Functional Magnetic Resonance Imaging (fMRI) of the Olfactory System
fMRI (functional magnetic resonance imaging) research wins
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Best practices for neuroimaging.
Transcript of fMRI (functional magnetic resonance imaging) research wins
5 fMRI Research Wins1) Have a Theory
2) Build a Behavioral Base
3) Design, Redesign
4) Create an Analysis Hitlist
5) Make Writing Fast (& Fun)
1) Have a Theory
A theory can be proved by experiment;but no path leads from experimentto the birth of a theory.
- Manfred Eigen
- Begin with the neuroanatomy
- Account for previous results
- Make specific, falsifiable predictions
1) Have a Theory
Ashby et al. (1998) Ashby, Paul, & Maddox (2011)
COVIS (Competition Between Verbal and Implicit Systems)
SPEED (Subcortical Pathways Enable Expertise Development)
Ashby, Ennis, & Spiering (2007)
Pessoa & Adolphs (2011)
Pessoa (2011)
Pessoa (2011)
2) Build a Behavioral Base
All life is an experiment.The more experiments you make the better.
- Ralph Waldo Emerson
2) Build a Behavioral Base
- Understand the literature
- Pick the low hanging fruit
- Simplify, simplify, simplify
Category Learning Task
Category Learning Stimuli
Unstructured Categorization
Rule-Based Categorization
Information-Integration Categorization
Experiment 1 - Within
Experiment 1 - Within
Training Accuracy
Experiment 1 - Within
Transfer Accuracy
Experiment 2 - Between
Experiment 2 - Between
Training Accuracy
Experiment 2 - Between
Transfer Accuracy
3) Design, Redesign
Design is not just what it looks like. Design is how it works.
- Steve Jobs
3) Design, Redesign
- Define project outcome
- Thrash Now
- Create a devil’s advocate
fMRI Methods
Results
Results
Results
ResultsResults
4) Create an Analysis Hitlist
It's not the plan that is important,it's the planning.
- Dr. Graeme Edwards
4) Create an Analysis Hitlist
- Door wide open
- Think through all steps
- 2 week sprints
Expectancy violation in cadence perception
Standard Ending
Deceptive Ending
Modulation Ending
Atonal Ending
Music-related Activations
Music > Silence Baseline
Ending-related Activations
All Ending > Music Baseline
Cortex Activation by Ending
Anatomical ROIs
Standard Ending - .01
Deceptive Ending - .02
Modulation Ending - .05
Atonal Ending - .99
Parametric Regressor
Basal Ganglia Parametric Activation
Granger Causality Modeling
5) Make Writing Fast (& Fun)
The faster I write the better my output.If I’m going slow I’m in trouble.It means I’m pushing the words instead of being pulled by them.
-Raymond Chandler
Analysis Paper
Door Open Door Closed
Team Single Advocate
Compile Winnow
Smith, Ashby, Berg, Murphy, Spiering, Cook, & Grace, 2011
F. Greg Ashby Carol A. Seger
Erik J. Peterson
Dan Lopez-Paniagua
Kurt Braunlich
Anastasia SaresAlexander Gonzalez
Catie AlpeterSarah Quraini
Collaborators
