ECOG-ACRIN Overview

November 2013

Organizational Overview as of November 2013

Introduction

As the ECOG-ACRIN Cancer Research Group, we:

• Are a multidisciplinary, membership-based scientific organization

• Design and conduct biomarker-driven translational and clinical research involving adults who have or are at risk of developing cancer

• Seek to achieve patient-centered research breakthroughs in all aspects of cancer care to

• Reduce the burden of cancer

• Improve quality of life and survival in patients with cancer

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Organizational Overview as of November 2013

History and Strengths

The 2012 merger combined the complementary strengths of two highly respected National Cancer Institute-sponsored Cooperative Groups:

• Eastern Cooperative Oncology Group (ECOG) large-scale treatment trials changed the standard of care in numerous cancer types and helped to individualize therapy

• American College of Radiology Imaging Network (ACRIN) trials encompassed the full range of medical imaging research, from pilot studies identifying imaging markers to landmark screening trials

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Organizational Overview as of November 2013

Unique Capacity

Because of our biomarker-driven approach and multidisciplinary membership, we are able to:• Integrate therapeutic and diagnostic imaging

research with the latest bioinformatic technologies• Provide laboratory researchers focused on

genetics, targeted therapy, and biomarkers with access to the best and newest technologies in functional imaging

• Explore integral biomarkers, including markers of prognosis and response

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Organizational Overview as of November 2013

Our Research Spans All Aspects of Cancer Care Through Three Scientific Programs Treatment

Prevention

Early Detection and Diagnosis

Symptom Management

Patient-reported Outcomes

Survivorship

Underserved Populations

Comparative and Cost Effectiveness

Experimental Imaging

Developmental Therapeutics

Laboratory Science and Pathology 5

Organizational Overview as of November 2013

Therapeutic Capabilities

• Scientific committees in 11 tumor types• Phase III, large phase II trials integrating laboratory

and advanced imaging science • Biomarker and imaging-based adaptive designs• Strong integrated laboratory programs

o Solid tumors, myeloma, lymphoma, leukemia, immunology, and cytogenetics

• Integrated clinical laboratory, molecular, and imaging databaseso Imaging Core Laboratory manages 100,000+ case

records consisting of >23 terabytes of data6

Organizational Overview as of November 2013

Imaging Capabilities

• Pilot studies to identify, validate imaging biomarkers

• Surveillance strategies for high-risk populations

• Prevention approaches in landmark screening trials

• Trials evaluating imaging markers to predict and monitor therapy response

• Studies of imaging-directed therapy for improving patient management and associated outcomes

• Comparative-effectiveness research and cost-effectiveness analysis

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Organizational Overview as of November 2013

Member Network of Nearly 650 Institutions Throughout 12 Countries

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Ireland

Peru

Argentina

ChinaIsrael

South Africa

The Netherlands

JapanSouth Korea

Australia

Puerto Rico

Canada

Organizational Overview as of November 2013

Members and Their Expertise

More than 6000 individuals involved:• Physicians, scientists, nurses, pharmacists, research associates,

statisticians, biomedical information technology specialists, and cancer research advocates

Broad experience across disciplines:• Clinical: Medical, surgical, and radiation oncology; hematology;

radiology; nuclear medicine; internal medicine; and preventive medicine

• Translational: Laboratory-based pathology, genetics, molecular biology, and experimental imaging

• Related: Biostatistics, bioinformatics, clinical psychology, behavioral sciences, epidemiology, and health services

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Organizational Overview as of November 2013

ECOG-ACRIN Science by the Numbers

• 3 scientific programs

• 17 scientific committees

• About 90 active clinical trials

• 11 tumor types

• 12 research support committees

• More than 6000 individual members

• Nearly 650 participating institutions

• 12 countries

• 41 international sites

• 8 repositories and core laboratories10

www.ecog-acrin.org

Please direct inquires to info@ecog-acrin.org