FcɛRI Signalling Pathway
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Transcript of FcɛRI Signalling Pathway
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FcɛRI Signalling Pathway
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The Ligand : IgE
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Mast and Basophil Cells
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• Fc receptors bind tail region of IgE antibodies.
•Histamine, proteases,
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The Receptor
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Tyrosine Kinases
Lyn
Syk
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The Pathway
•Binding of IgE•Aggregation of receptors
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Syk activation Cascade of reactions Degranulation
Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor.
Syk can also phosphorylate syk associated with adjacent receptor
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Allergy sufferers are at a lower risk of developing cancer
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•Inverse association between IgE and malignancies
•IgE-mediated immune responses against tumor cells
•IgE-based treatment options
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
Level
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
Level
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
Level
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
Level
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
Level
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
Level
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
LevelHistogram not generating all first passage times
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Second Outline Level
Third Outline Level
Fourth Outline Level Fifth Outline Level Sixth Outline
Level Seventh Outline
Level Eighth Outline
Level Ninth Outline
Level
But it wasn't so bad
Bngl easy to understand Easy to define chemical
reactions Can manipulate molecule
concentrations Can set time period of reaction