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Curriculum Vitae

Name: Edward F. Rosloniec, Jr.

Born: January 26, 1956; Grand Rapids, Michigan

Education1974-1978 B.S., Medical Technology, Michigan State University, E. Lansing, Michigan1978-1980 M.S., Microbiology, Michigan State University, E. Lansing, Michigan1980-1984 Ph.D., Immunology, Wayne State University, Detroit, Michigan

Honors and Awards Received1978 Graduation with honors, Michigan State University, with high honors from the School of

Medical Technology1979-1980 Outstanding Graduate Scholarship Award, Department of Microbiology and Public

Health, Michigan State University1980-1982 Awarded University Graduate Fellowship, Wayne State University1982-1984 NIH Predoctoral Trainee1983 Elected Member Sigma Xi1984 Recipient of Sanderson Memorial Award for Graduate Research1992 Elected Member of American Association of Immunologists2005 Faculty Research Advisor Award, University of Tennessee Health Science Center2009 Clifford M. Clarke Science Award, Arthritis Foundation.

Grants Awarded1987 NIH Postdoctoral Grant1991 University of Tennessee Medical Group Research Grant1992 NIH SCOR, Pathogenesis of Rheumatoid Arthritis: Project 1 - Structural Basis of Collagen

Induced Arthritis (co-investigator), 5 years1995 VA Merit Award (principal investigator), 3 years1998 NIH RO1 (principal investigator), 4 years1998 VA Merit Award (principal investigator), 4 years1998 VA Equipment Grant, for purchase of Flow Cytometer2001 NIH SCOR, Pathogenesis of Rheumatoid Arthritis, Project 2: T Cell and MHC Interactions in

the Pathogenesis of Autoimmune Arthritis (principal investigator), 5 years.2001 NIH Rheumatic Diseases Research Core Center, Core C: Animal Resource Core (principal

investigator and director), 5 years.2002 VA Merit Award (principal investigator), 4 years2002 VA REAP Award, Flow Cytometry Core (principal investigator and director of core)2006 VA Merit Review, (principal investigator), 4 years2006 VA Shared Instrumentation Grant2008 Arthritis Foundation Innovative Research Grant (principal investigator)2010 VA Merit Review (principal investigator), 4 years

Edward F. Rosloniec, Ph.D.Curriculum Vitae

2012 VA Program Project Award (principal investigator of Project 2, Associate Director of Program), 4 years

2016 VA Merit Review (principal investigator), 4 years

Research and Professional Experience1977-1979 Laboratory Research Assistant, Michigan State University,1979-1980 Graduate Research Assistant, Department of Pediatrics, Michigan State University 1980-1982 University Graduate Fellow, Wayne State University1982-1984 NIH Predoctoral Fellow1984-1990 Postdoctoral Fellow, National Jewish Center for Immunology and Respiratory Medicine,

Denver, CO (Laboratory of Dr. John Freed)1991-1998 Assistant Professor, Department of Medicine, University of Tennessee, Memphis1991-2003 Research Biologist, VA Medical Center, Memphis, TN1998-2002 Associate Professor, Department of Medicine, University of Tennessee, Memphis1998-2002 Associate Professor, Department of Pathology, University of Tennessee, Memphis2002-present Professor, Department of Medicine, University of Tennessee, Memphis2002-present Professor, Department of Pathology, University of Tennessee, Memphis2003-present Career Scientist, VA Medical Center, Memphis, TN

Teaching Experience1998-2003 Lecturer for Pathology 900, Cellular and Molecular Basis for Disease1999-2003 Lecturer for Pathology 920, Advanced Immunology2004-2006 Course Director, Pathology 834, Current Topics2004-present Lecturer for IP 842, Systems Biology course.2004-present Lecturer MSCI 931, Immunity and Inflammation course2010-present Lecturer for Rheumatology Fellows & Medical Students, MHC and T cell Function

Professional Activities1991 - 1998 Ad Hoc Reviewer for The Journal of Immunology1992 - present Reviewer for Arthritis & Rheumatism1996 - present Reviewer for Cellular Immunology1997 - present Reviewer for Life Sciences Journal1998 - 2002 Associate Editor for The Journal of Immunology2001 - 2004 Member of the Board of Directors of Research Inc.1998 - present Chairman of the Biosafety Committee, VA Medical Center1999 Ad Hoc reviewer for VA Merit Review Immunology study section2000 - 2003 Member of the Institutional Biosafety Committee, St. Jude Children’s Hospital2002 - 2014 Member of the Research & Development Committee, VA Medical Center2001 Member of NIH RFA study section “Sex based differences in the Immune Response”2002 Member of NIH RFA study section “Protective Role of Innate Immunity in

Autoimmune Disease”2003 - 2004 Member of Arthritis Foundation Study Section, Cell Biology

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2003 Member of NIH-NIAID RFA study section “Innovative grants in immune tolerance”2005 - 2007 Member of Arthritis Foundation Study Section, Molecular Immunology

2006 Member of NIH-NIAMS study section, Rheumatic Diseases Research Core Centers2007 - 2012 Member of VA Merit Review Immunology study section2009 Ad Hoc Reviewer for NIH Recovery Grants program2012 - present Biotechnology Employer Workforce Development Committee, Memphis Bioworks

Foundation2012 - 2014 Victory University Advisory Board2013 Reviewer for NIAID Special Emphasis Panel on Immunity in the Elderly2013 Reviewer for NIAID Special Emphasis Panel for Immunology Quality Assessment

Program2014 Reviewer for VA Shared Instrumentation Grants2016 – present Member of the Board of Directors of Research Inc.2016 – present Member Biosafety Committee, University of Memphis

SUPERVISORY AND MENTORING RELATIONSHIPS

Name Trainee Status Inclusive Dates Current status

Jennifer Lloyd Graduate 1989-1990 Veterinarian

Monique Casey Undergraduate 1992 College Graduate

David D. Brand Postdoctoral 1992-1995 Assoc. Prof., VA Investigator

Yu Lan Graduate 1994-1995 Clinician in China

Jonathan Lam Undergraduate 1995-1996 Investigator, MD, Ph.D.

