed (and convinced) about non-informativeness of affective pictures
Sexy Gambles: Procedure
Dependent Measures
Behavior (% gambles)
fMRI of “reward system”
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60
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Risky Choice Shifts to Risk
PositiveNeutralNegative
Sexy Gambles: Behavioral Results% of risky choices out of total
choicesPositive pictures enhance risky choice and shifts to risky choice
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“reward system”
Conjunction (ps<.01)
Anticipation of High vs. Low Risk Shfit
Positive vs. Negative Stimuli
Activation differences in Nucleus Accumbens (Nacc)
Mediation via “juicy” mechanisms?Anticipatory NAcc activation partially mediates the
influence of positive stimuli on subsequent shifts to the high risk option
(t-scores above paths, *p<.025, †p<.05; one
BIG PROBLEM IN PSYCHOPHYSIOLOGY:REVERSE INFERENCE
Example: Perils of Reverse Inference:New York Times Story on “Politics and the brain”
ORIGINAL
http://www.nytimes.com/2007/11/11/opinion/11freedman.html
RESPONSE
http://www.nytimes.com/2007/11/14/opinion/lweb14brain.html
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DISGUST = INSULA THEREFORE INSULA = DISGUST
BIG PROBLEM IN PSYCHOPHYSIOLOGY:REVERSE INFERENCE
Psychological state -> Physio. Change , Thus if Physio. change then Psychological state must
have occurred.
Polygraph: lying -> GSR, thus GSR = lying fMRI: mentalizing = OFC activity, thus OFC activity =
mentalizing. EMG: Happiness-> smile, thus smile->happiness
BUT: GSR = anxiety, OFC = complexity, Smile = politeness
What is the mapping between psychological and physiological domain? (cacioppo)
Many to one?
One to one?
One to Many?
Many to many!
What is the relative probability of an physiological activation given psychological event (and vice versa)
POLDRACK
MORE PROBLEMS IN PSYCHOPHYSIOLOGY:INFLATED CORRELATIONS
Many papers report very high correlation between physiological response and some behavioral measure.
Why? And How?
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Correlation between activity in a ventral MPFC cluster and ADI-R social score
r = 0.94(88% of variance!)
Correlations between the right posterior STS and ADI-R
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Slice Thicknesse.g., 6 mm
Number of Slicese.g., 10
SAGITTAL SLICE IN-PLANE SLICE
Field of View (FOV)e.g., 19.2 cm
VOXEL(Volumetric Pixel)
3 mm
3 mm6 mm
Slice Terminology
Matrix Sizee.g., 64 x 64
In-plane resolutione.g., 192 mm / 64
= 3 mm
They did what?Why running so many correlations ‘guarantees” some very high results?
The number of tests run statistically guarantees that regardless of the true correlations present, some will be very high.
Analogy: A new test of ‘coolness” to 12 people. The test has 1,000 questions. A subset or one of these questions will correlate highly with your external
criterion. SOME of this is just due to favorable noise (accidental lining up). Thus, there is an inflation. (i.e., this question would not correlate as
highly in the next sample).
Your “winner” in the correlation race, is not as strong/fast as he seems.
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Does this matter? YES!
Science is a quest to understand causal mechanisms. Theory 1 vs. Theory 2 vs Theory 3
Misleadingly high correlation give us false leads about what mechanisms/locations are important. E.g., mirror neuron area in autism vs. other areas?
Medical conclusions and implications for treatment.
Closing
Picking out the highest correlation out of thousands of voxels leads to overestimation
Highest correlations in “social neuroscience” are often obtained in this manner:
Simple solutions exist to avoid these problems!