Abolarin A. T, FMCPath Lecturer/Consultant Haematologist ...
Dr Abhay A. Bhave, MD, FRCPA Haematologist …...Uptodate Fletcher 2008 Evaluation of Peripheral...
Transcript of Dr Abhay A. Bhave, MD, FRCPA Haematologist …...Uptodate Fletcher 2008 Evaluation of Peripheral...
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Dr Abhay A. Bhave, MD, FRCPA
Haematologist
Lilavati , GLOBAL Hospitals
Empire Haematology Oncology Day care centre, Bandra (W), MUMBAI
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Size
Site
Consistency
Pain with palpation
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tendertender are more likely to be due to an infectious process,
painlesspainless adenopathy raises the concern of malignancy.
consistencyconsistency
lymph nodes containing metastatic carcinoma are rock hard,
lymph nodes containing lymphoma are firm and rubbery,
lymph nodes enlarged in response to an infectious process are soft.
largerlarger the lymph node more likely to be malignant esp if > 3 to 4 cm
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Right Supraclavicular
Mediastinum
Lungs
Upper 2/3 esophagus
Left Supraclavicular
Virchow node
Testes/ovaries
Kidneys
Pancreas
Prostate
Stomach
Lower Esophagus
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Virchows
Left supraclavicular (abdominal or thoracic ca)
Sister Joseph
Para-umbilical (gastric adenoca)
Delphian node
Prelaryngeal (thyroid or laryngeal ca)
Node of Cloquet (Rosenmuller node)
Deep inguinal near femoral canal
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CANCER
HYPERSENSITIVITY
I NFECTIONS
C ONNECTIVE TISSUE
ATYPICAL LPDS
GRANULOMATOUS
OTHERS
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Investigations
History
LN biopsy
AVOID FNAC
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CHRONIC LYMPHOPROLIFERATIVE DISORDER
CLL
NHL IN LEUKAEMIC PHASE
MANTLE CELL LYMPHOMA
HAIRY CELL LEUKAEMIA
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IMMUNOPHENOTYPING
CD 5+ , 19 + , 20+ , 23+, SmIG NEG
CD 5+ , 19 + , 20+ , 23 neg, SmIG NEG
CD 5+ , 19 + , 20+ , 23+, SmIG positive
CD 5+ , 19 + , 20+ , 25+, CD 103 + FMC 7 +
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IMMUNOPHENOTYPING
CD 5+ , 19 + , 20+ , 23+, SmIG NEG CLL
CD 5+ , 19 + , 20+ , 23 neg, SmIG NEG
CD 5+ , 19 + , 20+ , 23+, SmIG positive
CD 5+ , 19 + , 20+ , 25+, CD 103 + FMC 7 +
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IMMUNOPHENOTYPING
CD 5+ , 19 + , 20+ , 23+, SmIG NEG
CD 5+ , 19 + , 20+ , 23 neg, SmIG NEG MCL
CD 5+ , 19 + , 20+ , 23+, SmIG positive
CD 5+ , 19 + , 20+ , 25+, CD 103 + FMC 7 +
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IMMUNOPHENOTYPING
CD 5+ , 19 + , 20+ , 23+, SmIG NEG
CD 5+ , 19 + , 20+ , 23 neg, SmIG NEG
CD 5+ , 19 + , 20+ , 23+, SmIG POS SLL
CD 5+ , 19 + , 20+ , 25+, CD 103 + FMC 7 +
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IMMUNOPHENOTYPING
CD 5+ , 19 + , 20+ , 23+, SmIG NEG
CD 5+ , 19 + , 20+ , 23 neg, SmIG NEG
CD 5+ , 19 + , 20+ , 23+, SmIG positive
CD 5+ , 19 + , 20+ , 25+, CD 103 + FMC 7 + HAIRY CELL
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Physical examination
Imaging
Chest radiography
Lymphangiography
Ultrasonography
Computed tomography
Magnetic resonance imaging
Gallium scanning
Positron emission tomography
Sampling
Needle aspiration
Cutting needle biopsy
Excisional biopsy
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Can be done by bedside, open surgery, mediastinocopy or laparoscopy
FNA not recommended cannot distinguish between lymphomas (nodal architecture needs to be intact)
excisionalexcisional biopsybiopsy,
Provides the pathologist with adequate material to perform histologic,
immunologic, and genetic studies, is the most appropriate approach
FNA reserved for
established diagnosis and to demonstrate recurrence
Culture
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67 year old male Left sided cervical lymphadenopathy Presented 3 years ago with swelling No history of fever or type B symptoms No other lymphadenopathy is found.
LNBiopsy done
Pressure to treat
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Similar in architecture to normal
geminal centers.
