BV Injury

Platelet

Activation

Plt-Fusion

Blood Vessel

ConstrictionCoagulation

Activation

Stable Hemostatic Plug

Thromibn,

Fibrin

Reduced

Blood flow

Tissue Factor

Primary hemostatic plug

Neural

Fibrinogen

Fibrin Mononer

Fibrin Polymer

Cross LinkedFibrin

Thrombin

F-XIIIa

Realease of tissue factor

Widespread endothelial injury

Activation of coagulation

cascade

Widespread micro

thrombi

Consumption coagulopathy

Activation of fibrinolysis

Bleeding

Brain>heart>lungs>kidney>adrenals>spleen

Disseminated > localised

Endocrine

adrenals

pituitary

Platelet count ?

Coagulation factors ?

Fibrinogen level ?

PTT ?

PT ?

Thrombin time ?

Fibrin degradation products ?

Plasmin ?

Microangipathic HA picture

BT Plt PT PTT

Vascular Dis - - - -

PLT Disorder - - - -

Factor 8/9*Congenital - - -

Vit K / Liver*Acquired - - -

Combined (DIC) -