George Black Undergraduate 1997 College Graduate

Paul Botto Undergraduate 1998-1999 College Graduate

Yajaira Guedez Postdoctoral 1999-2002 Educator

Kary Latham Graduate/Postdoctoral 1999-2006 Assistant Professor, Victory University

Timothy Kayes Graduate 2003-2008 Postdoctoral Fellow

Zhaohui Qian Postdoctoral 2003-2007 Assistant Professor

Sheri Klas Graduate (guidance committee) 1999-2004 Investigator

Christy Lavine Graduate (guidance committee) 2000-2006 Investigator

Mark Lockett Graduate (guidance committee) 2001-2004 Assistant Professor

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Anna Cunningham Graduate (guidance committee) 2002-2004 Assistant Professor, Georgia Regents University

Iona Moisini Graduate (guidance committee) 2002-2007 Postdoctoral Fellow

Stephanie Nance Graduate (guidance committee) 2004-2007 Postdoctoral Fellow

Dawn Clarke Undergraduate 2006 & 2007 College Graduate

Kelly Andrews Graduate (guidance committee) 2010 - present Postdoctoral Fellow

Sarah Owens Summer Intern 2010 Fulbright Scholar, Medical School

Courtney Skaer Summer Intern 2011 Graduate School, Oklahoma State University

Pawandeep Kaur Undergraduate 2011 Southwest Tennessee College

Shelby Koszlowski Summer Intern 2012 Graduate, Northern Kentucky University

Abby Calametti Summer Intern 2012 Medical School, University of Alabama

Jayne Caron Summer Intern 2013 Senior, Dartmouth University

Courtney Woods Summer Intern 2014 College Graduate

Helen Shi Summer Intern 2014 Medical School, University of Cincinnati

Kelsey Fervier Summer Intern 2015 Senior, College of Charleston

Pawandeep Kaur Graduate Student (research advisor)

2016 Graduate School, Middle TN State University

Wendi Wang Summer Intern 2016 Senior, Albion University

Bibliography1. Pienkowski, M. M., L. C. Mann, E. F. Rosloniec, and C. W. Welsh. Accretion of biopsy

specimens of vaginal adenosis from patients exposed in utero to diethylstilbestrol when transplanted to athymic mice. J. Natl. Cancer Inst., 62:521-523, 1978.

2. Pienkowski, M. M., E. F. Rosloniec, R. Meyers, and C. W. Welsch. A visual display board used for efficient breeding and utilization of an athymic (nude) mouse colony. Lab. Animal Sci. 29:71-73, 1979.

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3. Silberg, D., E. Rosloniec, and M. Clay (editors). Laboratory Manual: Bacteriology, Mycology and Virology. Wayne State University School of Medicine. Wayne State University Press, 1983.

4. Rosloniec, E.F., M.H. Kuhn, C.G. Genyea, A.H. Reed, J.J. Jennings, A.G. Giraldo, K.W. Beisel, and S.P. Lerman. Aggressiveness of SJL/J lymphomas correlates with the absence of H-2Ds

antigens. J. Immunology, 132:945-953, 1984.

5. Rosloniec, E.F., C. Gottlieb, A.W. Butch, and S.P. Lerman. Comparative growth of SJL/J lymphomas in irradiated and normal SJL/J mice: Cell cycle distribution and tumor cell quantification. J. Natl. Cancer Inst., 75:877-883, 1985.

6. Rosloniec, E.F., R. Cleveland, and D.B. Kaufman. Induction of T cell proliferation and enhancement of NK activity by supernatants from Con-A stimulated human peripheral blood mononuclear cells: A new lymphokine. Cell. Immunology, 99:170-181, 1986.

7. Freed, J. H., and E. F. Rosloniec, Jr. Molecular aspects of the role of class II MHC molecules in antigen presentation to T cells. In The Year in Immunology, 1986-1987. J.M. Cruse and R. E. Lewis Jr., ed., Karger, Basel, pp. 161-178, 1987.

8. Freed, J. H., E. F. Rosloniec, D. Gay, L. J. Vitez, D. H. McKean, and D. Mathis. Epitopes of I-Ak

involved in antigen presentation to T-cell hybridomas. In H-2 Antigens: Genes, Molecules, Function. C.S. David, ed., Plenum Press, New York, pp. 451-464, 1987.

9. Rosloniec, E. F., and J. H. Freed. Structure-function studies of the class II molecule I-Ak using lysozyme as a model antigen. In The Immune Response to Structurally Defined Proteins: The Lysozyme Model. E. Sercarz and S. Smith-Gill, ed., Adenine Press, New York, pp.231-248 1989.

10. Rosloniec, E. F., D Gay, and J. H. Freed. Epitopic analysis by anti-I-Ak monoclonal antibodies of I-Ak-restricted presentation of lysozyme peptides. J. Immunology 142:4176-4183, 1989.

11. Rosloniec, E. F., L. J. Vitez, J.-M. Buerstedde, B. N. Beck, D. J. McKean, D. Landais, C. Benoist, D. Mathis, and J. H. Freed. I-Ak polymorphisms define a functionally dominant region for the presentation of hen egg lysozyme peptides. J. Immunology 143:50-58, 1989.

12. Rosloniec, E. F., L. J. Vitez, S. Buus, and J. H. Freed. MHC class II-derived peptides can bind to class II molecules, including self molecules, and prevent antigen presentation. J. Exp. Medicine 171:1419-1430, 1990.

