Demographic pattern of incidence of breast carcinoma by subtype - A comparative study
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Demographic pattern of incidenceof breast carcinoma by subtype
- A comparative study
Guvera vasireddy, Assistant professor
Dr. Triveni Bhopal, Professor
MNJ institute of Oncology / OMC
Dr. Ezhil Arasi. N, Professor and HOD
Department of pathology ,
Osmania Medical College, koti
Hyderabad, Telangana State
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Prevalence of Breast Cancer Subtypes According to Race and Menopausal Status in Carolina study
African American Non African American
TumorSubtype
All cases Pre menopausaln = 97
Post menopausaln = 99
Pre menopausaln = 164
Post menopausaln = 136
Triple negative 100 38 (39) 14 (14) 26 (16) 22 (16)
Her2 positive 33 9 (9) 7 (7) 9 (6) 8 (6)
Luminal A 255 35 (36) 58 (59) 83 (51) 79 (58)
Luminal B 77 9 (9) 16 (16) 30 (18) 22 (16)
unclassified 31 6 (6) 4 (4) 16 (10) 5 (4)
figures in brackets are percentage
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Therapy options In differentmolecular
subtypes
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IDCC with lymphocytic infiltrationAround the cell clusters.
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Er negativity In the same case
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Her2 3+ in plasma membrane
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Estrogen receptorNuclear positivity
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Progesterone positivityIn nuclei
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ER negative In nuclei
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Estrogen receptor Negativityin nuclei of the tumor cellshigher magnification
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Her2 3+Positive membraneStaining in more than 10% of contiguous tumor cells
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Her2 2+Membrane positivity In <10% of cells
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Her2 1+ occasional Membrane positivity
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Age Group No.of Cases Percentage
21-30 11 7
31-40 33 22
41-50 51 34
51-60 34 23
61 and Above 21 14
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Age Total
Total ER+ve ER-ve
HER1+ HER2+ HER3+
HER-
ve HER1+ HER2+ HER3+
HER-
ve
21-30 11 0 0 1 2 0 1 3 4
31-40 33 1 1 7 3 2 3 13 3
41-50 51 1 2 9 4 0 3 16 16
51-60 34 0 6 6 4 1 1 9 7
61 -
above 21 0 3 4 4 0 3 1 6
Actual observation of receptor status
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Her3+47%
Her2+21%
Her1+3%
Her Neg29%
Percentage of each category in ER+ve
ER+ve 58
Her3+ 27
Her2+ 12
Her1+ 2
Her Neg 17
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Her 3+46%
HER 2+12%HER1+
3%
HER -ve39%
Total Percentage in ER-ve
ER-ve Total 92
Her 3+ 42
HER 2+ 11
HER1+ 3
HER -ve 36
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Age Group Total cases Luminal A Luminal B Her2 Triple negative
HER 2+ER + ER -
21 - 30 11 2 1 3 4 0 131 - 40 33 4 7 13 5 1 341 - 50 51 5 9 16 16 2 351 - 60 34 4 6 9 8 6 161 and above 21 4 4 1 6 3 3Total 150 19 27 42 39 12 11
Categorization in to subtypes according to age
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Age Group Total cases
Luminal A Luminal B Her2 Triple negative
unclassified
Pre menopausal
95 11 (11.57) 17 (17.89) 32 (33.68) 25 (26.31) 10 (9.5)
Postmenopausal
55 8 (14.54) 10(18.18) 10 (18.18) 14 (25.45) 13 (23.63)
Total
150 19 (12.66) 27 (18) 42 (28) 39 (26) 23 (15.33)
Categorization according to menopausal state
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Study population African American population
Sub Types Pre Menopausal Post menopausal Pre menopausal Post menopausal
Triple Negative 25 (26.31) 14 (25.45) 38 (39) 14 (14)
Her 2 Positive 32 (33.68) 10 (18.18) 9 (9) 7 (7)
Luminal A 11 (11.57) 8 (14.54) 35 (36) 58 (59)
Luminal B 17 (17.89) 10(18.18) 9 (9) 16 (16)
Unclassifiable 10 (9.5) 13 (23.63) 6 (6) 4 (4)
Total 95 55 97 99
Incidence of different subtypes in study population and African American population in CBS
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Study population Non African Americans
Sub Types Pre Menopausal Post menopausal Pre menopausaln = 164
Post menopausaln = 136
Triple Negative
25 (26.31) 14 (25.45) 26 (16) 22 (16)
Her 2 Positive 32 (33.68) 10 (18.18) 9 (6) 8 (6)
Luminal A 11 (11.57) 8 (14.54) 83 (51) 79 (58)
Luminal B 17 (17.89) 10(18.18) 30 (18) 22 (16)
Unclassifiable 10 (9.5) 13 (23.63) 16 (10) 5 (4)
Total 95 55 164 136
Incidence of different subtypes in study population and Non African American population in CBS
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*Chandrika Rao, Jayaprakash Shetty, HL Kishan PrasadDepartment of Pathology, K S Hegde Medical Academy, Deralakatte, Mangalore, Karnataka, India
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"The most important takeaway for our colleagues in breast cancer diagnosis and treatment is the potential value of molecular subtyping to personalize and improve each woman's treatment,"
Thank you all
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Thankyou all