Featured Product of Selleck---INO-1001(Purity>99%)
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Product Information INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties. [1,2] INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5] Biological Activity [1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60 [2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1) [3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56 [4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23 [5] Szabó G et al. Shock. 2004 May;21(5):426-32 References S1132 INO-1001 Technical Data: M.Wt: Formula: Solubility: Purity: Storage: CAS No.: 136.15 C 7 H 8 N2O DMSO 99% at -20℃ 2 years 3544-24-9 Fax: +1-713-796-9816 Toll Free: (877)796-6397 -- USA and Canada only -- © Copyright 2010 Selleck chemicals. Orders +1-713-922-4115 [email protected] Web www.selleckchem.com Tech Support [email protected] (chemistry support) [email protected] (bio support) Please visit www.selleckchem.com to download MSDS and CoA. MSDS & CoA Return Policy Selleck Overnight Delivery Service » PARP NH 2 O NH 2 Novel Life Science Reagents for Cell Signaling Research Please inspect packages immediately upon receipt and notify customer service within 3 days of delivery of any damage or discrepancies.Our team will take quick and appropriate action to correct any problem. Goods ordered in error can only be accepted for return if made within 3 days of delivery, are unopened,have been stored correctly and are in good condition. Should you wish to return any item(s), prior authorization must be received from our customer service team. Returns accepted will be subject to a 30% restocking charge. For all product returns and product replace- ments,please contact Selleck directly by [email protected] or +1-713-922-4115 Please have on hand, the invoice number, purchase order number,air bill number and approximate date of shipment/receipt. Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended storage temperature,most are recommended stored at -20 . Many products are stable in the short-term at temperatures that differ from that required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage recommendations on the product data sheet. ℃ Notes NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE. PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
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Technical Data:M.Wt: 136.15Formula: C7H8N2OSolubility: DMSOPurity: >99%Storage: at -20℃ 2 yearsCAS No.: 3544-24-9Biological Activity of INO-1001:INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties[1,2]. INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5]References on INO-1001:[1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60[2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1)[3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56[4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23 [5] Szabó G et al. Shock. 2004 May;21(5):426-32
Transcript of Featured Product of Selleck---INO-1001(Purity>99%)
Product Information
INO-1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme PARP (poly (ADP-ribose) polymerase) with chemosensitization and radiosensitization properties.[1,2]
INO-1001 inhibits PARP, which may result in inhibition of tumor cell DNA repair mechanisms and, so, tumor cell resistance to chemotherapy and radiation therapy. PARP enzymes are activated by DNA breaks and have been implicated in the repair of DNA single-strand breaks (SSB). In addition,INO-1001 improves the recovery of myocardial and endothelial function after hypothermic cardiac arrest and reduces pulmonary injury associated with extracorporal circulation. [3,4,5]
Biological Activity
[1] Brock WA et al. Cancer Lett. 2004 Mar 18;205(2):155-60
[2] Kathryn A. Mason et al. Investigational New Drugs.2008 February;26(1)
[3] Besson VC et al.Brain Res. 2005 Apr 18;1041(2):149-56
[4] Tóth O et al. Life Sci. 2006 Jun 20;79(4):317-23
[5] Szabó G et al. Shock. 2004 May;21(5):426-32
References
S1132 INO-1001
Technical Data:M.Wt:Formula:Solubility:Purity:Storage:CAS No.:
136.15C7H8N2O DMSO99%at -20℃ 2 years3544-24-9
Fax: +1-713-796-9816
Toll Free: (877)796-6397-- USA and Canada only --
© Copyright 2010 Selleck chemicals.
Orders+1-713-922-4115
Webwww.selleckchem.com
Tech [email protected](chemistry support)
[email protected](bio support)
Please visit www.selleckchem.com to download MSDS and CoA.
MSDS & CoA
Return Policy
Selleck Overnight Delivery Service
» PARP
NH2
O
NH2
Novel Life Science Reagentsfor Cell Signaling Research
Please inspect packages immediately upon
receipt and notify customer service within
3 days of delivery of any damage or
discrepancies.Our team will take quick and
appropriate action to correct any problem.
Goods ordered in error can only be accepted
for return if made within 3 days of delivery,
are unopened,have been stored correctly and
are in good condition. Should you wish to
return any item(s), prior authorization must
be received from our customer service team.
Returns accepted will be subject to a 30%
restocking charge.
For all product returns and product replace-
ments,please contact Selleck directly by
+1-713-922-4115
Please have on hand, the invoice number,
purchase order number,air bill number and
approximate date of shipment/receipt.
Specific storage and handling information for each product is indicated on the product datasheet. Most Selleck products, stored under the
recommended conditions, are stable for two years. Products are sometimes shipped at a temperature that differs from the recommended
storage temperature,most are recommended stored at -20 . Many products are stable in the short-term at temperatures that differ from that
required for long-term storage. We ensure that the product is shipped under conditions that will maintain the quality of the product, but save
your shipping charges by using the most economical storage conditons for an overnight shipment. Upon receipt of the product, follow the storage
recommendations on the product data sheet.
℃
Notes
NOT FOR HUMAN OR VETERINARY DIAGNOSTIC OR THERAPEUTIC USE.
PLEASE KEEP THE PRODUCT UNDER -20℃ FOR LONG-TERM STORAGE.