13. Rosloniec, E. F., K. S. Beard, and J. H. Freed. Functional analysis of the antigen binding region of an MHC class II molecule. Molecular Immunology 30:491-501, 1993.

14. Myers, L. K., E. F. Rosloniec, J. M. Seyer, J. M. Stuart, and A. H. Kang. A synthetic peptide analog of a determinant of type II collagen prevents the onset of collagen-induced arthritis. J. Immunology 150:4652-4658, 1993.

15. Brand, D. D., L. K. Myers, K. B. Whittington, J. M. Stuart, A. H. Kang, and E. F. Rosloniec. Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine 1(II)-CB11 in H-2q mice. J. Immunology 152:3088-3097, 1994.

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16. Wade, W. F., E. De Pirro Ward, E. F. Rosloniec, and J. H. Freed. Truncation of the A chain of MHC class II molecules results in inefficient antigen presentation to antigen-specific T cells. International Immunology 6:1457-65, 1994.

17. Miyahara, H., L. K. Myers, E. F. Rosloniec, D. D. Brand, J. M. Seyer, J. M. Stuart, and A. H. Kang. Identification and characterization of a major tolerogenic T cell epitope of type II collagen which suppresses arthritis in B10.RIII mice. Immunology, 86:110-115, 1995.

18. Rosloniec, E. F., D. D. Brand, K. B. Whittington, J. M. Stuart, M. Ciubotaru and E. S. Ward. Vaccination with a recombinant V domain of a T cell receptor prevents the development of collagen induced arthritis. J. Immunology 155:4504-4511, 1995.

19. Rosloniec, E. F., K. B. Whittington, D. D. Brand, L. K. Myers, and J. M. Stuart. Identification of MHC class II and TCR binding residues in the type II collagen immunodominant determinant mediating collagen induced arthritis. Cellular Immunology 172:21-28, 1996.

20. Ballou, L. R., S. J. F. Laulederkind, E. F. Rosloniec, and R. Raghow. Ceramide Signaling and the Immune Response. Biochimica et Biophysica Acta 1301:273-287, 1996.

21. Brand, D. D., T. N. Marion, L. K. Myers, E. F. Rosloniec, W. C. Watson, J. M. Stuart, and A. H. Kang. Autoantibodies to murine type II collagen in collagen induced arthritis: A comparison of susceptible and non-susceptible strains. J. Immunology 157:5178-5184, 1996.

22. Rosloniec, E. F., A. H. Kang, L. K. Myers, and M. A. Cremer. Collagen-Induced Arthritis, Unit 15.5, In Current Protocols in Immunology, R. Coico and E. Shevach, eds., Wiley & Sons, NY, NY, pp. 15.5.1-15.5.24, 1996.

23. Rosloniec, E. F., D. D. Brand, L. K. Myers, K. B. Whittington, M. Gumanovskaya, D. M. Zaller, A. Woods, D. M. Altmann, J. M. Stuart, and A. H. Kang. An HLA-DR1 transgene confers susceptibility to collagen-induced arthritis elicited with human type II collagen. J. Exp. Medicine 185:1113-1122,1997.

24. Myers, L. K., E. F. Rosloniec, M. A. Cremer, J. M. Stuart, and A. H. Kang. Collagen Induced Arthritis. Life Science 61:1861-1878, 1997.

25. Kawamura, S., H. Miyahara, L. K. Myers, E. F. Rosloniec, J. M. Stuart, A. H. Kang. Restricted TCR V repertoire in the T cell response to a tolerogenic determinant of type II collagen. J. Immunology 158:6013-6018, 1997.

26. Cremer, M. A., Rosloniec, E. F., Kang, A. H. The Cartilage Collagens: A review of their structure function, and role in the pathogenesis of experimental arthritis in animals and in human rheumatic diseases. Journal of Molecular Medicine 76:275-288, 1998.

27. Rosloniec, E. F., D. D. Brand, L. K. Myers, Y. Esaki, K. B. Whittington, D. M. Zaller, A. Woods, J. M. Stuart, and A. H. Kang. Induction of autoimmune arthritis in HLA-DR4 (DRB1*0401) transgenic mice by immunization with human and bovine type II collagen. J. Immunology 160:2573-2578, 1998.

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26. Myers, L. K., B. Tang, E. F. Rosloniec, J. M. Stuart, and A. H. Kang. Characterization of a peptide analog of a determinant of type II collagen that suppresses collagen-induced arthritis. J. Immunology 161:3589-3595, 1998.

28. Tang, B., L. K. Myers, E. F. Rosloniec, K. B. Whittington, J. M. Stuart, and A. H. Kang. Characterization of signal transduction through the TCR zeta chain following T cell stimulation with analog peptides of CII 260-269. J. Immunology 160: 3135-3142 1998.

29. Rosloniec, E. F., L. R. Ballou, K. Hasty, R. Raghow, and A. H. Kang. Autoimmune Arthritis, In Molecular and Cellular Basis of Inflammation. P. Ward and C. N. Serhan, eds., Humana Press, Totowa, NJ, pp. 289-307, 1998.

30. Gumanovskaya, M. L., L. K. Myers, E. F. Rosloniec, J. M. Stuart, and A. H. Kang. Intravenous tolerization with type II collagen induces IL-4 and IL-10 producing CD4+ regulatory T cells. Immunology 97:466-73, 1999.

31. Fridkis-Hareli, M., E. F. Rosloniec, L. Fugger, and J. L. Strominger. Synthetic amino acid copolymers that bind to HLA-DR proteins and inhibit type II collagen reactive T cell clones. PNAS 95:12528-31, 1998.

