CURRICULUM VITAE Sue C. Bodine, Ph.D. University of California, Davis Office: 187 Briggs Hall One Shields Avenue Phone: (530) 752-0694 Davis, California 95616-8674 email: scbodine@ucdavis.edu

Personal Statement I am a Neuromuscular Physiologist whose general field of study is Skeletal Muscle Plasticity. My career path has been unconventional, having started in academia at UCSD School of Medicine then moving to private industry where I performed research and development at Regeneron Pharmaceuticals and Elixir Pharmaceuticals, and then moving back to academia at UC Davis where I am a Professor with a joint appointment in the College of Biological Sciences and School of Medicine. In 2012, I was granted a 5/8th position at the Northern California VA. My current research interests are in understanding the mechanisms that regulate skeletal muscle size under growth and atrophy conditions. Currently, my lab is studying the role of mTOR-mediated pathways in the regulation of muscle growth

and adaptive hypertrophy in young, obese, and aging animals. In addition, my lab is investigating the physiological function and transcriptional regulation of two muscle specific E3 Ubiquitin Ligases: MuRF1 and MAFbx, in both skeletal and cardiac tissues. I am interested in understanding the molecular and cellular mechanisms responsible for muscle’s adaptation to exercise and inactivity, and in determining the potential role for exercise in disease prevention and increased quality of life with aging. My lab integrates in vivo biology/pharmacology, mouse genetics, cell biology/biochemistry and molecular biology techniques to understand the mechanisms responsible for muscle atrophy and hypertrophy. My long-term objective is to develop therapies for the treatment of muscle atrophy under a variety of conditions. RESEARCH INTERESTS • Regulation of muscle size and function: postnatal growth to age-related muscle loss. • Identification of signaling pathways responsible for muscle atrophy. • Role of mTOR pathways in the regulation of muscle growth and adaptive hypertrophy. • Physiological function and regulation of muscle E3 ubiquitin ligases: MuRF1 and MAFbx. • Development of therapeutics to treat muscle atrophy and age-associated diseases. • Molecular and cellular mechanisms responsible for muscle’s adaptation to exercise and

inactivity. • Role of exercise in disease prevention/treatment and increased quality of life with aging.

EDUCATION Ph. D. in Kinesiology* University of California, Los Angeles 1985

Title: Anatomy of Motor Units in the Cat Soleus and Tibialis Anterior Muscles

M. S. in Kinesiology University of California, Los Angeles 1982 Title: Architectural, Histochemical and Contractile Characteristics of a Unique Biarticular Muscle: the Cat Semitendinosus

B. S. in Kinesiology University of California, Los Angeles 1981 * Department name and major changed to Physiological Sciences, and now Integrative Biology and Physiology.

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PROFESSIONAL EXPERIENCE

ACADEMIC POSITIONS and APPOINTMENTS 2003-present Professor (Step 7.5, July 1, 2016) (Joint Appointment) Department of Neurobiology, Physiology & Behavior, College of Biological Sciences

Department of Physiology and Membrane Biology, School of Medicine University of California, Davis

2012-present Research Physiologist, Research Service, Veteran’s Administration, Northern

California VA Health Care System 1995-1996 Associate Professor Department of Orthopedic Surgery, School of Medicine; University of California, San

Diego 1989-1995 Assistant Professor Department of Orthopedic Surgery, School of Medicine, University of California, San

Diego 1993-1996 Associate Faculty Biomedical Sciences Graduate Group, University of California, San Diego School of

Medicine 1992-1996 Member, Institute of Biomedical Engineering, University of California, San Diego 1990-1996 Research Physiologist (GS-13) Orthopedic Research Service, Department of Veteran’s Affairs Medical Center, San

Diego, CA 1987-1989 Assistant Researcher Brain Research Institute, University of California, Los Angeles 1985-1987 MDA Postdoctoral Fellow Department of Physiology, Jerry Lewis Neuromuscular Research Center, UCLA BIOTECHNOLOGY POSITIONS Regeneron Pharmaceuticals, Inc., Tarrytown, New York, 10591 1996-2002 1999-2002 Director, In Vivo Muscle Research Program 1997-1999 Associate Director, Muscle Biology Research 1996-1997 Staff Scientist, Neurobiology • Responsible for building Muscle Biology group. Served as Director of the In Vivo Muscle

Research Program that integrated in vivo biology/pharmacology, mouse genetics, cell biology/biochemistry and molecular biology techniques to understand the mechanisms responsible for muscle atrophy and hypertrophy.

