Dr Wong Tak Man Mandy Kwong Wah Hospital. The incidence of choledocholithiasis in patients...
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Transcript of Dr Wong Tak Man Mandy Kwong Wah Hospital. The incidence of choledocholithiasis in patients...
Dr Wong Tak Man MandyKwong Wah Hospital
• The incidence of choledocholithiasis in patients undergoing cholecystectomy varies with age, ranging from 6% in patients less than 80 years old to 33% in patients more than 80 years old.
Johnson AG, Hosking SW. Appraisal of the management of bile duct stones. Br J Surg 1987;74:555–560.
• Approximately 10% of patients who undergo laparoscopic cholecystectomy harbor common bile duct stones
Way LW, Admirand WJ, Dunphy JE (1972) Management of choledocholithiasis. Ann Surg 176: 347–359
• It is estimated that 5% to 12% of patients with choledocholithiasis may be completely asymptomatic and have normal liver function tests.
Acosta MJ. The usefulness of stool screening for diagnosing cholelithiasis in acute pancreatitis. A description of the technique. Am J Dig Dis 1977;22:168–172.
• 2-step approach:– Lap cholecystectomy, then post-cholecystectomy
ERCP
• 1-step approach:– Lap cholecystectomy and lap CBD exploration– Lap cholecystectomy and intra-operative ERCP– Open cholecystectomy and CBD exploration
• 2-step approach:– Lap cholecystectomy, then post-cholecystectomy
ERCP
• 1-step approach:– Lap cholecystectomy and lap CBD exploration– Lap cholecystectomy and intra-operative ERCP– Open cholecystectomy and CBD exploration
Failure rate: 2-4% Need further endoscopic procedure or re-
operation
Huntington TR. Laparoscopic biliary guide wire: a simplified approach to choledocholithiasis. Gastrointest Endosc 1997;45:295-7.
Transcystic biliary stenting◦ Insert a biliary stent through the cystic duct into
the CBD and through the sphincter of Oddi. ◦ Ensures access to the bile duct for postoperative
endoscopic sphincterotomy.◦ Increase the success rate of post-operative ERCP
• 2-step approach:– Lap cholecystectomy, then post-cholecystectomy
ERCP
• 1-step approach:– Lap cholecystectomy and lap CBD exploration
• Transcystic approach• Transcholedocal approach
– Lap cholecystectomy and intra-operative ERCP– Open cholecystectomy and CBD exploration
Methods for stone retrieval:◦ Irrigation◦ Balloon manipulation (Fogarty catheter)◦ Basket maneuver◦ Choledochoscopy ◦ Electrohydraulic lithotripsy
Completion cholangiogram to confirm ductal clearance, or to decide for open conversion in case of retained stones
Gallbladder is retracted toward right hemidiaphragm with forceps inserted through the most lateral port.
Cystic duct is dilated, if necessary, either with over-the-wire mechanical dilator or over-the-wire pneumatic dilator.
Choledochoscope is inserted through midclavicular port into cystic duct and guided into CBD with atraumatic forceps inserted through medial epigastric port.
• Advantage: • Less invasive• Minimal morbidity, no T-tube, no drain, and a
rapid return to normal activity in most cases
• Disadvantage: • Limited by cystic duct diameter• Depends on the stone that need to be removed
• Indications:• filling defects at cholangiography• Stones smaller than 10mm• fewer than 9 stones
• Contraindications:• stones larger than 1 cm• stones proximal to the cystic duct entrance into
the CBD• small friable cystic duct, <3mm in diameter• tortuous cystic duct• 10 or more stones
• Applicable in more than 85% of cases• Success rate of 85% to 95%• More cost effective than postoperative
endoscopic retrograde cholangiopancreatography (ERCP)
S. Lyass. Laparoscopic transcystic duct common bile duct exploration. Surg Endosc (2006) 20: S441–S445
Longitudinal incision at supraduodenal CBD Limited to 1 cm or diameter of the largest
stone Choledochoscope is inserted through mid-
clavicular port and guided into CBD with atraumatic forceps inserted through medial epigastric port
No stay suture is required
• Advantage:• Useful in cases when transcystic method is not
feasible, such as large stones, intrahepatic stones, or a miniscule or tortuous cystic duct
• Disadvantage:• Technically demanding
– Require suturing and knot-tying skills not necessary in the transcystic method
• Limited by CBD diameter• Increased risk of post-operative bile leakage and
late stenosis
Transcystic approach
N=218
Choledochotomy approach
N=44
Operating time 93.2 144.6
Hospital stay (hours) 39.2 69.8
Conversion rate (%) 0.9 0
Complication (%) 8.3 11.4
J. B. Petelin. Laparoscopic common bile duct exploration. Lessons learned from >12 years’ experience. Surg Endosc (2003) 17: 1705–1715
Transcystic or transcholedochal?
