Unguenta SalisilatUNGUENTA SALISILATPenimbangan bahan formulaASAM SALISILATFormulaIIIIIIIVWadah (g)14.50114.11214.55414.042Wadah + isi (g)15.02114.61215.06514.542Isi (g)0.520.50.5110.5VASELINFormulaIIIWadah (g)4645Wadah + isi (g)145.3139Isi (g)99.593.9CERA FLAVAFormulaIIWadah (g)44Wadah + isi (g)49.93Isi (g)5.6PEG 400FormulaIIIIVWadah (g)45.94960.721Wadah + isi (g)90.17288.37Isi (g)44.22327.649PEG 4000FormulaIIIIVWadah (g)94.68988.148Wadah + isi (g)149.998160.076Isi (g)55.30971.928UJI HOMOGENITASFormulaIIIIIIIVReplikasi123123123123HomogenHalusUJI DAYA SEBARFormula IFormula IIFormula IIIFormula IV05010015005010015005010015005010015044.024.124.223.884.034.154.233.43.43.43.42.22.22.3152.315UJI KEMAMPUAN PROTEKSIFormula IFormula IIFormula IIIFormula IV

15"v15"v15"v15"v30"v30"v30"v30"v45"v45"v45"v45"v60"v60"v60"v60"v180"v180"v180"v180"v300"v300"v300"v300"vUJI DISOLUSIPenimbanganFormulaI (basis vaselin)III (basis PEG)Berat sel disolusiBerat sel disolusi + unguentaBerat unguentaLarutan Stok (C = 1mg/mL)Cara:25mg as. salisilat ad aquadest 250mL

Absorbansi blankoSeri larutan bakuABSORBANSISeriC (mg/mL)Abs10.020.36920.030.5430.040.63840.050.76350.060.868a = 0.147b = 12.21r = 0.995y= 12.21x + 0.147PENGUJIAN DISOLUSI UNGUENTAFORMULA I (basis vaselin)Menit ke-AbsC (x/5mL)00.05-0.0079450.066-0.00663100.069-0.00639150.075-0.0059250.077-0.00573350.079-0.00557450.081-0.00541FORMULA III (basis PEG)Menit ke-AbsC (x/5mL)00.089-0.0047550.092-0.0045100.099-0.00393150.1-0.00385250.1-0.00385350.104-0.00352450.109-0.00311

Suspensi SulfadiazineSUSPENSI SULFADIAZINEMETODE PRESIPITASI & METODE DISPERSIPenimbangan Metode PresipitasiSulfa (g)As. sitrat (g)Met. paraben (g)NaOH (g)CMC-Na (g)Wadah (g)Wadah + zat (g)Zat (g)00000Penimbangan Metode DispersiSulfa (g)As. sitrat (g)Met. paraben (g)NaOH (g)CMC-Na (g)Wadah (g)Wadah + zat (g)Zat (g)00000Penimbangan Sukrosa untuk Metode Presipitasi & Metode DispersiSukrosa (g)Wadah (g)Wadah + zat (g)Zat (g)0UJI DIAMETER PARTIKELKalibrasi =

Metode PresipitasiDiameterFrekuensiDiameter sesungguhnyaLog DFrekuensi x log D

Jumlah000Rata-rata SD Antilog SD Metode DispersiDiameterFrekuensiDiameter sesungguhnyaLog DFrekuensi x log D

Jumlah000Rata-rata SD Antilog SD Metode PresipitasiHari0136ReplikasiV0VtV0 - VtVtV0 - VtVtV0 - VtI000II000III000Metode DispersiHari0136replikasiV0VtV0 - VtVtV0 - VtVtV0 - VtI000II000III000SISTEM FLOKULASI & DEFLOKULASI SUSPENSI // PENGAMATAN VOLUME SEDIMENTASIDerajat Flokulasi: B=