32. Myers, L. K., D. D. Brand, X. J. Ye, M. A. Cremer, E. F. Rosloniec, M. Bodo, J. Myllyharju, T. Helaakoski, M. Nokelainen, T. Pihlajaniemi, K. Kivirikko, C. L. Yang, L. Ala-Kokko, D. J. Prockop, H. Notbohm, P. Fietzek, J. M. Stuart, and A. H. Kang. Characterization of recombinant type II collagen: arthritogenicity and tolerogenicity in DBA/1 mice. Immunology 95:631-9, 1998.

33. Nakagawa, T. Y., W. H. Brissette, P. D. Lira, R. J. Griffiths, N. Petrushova, J. Stock, J. D. McNeish, S. E. Eastman, E. D. Howard, S. R. M. Clarke, E. F. Rosloniec, E. A. Elliott, and A. Y. Rudensky. Impaired invariant chain degradation and antigen presentation, and diminished collagen arthritis in cathepsin S-deficient mice. Immunity 10:219-226, 1999.

34. Kotzin, B. L., M. T. Falta, F. Crawford, E. F. Rosloniec, J. Bill, P. Marrack, and J. Kappler. Use of soluble peptide-DR4 tetramers to detect synovial T cells specific for cartilage antigens in patients with rheumatoid arthritis. PNAS 97, 291-296, 2000.

35. Fridkis-Hareli,M., E. F. Rosloniec, L. Fugger, and J. L. Strominger. Synthetic peptides that inhibit binding of the collagen type II 261-273 epitope to rheumatoid arthritis-associated HLA-DR1 and -DR4 molecules and collagen-specific T-cell responses. Human Immunology 61:640-650, 2000.

36. Myers, L. K., A. H. Kang, A. E. Postlethwaite, E. F. Rosloniec, S. G. Morham, B. V. Shlopov, S. Goorha, and L. R. Ballou. The genetic ablation of cyclooxygenase-2 prevents the development of autoimmune arthritis. Arthritis and Rheumatism 43:2687-93, 2000.

37. Chen, Y., Rosloniec, E. F., Goral, M. I., Boothby, M., and Chen, J. Redirection of T cell effector function in vivo and enhanced collagen-induced arthritis mediated by an IL-2R/IL-4R chimeric cytokine receptor transgene. J. Immunology 166(6):4163-9, 2001.

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38. Guedez, Y., K. B. Whittington, J. Clayton, and E. F. Rosloniec. Genetic ablation of IFN- upregulates IL- expression and increases susceptibility to autoimmune arthritis. Arthritis & Rheumatism 44:2413-242, 2001.

39. Brand, D. D., K. B. Whittington, and E. F. Rosloniec. Reduced affinity between MHC class II and an immunogenic type II collagen peptide accords resistance of H-2

p mice to autoimmune arthritis.

Autoimmunity 34:133-145, 2001.

40. Rosloniec, E. F., K. B. Whittington, D. M. Zaller, and A H. Kang. HLA-DR1 (*0101) and DR4 (*0401) share the same peptide binding motif for a peptide derived from human type II collagen. J. Immunology 168:253-259, 2002.

41. Brand, D. D., Myers, L. K., Whittington, K. B., Latham, K. A., Stuart, J. M., Kang, A. H., and Rosloniec, E. F. Detection of early changes in autoimmune T cell phenotype and function following intravenous administration of type II collagen in a TCR transgenic model. J. Immunology 168:490-498, 2002.

42. Chen, Y., Rosloniec, E. F., Price, J., Boothby, M., and Chen, J. Constitutive expression of Bcl-xl in the T lineage attenuates collagen-induced arthritis in Bcl-xl transgenic mice. Arthritis & Rheumatism 46(2):514-521, 2002.

43. Zuo L, Cullen C. M. , DeLay, M. L., Thornton, S., Myers, L. K., Rosloniec, E. F., Boivin, G. P., Hirsch, R. A single-chain class II MHC-IgG3 fusion protein inhibits autoimmune arthritis by induction of antigen-specific hypo-responsiveness. J. Immunology 168(5):2554-9, 2002.

44. Rosloniec, E. F., Latham, K., and Guedez, Y. Paradoxical roles of IFN- in models of Th1-mediated autoimmunity. Arthritis Research 4(6):333-336, 2002.

45. Myers, L. K., Sakurai Y., Tang, B., He, X., Rosloniec, E. F., Stuart, J. M. and Kang, A. H. Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice. Arthritis & Rheumatism 46(12):3369-77, 2002.

46. Latham. K. A., Zamora, A., Drought, H., Subramanian, S., Matejuk, A., Offner, H., and Rosloniec, E. F. Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis. J. Immunology 171:5820-5827, 2003.

47. Brand, D. D., Kang, A. H., and Rosloniec, E. F. Immunopathogenesis of collagen induced arthritis. Springer Seminars in Immunopathology 25(1):3-18, 2003.

48. Brand, D.D., Kang, A. H., and Rosloniec, E. F. The Mouse Model of Collagen-Induced Arthritis. Methods Mol Med. (Humana Press) 2004;102:295-312, 2004.

49. Myers, L. K., Sakurai, Y., Rosloniec, E. F., Stuart, J. M., Kang, A. H. An analog peptide that suppresses collagen-induced arthritis. American Journal of Medical Sciences 327(4):212-6,2004.

50. He, X., Rosloniec, E. F., Myers, L. K., McColgan, L., Gumanovskaya, M., Kang, A. H., and Stuart, J. M. T cell receptors recognizing type II collagen in HLA-DR transgenic mice are characterized by highly restricted V usage. Arthritis & Rheumatism 50(6):1996-2004, 2004.