Can Resemble Reactive Follicular
Hyperplasia
Low proliferation rate in
comparison to RFH
Bcl-2 staining absent in RFH
Residual benign mantle zones not
seen
Dendritic cells are present and
stains can highlight diffuse areas
FLIPI AND FLIPI 2
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PARATRABECULAR AGGREGATES OF LYMPHOID CELLS
HOW DO I TREAT SUCH PATIENTS?
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13 year old female Right sided cervical lymphadenopathy persistent
2 months No history of fever or type B symptoms No sore throat, ear pain or dental problems. Vital signs are stable. O/E 3cm anterior cervical lymph node which is
firm, non-tender and mobile. Others NAD No other lymphadenopathy is found.
CT scan – no other LN group
LN biopsy done
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Castleman’s Disease Hyaline Vascular
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Castleman’s Disease – Plasma cell
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58 year old female, obese Difficulty in vision Retinal haemorrhages CBC showed anaemia with raised ESR Right sided cervical lymphadenopathy No history of fever or type B symptoms PET CT scan Multiple LN on PET CT LN biopsy done
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Plasmacytoma
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IgG Kappa Myeloma ISS III
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26 year old male PUO for 2 months, multiple antibiotics Right sided cervical lymphadenopathy Axillary Lnpathy Bicytopenia- low WBC and PLTS
Bone marrow done- suspect T Lymphoblastic leukaemia
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Lymphoblastic Lymphoma
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TdT Positive
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52 year old female History of fever and weight loss over 2-4 weeks Right sided cervical lymphadenopathy CXR – mediastinal LN pathy Easy bruisability (plts 1000) No drugs No organomegaly Bone marrow done
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Granuloma
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63 MALE
PAIN/ SWELLING ON LEFT LOWER LIMB
TREATED WITH PAIN KILLERS
NO RESPONSE
CT SCAN OF CHEST ABD AND PELVIS
MULTIPLE LNS IN THE ILIAC AND INGUINAL GROUPS
FNAC NON-DIAGNOSTIC
TREATED WITH AKT ON SPECULATION
NO RESPONSE AT 4 WEEKS
DVT
RETROSPECTIVELY WEIGHT LOSS
FEVER
LN BIOPSY
HODGKINS LYMPHOMA
ADVANTAGE OF EARLY DETECTION
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RS cell
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21 year old male PUO for 3 months Right sided cervical lymphadenopathy, axillary and
inguinal LNs bulky Mediastinal LNs LN biopsy done and assessed at one centre-
? NLPHL ?HD
LN biopsy reviewed at another centre –
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Classical HD –negated
(LCA - +ve,CD15,CD30 –ve)
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??TCRBCL
PET – CT EXTENSIVE STAGE IV DISEASE
MARROW UNINVOLVED
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HD –negated
(LCA - +ve,CD15,CD30 –ve)
??TCRBCL
Large CD20+ve cells in a nodular small l’cyte background
?NLPHL
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Single NLPHL nodule
Strong diffuse CD57 +ve
>>>TCRBCL like NLPHL
because
Background is T cells
Loss of dendritic network
HOW DO I TREAT THIS PATIENT ?
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Uptodate Fletcher 2008 Evaluation of Peripheral Lymphadenopathy Aster 2008 Castleman’s Disease Glazer. G. Normal Mediastinal Nodes AJR 144:261-265 Feb 1985 Ghirardelli, M. Diagnositc approach to lymph node enlargement. Haematologica 1999 84:242-247 Ferrer, R. Lymphadenopathy: Differential Diagnosis and Evaluation 1998 Haberman, T Lymphadenopathy Mayo Clinic Proc. 2000 75:723-732 Lee,Y. Lymph Node Biopsy for Diagnosis: A statistical study. Journal of Surgical Oncology 14:53-60
1980 Skolnik, P Case 5-1999 37 yo male with fever and lymphadenopathy Volume 340: 545-554 Lichtman et al. (2006) Williams Hematology New York. McGraw-Hill Parslow et al. (2001) Medical Immunology new York. McGraw-Hill Malin, Ternouth (1994) Epitrochlear lymph nodes as a marker of HIV disease in Subsaharan Africa
BMJ 1994; 309 1550-1551 Bazemore and Smucker Lymphadenopathy and Malignancy AAFP 2002 Ashley Rosko, MD presentation
ACKNOWLEDGEMENT: Dr Minal Hastak, hematopathologist, Lilavati Hospital and research
centre Dr Chandalekha Tampi hematopathologist, Lilavati Hospital and
research centre
54 PUNE HAEMATOLOGY CONFERENCE 2013
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