FENOMENE DEFENOMENE DE TRANSPORT -...
Transcript of FENOMENE DEFENOMENE DE TRANSPORT -...
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FENOMENE DEFENOMENE DEFENOMENE DE FENOMENE DE TRANSPORTTRANSPORTTRANSPORT TRANSPORT
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OSMOZA
Dispozitiv experimental, definiţie
1877
WILHELM PFEFFERWILHELM PFEFFERWILHELM PFEFFERWILHELM PFEFFER
1845 1845 -- 19201920
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DEFINIŢIE:DEFINIŢIE:
TRANSPORTUL MOLECULELOR DE SOLVENT PRINTR-O MEMBRANĂ SEMIPERMEABILĂ
Ă ÎDINTR-O SOLUŢIE MAI DILUATĂ ÎNTR-O SOLUŢIE MAI CONCENTRATĂ
SOLUŢIE DILUATSOLUŢIE DILUATĂĂSOLUŢIE DILUATSOLUŢIE DILUATĂĂ
SOLVENTSOLVENT
SOLUŢIE CONCENTRATSOLUŢIE CONCENTRATĂĂ
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p
hggShgVgmGp ρρρ===== presiune
Presiunea osmotică = presiunea mecanică necesară împiedicării osmozei
hgSSSS
p ρ===== presiunehidrostatică
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hg= ρπOsmometrul Dutrochet hg ⋅⋅= ρπ
hh
HENRI DUTROCHETHENRI DUTROCHET
1776 1776 -- 18471847
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Formula presiunii osmotice
VTRVp :⋅⋅=⋅ ν TRc ⋅⋅=π
LEGEA VAN’T HOFFLEGEA VAN’T HOFF
)25(atmL25 CtTR o=⋅
=⋅ )25(mol
25 CtTR
1901 1901 P mi l N b l (Chimi )P mi l N b l (Chimi )
JACOBUS HENRICUS JACOBUS HENRICUS
1901 1901 –– Premiul Nobel (Chimie)Premiul Nobel (Chimie)
VAN’T HOFFVAN’T HOFF
1852 1852 -- 19111911
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cTR ⋅⋅=π osmcTR ⋅⋅=π∑ ⋅= iiosm cnc ∑
iiiosm
LEGEA VAN’T HOFF GENERALIZATĂLEGEA VAN’T HOFF GENERALIZATĂ
ni > 1 pentru electroliţii tari
ni ≈ 1 pentru electroliţii slabi
ni = 1 pentru neelectroliţini 1 pentru neelectroliţi
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?APLICAŢIEAPLICAŢIE
111 mg ( 111)m CaCl MmLV 100=
os ?c = 1 2 1111 mg ( 111)m CaCl M= =
2 260 mg ( 60)m uree M= =2 2g ( )3 3 317 mg ( 17)m NH M= =
32 12
2 =+⎯→⎯ −+ nClCaCaCl
12 =⎯→⎯ nureeuree
133 ≅− nslabelectrolitNH
2os 1 1 2 2 3 3 5 10 osMc n c n c n c −= + + = ⋅
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)25(l
atmL25 CtTR o=⋅
=⋅
⎛ ⎞ ⎛ ⎞
mol
2os
mol L×atm5 10 25 1,25 atmL mol
c RTπ − ⎛ ⎞ ⎛ ⎞= = ⋅ ⋅ =⎜ ⎟ ⎜ ⎟⎝ ⎠ ⎝ ⎠
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1 METODE DIRECTE (OSMOMETRU)
Metode de determinare a presiunii osmotice1. METODE DIRECTE (OSMOMETRU)
hh
hg ⋅⋅= ρπ
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k ⎞⎛⎞⎛ Pamsm
mkghgp 5
233 10)(101010 =⋅⎟
⎠⎞
⎜⎝⎛⋅⎟
⎠⎞
⎜⎝⎛== ρ
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E D EB P E D EB P ĂĂ2. METODE INDIRECTE
A. METODA EBULIOSCOPICA. METODA EBULIOSCOPICĂĂ
l tl ti pursolventf
solutiefeb ttt −=Δ
osebeb cKt ⋅=Δ )(/52,0 apaMCK oeb =
LEGEA LUI RAOULTLEGEA LUI RAOULT
ebtTR Δπ )(32
)(52,0 2
CClinCt
OHinCto
b
oeb
=Δ
=Δ
eb
eb
KTR ⋅=π )(32 4CClinCteb =Δ
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B. METODA CRIOSCOPICB. METODA CRIOSCOPICĂĂ
solutiet
pursolventtcr ttt −=Δ
cKt ⋅=Δ
LEGEA LUI RAOULTLEGEA LUI RAOULT
oscrcr cKtΔ)(/86,1 apaMCK o
cr =LEGEA LUI RAOULTLEGEA LUI RAOULT
APLICAŢII: APLICAŢII:
crtTR Δ⋅=π
-- antigelulantigelul
-- topirea topirea gheţii (NaCl sau CaCl2 ?)