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51. Rosloniec, E. F., Whittington, K. B., He, X., Stuart, J. M., and Kang, A. H. Collagen induced arthritis mediated by HLA-DR1 (*0101) and HLA-DR4 (*0401). American Journal of Medical Sciences 327(4):169-79, 2004.

52. Cremer, M. A., Ye, X. J., Myers, L. K., Brand, D. D., Rosloniec, E. F., and Kang, A. H. T cell immunity to type II collagen in the bio-breeding rat: the identification and characterization of RT1u-restricted T cell epitopes on alpha 1(II). J. Immunology 173(3):1795-801, 2004.

53. Myers, L. K., Tang, B., Brand, D. D, Rosloniec, E. F., Stuart, J. M., and Kang, A. H. Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis. Arthritis & Rheumatism 50:3004-11, 2004.

54. Latham, K. A., Whittington, K. B., Zhou, R., Qian, Z., and Rosloniec, E. F. Ex vivo characterization of the autoimmune T cell response in the HLA-DR1 mouse model of collagen-induced arthritis reveals long-term activation of CII-specific cells and their presence in arthritic joints. J. Immunology 174:3978-3985, 2005.

55. Falta, M. T., Fontenot, A. P., Rosloniec, E. F., Crawford, F. Roark, C. L., Bill, J., Marrack, P., Kappler, J., and Kotzin, B. L. MHC class II/peptide tetramer staining in relation to functional avidity and TCR diversity in the mouse CD4+ T cell response to a rheumatoid arthritis associated antigen. Arthritis & Rheumatism 52:1885-1896, 2005.

56. Sakurai, Y., Tang, B., Rosloniec, E. F., Stuart, J. M., Kang, A. H., and Myers, L. K. Molecular characterization of an arthritogenic collagen peptide interacting with I-Ar. Immunology 117:136–142, 2006.

57. Rosloniec, E.F., R. Ivey, K. Whittington, A. H. Kang, and H. Park. Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen. J. Immunology 177: 3884-3892, 2006.

58. Latham, K. A., Kayes, T. D., Qian, Z. and Rosloniec, E. F.. The use of humanized MHC mouse strains for studies of rheumatic diseases. Progress in Inflammation Research, The Hereditary Basis of Rheumatic Diseases. R. Holmdahl, ed. pp. 131-146, 2006.

59. Rosloniec, E. F., Brandstetter, T., Leyer, S., Schwaiger, F. W, and Nagy, Z. A. Second-generation peptidomimetic inhibitors of antigen presentation effectively treat autoimmune diseases in HLA-DR-transgenic mouse models. J. Autoimmunity 27(3):182-95, 2006.

60. Sakurai, Y., Brand, D. D., Tang, B., Rosloniec, E. F., Stuart, J. M., Kang, A. H., and Myers, L. K.. Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice. Arthritis Research & Therapy 8:R150, 2006.

61. Brand, D. D., Latham, K.A., Rosloniec, E. F. Collagen-Induced Arthritis. Nature Protocols 2(5):1269-75, 2007.

62. Myers, L.K, Tang, B., Rosloniec, E. F., Stuart, J. M., and Kang, A. H. An altered peptide ligand of type II collagen suppresses autoimmune arthritis. Critical Reviews in Immunology, 27:345-56, 2007.

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63. Huan, J., Kaler, L., Mooney, J., Subramanian, S., Hopke, C., Vandenbark, A., Rosloniec, E., Burrows, G., and Offner, H. MHC class II derived recombinant T-cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis. J. Immunology 180:1249-1257, 2008.

64. Qian, Z., Latham, K., Whittington, K. B., Miller, D. C., Brand, D. D., and Rosloniec, E. F. An Autoantigen-specific, highly restricted T Cell repertoire infiltrates the arthritic joints of mice in an HLA-DR1 humanized mouse model of autoimmune arthritis. J. Immunology 185:110-8, 2010. PMID: 20511555

65. Rosloniec E. F., Cremer M., Kang A. H., Myers L. K., Brand D. D. Collagen Induced Arthritis. Current Protocols in Immunology. Chapter 15:Unit 15.5.1-25, 2010.

66. Kimata, M., Cullins, D. L., Brown, M. L., Brand, D. D., Rosloniec, E. F., Myers, L. K., Stuart, J. M., Kang, A. H. Characterization of inhibitory T cells induced by an analog of type II Collagen in an HLA-DR1 humanized mouse model of autoimmune arthritis. Arthritis Research & Therapy 2012, 14:R107

67. Qian, Z., Latham, K. A., Whittington, K. B., Miller, D. C., Brand, D. D. and Rosloniec, E. F. Engineered T regulatory cells co-expressing MHC class II:peptide complexes are efficient inhibitors of autoimmune T cell function and prevent the development of autoimmune arthritis. J. Immunology 190(11): 5382-5391, 2013.

68. Tang, B., Kim, S., Hammond, S. E., Cullins, D. L., Brand, D. D., Rosloniec, E. F., Stuart, J., Postlethwaite, A. E., Kang, A. H., and Myers, L. K. Characterization of T cell phenotype and function in a double transgenic (collagen-specific TCR/HLA-DR1) humanized model of arthritis. Arthritis Res Ther. 16(1):R7, 2014.

69. Myers, L. Cullins, D., Park, J., Yi, A., Brand, D., Rosloniec, E., Stuart, J., and Kang, A. Peptide Ligand Structure and I-Aq Binding Avidity Influence T Cell Signaling Pathway Utilization. Clinical Immunology 160:188-197, 2015.

70. Miller, D. C., Whittington K. B., Brand, D. D., Hasty, K. A., and Rosloniec E. F. The CII-specific autoimmune T-cell response develops in the presence of FTY720 but is regulated by enhanced Treg cells that inhibit the development of autoimmune arthritis. Arthritis Research & Therapy 18(1):8, 2016.