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• Director, Research Animal Facility 1998-2001

Served as Director of the Rodent Animal Facility until a full time veterinarian was hired. Managed budgets, purchasing of major equipment, hiring, and direct supervision of the Animal Facility Manager and IACUC Coordinator. Established a mouse barrier facility for transgenic and knock out mice. Provided oversight and planning of Animal Facility renovation in 1999. Wrote long-term strategic plan for operations and expansion of the Animal Research Program and Animal Facility. I also served as Chair of Institutional Animal and Care Committee from 1997-2001.

Elixir Pharmaceuticals, Inc., Cambridge, MA 02139 2002-2003 Director of Pharmacology • The general mission of the company was to develop therapeutics that could slow down the aging

process, as well as delay the onset and progression of various age-related diseases. As Director of Pharmacology it was my responsibility to work with the Chief Scientific Officer to establish the research and development goals of the company. I was charged with identifying relevant animal disease models to meet the goals and to establish the models in house or set up outside collaborations.

PATENT APPLICATIONS

METHODS OF IDENTIFYING AGENTS THAT INHIBIT MUSCLE ATROPHY AND PROMOTE MUSCLE HYPERTROPHY, AND METHODS OF USE THEREOF U.S. Provisional Application No. 60/167,086 NOVEL NUCLEIC ACID AND POLYPEPTIDE MOLECULES U.S. Provisional Application No. 60/338,742 AWARDS AND HONORS 2014 Faculty of 1000 in Pharmacology and Drug Discovery 2013 Nomination for Dean’s Excellence in Mentoring Award, UCD School of Medicine 2010 Star Reviewer, Journal of Applied Physiology 2010 ASUCD Excellence in Education Award 1992-93 Affirmative Action Faculty Career Development Award, UCSD 1985 Graduate Woman of the Year, UCLA Association of Academic Women 1984 Graduate Division Research Grant, UCLA 1984 Honorable Mention, National Science Foundation Graduate Fellowship 1983-84 Cubberly Scholarship, Department of Kinesiology, UCLA 1981-82 Edith Hyde Scholarship, Department of Kinesiology, UCLA 1980-82 Departmental Scholar, Department of Kinesiology, UCLA 1981 Magna cum Lauda, College of Letters and Science, UCAL 1981 Highest Honors, Department of Kinesiology, UCLA 1977-81 Honors Program, College of Letters and Science, UCLA

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LEADERSHIP POSITIONS: 2008-09 Chair, Executive Committee, College of Biological Sciences, UCD

2008-10 Executive Vice Chair; Department of Neurobiology, Physiology & Behavior, College of Biological Sciences

2013-15 Chair, NIH Grant Review Panel: Skeletal Muscle and Exercise Physiology 2013-16 Councilor, Environmental and Exercise Physiology Section, American Physiological

Society 2014-15 Chair, Animal Research Subcommittee of the Academic Senate Committee on

Research

2015-16 Co-Chair, Joint UC Davis Senate-Administration Teaching and Research Animal Program Task Force

2016-17 Chair, Special Animal Research and Care Subcommittee of the Executive Council

2016-17 Chair, Committee on Committees, UC Davis Academic Senate

2017- Editor-In Chief, Journal of Applied Physiology (Incoming, July 1, 2017; appointed Oct 21, 2016)

UNIVERSITY SERVICE University of California, Davis Systemwide 2016-present Member, UC Systemwide Committee on Committees

Campus 2014-2017 Member, Academic Senate, Committee on Committees

2016-2017 Member, Executive Council, Academic Senate

2014-2016 Member, Institutional Biosafety Committee

2015 Reviewer/Selection Committee, Hartwell Individual Research Proposals, Limited Submission Grants

2015 Reviewer, Limited Submission Grants, Edward Mallinckrodt Jr. Foundation Grant Program

2014 Reviewer/Selection Committee, Hartwell Individual Research Proposals, Limited Submission Grants

2012 Search Committee, Women’s Golf Coach

2011-12 Special Academic Senate Committee on Athletics

2011-14 Academic Senate, Committee on Research

2009-11 Academic Senate Representative, Student Services and Fee Administrative Advisory Committee, UC Davis

