DEVELOPING A RESEARCH PROJECT DURING

RESIDENCY

Mohammad Hassan Pervaiz, MD

September 2005

OBJECTIVES

To familiarize new residents with available RESEARCH RESOURCES

To identify key steps for research PROJECT DEVELOPMENT

"Every path to a new understanding begins in confusion." Mason Cooley

WHAT IS “RESEARCH”

inquire into

systematic investigation to establish facts

“Research” is an active, diligent and systematic process of inquiry in order to discover, interpret or revise facts, events, behaviors, or theories, or to make practical applications with the help of such facts, laws or theories.

TYPES OF MEDICAL RESEARCH

• Clinical Research

a-Retrospective (chart review)

b-Prospective

c-Meta-Analysis

d-Clinical Trials

e-Epidemiological Research f- Health services/ Policy analysis

• Basic Science

a-Animal research

b-Non-animal research

Which ones are for residents ??

RESOURCES

PEOPLE

• RESIDENT RESEARCH COORDINATOR

• MSU/ SPARROW FACULTY

FACULTY INTERESTS

• DEPARTMENT OF MEDICINE FACULTY

• OTHER MSU FACULTY

• NON-MSU FACULTY

• OUT-OF-TOWN FACULTY

DIVISION CHIEF

HEME-ONC DR.CONLEY

CARDIOLOGY DR. ABELA

ENDOCRINOLOGY DR. GOSSAIN

GENERAL IM DR. FERENCHICK

IMMUNOLOGY AND SEROLOGY

DR. GERLACH

INFECTIOUS DISEASE

DR. HAVLICHECK

OCUPATIONAL MEDICINE

DR. ROSENMAN

THROMBOSIS DR. PENNER

FACULTY INTERESTSDr. George AbelaChief, CardiologyThrombosis, plaque rupture, platelet aggregation, vascular injury

Dr. Ved GossainChief, EndocrinologyDiabetes, obesity, thyroid and growth hormone disorders

Dr. Gary FerenchickChief, General MedicineMedical student education, information technology

Dr. John GerlachChief, Immunology & SerologyImmunogenetics of human, transplant immunology, transfusion medicine

Dr. Daniel HavlichekChief, Infectious DiseasesHIV and Hepatitis

Dr. Ken RosenmanChief, Occupational MedicineDisease from chemicals, heavy metals and mineral dusts

Dr. John PennerChief, ThrombosisThrombosis and homeostasis, hemophilia

Dr. Barbara ConleyChief, Heme/OncCancer drug development; Pancreatic, head and neck cancer; molecular markers for cancer

FACULTY INTERESTS

Dr. Mary Nettleman, chairepidemiologic and health outcomes research

Dr. Davoren Chick, Program Directorhealthcare services and healthcare quality, COPD

INTERNAL MEDICINE

Dr. Heather Laird-Fickgraduate and undergraduate medical education, health care quality and disparities

Dr. Francesca Dwamenausing the principles of effective doctor-patient relationships to understand and manage patients' symptoms

Dr. Rey Bouknighthealth services and outcomes research for minority and poor populations especially in the areas of diabetes and cancer; healthcare quality for IM clinic

Dr. Robert Smithdoctor-patient communications and relationships, medically unexplained symptoms, somatization, teaching patient-centered interviewing, and other psychosocial principles

Dr. Ade Olomutranslating research into practice in the area of improving secondary prevention of myocardial infarction.

Dr. Asad MohmandUndergraduate medical education

Dr. Michael Zaroukianmedical education, information technology and informatics, internal medicine curriculum development, and web-based education and evaluation systems in medical education.

Dr. Ralph Watsonbasic and clinical research in hypertension.

Dr. Aron Sousaelectronic medical record to teach students and residents how to use population health skills and techniques in their own practices

INSTITUTIONAL REVIEW BOARD• UCRIHS is an Institutional Review Board (IRB)

UNIVERSITY COMMISION ON RESEARCH INVLOVING HUMAN

SUBJECTS

Federal and University regulations require that all research projects involving human subjects and materials of human origin be reviewed and approved by an IRB before initiation

UCHRIS

Under the regulations, all investigators (faculty &/or graduate students) who will conduct research that involves human subjects or materials of human origin (blood or tissue samples taken from live humans) must submit an application to UCRIHS

Approval of the research protocol must be in place before the investigator begins data collection.