71. Anderson K.M., Roark, C.L., Portas, M., Aubrey, M.T., Rosloniec, E.F., and Freed, B.M. A Molecular Analysis of the Shared Epitope Hypothesis Binding of Arthritogenic Peptides to DRbeta1*04 Alleles. Arthritis & Rheumatology 68(7):1627-36, 2016.

72. Roark, C.L., Anderson, K.M., Aubrey, M.T., Rosloniec, E.F., and Freed, B.M. Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis. J. Autoimmunity 72:25-32, 2016.

73. Sandal I, Karydis A, Luo J, Prislovsky A, Whittington KB, Rosloniec EF, Dong C, Novack DV, Mydel P, Zheng SG, Radic MZ, Brand DD. Bone loss and aggravated autoimmune arthritis in HLA-DRβ1-bearing humanized mice following oral challenge with Porphyromonas gingivalis. Arthritis Research & Therapy. 18(1):249, 2016.

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Abstracts and Presentations1. Rosloniec, E. F., and D. B. Kaufman. Helper and suppressor factors from concanavalin-A

stimulated human lymphocytes. Fourth International Congress of Immunology, 4.3.22, 1980.

2. Kaufman, D. B., and E. F Rosloniec. Effects of the supernatant of concanavalin-A stimulated human lymphocytes (SIRSH) on natural killer activity. Fourth International Congress of Immunology, 11.6.11, 1980.

3. Rosloniec, E. F., L. Mayo, K. Jagdish Babu, A. Giraldo, M.A. Leon, Y. Kong, and S. P Lerman. Chronic autoimmune thyroiditis accelerates lymphomagenesis in SJL mice. Fed. Proc. 41:954, 1982.

4. Rosloniec, E., J. Jennings, C. Genyea, and S. Lerman. Loss of MHC antigen expression as measured by flow cytometry on SJL lymphoma cells. 1983. Presented at the Annual Flow Cytometry Meeting, Michigan Cancer Foundation, Detroit, Michigan, 1983.

5. Rosloniec, E. F., J. J. Jennings, K. W. Beisel, A. G. Giraldo, C. G. Genyea, and S. P. Lerman. Spontaneous lymphomas of SJL/J mice: Expression of H-2Ds and the capacity to induce syngeneic lymphoproliferation. Fed. Proc. 42:399, 1983.

6. Rosloniec, E., M. Kuhn, M. Kukuruga, and S. Lerman. Aggressiveness of SJL/J lymphomas and its relationship to MHC antigen expression and cell cycle distribution. Presented at the Midwestern Immunology Meeting, Chicago, Illinois, 1983.

7. Rosloniec, E. F., D. Gay, and J. H. Freed. Anti-I-Ak monoclonal antibody inhibition of antigen presentation. Sixth International Congress of Immunology, 2.34.33, p. 147, 1986.

8. Rosloniec, E., D. Gay, and J. Freed. Functional epitopes of I-Ak involved in antigen presentation. J. Cellular Biochemistry, 11D (supplement): 283, 1987.

9. Rosloniec, E. F., L. J. Vitez, and J. H. Freed. Effect of I-Ak hypervariable-region peptides on I-Ak

and I-Ad restricted antigen presentation. FASEB Journal, 2(5):A1446, 1988.

10. Freed, J., D. McKean, D. Mathis, L. Vitez, and E. Rosloniec. Functional dominance of I-Ak

hypervariable regions in antigen presentation. FASEB Journal, 2(6):A1638, 1988.

11. Rosloniec, E., C. Benoist, D. Mathis, D. McKean, and J. Freed. Structural requirements of I-Ak for antigen presentation. J. Cellular Biochemistry, 13a(supplement) (241), 1989.

12. Freed, J. H., E. F. Rosloniec and J. C. Lloyd. Amino acid substitutions in MHC class II molecules modulate their function as ligands for the T cell receptor. Presented at the Denver T-cell Receptors Symposia, 1990.

13. Rosloniec, E. F., J. H. Freed, and T. A. Potter. Identification of MHC class II residues involved in the interaction with murine CD4. Presented at the Denver T-cell Receptors Symposia, 1990.

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14. Freed, J. H., and E. F. Rosloniec. Self peptides derived from MHC class II molecules bind to class II and are immunogenic. J. Cellular Biochemistry, 1991.

15. Myers, L. K., Rosloniec, E. F., Terato, K., Seyer, J., Stuart, J., Kang, A. H. Characterization of the primary structure of an immunodominant T cell epitope of type II collagen important in collagen induced arthritis. Presented at the Boston ACR Meeting, 1991.

16. Freed, J. H., Ward, E. D. P., Rosloniec, E. F., and Beard, K. S. Point Mutation s in polymorphic regions of the I-A molecule regulate its ability to bind and present peptides. J. Cellular Biochemistry 16D:30, 1992.

17. Rosloniec, E. F. Myers, L. K., Kent, P., and Stuart, J. M. Characterization of I-Aq binding sites in a chick type II collagen peptide. J. Cellular Biochemistry 16D:39, 1992.

18. Myers, L. K., Rosloniec, E. F., Seyer, J. M., Stuart, J. M., and Kang, A. H. Immunotherapy of collagen-induced arthritis using a synthetic peptide. FASEB Journal 6:A1794, 1992.

19. Myers, L. K., Rosloniec, E. F., Seyer, J. M., Stuart, J. M., and Kang, A. H. Design of a synthetic peptide capable of treating collagen-induced arthritis via MHC blockade. Arthritis and Rheumatism, 35:S51.

20. Myers, L. K., Rosloniec, E. F., Seyer, J. M., Stuart, J. M., and Kang, A. H. A synthetic peptide analog of a determinant of type II collagen prevents the onset of collagen-induced arthritis. J. Cellular Biochemistry 17B:154, 1993.

