FcɛRI Signalling Pathway

The Ligand : IgE

Mast and Basophil Cells

• Fc receptors bind tail region of IgE antibodies.

•Histamine, proteases,

The Receptor

Tyrosine Kinases

The Pathway

•Binding of IgE•Aggregation of receptors

Syk activation Cascade of reactions Degranulation

Lyn binds beta unit of one receptor and transphosphorylates the beta ITAM, gamma ITAM, and Syk associated with adjacent receptor.

Syk can also phosphorylate syk associated with adjacent receptor

Allergy sufferers are at a lower risk of developing cancer

•Inverse association between IgE and malignancies

•IgE-mediated immune responses against tumor cells

•IgE-based treatment options

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Second Outline Level

Third Outline LevelFourth Outline Level

Fifth Outline Level Sixth Outline

Level Seventh Outline

Level Eighth Outline

Level Ninth Outline

LevelHistogram not generating all first passage times

Level Ninth Outline

But it wasn't so bad Bngl easy to understand

Easy to define chemical reactions

Can manipulate molecule concentrations

Can set time period of reaction

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