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College 2016- School of Medicine, Compensation Advisory Committee

2016 College of Biological Sciences Seminar Committee

2016 School of Veterinary Medicine, Musculoskeletal Task Force

2014 Member, Animal Space Committee, College of Biological Science

2014 Member, Faculty Teaching Award Committee, College of Biological Sciences

2012-13 Member, Diabetes/Vascular Medicine Faculty Search Committee, Division of Endocrinology, School of Medicine

2008-14 Member, Executive Committee, Molecular, Cellular and Integrative Physiology Graduate Group

2008-14 Chair, Membership Committee, Molecular, Cellular and Integrative Physiology Graduate Group

2008-09 Member, Executive Council of the Academic Senate, UCD

2007-08 Vice Chair, Executive Committee, College of Biological Sciences, UCD

2007-08 Admissions Committee, Molecular, Cellular and Integrative Physiology Graduate Group

2005-07 Executive Committee, NPB representative, College of Biological Sciences

2005-09 Executive Committee & Membership Committee, Exercise Science Graduate Group

2003-04 Division of Biological Sciences Strategic Planning Committee, UC Davis

2003-07 Faculty Development Advisory Committee, UC Davis School of Medicine

2003-04 Faculty Search Committee, Department of Medical Pharmacology and Toxicology, UC Davis School of Medicine

Departmental 2014 Member, Search Committee, Grants Administrator

2014 Member, Department 5 yr planning Committee

2014-15 Member, Biological Sciences Core Curriculum Development Committee (new BIS 2 level course)

2014 Research Advisor to the Chair, Department of Neurobiology, Physiology and Behavior

2014 Member, LPSOE Search Committee, Department of Neurobiology, Physiology and Behavior

2009-11 Member, Curriculum Committee, Neurobiology, Physiology and Behavior

2007-08 Chair, Faculty Search Committee, Neurobiology, Physiology and

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Behavior Section, College of Biological Sciences, UC Davis

2006-07 Chair, Faculty Search Committee, Neurobiology, Physiology and Behavior Section, College of Biological Sciences, UC Davis

2005-06 Faculty Search Committee, Neurobiology, Physiology and Behavior Section, College of Biological Sciences, UC Davis

University of California, San Diego

1995-1996 Executive Committee, Recruitment and Admission, UCSD School of Medicine

1989-1996 Recruitment and Advisory Committee, UCSD School of Medicine

1992-1996 Mentor Program, American Medical Women’s Association, UCSD School of Medicine

1993-1996 Animal Issue Speaker Group, UCSD School of Medicine

1992-1996 Research Advisory Committee, Department of Orthopedic Surgery, UCSD School of Medicine

1993-1996 Animal Studies Subcommittee (IACUC), VA Medical Center, San Diego

PROFESSIONAL SERVICE NASA Member, Rodent Research Science Working Group, July 2015-present NIH: Participant: NIH Common Fund Meeting, The Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits (October 30-31, 2014) Bethesda, MD Participant, NIH Working Group on “Research and Research Training Needs of Women and Women’s Health Issues, Oct. 3, 1991; Bethesda, MD Veteran Administration: Member, Subcommittee on Research Safety VA Northern California Health Care System (2013-present) Regular Member, Veteran’s Administration RR&D Grant Review Study Section: Neurodegenerative Diseases and Aging (2010-2015) Grant Review 2002 NASA Proposal Review Panel: Musculoskeletal Biology Exercise and

Countermeasures 2005, 2009 Ad Hoc Reviewer , Wellcome Trust: Physiological Sciences 2004, 2008, 2009 Ad Hoc Reviewer , Natural Sciences and Engineering Research

Council of Canada

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2008 Ad Hoc Reviewer , US Army Medical Research and Materiel Command 2009 Ad Hoc Reviewer, National Institute in Aging: Program Project Review 2009-2010 Ad Hoc Member, Veteran’s Administration RR&D Grant Review Study

Section: Neurodegenerative Diseases and Aging. 2010-present Member, Veteran’s Administration RR&D Grant Review Study Section:

Neurodegenerative Diseases and Aging 2010-2011 Ad Hoc Member, NIH Grant Review Panel: Skeletal Muscle and

Exercise Physiology (June, Oct, Feb, June) 2010 Ad Hoc Reviewer, Skeletal Muscle SBIR Grant Review Panel (Nov) 2011-present Member, NIH Grant Review Panel: Skeletal Muscle and Exercise

Physiology 2011 Ad Hoc Reviewer, Association Francaise contre les Myopathies (AFM) 2011 Ad Hoc Reviewer, Department of Defense: Congressionally Directed

Medical Research Program (April) 2011 Ad Hoc Member, NIH Grant Review Panel: Cardiovascular Science.