crKTR=π pp g ţ ( 2 )
- determinarea masei molecularemoleculare
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1)1) METANOL CHMETANOL CH33OHOH
toxic;toxic;toxic;toxic;
foarte volatil;foarte volatil;
i fl bili fl bil
2) ETILENGLICOL (CH2) ETILENGLICOL (CH22))22(OH)(OH)22
inflamabil.inflamabil.
) E LEN L L ( H) E LEN L L ( H22))22( H)( H)22folosit din 1926;folosit din 1926;
foarte solubil în apă;foarte solubil în apă;foarte solubil în apă;foarte solubil în apă;
toxic (toxic (insuficienţă renală)insuficienţă renală)
3) PROPILENGLICOL (CH3) PROPILENGLICOL (CH22))33(OH)(OH)22f l it î i d t i li t ă f l it î i d t i li t ă folosit în industria alimentară, folosit în industria alimentară,
farmaceutică şi cosmeticăfarmaceutică şi cosmetică
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Presiunea osmotică a plasmei sanguine
COMPOZIŢIA PLASMEICOMPOZIŢIA PLASMEI
IONI: NaIONI: Na++, K, K++, , ClCl––, Ca, Ca2+2+
MOLECULE MICI: GLUCOZMOLECULE MICI: GLUCOZĂĂ UREE UREEMOLECULE MICI: GLUCOZMOLECULE MICI: GLUCOZĂĂ, UREE, UREE
PROTEINE: ALBUMINE, GLOBULINEPROTEINE: ALBUMINE, GLOBULINE
PRESIUNEA OSMOTICPRESIUNEA OSMOTICĂ A PLASMEIĂ A PLASMEI
∑∑∑ ++= PROTEINEMICIMOLECULEIONIPLASMA ππππ ∑∑∑ ++ PROTEINEMICIMOLECULEIONIPLASMA ππππ
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SOLUT PLASMĂ LICHID
INTERSTIŢIAL CITOPLASMĂ SOLUT PLASMĂ (mosM)
INTERSTIŢIAL (mosM)
CITOPLASMĂ (mosM)
Na+ 144 137 10Na+ 144 137 10K+ 5 4,7 141
C 2+ 4Ca2+ 2,5 2,4 10 -4Cl- 107 112 4
AMINOACIZI 2 2 8ATP – −− 5
GLUCOZĂ 5,6 5,6 –PROTEINE 1,45 0,2 4
UREE 4 4 4
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osll cTR ⋅⋅=π
Mos 3030
plasmaplasma cTR=π
673030425
osMcosplasma 303,0=
atmplasma 6,7303,04,25 =⋅=π
SERUL FIZIOLOGIC (soluţie 0,9% NaCl)SERUL FIZIOLOGIC (soluţie 0,9% NaCl) !!!!!!
