Endocytosis of virus and escape

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SYSTEMSSYSTEMSPR

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BIOCHEM GENETICS GENOMICSMOL. BIO

STEM

CELLS,

CLONING

REC. DNA

CELL

TYPE

3DSTRUCTURE

CELL BIOL

VIRUSES

CANCER

HUMAN

DISEASE

LIFELIFE

NERVOUS

FUTUREFUTURE

IMMUNE

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Virus: from the Latin noun virus,

meaning toxin or poison

“A virus is a bit of nucleic acid

surrounded by bad news.”

Sir Peter Medawar

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Viruses: Size and Shapes

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Herpes

Simplex

Virus

Ebola Virus

http://phil.cdc.gov/PHIL

ATTACHMENT

EN !DOSOME

ESCAPE

Fig. 13.4 modified

Endocytosis of virus and escape from endosome/lysosome

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HIV-1 ON SURFACE OF T CELL

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ATTACHMENT

EN !DOSOME

Fig. 13.4 modified

RNA

REPLICATION Influenza A

Life Cycle

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Fig. 19.17

The TCR-MHC complex

(MHC Class I or

MHC Class !II)

(CD4 or CD8)

(7-11 aa peptide)

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Vaccine types Example Good Bad

Killed Salk Polio safe not highly protective

Live attenuated Sabin Polio mimics disease possible reversion

Recombinant Hepatitus safe

SOME VIRAL VACCINES

Image from: en.wikipedia.org/wiki/Image:Rhinovirus.PNG

Surface of the capsid of human rhinovirus 16,

one of the viruses which cause the common cold

Slide 10 - 7.013 - 5/9/07 Image from: CDC Public Health Image Library (PHIL)

Influenza Virus

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Influenza Virus

1. The HA gene. It encodes the hemagglutinin, which helps virus bind to

epithelial cells. 3 distinct hemagglutinins, H1, H2, and H3) are found in

human infections; 13 others have been found in animal flu viruses.

2. The NA gene. It encodes the neuraminidase, which helps virus bud off

plasma membrane. 2 different neuraminidases (N1 and N2) have

been found in human viruses; 7 others in other animals.

Two of the RNA molecules encode:

Slide 12 - 5/9/07

Genome: 8 different RNA molecules

Endocytosis of virus and escape

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