(Nov) 2012 External Reviewer, Pepper Center Pilot Grants, Boston University 2012 Ad Hoc Reviewer: Princes Beatrix Fonds, Netherlands 2012 Ad Hoc Reviewer: Medical Research Council, United Kingdom

2012 Ad Hoc Reviewer: National Science Foundation, 2013 Chair and Ad Hoc Reviewer: NIH Skeletal Muscle SBIR Grant Review Panel

(Mar) 2014 Ad Hoc Reviewer: NIH Special Emphasis Panel, Brain Disorders and Clinical

Neuroscience (July) 2015 Ad Hoc Reviewer: NIH Fellowships: Physiology and Pathobiology of

Musculoskeletal, Oral and Skin Systems (March) 2015 Ad Hoc Reviewer: NIH Special Emphasis Panel, Brain Disorders and Clinical

Neuroscience (July) 2015 Ad Hoc Reviewer: NIH Special Emphasis Panel ZAT1 SM (38) S (Nov) 2015 Ad Hoc Reviewer: Medical Research Council, United Kingdom (Nov) 2016 Ad Hoc Reviewer: BSF:US-Israel Binational Science Foundation 2016 Ad Hoc Reviewer: Muscular Dystrophy Council-UK 2016 Ad Hoc Reviewer: NIH Member Conflict: Disorders in Brain Development and

Aging ZRG1 BDCN-M 2016 Ad Hoc Reviewer: Center for the Advancement of Science in Space. 2016 Ad Hoc Reviewer: NASA AGBRESA Musculoskeletal Panel (May) 2016 Ad Hoc Reviewer: NIH Molecular Transducers of Physical Activity Clinical

Centers Study Panel (July) 2016 Chair and Ad Hoc Reviewer: NIH Special Emphasis Panel ZRG1 MOSS C-02,

SMEP Member Conflict Panel (July) 2016 Ad Hoc Reviewer: NIH Review Panel, Integrative Nutrition and Metabolic

Processes (Oct) 2017 Ad Hoc Reviewer: NIH Review Panel, Skeletal Muscle and Exercise

Physiology (Feb)

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JOURNALS Associate Editor: American Journal of Physiology; Cell Physiology (July 1, 2016-present) American Journal of Physiology; Endocrinology and Metabolism (July 1, 2010-July 1, 2016) Journal of Applied Physiology (July 1, 2011-July 1,2014) Editorial Boards: Journal of Applied Physiology (2008-2011) American Journal of Physiology: Endocrinology and Metabolism (2009-10) Frontiers in Skeletal Muscle Physiology (2012-present) Skeletal Muscle (2014-present) Physiology (2016-present) Scientific Conference Organization: Member of Organizing Committee for “Advances in Skeletal Muscle Biology in Health and Disease Conference” at the University of Florida, March 5-7, 2014. Member of Organizing Committee for “Advances in Skeletal Muscle Biology in Health and Disease Conference” at the University of Florida, Jan 20-23, 2016. Member of Organizing Committee for “APS: Integrative Biology of Exercise”, Phoenix, AZ, Nov 2-5 2016. Academic Program Review: External Reviewer, Department of Physiology and Developmental Biology, BYU, Nov 3-4, 2011. PROFESSIONAL SOCIETY MEMBERSHIPS American Physiological Society American College of Sports Medicine Society for Neuroscience (1981-2000)

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RESEARCH

PUBLICATION ARTICLES: 1. Bodine, S.C., Roy, R.R., Meadows, D.A., Zernicke, R.F., Sacks, R.D., Fournier, M. and

Edgerton, V.R. Architectural, histochemical and contractile characteristics of a unique biarticular muscle: the cat semitendinosus. J. Neurophysiol. 48: 196-201, 1982.