Which method should we choose?
Factor Transcystic approach
Transcholedochal approach
Single stoneMultiple stone
++
++
Stones <6mm diameterStones >6mm diameter
+-
++
Intrahepatic stones - +
Cystic duct < 4mm diameterCystic duct > 4mm diameter
-+
++
CBD < 6mm diameterCBD > 6mm diameter
++
-+
Cystic duct entrance – lateralCystic duct entrance – posteriorCystic duct entrance – distal
+--
+++
Inflammation – mild Inflammation – marked
++
+-
Suturing ability – poorSuturing ability – good
++
-+
+, positive or neutral effect. -, negative effect
Factors influencing duct exploration approach:
• 2-step approach:– Lap cholecystectomy, then post-cholecystectomy
ERCP
• 1-step approach:– Lap cholecystectomy and lap CBD exploration– Lap cholecystectomy and intra-operative ERCP
• Rendezvous technique (transcystic guide wire)– Open cholecystectomy and CBD exploration
Endoscopic sphincterotomy
Advantage:◦ Allows immediate conversion under the same
anaesthesia to open surgery if ERCP fails.
Disadvantage:◦ Difficult due to supine position◦ Difficult cannulation◦ Injection of contrast into pancreatic duct◦ Post-ERCP pancreatitis◦ Require collaboration of 2 teams – surgeon,
endoscopist +/- radiologist.
Rendezvous technique:◦ After intra-operative cholangiogram, a transcystic
guide wire in inserted through a small incision at cystic duct, advanced into duodenum through papilla
◦ The tip of the guide wire is viewed using endoscope, and pulled out of patient’s mouth by a polypectomy snare
◦ A traditional sphincterotome is introduced along the guide wire that allow direct cannulation of papilla and sphincterotomy
◦ Stone extraction can also be performed using the guidance of the wire
Saccomani G. Combined endoscopic treatment for cholelithiasis associated with choledocholithiasis. Surg Endosc. 2005;19 (7):910-914.
Advantage:◦Easy cannulation of CBD◦Avoid contrast injection into pancreatic
duct
Rendezvous technique (case series): ◦ Success rate: 95% ◦ Failure due to difficulty in passing guide wire
through the papilla◦ CBD stone clearance can still be achieved with
traditional sphincterotomy◦ Complication rate: 3.7%
post-sphincterotomy bleeding (2) post-sphincterotomy perforation (2) death due to post-ERCP pancreatitis (1)
Giuseppe Borzellino. Treatment for Retrieved Common Bile Duct Stones During Laparoscopic Cholecystectomy. The Rendezvous Technique. ARCH SURG/VOL 145 (NO. 12), DEC 2010
Post-op ERCP (n=45)
LCBDE (choledochotomy)
(n=41)
Bile leak 0 6
Pancreatitis
Biochemical 4 3
Clinical (Glascow score)
1 (2) 1 (4)
Severe sepsis 1 1
Retained stone 2 1
GI bleed 2 0
Open conversion 1 1
Re-operation 3 (6.6%) 3 (7.3%)
Significant morbidity 6 (13%) 7 (17%)
Hospital stay (days) 7.7 6.4 Nathanson LK. Postoperative ERCP versus laparoscopic choledochotomy for clearance of selected bile duct calculi: a randomized trial. Ann Surg. 2005;242(2):188-192.
