Dear EDSA members,

As part of our continued efforts to promote research activities and offer dental students the opportunity to research in an international setting, we are delighted to announce the second year of the EDSA Research Programme.

This year we have been able to secure 12 positions in Yeditepe University (Istanbul, Turkey ) and due to popular demand we have been in discussion with the Dental Institute at Guy’s, King’s & St. Thomas’ Hospitals, King’s College London (London, UK) to offer 4 more positions in London this summer.

Various projects are available, ranging from radiographic interpretation to formulation of artificial saliva, toothpastes and mouth rinses.

To apply for participation in this programme please fill out the attached application form and send an email to edsa.research@gmail.com, providing the following documents:

- Your CV

- Letter of recommendation

Deadline for application is May 20, 2012.

Selection of applicants will commence at the end of May, primarily by the project supervisor with assistance from a panel composed of representatives from the IADR, Colgate-GABA and the EDSA. Applicants will be notified of the outcome with sufficient time to make arrangements to attend the project dates which they have applied for.

EDSA partner Colgate-GABA has kindly provided 6000 EURO to the research programme; Successful applicants will be given the opportunity to apply for a bursary in order to cover the costs of living and transport during their research period (details will follow upon notification of a successful application).

Yeditepe University has generously offered to assist students with accommodation placement and costs for projects undertaken in Turkey.

Upon completion of the projects, students participating in the programme are required to submit a report to the EDSA Research Programme and to Colgate-GABA. Students who successfully complete the programme will be awarded a certificate and will be given an opportunity to present results of their research at the next EDSA meeting or congress.

Please feel free to contact us at edsa.research@gmail.com if you require further information.

Sincerely,EDSA Research Team

The aim of the research programme of the European Dental Students` Association is to promote research activities and networking among dental students and to offer them research and development opportunities in an international setting.

As part of the programme this summer, several students will be given the opportunity to take on the role of research, clinical or laboratory assistant at EDSA partner institutions - King’s College London Dental Institute and Yeditepe University, Istanbul.

Please find enclosed a short synopsis, written by each supervisor, for the projects offered this year.

Please note that the projects in London have not yet been finalised and are not included in this list, once available these will be distributed via the EDSA website: http://www.edsaweb.org .

(These are likely to be in Basic Sciences, Stem Cell research and Technology in Dental Education.)

The aim of the new project of the European Dental Students` Association is to promote research activities and networking among dental students and to offer them research and development opportunities in an international setting.

As part of the programme this summer, several students will be given the opportunity to take on the role of research, clinical or laboratory assistant at EDSA partner institutions - King’s College London Dental Institute and the University of Zagreb, School of Dental Medicine.

Various research projects will be offered to EDSA students, ranging from basic science to clinical work. The list of projects available includes projects in the field of craniofacial development, oral medicine, stem cells/ tissue engineering and haptic technologies in dentistry.

Please find below more information about the institutions and projects offered:

The aim of the new project of the European Dental Students` Association is to promote research activities and networking among dental students and to offer them research and development opportunities in an international setting.

As part of the programme this summer, several students will be given the opportunity to take on the role of research, clinical or laboratory assistant at EDSA partner institutions - King’s College London Dental Institute and the University of Zagreb, School of Dental Medicine.

Various research projects will be offered to EDSA students, ranging from basic science to clinical work. The list of projects available includes projects in the field of craniofacial development, oral medicine, stem cells/ tissue engineering and haptic technologies in dentistry.

Please find below more information about the institutions and projects offered:

Research project coordinator/ Mentor: Assistant Professor Gulengul Duman gduman@yeditepe.edu.tr of available research project:

Type of project: Formulation study with lab work

Aim of the project: Edible Film Formulation for Oral Hygiene

Number of students: 2

Short description of the project: The aim of this study is to assist the formulation of an edible film. An edible film that

dissolves or disintegrates rapidly in the oral cavity, resulting in solution or suspension without the

need of water is known as a ‘fast dispersing dosage form’ or ‘mouth dissolving film’. When this

type of film is placed into the mouth, the saliva will rapidly dissolve the film. Thus there is a need

for delivering drugs to patients efficiently with few side effects; the aim is to work on the

development of new drug delivery systems. Oral mucosal delivery is currently the safest, most

convenient and most economical method of drug delivery, having the highest patient compliance.