2. Edgerton, V.R., Roy, R.R., Bodine, S.C., and Sacks, R.D. Matching of neuronal and

muscular physiology. In: Future Issues in Exercise Biology. K.T. Borer, D.W. Edington and T.P. White (eds) Human Kinetics Publishers, Inc., Illinois, 1983 pp.51-70.

3. Edgerton, V.R., Martin, T.P., Bodine, S.C., and Roy, R.R. Just how flexible is the neural

control of muscle properties? J. Exp. Biol. 115: 393-402, 1985. 4. Cope, T.C., Bodine, S.C., Fournier, M., and Edgerton, V.R. Soleus motor units in chronic

spinal transected cats: physiological and morphological alterations. J. Neurophysiol. 55: 1202-1220, 1986.

5. Bodine, S.C., Roy, R.R., Eldred, E., and Edgerton, V.R. Maximal force as a function of

anatomical features of motor units in the cat tibialis anterior. J. Neurophysiol. 57: 1730-1745, 1987.

6. Edgerton, V.R., Bodine, S.C. and Roy, R.R. Muscle architecture and performance: Stress and

strain relationships in a muscle with two compartments arranged in series. In: Med. Sport Sci. Muscular Function in Exercise and Training 26: 12-23, 1987.

7. Bodine, S.C., Garfinkel, A., Roy, R.R. and Edgerton, V.R. Spatial distribution of motor unit

fibers in the cat soleus and tibialis anterior muscles: local interactions. J. Neurosci. 8: 2142-2152, 1988.

8. Martin, T.P., Bodine, S., Roy, R.R., Eldred, E. and Edgerton, V.R. Metabolic and fiber size

properties of cat tibialis anterior motor units. Am. J. Physiol. (Cell Physiol) 255:C43-C50, 1988.

9. Martin, T.P., Bodine, S. and Edgerton, V.R. Coordination of electromechanical and metabolic

properties of cat soleus motor units. Am. J. Physiol. (Cell Physiol) 255:C684-C693, 1988. 10. Hutchison, D.L., Roy, R.R., Bodine, S., Hodgson, J.A., and Edgerton, V.R. EMG amplitude

patterns in proximal and distal portions of the cat semitendinosus during various motor tasks. Brain Research 479: 56-64, 1989.

11. Miu, B., Martin, T.P., Roy, R.R., Oganov, V., Ilyina-Kakueva, E., Marini, J.F., Legar, J.J.,

Bodine, S.C., and Edgerton, V.R. Metabolic and morphologic properties of single muscle fibers in the rat after space flight, Cosmos 1887. FASEB J. 4:64-72, 1990.

12. Bodine, S., Garfinkel, A., Roy, R. R., and Edgerton, V.R. Spatial distribution of muscle fibers

within the territory of a motor unit. Muscle & Nerve 13: 1133-1145, 1990. 13. Edgerton, V.R., Roy, R.R., Bodine, S., Pierotti, D.J., Unquez, G.A., Martin, T.P., Jiang, B.,

and Chalmers, G. Motoneuron muscle fiber connectivity and interdependence. In: The

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Dynamic State of Muscle Fibers. (ed) D. Pette 1990, pp. 217-231. 14. Roy, R.R., Bodine, S.C., Kim, J., Rudolph, W., Haque, N., deLeon, D., and Edgerton, V.R.

Architectural and fiber type distribution properties of selected Rhesus leg muscles: feasibility of multiple independent biopsies. Acta Anatomica 140:350-356 1991.

15. Pierotti, D.J., Roy, R.R., Bodine, S.C., Hodgson, J.A., and Edgerton, V.R. Mechanical and

morphological properties of chronically inactive cat tibialis anterior motor units. J. Physiol. (London) 444: 175-192, 1991.

16. Hodgson, J.A., Bodine, S.C., Roy, R.R., deLeon, R.D., deGuzma, C.P., Koslovskaya, I.,

Sirota, M. and Edgerton, V.R. Changes in recruitment of Rhesus soleus and gastrocnemius muscles following a 14-day spaceflight. Physiologist 34 (Suppl) S102-S103, 1991.

17. Graham,S.C., Roy, R.R., Navarro, C., Jiang, B., Pierotti, D., Bodine, S.C. and Edgerton, V.R.

Enzyme and size profiles in chronically inactive cat soleus muscle fibers. Muscle & Nerve 15: 27-36, 1992.

