DNA Mutations
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Transcript of DNA Mutations
DNA Mutations
Section 11.3
Review
• DNA controls structure and function of cells because it holds the code to build all proteins.
DNA
transcription translation
mRNAAmino acid sequence
Mutation—mistakes in the DNA
• Mistakes can occur randomly through errors in replication, transcription, or cell division.
• External factors can also cause mutations.
• Mutations can occur in reproductive cells (sperm or egg) or in body cells.
Only adult cells affectedOnly offspring affected
New protein that is better than before
New protein hurts organism or doesn’t work at all.
Mutation in body cellMutation in
sperm or egg
Cell may no longer work properly
Cell doesn’t reproduce properlymay lead to cancer
Certain types of mutations are found in the genes or DNA
• Point (substitution) mutation is the change in a single base pair.– EX. When you change one letter in a
sentence:• THE DOG BIT THE CAT.• THE DOG BIT THE CAR.
DNA mutations con’t
• Frameshift mutation is when one base is deleted or inserted and the whole sequence shifts.– EX: If you delete the letter G, from the original
sentence: • THE DOG BIT THE CAT.• THE DOB ITT HEC AT.
– EX: If you insert the letter A, into the sequence.
• THE DOG ABI TTH ECA T.
Chromosomes carry large amounts of genetic material and can also have
mutations
Mutation causes are called mutagens.
• Radiation (nuclear, x-ray, UV, etc), asbestos, formaldehyde all can lead to mutations.
• Organisms have evolved several enzymes that check and repair DNA, but the more exposure to a substance, the more chances for mistakes.