The edible film is designed to allow administration in the absence of water or fluid intake. Fast

dissolving films are also called as mouth-dissolving edible film, melt-in mouth films. Fast

dissolving films are the ones when put on tongue disintegrate instantaneously releasing the drug

which dissolves or disperses in the saliva. The faster the drug dissolves the quicker the absorption

is done and the onset of clinical effect. Some drugs are absorbed from the mouth, pharynx and

esophagus

as the saliva passes them down into the stomach. In such cases, bioavailability of drug is

significantly greater than those observed from conventional oral dosage form. The advantage of

the mouth dissolving dosage forms are being recognized in both, industry and academics. The

present study relates to film strips which comprise natural product and biotechnological product

formulations and can be absorbed from oral mucosa. However apart from these in drug

formulation (edible film) property there are pollutant structures with polysaccharide and its

polymer that does not have a pharmacological effect and is composed of maltriose molecules

used for oral hygiene and can be absorbed from oral mucosa. The product is of daily use in order

to assist oral hygiene. On the market are sold as film

strips which can be absorbed from oral mucosa. For example, Listerine® is a product of this

structure.

Duration of the project: 4 weeks, 22 June - 22 July, 2013

Language: English

Role of the student: Clinical assistant

Student contact: For more information on accommodationplease contact: Mustafa Özcan , dt.mustafaozcan@hotmail.com

or +90 542 523 38 00

Research project coordinator/ Mentor: Assistant Professor Gulengul Duman gduman@yeditepe.edu.tr, Associate Professor Senem Selvi Kuvvetli senem.kuvvetli@yeditepe.edu.tr of available research project:

Type of project: Formulation study with lab work

Aim of the project: Development of Formulation and Calculation of Artificial Saliva, Remineralization and Demineralization Solution

Number of students: 2

Short description of the project:

The aim of this study is to assist in formulation development of artificial saliva and remineralization

and demineralization solution. Artificial saliva is a product that is used by people who have too

little of their own naturally occurring saliva (a condition known as dry mouth). Products are

available in an aerosol or a liquid that is deposited into the mouth. The formulation of solutions

will be performed at Yeditepe University, Faculty of Pharmacy (Department of Pharmaceutics).

Finally, the formulation of the saliva-substitute solution will be generally used in the dental

research studies. Students are involved in calculation and development of formulation for all

solutions.

Duration of the project: 2 weeks, 8 July- 21 July, 2013

Language: English

Role of the student: Research & Development formulation study

Student contact: For more information on accommodationplease contact: Mustafa Özcan , dtmustafaozcan@hotmail.com or +90 542 523 38 00

Research project coordinator/ Mentor: Prof. Dr. Fikrettin Şahin, fsahin@yeditepe.edu.trAssistant Professor Gulengul Duman gduman@yeditepe.edu.tr,

Type of project: Formulation study with lab work

Aim of the project: Development of a new antimicrobial/antiviral oral rinse

Number of students: 2

Short description of the project: The aim of this study is to formulate and develop a new oral rinse with antimicrobial and antiviral

properties. Products that enable the inhibition of microbial growth are promising approaches for

preventing the development of mouth sore or tooth decay. Apart from dental related or bacterial

problems, viral infections are also great of interest. Solutions preventing viral infections such as

herpes simplex are important for mouth hygiene. The research will be performed at Yeditepe

University, Genetics and Bioengineering Department.

Duration of the project: 2 weeks, 1 July- 15 July, 2012

Language: English

Role of the student: Research & Development formulation study

Student contact: For more information on accommodationplease contact: Mustafa Özcan , dt.mustafaozcan@hotmail.com or +90 542 523 38 00

Research project coordinator/ Mentor: Associate Professor Meriç Karapınar Kazandağ meric.karapinar@yeditepe.edu.tr of available research project:

Type of project: Research on radiography database of dental school Aim of the project: To asses reliability of radiographic interpretations of endodontic lesionsNumber of students: 2

Short description of the project: Diagnostic and follow-up radiographies are indispensable aids to track prognosis of endodontic therapy. Reliability of radiographic interpretation is of crucial importance; however remains to be a concern due to its subjective nature. There are several articles reporting low intra and inter-examiner agreement on teeth with periapical lesions. A true knowledge of the factors effecting reproducibility of the outcome is necessary to improve the reliability of radiographic interpretation.

The purpose of this study is to evaluate the effect of education on reproducibility of radiographic interpretation of endodontic lesions.