18. Bodine, S.C., Roy, R.R., Rudolph, W., Haque, N., Kozlovskaya, I.B., and Edgerton, V.R.

Spaceflight and growth effects on muscle fibers in the rhesus monkey J. Appl. Physiol. 73: 82S-89S, 1992.

19. Bodine, S.C., Unquez, G.A., Roy, R.R., Armstrong, A.N., and Edgerton, V.R. Innervation

patterns in the cat tibialis anterior 6-months after self-reinnervation Muscle & Nerve 16: 379-391, 1993.

20. Unquez, G.A., Bodine, S.C., Pierotti, D.J., Roy, R.R., and Edgerton, V.R. Evidence of

incomplete neural control of motor unit properties in adult cat tibialis anterior after self-reinnervation. J. Physiol.(London) 472: 103-125,1993.

21. Lieber, R.L. and Bodine, S.C. Skeletal muscle mechanics: Implications for rehabilitation.

Physical Therapy 73 (12): 844-856, 1993. 22. Lieber, R.L., Bodine, S.C., Burkholder, T.J., Pierotti, D.J. and Ryan, A.F. Cloning and in situ

hybridization of type 2A and 2B rat skeletal muscle myosin: implications for filament assembly. Biochem. Biophy. Res. Comm. 197 (3): 1312-1318, 1993.

23. Bodine, S.C. Skeletal muscle regeneration after injury: An overview. J. Voice 8: 53-62,

1994. 24. Botte, M.J., Abrams, R.A. and Bodine, S.C. Treatment of acquired muscle spasticity using

phenol peripheral nerve blocks. Orthopaedics 18: 1-9, 1995. 25. Unquez, G.A. Roy, R.R., Pierotti, D.J., Bodine, S.C. and Edgerton, V.R. Further evidence of

incomplete neural control of muscle properties in cat tibialis anterior motor units. Am. J. Physiol. 268: C527-C534, 1995.

26. Talmadge, R.J , Roy, R.R., Bodine, S.C., Pierotti, D.J. and Edgerton, V.R. Adaptations in

myosin heavy chain profile in chronically unloaded muscles. Basic and Applied Myology 5: 114-134, 1995.

27. Bodine, S.C., Pierotti, D.J., and Talmadge, R.J. Functional and cellular adaptation to

weightlessness in primates. J. Gravitational Physiol. 2: 43-46, 1995.

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28. Bodine, S.C., Allsing, S., and Botte, M.J. Time course of muscle atrophy and recovery

following a phenol-induced nerve block. Muscle Nerve 19: 497-504, 1996. 29. Unguez, G.A., Roy, R.R., Bodine, S.C., and Edgerton, V.R. Limited fiber type grouping in

self-reinnervated cat tibialis anterior muscles. Muscle Nerve 19: 1320-1327, 1996. 30. Merati, A.L., Bodine, S.C., Bennet, T. and Ryan A.R. Identification of a novel myosin heavy

chain gene expressed in the rat larynx. Biochimica et. Biophysica Acta 1306: 153-159, 1996. 31. Bodine, S.C. and Pierotti, D.J. Myosin heavy chain mRNA and protein expression in single

fibers of the rat soleus following reinnervation. Neuroscience Letters 215: 13-16, 1996. 32. Huey, K.A. and Bodine, S.C. Altered expression of myosin mRNA and protein in rat soleus

and tibialis anterior following reinnervation. Am. J. Physiol. (Cell) 271: C2016-C2026, 1996. 33. Bodine, S.C., Meyer, R.S., Moskovitz, A., Abrams, R.A., and Botte, M.A. Inaccurate

projection of rat soleus motoneurons: A comparison of nerve repair techniques. Muscle Nerve 20: 29-37, 1997.

34. Meyer, R.S., Abrams, R.A., Botte, M.J., Davey, J.P. and Bodine, S.C. Improvement of

muscle force following crush and transection injuries to the rat sciatic nerve. J. Ortho. Res. 5:664-669, 1997.