21. Rosloniec, E. F. Myers, L. K., Brand, D. D., and Stuart, J. M. Characterization of type II collagen antigenic determinants presented by a CIA susceptible class II allele. J. Cellular Biochemistry 17B:135, 1993.

22. Myers, L. K., Terato, K., Seyer, J. M., Brand, D., Rosloniec, E. F., Stuart, J. M, and Kang, A. H. Collagen-induced arthritis: characterization of T and B cell epitopes. Presented at 2nd Annual Pan American Conference on Collagen, 1993.

23. E. F. Rosloniec, L. K. Myers, D. D. Brand, and J. M. Stuart. Difference in susceptibility of H-2q

and H-2p mice to collagen arthritis is not a result of their A polymorphisms, but may be the result of differential antigen processing. Poster presented at the FASEB Autoimmunity Conference, 1993.

24. E. F. Rosloniec. “Recognition of collagen T cell determinants by closely related strains that differ in their susceptibility to collagen induced arthritis”, an oral presentation given at FASEB Autoimmunity Conference, 1993.

25. D. D. Brand, L. K. Myers, K. Terato, K. B. Whittington, J. M. Stuart, A. H. Kang, and E. F. Rosloniec. The induction of autoimmune arthritis by bovine 1(II)-CB11 is mediated by a single immunodominant T cell determinant in H-2q mice. J. Cellular Biochemistry 18D:314, 1994.

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26. Myers, L. K., H. Miyahara, S. Kawamura, E. F. Rosloniec, D. D. Brand, J. M. Seyer, J. M. Stuart, and A. H. Kang. Identification and characterization of a major tolerogenic T cell epitope of type II collagen which suppresses arthritis in B10.RIII mice. Journal of Investigative Medicine (in press), 1995.

27. Rosloniec, E., D. Brand, K. Whittington, J. Stuart, M. Ciubotaru, and E.S. Ward. Vaccination with a recombinant TCR V domain prevents the development of collagen induced arthritis. 9th International Congress of Immunology, p. 843, 1995.

28. Brand, D. D., W. Watson, K. B. Whittington, J. Stuart, E. F. Rosloniec, and A. H. Kang. Anti mouse 1(II)-CB11 antibody epitope profiles differ between chick 1(II)-CB11 immunized collagen arthritis susceptible and resistant mice. 9th International Congress of Immunology, p. 622, 1995.

29. Ober, B., M. Ciubotaru, S. Popov, G. Hubbard, D. Brand, K. Whittington, J. Stuart, E. Rosloniec, E. S. Ward. Soluble T cell receptor expression using Escherichia coli as a host. 9th International Congress of Immunology, p. 849, 1995.

30. Rosloniec, E. F., K. B. Whittington, and J. M. Stuart. Affinity differences of an immunodominant collagen peptide for I-Aq and I-Ap control susceptibility to collagen-induced autoimmune arthritis. Lymphocyte Activation, Keystone Symposia, p. 86, 1996.

31. Cremer, M. A., X. J. Ye, L. K. Myers, K. Terato, E. Rosloniec, D. Brand, and A. H., Kang. Mapping of T cell epitopes on the bovine type II collagen molecule recognized by arthritis-susceptible BB rats. American Congress of Rheumatology, 1996.

32. Gumanovskaya, M., Rosloniec, E. F., and Stuart, J. M. . Role of / and / T cells in collagen-induced arthritis.. American Congress of Rheumatology, 1996.

33. Rosloniec, E. F., Whittington, K. B., Brand D. D., Zaller, D. M., and Kang, A. H. 1997. HLA-DR1 (DRB1*0101) and DR4 (DRB1*0401) bind and present peptides derived from human type II collagen and as transgenes confer susceptibility to autoimmune arthritis. Presented at the FASEB Autoimmunity Meeting, 1997.

34. Rosloniec, E. F., K. B. Whittington, D. M. Zaller, and A H. Kang. HLA-DR1 (*0101) and DR4 (*0401) share the same peptide binding motif for a peptide derived from human type II collagen. Keystone Symposia, 1999.

35. Guedez, Y., K B. Whittington, M. Gumanovskaya, and E. F. Rosloniec. Elicitation of Collagen-induced Arthritis in a non-susceptible strain after disruption of the IFN- gene. FASEB Autoimmunity Conference, 1999.

36. Rosloniec, E. F., J. L. Clayton, and K. B. Whittington. Clonotypic variation in T cell receptor binding of a DR1 tetramer covalently linked to a type II collagen peptide. FASEB Meeting, 2000.

37. Brand, D. B., C. L. Kelley, A. H. Kang, and E. F. Rosloniec. Induction of IV tolerance in a T cell receptor transgenic mouse model of Collagen Induced Arthritis. FASEB Meeting, 2000.

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38. Latham, K. A., K. B. Whittington, K. L. Brown, and E. F. Rosloniec. Class II-tetramer binding to antigen-specific T cells is enhanced following stimulation of the T cells. FASEB Autoimmunity Conference, 2001.

39. Guedez, Y., K B. Whittington, and E. F. Rosloniec. Upregulated expression of IL-1 and MIP-2 after ablation of IFN- gene in a murine model of autoimmune arthritis. FASEB Autoimmunity Conference, 2001.

40. He, X., Myers, L. K., Rosloniec, E. F., Wang, W., Kang, A. H., and Stuart, J. M. The T cell response to type II collagen in HLA-DR1 transgenic mice is restricted to distinct CDR3 region that correlate with fine specificity. ACR 65th Annual Scientific Meeting, 2001.

