Economics of Scaling up New HIV Prevention Interventions: Male Circumcision Example
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Transcript of Economics of Scaling up New HIV Prevention Interventions: Male Circumcision Example
Economics of Scaling up New HIV Prevention Interventions: Male Circumcision Example
Nalinee Sangrujee and Albena GodloveConstella Futures, Gayle Martin, World Bank
International AIDS Economics Network22 February 2008
Outline
• Background• Estimating resource needs• Resource allocation• Implementation challenges
– Supply side– Demand side
• Monitoring and evaluation• Areas for further economics research
Epidemiology behind the intervention
• Weiss et al. (2000): Meta-analysis – 48% (95% CI: 32%-60%)
• Auvert et al. (2005): Randomized clinical trial– 60% (95% CI: 32%–76%)
• Siegfried et al. (2006): Cochrane Review/Meta-analysis– “We found insufficient evidence to support an interventional effect
of male circumcision on HIV acquisition in heterosexual men.” – Pointed to protective effect among high risk males– Pointed to limitations of observational studies and the need for
RCT evidence
• NIH funded trials (2006): Randomized clinical trials– 51% (Uganda)– 60% (Kenya)
Male circumcision intervention could have two benefits:
DIRECT - accrues to men that receive circumcisionINDIRECT – accrues to everyone in the population (to different degrees)
HIV infections averted over the first 20 years of the intervention
0
20
40
60
80
Circumcised men Women Uncircumcised men
Infe
ctio
ns
avert
ed (
%)
Direct effect (+ 2nd-hand indirect effect)
1st-hand indirect effect
2nd-hand indirect effect
5-times less 5-times less
Indirect effects
Source: Jennifer Smith, Tim Hallett, Simon Gregson, Ben Lopman, Kamal Desai, Marie-Claude Boily, Geoff GarnettDepartment of Infectious Disease Epidemiology Imperial College London
Estimating Resource Needs
Cost Analysis
Resource Needs
Cost of Male Circumcision and Implications for Cost-Effectiveness of Circumcision as an HIV Intervention*
• 3 countries: Lesotho, Swaziland, Zambia• Cost data collected on how circumcision currently
implemented– Adult circumcision– Public provider perspective
• Considered also services not currently part of circumcision (counseling with or without testing, training, communications)
* In alphabetical order: Lori Bollinger, Steven Forsythe, Bafana Khumalo, Gayle Martin; Rejoice Nkambule, Tanvi Pandit-Rajani, Dean Peacock, Tshehlo Relebohile, John Stover conducted in 2007
Comprehensive MC services
Excluded: training costs, policy formulation, community consultation etc.
Breakdown of Comprehensive MC Services
$0.00
$10.00
$20.00
$30.00
$40.00
$50.00
$60.00
Lesotho Swaziland Zambia
Communications
Testing
Counseling
Surgical procedure
$56$51
$47
Breakdown of Comprehensive MC Services
$0.00
$10.00
$20.00
$30.00
$40.00
$50.00
$60.00
Lesotho Swaziland Zambia
Communications
Testing
Counseling
Surgical procedure
$56$51
$47
Variation in Direct Costs
Direct Costs
$0
$10
$20
$30
$40
$50
$60
1 2 3 4 5 6 7 8 9 10 11
Facilities
Variation in Indirect Costs
Indirect Costs
$0
$5
$10
$15
$20
$25
$30
1 2 3 4 5 6 7 8 9 10 11
Facilities
How do the costs compare to existing cost estimates?
• Other cost studies:– Orange Farm (South Africa) $55– Rakai (Uganda) $69– Kisumu (Kenya) $25– Mankayane (Swaziland) $82– Mozambique (Fieno) $45
• Problems:– These costs are not directly comparable because it is unclear what is
included in the studies
Resource estimates for scaling upHealth service implications (2008-2020)
Lesotho Swaziland Zambia Mozambique
Program coverage target 52.5% 57% 58%
# MC per month 2,289 964 13,948 10,000
Average annual cost of MC$1.3
million $0.5
million $6.5
Million$5.4 Million
Cumulative cost of MC (2008-2020)
$17.2 M $6.6 M $84.9 M $26 M
Number of physicians needed 6.1 FTE120 surgeons (50% effort), 500 doctors
in country
Number of other key personnel needed
4.5 FTE surgical nurses
240 medical assts (50%)
Resource needs estimates: current approach for male circumcisionCatherine Hankins, Chief Scientific Adviser to UNAIDS and Associate Director,Department of Evidence, Monitoring and Policy
• Only for sub-Saharan African countries • Overall target is 80% of 15-24 year old males circumcised
• Three scenarios being considered: 1. Historical growth in coverage of VCT and PMTCT applied to prevention and care
& treatment 2. Universal access by 2015 3. Universal access to prevention by 2010 and to care and treatment by 2015.