FORMULA AReplikasiWaktu (Menit)05101520253040I (cm)II (cm)III (cm)Rata-rataBFORMULA BReplikasiWaktu (Menit)05101520253040I (cm)II (cm)III (cm)Rata-rataBFORMULA CReplikasiWaktu (Menit)05101520253040I (cm)II (cm)III (cm)Rata-rataBFORMULA DReplikasiWaktu (Menit)05101520253040I (cm)II (cm)III (cm)Rata-rataBFORMULA EReplikasiWaktu (Menit)05101520253040I (cm)II (cm)III (cm)Rata-rataBPersentase PemisahanFormulaAMenit05101520253040Vo(mL)V (mL)%Pemisahan

FormulaBMenit05101520253040Vo(mL)V (mL)%Pemisahan

FormulaCMenit05101520253040Vo(mL)V (mL)%Pemisahan

FormulaDMenit05101520253040Vo(mL)V (mL)%Pemisahan

FormulaEMenit05101520253040Vo(mL)V (mL)%Pemisahan

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EmulsiEMULSIUJI STABILITASEmulsi MixerEmulsi BlenderEmulsi HomogenizerVol. Pengendapan (mL)Vol. Pengendapan (mL)Vol. Pengendapan (mL)123123123H0H + 30'H + 60'H + 1H + 2H + 3SENTRIFUGASIReplikasiEmulsi MixerEmulsi BlenderEmulsi HomogenizerIIIIIIPERSENTASE PEMISAHANDengan SentrifugasiReplikasiEmulsi MixerEmulsi BlenderEmulsi HomogenizerIIIIIIRata-rata Tanpa SentrifugasiEmulsi Mixer (%)Emulsi Blender (%)Emulsi Homogenizer (%)123Rata-rata123Rata-rata123Rata-rataH0 H + 30' H + 60' H + 1 H + 2 H + 3 PERHITUNGAN RESEPOleum arachidis80g x 3 = 240gTween - SpanFormula 1Formula 2Formula 3Tween 80Span 80Tween 80 Span 80Tween 80Span 80

Aquadest500 - (80+20) = 400g400g x 3 = 1200gData Hubungan HLB dengan Stabilitas EmulsiFormula 1Formula 2Formula 3Tween 80Span 80Oleum ArachidisTween 80Span 80Oleum ArachidisTween 80Span 80Oleum ArachidisWadah (g)31.797.932.991.730148Wadah + zat (g)37.95197.945.4191.748.75248Wadah + sisa (g)31.797.932.991.730148Zat (g)18.756.2510012.512.51006.2518.75100NILAI HLB CAMPURANFormulaHLB TweenHLB SpanHLB CampuranI11,251,07512,325II7,52,159,65III3,753,2256,97VISKOSITAS EMULSIReplikasiWaktuForm. IForm. IIForm. IIIAir106,374,764,697,41205,305,144,526,53305,285,204,895,43Perhitungan Viskositas Emulsi air pada suhu 28oC = 0.8904KV air =0,92Koefisien alat (KV) = V= FormulaVKVI1,16810.401866496II1339.1911.92414776III1562.513.9125Rata-rata12.079504752VISKOSITAS FORMULA 1 = KV x FormulaVHI9811.2313460502II1179.241.024346592III1183.711.02047839011.0920570108VISKOSITAS FORMULA 2 = KV x FormulaVHI1313.020.9199787324II1215.950.9934211729III1201.921.00501736820.9728057578VISKOSITAS FORMULA 3 = KV x FormulaVHI1332.620.906447806II1382.740.8735919082III1291.320.93543852430.9051594128UJI PEMISAHAN EMULSIPersen Pemisahan EmulsiTF I (cm)F II (cm)F III (cm)R IR IIR IIIR IR IIR IIIR IR IIR III0000000000145Persen PemisahanHari0145R IR IIR IIIR IR IIR IIIR IR IIR IIIR IR IIR IIIF I100100100100100100100100100100100100F II100100100100100100100100100100100100F III100100100100100100100100100100100100Rata-rataHari0145F I100100100100F II100100100100F III100100100100

75/100 20=1525/100 20=550/100 20=1050/100 20=1025/100 20=575/100 20=15