Nathanson (n=86) Rhodes (n=80)
LCBDE (choledochoto
my)
n=43
Post-op ERCP n=43
LCBDE (transcystic
) n= 40
Post-op ERCPn=40
Primary ductal clearance (%)
100 74 75 75
Final ductal clearance (%)
100 100 100 93
Morbidity (%)
17 13 0 0
Mortality (%)
0 0 0 0
Hospital stay (days)
6.4 7.7 1 3.5Edward H. Phillips. Treatment of Common Bile Duct Stones Discovered during Cholecystectomy. J Gastrointest Surg (2008) 12:624–628
Nathanson 2005 Berci 1994
Re-operation after Lap CBDE
7.3% 5%
Re-operation after failed post-op ERCP
6.6% 4-8%
The re-operation rate for LCBDE is comparable to post-op ERCP
Berci G, Morgenstern L. Laparoscopic management of common bile duct stones: a multi-institutional SAGES study. Society of American Gastrointestinal Endoscopic Surgeons. Surg Endosc. 1994;8:1168–1174.
CBD less than 7 mm Severely inflammed friable tissue for post-op ERCP
Patient with Billroth II gastrectomy Failed ERCP access Long delay to transfer patient to other locations for
ERCP for LCBDE
Nathanson LK. Postoperative ERCP versus laparoscopic choledochotomy for clearance of selected bile duct calculi: a randomized trial. Ann Surg. 2005;242(2):188-192.
• Rendezvous technique:
• High success rate in clearing ductal stones (94%)• Less complications (especially pancreatitis) • Mean hospital stay is similar to simple lap
cholecystecyomy
• Although operating room time of combined method is longer than simple lap cholecystectomy
Iodice G. Single-step treatment of gallbladder and bile duct stones: a combined endoscopic-laparoscopic technique. Gastrointest Endosc. 2001;53(3):336-338.
Rabago 2006 Morino 2006
Rendezvous (n=59)
2-stage(n=64)
Rendezvous (n=46)
2-stage(n=45)
Success rate of CBD clearance
90.2% 96.6% 95.6% 80% (p=.06)
Post-ERCP pancreatitis
1.7% 12.7%(p=.03)
2.2% 0%
Mean hospital stay 4.3 days 8 days
Mean hospital cost 2829€ 3834€
Rabago LR. Two-stage treatment with preoperative endoscopic retrograde cholangiopancreatography (ERCP) compared with single stage treatment with intraoperative ERCP for patients with symptomatic cholelithiasis with possible choledocholithiasis. Endoscopy. 2006;38(8):779-786.Morino M. Preoperative endoscopic sphincterotomy versus laparoendoscopic rendezvous in patients with gallbladder and bile duct stones. Ann Surg. 2006;244(6):889-896.
Intra-operative ERCP (Rendezvous technique) has high success rate of CBD clearance, and less post-ERCP pancreatitis when compared to the 2-stage method.
LCBDE (n=141) LC + IO ERCP (93)
Surgical time (min) 133.83 +/- 58.24 140.32 +/- 56.55
Stones (n) 2.52 +/- 1.62 2.26 +/- 1.55
Surgical success rate (%) 89.36 91.4
Stone size (mm) 4-40 5-15
Retained stones (%) 2.38 1.17
Complications (%) 5.55 9.42
Hospital charge (RMB) 13559.20 +/- 3452.10
17279.96 +/- 4097.43
Post-op hospital stay (day)
4.66 +/- 3.07 4.25 +/- 3.46
No difference in terms of surgical time, number of extracted stones, retained CBD stones, hospital charges and post-operative hospital stay. Hong DF. Comparison of laparoscopic cholecystectomy combined with intraoperative endoscopic sphincterotomy and laparoscopic exploration of the common bile duct for cholecystocholedocholithiasis. Surg Endosc. 2006;20(3):424-427.
Tranter SE, Thompson MH (2002) Comparison of endoscopic sphincterotomy and laparoscopic exploration of the common bile duct. Br J Surg 89: 1495–1504
LCBDE LC + intra-op ERCP
Surgical success rate (%)
80-99 (96) 79-98 (92)
Stone clearance (%) 81-100 (95) 75-96 (91)
Mortality (%) 0-5 (1) 0-6 (1)
Complications (%) 2-17 (8) 3-16 (13)
Both LCBDE and LC + intra-op ERCP are safe and effective
Stones larger than 20 mm are not suitable for stone removal by endoscopic sphincterotomy
Excessive cutting of sphincter may increase complications
Hong DF. Comparison of laparoscopic cholecystectomy combined with intraoperative endoscopic sphincterotomy and laparoscopic exploration of the common bile duct for cholecystocholedocholithiasis. Surg Endosc. 2006;20(3):424-427.
