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Transcript of Elske Brouwer-Brolsma. Презентация в рамках сессии о питании и...
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Intake of different types of dairy and the impact on type 2 diabetes risk in Dutch adults
Dr. Ir. EM Brouwer-Brolsma
Division of Human Nutrition, Wageningen University
Health effects of cheese/dairy matrix
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Outline
Background – dairy and type 2 diabetes
The Rotterdam Study
• Aim
• Dairy product classification
• Assessment of type 2 diabetes
• Results
• Our findings in a broader context
The next step: analyses within the LifeLines cohort study
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Overweight & chronic diseases
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Risk factors: ±23-31%* lifestyle!
*Estimation RIVM
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Dietary factors
DAIRY
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Why dairy?
For instance: Calcium → lipogenesis,
inflammation, oxidativestress, insulin secretion, and insulin sensitivity
Whey protein → satietyrelated hormones, lipidmetabolism, and insulinsecretion
Vitamin K → inflammation, and insulinsensitivity
For instance Saturated fats
cholesterol levels, blood pressure
Added sugars insulin sensitivity
Sodium blood pressure
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Products instead of single nutrients
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Cohort studies on dairy and T2DM
#20
#11 low-fat dairy
#9 high-fat dairy
#9 milk
#5 low-fat milk
#6 high-fat milk
#9 yoghurt
#9 cheese
#17 total dairy
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Dairy consumption and T2DM: the gap
The impact of total dairy consumption on the development of T2DM has
already been investigated in several prospective studies, but results are
inconclusive
Literature on a broad range of individual dairy products in one population is
limited (e.g. low vs. high fat products, product type (e.g. milk, yogurt,
buttermilk, cheese, butter), and processing type (fermented, non-fermented)
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Goal of this study
To investigate associations between a broad variety of dairy products and the
development of type 2 diabetes in the Rotterdam Study.
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The Rotterdam Study
2974 men and women, ≥55 years, followed for ±10y
Dietary intake: 170-item validated FFQ
Type 2 diabetes: information from general practitioners, pharmacies’ databases, and follow-up examinations were used to identify cases of diabetes.
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Dairy consumption subgroupsDefinition of the dairy product groups
Dairy product group
Included dairy products
Total dairy All dairy products, except butter. Skimmed dairy
All milk and milk products with a fat content ≤0.5%, cheeses with a fat content ≤10%, and curd cheeses and cream cheeses with a fat content <10%.
Semi-skimmed dairy
All milk and milk products with a fat content ≥1.50% - ≤1.80%, cheeses with a fat content >10% - <50%, and curd cheeses and cream cheeses with a fat content ≥10% - ≤34%.
Full-fat dairy
All milk and milk products with a fat content >1.80%, cheeses with a fat content ≥50%, and curd cheeses and cream cheeses with a fat content ≥35%.
Milk All types of milk, including raw milk, pasteurised milk, fluid milk, milk powder, plain milk, and chocolate milk.
Yogurt All types of yogurt, including plain yogurt, and flavoured/fruit yogurt. Buttermilk All types of buttermilk. Curd cheese All types of curd cheese, including plain curd cheese, and flavoured/fruit curd cheese. Cheese All types of cheese, including plain cheeses, cheeses with cumin, sodium reduced
cheeses, hard cheeses, and cheese spreads. Butter All types of (unsalted) butter. Fermented dairy All types of yogurt, curd cheese, buttermilk, and cheese. Non-fermented dairy All types of milk, and cream.
1
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Statistical analyses & interpretation
By quartile of dairy intake: lowest quartile served as reference
Cox proportion hazards analyses Hazard Ratio (HR)
Example: HR 0.80 (95% CI: 0.60-0.90)
Note: in this presentation the fully adjusted models are shown, incl.
age, sex (model 1), alcohol, smoking, education, physical activity (model 2), total energy intake,
energy adjusted meat intake, energy-adjusted fish intake (model 3), and BMI (model 4).
20% risk reduction0.60-0.90 CI below 1.0 statistically significant risk reduction
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Results – general characteristics
65±7 y26±3 kg/m2
40%
22%
22% family history T2DM 398 g/d (IQR 259-559)
10±4 y
393 T2DM cases
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Results – total and split for fat contentHazard Ratios (95% CI) by dairy quartile in g/day (n=2974)
Q1 Q2 Q3 Q4 P for trend
Total dairy ≤258 259-397 398-557 ≥558
T2DM cases/total n 108/746 91/742 91/738 103/748
Fully adjusted model 1.0 0.81 (0.61-1.08) 0.83 (0.62-1.11) 0.93 (0.70-1.23) 0.76
Skimmed dairy ≤13 14-93 94-224 ≥225
T2DM cases/total n 95/753 101/732 97/751 100/738
Fully adjusted model 1.0 1.11 (0.83-1.47) 0.99 (0.74-1.32) 1.01 (0.76-1.35) 0.80
Semi-skimmed dairy ≤7.7 7.8-63 64-218 ≥219
T2DM cases/total n 92/747 103/740 102/742 96/745
Fully adjusted model 1.0 1.00 (0.73-1.39) 0.99 (0.73-1.34) 0.93 (0.69-1.26) 0.57
Full-fat dairy ≤59 60-103 104-168 ≥169
T2DM cases/total n 108/751 88/735 103/746 94/742
Fully adjusted model 1.0 0.74 (0.55-1.01) 0.88 (0.66-1.19) 0.96 (0.71-1.29) 0.67Models are adjusted for age (years, continuous), sex (men/women), alcohol (categorical), smoking (categorical), education (categorical), physical activity (MET/hours, continuous), total energyintake (kcal/day, continuous), energy adjusted meat intake (g/day, continuous), and energy-adjusted fish intake (g/day, continuous), and BMI (kg/m2, continuous).
