Do oligomers damage membranes?. Oligomers bind to vesicle membranes (in vitro incubation with...
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Do oligomers damage membranes?
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Transcript of Do oligomers damage membranes?. Oligomers bind to vesicle membranes (in vitro incubation with...
Do oligomers damage membranes?
Oligomers bind to vesicle membranes (in vitro incubation with ex-vivo or artificial lipids)
Brain derived lipids
Phosphatidylglycerol
E57K mutant promotes the formation of ring-like structures (in vitro incubation with lipid monolayer)
Disrupting the organization between -helix and -sheet strands improves the formation of oligomers versus fibrils, making the -synuclein more toxic
Can -synuclein oligomers cause mitochondrial damage in PD?
Overexpression of -syn induces mitochondrial fragmentation
-syn dependent mitochondrial fragmentation precedes mitochondrial dysfunction…
…and neuronal death
-syn disrupts intramitochondrial structure in vitro and…