• Target for each country: reduce the gap between current male circumcision prevalence and the 80% target by half by 2015 (scenario 2) or by half by 2010 (scenario 3)
• With these assumptions, resources needed for male circumcision:– $60-160 million in 2010 (implying about 950,000 - 2.5 million circumcisions in
the year 2010)– $50-60 million in 2015
Key Methodological Assumptions for Cost Analysis
• Differences defining the “MC service package”
• Establishment of targets – Age groups– By HIV status
• Number of trained providers needed to reach targets
• Estimation of complication rates and their cost in a non clinical setting
• Non-service delivery costs:– Provider training, policy formulation, operationalization and
enforcement; quality control; advocacy, community outreach
Resource Allocation
Global perspective
National perspective
MALE CIRCUMCISION AND POPULATION BASED HIV PREVALENCE IN AFRICA
0 10 20 30
Botswana
Zambia
Kenya
Cameroon
Ghana
Burkina Faso
Guinea
Sierra Leone
Senegal
Sources:Helen Jackson, UNFPA CST, Harare presentation to ESA Regional Consultation Safe Male Circumcision & HIV Prevention Harare, 7-9 May 2007 Data source: ORC/MACRO, 2005, USAID, 2002
High (>80%) male circumcision
Low (<20%) male circumcision
What is the impact of the pace of scale-up of circumcision?
Swaziland
Linear scale-up Slower scale-up Faster scale-up
2008-2020 % difference with linear scale-up
Avg annual # MCs
11,297 -1.2% +1.3%
Avg annual # IAs
2,809 -14.5% +13.7%
Cost per IA* $292 +12.1% -8.2%
*Real discount rate = 3%
Due to the first, second and third hand indirect effects associated with MC (Hallet et al. 2007)
How cost-effective is MC relative to other prevention interventions?
• Cost per infection averted: – Lesotho: $292– Swaziland: $180– Zambia: $315
• Cost per HIV infection averted for selected HIV interventions (from cost-effectiveness literature)*:– condom distribution: $10–$2,188– VCT: $393–$482 – PMTCT: $20–$2,198 – STI treatment: $271–$514– school-based education: $7,288–$13,326
Alban, Kahn et al, 2006
Financing
Country PreventionFunding
Addt’l Funding June 07
MC FundingFrom
Addt’l Funding
HIV Prevalence²
On-going MC
Service
delivery
MCSvce
Planned
Situat’lAssess-ments
For MC
Provision
CORE Countries
Botswana 15,739 5,500 N/A 24.10%
Kenya 72,449 60,000 5,000 6.10%
Training Facility
Mozambique 38,282 15,500 N/A 16.10%
Namibia 19,332 8,130 N/A 19.60%
Rwanda 17,776 10,600 N/A 3.10%
South Africa 54,480 35,050 1,000 18.80%
Uganda 43,560 23,926 1,200 6.70%
Zambia 45,147 25,249 3,000 15.60%
Training Facility
Other Countries
Lesotho N/A N/A N/A 23.20%
Malawi N/A N/A N/A 14.10%
Swaziland N/A N/A N/A 33.40%
Total Lesotho, Malawi and Swaziland 1,000
Total PEPFAR FY07 Funding for MC Activities 16,000 * Prepared by A. Godlove, Constella Futures
Implementation Challenges
Supply side
Demand side
Supply side:• Who will carry out safe MC?
– Traditional practitioners of ritual circumcision– Private sector
• HR shortages in Government facilities already significantly affects service delivery before MC demands came into effect.
• How does this procedure become part of the overall package of HIV Interventions
– MC is an elective surgery– Circumcision Sundays – Coordinated with other health services– What screening procedures are needed if only circumcise HIV+ men
• What Quality Assurance measures – Rapid scale up without proper training could increase complication rates– What services need to be scaled up to address complications?
Demand side
• Biggest barriers to MC are cost, and concerns about safety (risk of infection or mutilation), and pain
• What are the out-of-pocket costs to the individual? Subsidies?
• What additional barriers (cultural, economic) to demand and access?
• Shifting demand from ritual circumcision.
Monitoring and Evaluation
• Financial– Funding flows– Provider payments
• Programmatic – Exposure to other programs– Number of HIV+ and non HIV+ men circumcised
• Behavioral – Risk compensation– Attribution of program effect
• Epidemiological – new infections– STIs– complication rates
Conclusion
• Cost analysis suggests that:– Level in the health service where MC is provided matters– Pace of scaling up matters
• Cost effectiveness analysis suggests:– MC can be a cost effective intervention– Benefits accrue over time
• Scaling up MC is not without challenges …– Carefully crafted communication messages needed– Indirect costs should not be underestimated – Health service, financial and human resource implications are
significant but not insurmountable– Innovative ways have to be found to involve all providers (including
the private sector and NGOs)
Areas for further research
• Neonatal MC (more complicated and the trainings costs higher)• Age differential in risk of infection and circumcision (young men
compared to older men given their wealth and sexual behavior)• Rate of complications outside of a trial setting• Estimating additional benefits and costs (complications)• Examining other implementation strategies
– combined with other (male) RH services, PMTCT, safe delivery– Analysis of synergies with other HIV prevention interventions
• Is there a impact on gender imbalance? Effect of male circumcision on women’s services and deliveryTask shifting – this further complicates the problem.
• Legal obstacles: the context in which non physicians (nurses) cannot conduct procedures
• Protective effect for other groups: women, MSM, uncircumcised men
Thank You!