41. Latham, K. A., Whittington, K., Brown, K., and Rosloniec, E. F. Variability in the use of MHC class II tetramers to detect CII-specific T cells mediating the development of autoimmune arthritis. FASEB, 2002.

42. Offner, H, Zamora, A., Matejuk, A., Dwyer, J., Drought, H., Auci, D., Reading, C., Latham, K.A., and Rosloniec, E. F. Effect of estrogen on EAE and CIA. 6 th International Symposium on the Immunotherapy of the Rheumatic Diseases, 2002.

43. Latham, K. A., Whittington, K., and Rosloniec, E. F. Enumeration and characterization of autoimmune T cells during the development of autoimmune arthritis using HLA-DR1 and DR4 multimers. FASEB-AAI, 2003.

44. Latham. K. A., Zamora, A., Drought, H., Subramanian, S., Matejuk, A., Offner, H., and Rosloniec, E. F. Estradiol treatment redirects the isotype of the autoantibody response and prevents the development of autoimmune arthritis. FASEB-AAI, 2003.

45. He X, Zhou F, Wang W, Tang B, Rosloniec EF, Myers LK, Kang AH and Stuart JM. T cell receptors recognizing type II collagen in both DR4 and DR1 transgenic mice exhibited restricted Vb usage and shared amino acid motifs in the CDR3 region. FASEB J. 17(7):C42 (34.19), 2003.

46. Latham, K. A., Whittington, K. B., Zhou, R., and Rosloniec, E. F. Detection and Characterization of CII-specific T cells in the Lymph Nodes and Joints of CII-immunized DR1 Mice. FASEB-AAI 2005.

47. Qian, Z., Whittington, K. B., Zhou, R., Latham, K. A., and Rosloniec, E. F. A limited TCR repertoire in the periphery and in arthritic joints mediates the pathogenesis of autoimmune arthritis in the DR1 transgenic mouse model of collagen induced arthritis. FASEB-AAI 2005.

48. Ivey, R. Whittington, K. B., Zhou, R., Park, H.-W. and Rosloniec, E. F. Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen. FASEB-AAI 2005.

49. Kayes, T. D. and Rosloniec, E. F. IL-18 binding protein regulates susceptibility to autoimmune arthritis in C57BL/6 IFN- deficient mice. Arthritis Foundation Meeting, 2007.

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50. Latham, K., Whittington, K. B., and Rosloniec, E. F. Collagen-specific T cells are not down regulated following treatment with 17-estradiol in CIA. American Association of Immunologist meeting, 2007.

51. Rosloniec, E. F., Brand, D. D., Latham, K., Whittington, K., Qian, Z. Development of Genetically Engineered T cells for Antigen Specific Regulation of Autoimmune Arthritis. Keystone Symposia, 2008.

52. Rosloniec, E. F., Whittington, K. B., Brand, D., Hasty, K. A., and Miller, D. C. FTY720 increases the ratio of Treg:CD4 T cells in vivo and inhibits the development of autoimmune arthritis. American Association of Immunologist meeting, 2011.

53. Cho, H., Tidwell, W. J., Aiken, J. W., Lee, M., Pinkhassik, E., Stuart, J. M., Rosloniec, E. F., and Hasty, K. A. Use of Targeted Nanosomes to Detect Damaged Cartilage in Collagen Induced Arthritis. Orthopaedic Research Society meeting, 2011.

54. Neunkirchner, A., Mager, L., Reichl, V., Schmetterer, K., Haiderer, D., Rosloniec, E., Naumann, R., Jahn-Schmid, B., Bohle, B. and Pickl, W. F. Creation of a Humanized Model for Respiratory Allergy Using a Human Mugwort-Specific T-Cell Receptor and HLA-DR1. World Allergy Congress, 2011.

55. Alina Neunkirchner, Lukas Mager, Victoria Reichl, Klaus Schmetterer, Daniela Haiderer, Edward Rosloniec, Ronald Naumann, Beatrice Jahn-Schmid, Barbara Bohle, Winfried F. Pickl. Creation of a Humanized Model for Respiratory Allergy Using a Human Mugwort-specificT-Cell Receptor and HLA-DR1. World Allergy Organ J. 2012 February; 5(Suppl 2): S59.

56. Rosloniec, E. F., Whittington, K. B., Hasty, K. A., Brand, D. D. and Miller, D. C. FTY720 inhibition of autoimmune arthritis is accompanied in vivo by enhanced Treg cell function and autoimmune T cell inactivation. Keystone Symposia, Advances in the Knowledge and Treatment of Autoimmunity, 2013.

57. Christina L. Roark, Kirsten M. Anderson, Michael T. Aubrey1, Edward F. Rosloniec, Brian M. Freed. Comparison of arthritogenic peptide binding to DRB1*01:01 and DRB1*01:02. Human Immunology Volume 76 (Supplement):22, 2015.

58. Kirsten M. Anderson, Christina L. Roark, Mary Portas, Michael T. Aubrey, Edward F. Rosloniec, Brian M. Freed. Four DRβ1 amino acids mediate preferential binding of citrullinated peptides and collagen. Human Immunology Volume 76 (Supplement):35, 2015.

59. I. Sandal, D. D. Brand, J. Luo, A. Prislovsky, K. Whittington, C. Dong, E. F. Rosloniec and A. Karydis. Host Responses to Oral Challenge with Porphyromonas gingivalis and Nicotine in HLA-DRβ1-Bearing “Humanized” Mice. American Society for Microbiology meeting, 2016.

60. David D Brand, Indra Sandal, Jiwen Luo, Amanda Prislovsky, Karen Whittington, Chen Dong, Edward Rosloniec, and Anastasios Karydis. Bone loss in HLA-DRβ1-bearing “humanized”

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mice following oral challenge with Porphyromonas gingivalis. American Association of Immunology Meeting, 2016.

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