• 2-step approach:– Lap cholecystectomy, then post-cholecystectomy
ERCP
• 1-step approach:– Lap cholecystectomy and lap CBD exploration– Lap cholecystectomy and intra-operative ERCP– Open cholecystectomy and CBD exploration
Open CBDE remains the “gold standard” for selected, rare patients such as those with Mirizzi syndrome, Billroth II anatomy, and those requiring a drainage procedure.
Morbidity from 11% to 14% Mortality from 0.6% to 1%.
Morgenstern L, Wong L, Berci G. Twelve hundred open cholecystectomies before the laparoscopic era. A standard for comparison. Arch Surg 1992;127:400–403.
• 2-step approach:– Lap cholecystectomy, then post-cholecystectomy
ERCP• Transcystic biliary stenting
• 1-step approach:– Lap cholecystectomy and lap CBD exploration
• Transcystic approach• Transcholedocal approach
– Lap cholecystectomy and intra-operative ERCP• Rendezvous technique
– Open cholecystectomy and CBD exploration
Edward H. Phillips. Treatment of Common Bile Duct Stones Discovered during Cholecystectomy. J Gastrointest Surg (2008) 12:624–628
However, it is unrealistic to extrapolate standards of care based on the available RCTs given the wide variation in skills and resources available in different communities.
Individual surgeons must recognize their own limitations and the limitations of available endoscopists and perform the safest approach.
Lap CBD exploration is comparable to post-op ERCP in terms of ductal clearance, morbidity and re-operation rate.
Lap CBD exploration is comparable to intra-operative ERCP in terms of success rate, stone clearance and complications.
Intra-operative ERCP has higher success rate and less complications (esp. pancreatitis) when compared to post-op ERCP
Decision depends on:◦ Stone number and size◦ Cystic duct size and anatomy◦ CBD size◦ Severity of tissue inflammation◦ Past surgical history ◦ Surgeon’s experience
What are the methods for closing choledochotomy?
Choledochotomy can be closed by either primary closure or insertion of T-tube
Primary closure:◦ Choledochotomy is closed with 40 or 50 vicryl,
either interrupted or continuous suture. T-tube:
◦ The entire 14-French T-tube is placed into abdomen
◦ Then the “T” is inserted into the CBD
• Use of T-tube is based on for three primary factors: • decompression of the duct, in the case of residual
distal obstruction;• ductal imaging in the postoperative period• provision of an access route for removal of
residual CBD stones, should they be left after CBD exploration
Williams JAR. (1994) Primary duct closure versus T-tube drainage following exploration of the common bile duct. Aust N Z J Surg 64: 823–826
• Drawbacks of T-tubes during postoperative period:• Bacteremia• Dislodgment of the tube• Obstruction by the tube• Fracture of the tube
• Removal of T-tubes has been associated with bile leaks, peritonitis, and reoperation
• T-tube cholangiography should be performed before removal of the tube
• Removal of T-tubes has been suggested as early as 4 days postoperatively and as late as 6 weeks after surgery
Norrby S (1988) Duration of T-tube drainage after exploration of the common bile duct. Acta Chir Scand 154: 113–115
• Selective laparoscopic placement of T-tubes in patients requiring choledochotomy is a safe and effective alternative to routine T-tube drainage of the ductal system
J. B. Petelin. Laparoscopic common bile duct exploration. Lessons learned from >12 years’ experience. Surg Endosc (2003) 17: 1705–1715
With T-tube Primary closure
No. of cases 33 12
Operating time 155.3 115.4
Hospital stay (hours) 80.9 39.4
Conversion rate (%) 0 0
Complication (%) 15.2 8.3
Emergency LCBDE N=48 Elective LCBDE N=33
Bile leak 2 (4%) Bile leak 1 (3%)
Supraventricular tachycardia
1 (2%) Supraventricular tachycardia
1 (3%)
Hyperkalaemia 1 (2%) Incisional hernia 1 (3%)
Jaundice and ERCP 1 (2%) Impacted dormia basket 1 (3%)
Urinary retention 1 (2%) Paralytic ileus 1 (3%)
Sepsis 1 (2%)
Death 1 (2%) Death 0
Ali Alhamdani. Primary closure of choledochotomy after emergency laparoscopic common bile duct exploration. Surg Endosc (2008) 22:2190–2195
• Safe for primary closure in emergency setting by comparing it to the elective setting.
• Moreover, no difference was shown in operative time or the hospital stay between the two groups