Fast actingComplex formulations

Clinically proven ingredients

PharmaClinix Ltd, 130 Bramley Road, Kensington, London, W10 6TJ, UK

UK’s top selling Professional Skincare

LIGHTENEX® GOLD

SCAR REPAIREX® ULTRA

PHOTO AGEX®

ANTI AGEX®

PHOTO AGEX®

INGREDIENTS:L-ASCORBIC ACID -10%ASCORBYL TETRA ISOPALMITATE -5%GLYCOLIC ACID - 6%L-LACTIC ACID - 5%RETINALDEHYDE - 0.6% (HIGH STRENGTH)HYALURONIC ACID - 5%FERULIC ACID 0.5% & MIXED TOCOPHEROLSSALICYLIC ACID - 2%ALOE VERA (SOOTHING)

The scientific supporting evidence for using these ingredients and concentrations to manage Photo damage is presented in the following slides.

*Store in cool place

PHOTO AGEX®

Vitamin C

10% L- ASCORBIC ACID & 7% ASCORBYL TETRA ISOPALMITATE

COMBINATION OVER 12 WEEKS: REDUCES PIGMENTATIONREDUCES WRINKLESREDUCES INFLAMMATIONIMPROVES HYDRATIONINCREASES GRENZ ZONE COLLAGEN & mRNA FOR TYPE 1 COLLAGEN.

Photo Agex® contains 10% L-Ascorbic acid & 5% Ascorbyl Tetraisopalmitate.

REF 1Fitzpatrick RE,Rostan EF.Dept of Medicine/Dermatology, University of California, San Diego, California.Double Blind half-face study comparing topical Vitamin C and vehicle for Rejuvination of Photo damage. Dermatol Surgery 2002;28:231-236

PHOTO AGEX®

Alpha hydroxy acids

Photo agex® contains Glycolic acid 6% & Lactic acid 5%Topical 8% Glycolic acid is superior to vehicle cream in overall reversal of Photo damage.Topical 8% Lactic acid is Significantly Superior to vehicle cream in reversing Photo damage, mottled hyper-pigmentation, sallow skin and roughness.

REF 2Topical 8%Glycolic acid and 8% L-lactic acid creams for the treatment of Photo damaged Skin.A double-blind vehicle controlled clinical trial. Arch Dermatology 1996 June;132(6):631-6.Stiller MJ, Bartolone J,Stem R,Smith S,Kollias N,Gillies R,Drake LA.Dermatology Clinical Investigations Unit, Massachusetts General Hospital, Boston USA.

PHOTO AGEX®

Best Retinoid

Cosmeceuticals containing Retinaldehyde have been shown in large randomized clinical trials to have the most beneficial effect on ageing skin.Photo agex® has 0.6% (high strength) Retinaldehyde.

REF3Aesthetic Surg Journal.2010 Jan;30(1)74-77.Cosmeceuticals:the evidence behind the retinoids.Babamiri K,Nassab R.Wrightington,Wigan and Leigh NHS Foundation Trust.UK.

PHOTO AGEX®

Retinaldehyde

Epidermal and Dermal concentrations of Retinaldehyde and Retinoic acid were higher after Retinaldehyde with Glycolic acid as compared to both Retinaldehyde 0.1%alone and Retinoic acid 0.05% alone, the presence of glycolic acid increases conversion of Retinaldehyde to Retinoic acid

Photo Agex® contains 0.6% retinaldehyde & 6% Glycolic acid.

REF 4) Pharmacology of RALGA, a mixture of Retinaldehyde & Glycolic acid. Christian tran, Behrooz Kasree, Denise Grand, Pierre Carraux, Liliane Didierjan, Oliver Sorg, Jean-Hilaire Saurat. Dept of Dermatology, University Hospital, Geneva, Switzerland. Dermatlogy2005;212(suppl.1):6-13(DOI:10.1159/000082542).

PHOTO AGEX®

Retinaldehyde & Glycolic synergy (RALGA)

A Review of efficacy results of Pre-clinical & Clinical trials of Retinaldehyde 0.1% and Glycolic acid 6% tend to confirm the expectation for acne & post inflammatory hyperpigmentation treatment.

REF 5)Katsambas AD-Asygros Hospital,University of Athens,Greece.Dermatology.2005;210 Suppl1:39-45.

PHOTO AGEX®

RALGA

A combination of Retinaldehyde (0.1%) and Glycolic Acid ( 6%)has a higher skin depigmentation potential than Retinoic Acid (0.05%) in the tail skin of C57BL/6 MICE. Its depigmenting result was seen earlier than Retinoic acid ie only one week of application.

REF 6)The depigmenting effect of RALGA in C57BL/6 Mice.Kasree b,Tran C,Song O,Saurat JH.Dept of Dermatology,Geneve,Switzerland.Dermatology 2005;210 Suppl1:30-4.

PHOTO AGEX®

RALGA

Human skin explants were treated with Retinaldehyde 0.1% and Glycolic acid 6.4% for 14 days showed decrease in melanin content.The number of Melanocytes was not modified.

REF 7)

RALGA(Retinaldehyde&Glycolic acid )decreases melanin content in human skin model.Boisnic S,Brauchet-Guiula MC,Nocera T,Verriere F.Prof J C Bertrand Hospital,Pitie -Salpetriere ,Paris,France.Dermatology.2005;210Suppli1:35-38.

PHOTO AGEX®

Hyaluronic acid

Hyaluronic acid labelled with heavy hydrogen (3H) was shown by autoradiography to disseminate through all layers of intact skin in mouse and human skin.

Polymers of 360-400KDa were recovered from both blood and skin suggesting active absorption as such large molecules would not enter by diffusion alone.

Assist in carrying large vitamin C molecules deep into the dermis.

REF8)Brown TJ,Alcom D,Fraser JR.Det of Biochemistry&Molecular Biology,Monash University,Melbourne,Victoria,Australia.The Journal of Investigative Dermatology(1999,113(5):740-746.

PHOTO AGEX®

Vit C, E & F Synergy

Ferulic acid Stabilizes a solution of Vitamins C & E and doubles the photo protection of skin.Photo agex contains 0.5% ferulic acid with vitamin C and mixed tocopherols.

REF9)J Investigative Dermatol.2005Oct;125(4):xii-xiii.Lin FH,Lin JY,Gupta RD,Tournas JA,Burch JA,SelimMA,Monteiro-Rriviere NA,Grichnik JM,Zielinski J,Pinnell SR.Duke University Medical Centre,Durham,North Carolina, 27710.USA.

PHOTO AGEX®

SUITABLE CASES FOR USING PHOTO-AGEX

Combination of Wrinkles & Hyper pigmentation with rough, sallow underlying

skin.

One week after peels of superficial acne skin as Retinaldehyde with Glycolic

acid and Vitamin C has very good anti-comedogenic action.

1 week after Fraxel for rejuvenation where hyperpigmentation is also present.

Start using initially three nights a week increasing frequency by one night per

week.

One week after Derma rolling or Microdermabrasion.

Conclusion

Photo Agex®Works

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