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Results – processing type
Hazard Ratios (95% CI) by dairy quartile in g/day (n=2974)
Q1 Q2 Q3 Q4 P for trend
Non-fermented dairy ≤89 90-205 206-343 ≥344
T2DM cases/total n 102/742 97/745 92/743 102/744
Fully adjusted model 1.0 0.89 (0.67-1.19) 0.86 (0.64-1.15) 1.01 (0.76-1.34) 0.85
Fermented dairy ≤59 60-148 149-255 ≥256
T2DM cases/total n 92/743 103/744 103/744 95/743
Fully adjusted model 1.0 1.13 (0.85-1.51) 1.08 (0.81-1.45) 0.98 (0.73-1.32) 0.65
Models are adjusted for age (years, continuous), sex (men/women), alcohol (categorical), smoking (categorical), education(categorical), physical activity (MET/hours, continuous), total energy intake (kcal/day, continuous), energy adjusted meat intake(g/day, continuous), and energy-adjusted fish intake (g/day, continuous), and BMI (kg/m2, continuous).
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Results – product type (1)Hazard Ratios (95% CI) by dairy quartile in g/day (n=2974)
Q1 Q2 Q3 Q4 P for trend
Milk ≤65 66-180 181-315 ≥316
T2DM cases/total n 96/739 94/745 102/747 101/743
Fully adjusted model 1.0 0.93 (0.69-1.24) 1.00 (0.75-1.34) 1.04 (0.78-1.39) 0.60
Yogurt ≤1 2-45 46-108 ≥109
T2DM cases/total n 113/743 88/744 94/744 98/743
Fully adjusted model 1.0 0.76 (0.57-1.02) 0.84 (0.63-1.12) 0.86 (0.65-1.14) 0.68
Buttermilk 0 0-1 2-140 ≥141
T2DM cases/total n 86/739 99/751 111/741 97/743
Fully adjusted model 1.0 1.08 (0.77-1.51) 1.15 (0.83-1.60) 1.01 (0.73-1.39) 0.62
Models are adjusted for age (years, continuous), sex (men/women), alcohol (categorical), smoking (categorical), education(categorical), physical activity (MET/hours, continuous), total energy intake (kcal/day, continuous), energy adjusted meat intake(g/day, continuous), and energy-adjusted fish intake (g/day, continuous), and BMI (kg/m2, continuous).
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Results – product type (2)Hazard Ratios (95% CI) by dairy quartile in g/day (n=2974)
Q1 Q2 Q3 Q4 P for trend
Curd cheese/quark No (0) Yes (>0)
T2DM cases/total n 182/1324 211/1650
Fully adjusted model 1.0 1.01 (0.78-1.31)
Cheese ≤23 24-33 34-46 ≥47
T2DM cases/total n 94/746 91/746 97/740 111/745
Fully adjusted model 1.0 0.92 (0.68-1.24) 0.94 (0.70-1.25) 1.08 (0.81-1.43) 0.50
Butter No (0) Yes (>0)
T2DM cases/total n 124/956 269/2018
Fully adjusted model 1.0 0.96 (0.73-1.27)
Models are adjusted for age (years, continuous), sex (men/women), alcohol (categorical), smoking (categorical), education(categorical), physical activity (MET/hours, continuous), total energy intake (kcal/day, continuous), energy adjusted meat intake(g/day, continuous), and energy-adjusted fish intake (g/day, continuous), and BMI (kg/m2, continuous).
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Thus.....
No evidence for a beneficial or adverse association between dairy consumption and
the development of T2DM, which was monitored for on average 10 years
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Discussion
Assessment of dairy intake: 170-item FFQ
validated for calcium (r=0.72) and protein (r=0.66) against 15 24-h recalls
broad range of dairy products
administered only once
Dutch population: relatively high dairy consumption
Relatively small sample size – replication is warranted!