Studiu individualStudiu individual: Să se calculeze concentraţia procentuală
a unei soluţii de glucoză izotonice cu sângele de densitate ţ g g
1,091 g/mL
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CLASIFICAREA SOLUŢIILOR ÎN RAPORT CU CLASIFICAREA SOLUŢIILOR ÎN RAPORT CU SÂNGELE SÂNGELE
•• HIPOTONICEHIPOTONICE)67(
)3,0( osMccosos
osplasma
ossolutie <
SÂNGELE SÂNGELE
)6,7( atmosplasma
ossolutie ππ <
•• IZOTONICEIZOTONICE)(
)3,0( osMccosos
osplasma
ossolutie =
)6,7( atmosplasma
ossolutie ππ =
•• HIPERTONICEHIPERTONICE)3,0( osMcc os
plasmaossolutie >
HIPER ONICEHIPER ONICE)6,7( atmos
plasmaossolutie ππ >
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PRESIUNEA COLOID PRESIUNEA COLOID -- OSMOTICĂOSMOTICĂ
atmcTR t iplasma 036,01045,125 3 =⋅⋅=⋅⋅= −π atmcTR proteineco 036,01045,125π
lplasma
plasmaco mmHg ππ %5,028 ==
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ROLUL ROLUL ππco ÎN SCHIMBURILE CAPILAREco ÎN SCHIMBURILE CAPILARE
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p cahidrostatip
coπ
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•• CAPCAPĂĂT ARTERIAL:T ARTERIAL:CAPCAPĂĂT ARTERIALT ARTERIAL
Soluţia micromoleculară iese cocahidrostatip π>
ţdin capilar
(ULTRAFILTRARE)( )
ĂĂ•• CAPCAPĂĂT VENOS:T VENOS:
cocahidrostatip π<Soluţia micromoleculară
intră în capilar
(REABSORBŢIE)
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ÎnÎn cazulcazul malnutriţieimalnutriţiei::↓ sinteza proteinelor plasmatice- ↓ sinteza proteinelor plasmatice
- ↓ presiunea coloid – osmotică- ↑ fluxul de ultrafiltrarefluxul de ultraf ltrare- ↓ fluxul de reabsorbţie
⇒⇒ acumulareaacumularea de de lichidlichid înîn cavitateacavitatea abdominalabdominalăă
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DIFUZIA
DEFINIŢIE:DEFINIŢIE:
TRANSPORTUL DE SUBSTANŢTRANSPORTUL DE SUBSTANŢĂĂ DIN ZONELE DIN ZONELE DE CONCENTRAŢDE CONCENTRAŢIE MARE CĂTRE CELE DE IE MARE CĂTRE CELE DE DE CONCENTRAŢDE CONCENTRAŢIE MARE CĂTRE CELE DE IE MARE CĂTRE CELE DE
CONCENTRACONCENTRAŢŢIE MICĂ DATORITIE MICĂ DATORITĂĂ AGITAAGITAŢŢIEI IEI TERMICETERMICE
CARACTERISTICCARACTERISTICĂ:Ă:
GAZELORGAZELOR
LICHIDELORLICHIDELORLICHIDELORLICHIDELOR
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LEGILE LUI FICKLEGILE LUI FICK
1845 1845 –– legile difuzieilegile difuziei
ADOLF FICKADOLF FICK1829 1829 –– 19011901
1887 1887 –– lentila de contactlentila de contact1829 1829 19011901
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cddν1 2
LEGEA I A LUI FICK:LEGEA I A LUI FICK:
xdcdD
tdd
S−=
ν1s
cmD2
=
Flux (J ) Forţă (grad c)
kdcjdcidcc ++=grad
Flux (Jx) Forţă (gradxc)
LEGEA II A LUI FICK:LEGEA II A LUI FICK:
kdz
jdy
idx
c ++=grad
2 cdDcd= 2xd
Dtd=
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COEFICIENT DE DIFUZIECOEFICIENT DE DIFUZIE
MICROMOLECULE (M 10MICROMOLECULE (M 1033 D )D )• MICROMOLECULE (M < 10MICROMOLECULE (M < 1033 Da):Da):
/scm108 25
D−⋅ /scm10 25−≈D/scm
MD = /scm10≈D
• MACROMOLECULE (10MACROMOLECULE (1033 Da < M < 10Da < M < 1088 Da):Da):
1023 5−
/scm102,3 23 M
D ⋅= /scm10 28−≈D
• PARTICULE SFERICE:PARTICULE SFERICE:
Tk ⋅r
TkDηπ6⋅
= Stokes - Einstein
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ROBERT BROWNROBERT BROWNROBERT BROWNROBERT BROWN
1773 1773 -- 18581858
1827
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Ei t i Ei t i S l h kiS l h kitD22 Einstein Einstein -- SmoluchowskiSmoluchowskitD2x 2 =
D = 10 – 5 cm2/s
Ф = 10 – 3 cm (celulă bacteriană)t = 50 ms
0 c (celulă bacteriană)
D = 10 – 5 cm2/sD 10 cm /s
d = 1 cm (organism pluricelular)t ≅ 14 h
t2φ
=SISTEM CIRCULATORSISTEM CIRCULATOR D
t2
=
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Schimbul de gaze la nivelul alveolelor pulmonareSchimbul de gaze la nivelul alveolelor pulmonareşi l ţ sutu ilşi l ţ sutu ilşi al ţesuturilorşi al ţesuturilor
300 milioane300 milioanesuprafasuprafaţăţă 50 50 –– 100 m100 m22
puternic vascularizateputernic vascularizateperete subperete subţţire (30 ire (30 μμm)m)
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Oxigenul este transportat:Oxigenul este transportat:2% dizolvat 2% dizolvat în plasmăîn plasmă98% sub forma complexului Hb(O98% sub forma complexului Hb(O22))44