Exposure Reconstruction for the Epidemiologic Study June 2010.
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Transcript of Exposure Reconstruction for the Epidemiologic Study June 2010.
Exposure Reconstruction for the Epidemiologic Study
June 2010
Exposure Reconstruction
• Defines common exposure subgroups• Quantifies exposures for subgroups• If there is an excess, then seeks
association between exposures and effects
• If there is no excess effect, exposure reconstruction however refined will not associate an agent with an effect or explain an effect
UIC 2010
Exposure Reconstruction
• Performed on:– Parts manufactured– Processes used to manufacture parts– Individual agents
• Part and process analyzed to ensure any unsuspected agent that may be associated with a possible effect would not be missed
UIC 2010
Individually Examined Contaminants
• Cohort– Evaluate mortality and
work exposures• Chromium • Cobalt • Degreasing solvents• Ionizing radiation• Lead-cadmium• Magnetic fields• Metalworking fluids (oil
& water based)• Nickel
• Case-control– Evaluate CNS incidence
and more detailed work exposures
• All of the cohort exposures as well as:
• PCB’s• Metalworking fluid
combustion products specific to North Haven
UIC 2010
Exposure Reconstruction Protocol
• Leaves no stone unturned– Considers all suspected agents– Considers all employment categories as
defined by job dictionary – Considers all significant subgroups as defined
by parts– Considers all different aspects of work as
defined by manufacturing processes involved
UIC 2010
UIC 2010
Acknowledgement
The researchers would like to thank the Communications Facilitation Workgroup, P&W employees, union, and management personnel, and the CT Department of Public Health for their continued support and contributions to the study.