IRB Reliance is an agreement between MSU and Sparrow Hospital which allows an investigator to have a research protocol undergo IRB review through UCRIHS, and Sparrow will accept the review of the lead institution

UCRIHS• Peter Vasilenko, Ph.D., Chair

202 Olds Hall, Michigan State UniversityEast Lansing, MI 48824-1047

Phone: (517) 355-2180Fax: (517) 432-4503

E-mail: ucrihs@msu.edu

http://www.humanresearch.msu.edu

HIPAA

The Health Insurance Portability and

Accountability Act

UCRIHS reviews HIPAA related research protocols at the same time as the regular UCRIHS review

DEVELOPING YOUR OWN PROJECT

• SELECT YOUR AREA OF INTEREST• SELECT A RESEARCH MENTOR• FORMULATE A RESEARCH QUESTION• COLLECT BACKGROUND INFORMATION AND DEVELOP

A HYPOTHESIS• DEVELOP A PROJECT PROTOCOL• APPLY TO IRB (UCRIHS)• START PROJECT AFTER IRB APPROVAL• INTERPRET AND ANALYZE COLLECTED DATA• FUTURE PLANS (may include one or more of following)

~ Dissemination of results (presentation, publication, etc) ~ Further data collection ~ Grant submission

IRB REQUIREMENTS FOR RESEARCH PROTOCOL

• RESEARCH STATEMENT• ABSTRACT• PROJECT DESCRIPTION

~ STUDY DESIGN~ SAMPLE SIZE JUSTIFICATION~ STATISTICAL ANALYSIS~ BACKGROUND

INFORMATION~ REFRENCES

• CONSENT PROCESS• HIPAA

“EMR”

• COMPUTERIZED DATABASE• AVAILABLE ONLINE• EXCELLENT RESOURCE FOR EFFICIENT DATA EXTRACTION• CONTACT DR. ZAROUKIAN• IMPORTANT TO INFORM DR.ZAROUKIAN EARLY DURING

RESEARCH DESIGN DEVELOPMENT• CONTACT DRS. BOUKNIGHT AND/OR DR.LAIRD-FICK IF

INTERESTED IN CLINIC QUALITY ASSESEMENT STUDIES USING EMR.

• WEB: http://www.emr.msu.edu

RESOURCES FOR STATISTICS

• MSU INTERNAL MEDICNE FACULTY• MSU CENTER FOR STATISTICAL TRAINING AND

CONSULTING: (CSTAT)• CSTAT can provide consulting on

• Research design/experiments/surveys • Selection of appropriate statistical methods • Selection of statistical software • Statistical analyses • Interpretation of results • Presentation of results

• Referrals • CONTACT: www.cstat.msu.edu

MSU RESEARCH ELECTIVE• 2 blocks of research time allowed

• all paperwork to be submitted at least 6 weeks prior to the start of elective.• A letter from you stating your desire to do a research rotation or continuity

experience. Letter must identify:• Your research mentor • The research topic• Outline of the research plan• Expected product of research experience (e.g. paper or poster)

• A letter from your research mentor. In the letter it must be stated that the mentor has agreed to work with you and the letter specifies:

• Research topic• Research plan• Any patient contact during the research rotation.• Agreement to evaluate you at the end of the rotation using our form.• If you are requesting a weekly research experience spanning several months, your

research mentor must agree to fill out an evaluation each quarter that you are involved in the weekly research experience.

• Web: http://www.im.msu.edu/program/research3.htm

SUMMARY

• Go to available MSU web links to learn about the resources in greater details

• Familiarize yourself with the research interests of the appropriate faculty researcher before approaching them

• Ask Dr.Dwamena for help !

• Start Early!

• "I know quite certainly that I have no special gift. Curiosity, obsession and dogged endurance have brought me my ideas."Albert Einstein

IMPORTANT WEB-LINKS• MSU IM ~ Research

http://im.msu.edu/program/research3.htm

• UCRIHShttp://www.humanresearch.msu.edu/

• SPARROW IRBhttp://www.sparrow.org/irrc/irrc_aboutirrc.asp

• CSTATwww.cstat.msu.edu

• MSU INTRAMURAL RESEARCH GRANThttps://www.vprgs.msu.edu

• CHM ~ Researchhttp://humanmedicine.msu.edu/research/

• HEALTH TEAM ~ Researchhttp://www.healthteam.msu.edu/medicine/research.htm

QUESTIONS !