Null hypothesis is no difference between non-dental staff, dental students, residents and endodontists in terms of reproducibility of radiographic interpretation of periapical pathology.A set of radiographs consisting of 240 teeth - upper incisors (20), upper premolars (20), upper molars (20), lower anteriors (20), lower premolars (20), lower molars (20) - with periapical lesions selected from the database of Yeditepe University, Faculty of Dentistry. Each radiograph will be scored according to “Periapical Index (PAI)” by a non-dental staff (control), by a dental student, by a resident and by an endodontist twice with a one week interval. The scores will be recorded. Intraexaminer and Interexaminer agreement will be assessed by Kappa statistics.

Role of the student: 1) To Collect the radiographs according to predetermined criteria from the database of the school 2) To asses the radiographs assessor 3) Collect the scores released from all other assessors 4) Write the abstract under supervision following statistical analysis

Duration of the project: 4 weeks, 1 July- 30 July, 2012Language: EnglishStudent contact: For more information on accommodationplease contact: Mustafa Özcan , dt.mustafaozcan@hotmail.com or +90 542 523 38 00

Research project coordinator/ Mentor: Associate Professor Haktan Yurdagüven hyurdaguven

Type of project: Shear bond strength test with hard tissue lab

Aim of the project: Determination of shear bond strength of new generation adhesive systems to dentin and enamel

Number of students: 2

Short description of the project:

In recent years, manufacturers have produced new generation bonding systems wich can use used

as both self-etch adhesive and total etch adhesives. Application choice of this adhesive system is

case depended. The aim of this study is to evaluate shear bond strength of this adhesive systems

to dentin and enamel. Shear bond strength test will be performed at Yeditepe university, Faculty

of Dentistry.

Duration of the project: 2 weeks, 1 June- 15 June, 2013Language: EnglishRole of the student: Prepare the test samples and perform to shear bond strength.Student contact: For more information on accommodationplease contact: Mustafa Özcan , dtmustafaozcan@hotmail.com or +90 542 523 38 00

Research project coordinator/ Mentor: Prof. Dr. Fikrettin Şahin, fsahin@yeditepe.edu.trGulengul Duman gduman@yeditepe.edu.tr,

Type of project: Formulation study with lab work

Aim of the project: Development of a new antimicrobial tooth paste

Number of students: 2

Short description of the project: The aim of this study is to formulate and develop a new tooth paste providing antimicrobial

properties. Products that enable the inhibition of microbial growth present a promising approach

for preventing the development of mouth sore or tooth decay. Products that are non toxic to cells

and antimicrobial could be potential candidates for mouth care. The research will be undertaken

at Yeditepe University, Genetics and Bioengineering Department.

Finally, the formulation of the saliva-substitute solution will be generally used in the dental

research studies. Students are involved in calculation and development of formulation all

solutions.

Duration of the project: 2 weeks, 1 July- 15 July, 2012Language: EnglishRole of the student: Research & Development formulation study Student contact: For more information on accommodationplease contact: Mustafa Özcan , dt.mustafaozcan@hotmail.com or +90 542 523 38 00

! Contacts

! Simran Chana! EDSA Scientific Officer! The Dental Institute at Guy’s, King’s & St. Thomas’ Hospitals,! Kings College London, UK

! simran.chana@kcl.ac.uk! +447791062614

! Maja Sabalić! EDSA Immediate Past President!! University of Zagreb, School of Dental Medicine, Croatia

! msabalic@sfzg.hr! +385981845376

EDSA RESEARCH PROGRAMME 2013 - APPLICATION FORM (1)

Q1 DETAILS OF STUDENT

Name:

Date of Birth (dd/mm/yy):

E-mail address:

Year of course:(e.g. 2nd year of 5 year course = 2/5)

University/ Country:

Q2 PROJECT CHOICE

Please indicate your preference of research project:

(If you would like to work in London please indicate ‘Guy’s Hospital’ as one of your choices below)

1.

2.

3.

Q3 SUPPORTING INFORMATION Please answer on page 2

a) Why do you wish to work on this project? (no more than 300 words)

b) What are your career intentions at present? (100 words)

c) Have you had any previous research experience? If so, please give details. (200 words)

Q4 SOURCE OF FUNDING

Do you intend on applying for the EDSA Research Bursary?

If unsuccessful, how do you intend on funding your research placement?

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EDSA RESEARCH PROGRAMME 2013 - APPLICATION FORM (2)

Please answer Q3 below:

DEADLINE FOR APPLICATIONS 20.05.2013 - THANK YOU

a) Why do you wish to work on this project? (no more than 300 words)

b) What are your career intentions at present? (100 words)

c) Have you had any previous research experience? If so, please give details. (200 words)

2