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The next step.....LifeLines Cohort Study
Ca. n=115,000 men and women, ≥18 years
Dietary intake: FFQ
Anthropometric measures: weight, BMI, waist circumference, waist-to-hip ratio
Glucose metabolism: fasting glucose, HbA1c, diabetes prevalence
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LifeLines Cohort Study Dairy product classification
Total dairy All dairy products mentioned below
Skimmed dairy All types skimmed milk and yogurt, buttermilk, and flavoured yogurt drinks
Semi-skimmed dairy All types semi-skimmed milk and low-fat cheeses
Full-fat dairy All types of full-fat milk, yogurt, and cheese, cream, milk-based ice cream, chocolate milk, full-
fat cheese
Milk All types of milk, including liquid plain milk, liquid coffee milk, creamer, and chocolate milk.
Yogurt All types of yogurt, including plain yogurt, and flavoured/fruit yogurt.
Buttermilk All types of buttermilk.
Curd cheese/quark All types of curd cheese/quark, including plain and flavoured/fruit types.
Cheese All types of cheese, including hard cheeses, soft cheeses, full-fat cheeses, fat reduced
cheeses, cheese spreads, and foreign cheeses.
Custard All types of custard
Flavoured yogurt drinks All types of flavoured yogurt drinks
Fermented dairy All types of yogurt, curd cheese/quark, buttermilk, cheese, and flavoured yogurt drinks
Non-fermented dairy All types of milk, custard, porridge, milk-based ice cream, and cream.
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Lifelines – general characteristics
45±13 y26±4 kg/m2
42%
2386 T2DM cases
Q1 Q2 Q3 Q4 Q5
≤197 197-282 283-367 368-479 ≥480
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The next step..... analysesLifeLines Cohort Study
Analysing associations between dairy intake and measures of glucose tolerance(i.e. fasting plasma glucose, HbA1c, and T2DM).
Analysing associations between dairy intake and anthropometric measures (i.e. body weight, BMI, waist circumference, and waist-to-hip ratio).
Stratifying associations between dairy intake, measures of glucose tolerance, and antropometric measures according to age (<65 and ≥65 years), sex (men/women), (and BMI (<25 and ≥25 kg/m2))
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Results...LifeLines Cohort Study
Will follow soon...
First paper is planned to be submitted in the first half of 2017!
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Thank you!
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Models without and with BMI (1)Q1 Q2 Q3 Q4 P for trend
Total dairy, g/day ≤258 259-397 398-557 ≥558
Median 174 327 472 682
T2DM cases/total n 108/746 91/742 91/738 103/748
Model 3 1.0 0.84 (0.63-1.12) 0.87 (0.65-1.16) 0.99 (0.74-1.32) 0.90
Model 4 1.0 0.81 (0.61-1.08) 0.83 (0.62-1.11) 0.93 (0.70-1.23) 0.76
Skimmed dairy, g/day ≤13 14-93 94-224 ≥225
Median 1 48 150 336
Model 3 1.0 1.11 (0.84-1.48) 1.02 (0.76-1.36) 1.07 (0.80-1.43) 0.85
Model 4 1.0 1.11 (0.83-1.47) 0.99 (0.74-1.32) 1.01 (0.76-1.35) 0.80
Semi-skimmed dairy,
g/day
≤7.7 7.8-63 64-218 ≥219
Median 0 24 151 344
T2DM cases/total n 92/747 103/740 102/742 96/745
Model 3 1.0 1.02 (0.74-1.41) 1.02 (0.76-1.38) 0.98 (0.73-1.32) 0.84
Model 4 1.0 1.00 (0.73-1.39) 0.99 (0.73-1.34) 0.93 (0.69-1.26) 0.57
Full-fat dairy, g/day ≤59 60-103 104-168 ≥169
Median 32 82 129 261
T2DM cases/total n 108/751 88/735 103/746 94/742
Model 3 1.0 0.74 (0.55-1.00) 0.88 (0.66-1.19) 0.90 (0.67-1.20) 0.96
Model 4 1.0 0.74 (0.55-1.01) 0.88 (0.66-1.19) 0.96 (0.71-1.29) 0.67
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Models without and with BMI (2)
Q1 Q2 Q3 Q4 P for trend
Total non-fermented
dairy, g/day
≤89 90-205 206-343 ≥344
Median 37 142 265 471
T2DM cases/total n 102/742 97/745 92/743 102/744
Model 3 1.0 0.89 (0.67-1.19) 0.87 (0.65-1.17) 1.02 (0.77-1.35) 0.76
Model 4 1.0 0.89 (0.67-1.19) 0.86 (0.64-1.15) 1.01 (0.76-1.34) 0.85
Fermented dairy, g/day ≤59 60-148 149-255 ≥256
Median 34 100 190 370
T2DM cases/total n 92/743 103/744 103/744 95/743
Model 3 1.0 1.17 (0.88-1.57) 1.13 (0.85-1.50) 1.06 (0.79-1.43) 0.97
Model 4 1.0 1.13 (0.85-1.51) 1.08 (0.81-1.45) 0.98 (0.73-1.32) 0.65