35. Abrams, R.A., Butler, J.M., Bodine, S.C., Botte, M.J. Tensile properties of the neurorrhaphy

site in the rat sciatic nerve. J. Hand Surg. 23:465-470, 1998. 36. Cliffer, K.D., Siuciak, J.A., Carson, S.R., Radley, H.E., Park, J.S., Lewis, D.R., Zlotchenko, E.,

Nguyen, T., Garcia, K., Tonra, J.R., Stambler, N., Cedarbaum, J.M., Bodine, S.C., Lindsay, R.M., and DiStefano, P.S. Physiological characterization of taxol-induced large-fiber sensory neuropathy in the rat. Ann. Neurol. 43: 46-55, 1998.

37. Fitts, R.H., Bodine, S.C., Romantowski, J., and Widrick, J.J. Velocity, force, power, and Ca2+

sensitivity of fast and slow monkey skeletal muscle fibers. J. Appl. Physiol. 84: 1776-1787, 1998.

38. Bowen, D.C., Park, J.S., Bodine, S., Stark, J.L., Valenzuela, D.M., Stittt, T.N., Yancopoulos,

G.D., Lindsay, R.M., Glass, D.J., and DiStefano, P.S. Localization and regulation of MuSK at the neuromuscular junction. Dev. Biol. 199: 309-319, 1998.

39. Cliffer, K.D., Tonra, J.R., Carson, S.R., Radley, H.E., Cavnor, C., Lindsay, R.M., Bodine,

S.C., and DiStefano, P.S. Consistent repeated M-and H-wave recording in the hind limb of rats. Muscle & Nerve 21: 1405-1413, 1998.

40. Huey, K.A. and Bodine, S.C. Changes in myosin mRNA and protein expression in

denervated rat soleus and tibialis anterior. Eur. J. Biochem. 15: 45-50, 1998. 41. Roy, R.R., Bodine, S.C., Pierotti, D.J., Talmadge, R.J., Barkhoudarian, G., Kim, J., Fanton,

J.W., Kozlovskaya, I.B., and Edgerton, V.R. Fiber size and myosin phenotypes of selected Rhesus hindlimb muscles after a 14-day spaceflight. J. Gravit. Physiol. 6: 55-62, 1999.

42. Tonra, J.R., Cliffer, K.D., Carson, S.R., Lindsay, R.M., Bodine, S.C., and DiStefano, P.S.

Reduced Ia-afferent mediated Hoffman reflex in streptozotocin–induced diabetic rats.

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Experimental Neurology 172:220-227, 2001. 43. Bodine, S.C., Stitt, T.N., Gonzalez, M., Kline, W.O., Stover, G.L., Bauerlein, R., Zlotchenko,

E., Scrimgeour, A., Lawrence, J.C., Glass, D.J., and, Yancopoulos, G.D. The AKT/mTOR pathway is a critical regulator of skeletal muscle hypertrophy, and can prevent muscle atrophy in vivo. Nature Cell Biology 3: 1014-1019, 2001.

44. Rommel, C., Bodine, S.C., Clarke, B.A., Rossman, R., Nunez, L., Stitt, T.N., Yancopoulos,

G.D., and Glass, D.J. Mediation of IGF-1-induced skeletal myotube hypertrophy by PI3K/AKT/mTOR and PI3K/AKT/GSK3 pathways. Nature Cell Biology 3: 1009-1013, 2001.

45. Bodine, S.C., Latres, E., Baumhueter, S., Lai, V.K.-L., Nunez, L., Clarke, B., Poueymirou, W.,

Panaro, F., Na, E., Dharmarajan, K., Pan, Z-Q., Valenzuela, D.M., .DeChiara, T.M., Stitt, T.N., Yancopoulos, G.D., and Glass, D.J. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294:1704-1708, 2001 (published in Scienceexpress/ 25 October 2001/10.1126/science 1065874).

46. Roy, R.R., Zhong, H., Talmadge, R.J., Bodine, S.C., Fanton, J.W., Koslovskaya, I., and

Edgerton, V.R. Size and myonuclear domains in Rhesus soleus muscle fibers: short-term spaceflight. J. Grav. Physiol. 8: 49-56, 2001.

47. Isfort, R.J., Wang, F., Greis, K.D., Sun, Y., Keogh, T.W., Farrar, R.P., Bodine, S.C., and

Anderson, N.L. Proteomic analysis of rat soleus muscle undergoing hindlimb suspension-induced atrophy and reweighting hypertrophy. Proteomics 2: 543-550, 2002.

48. Isfort, R.J., Wang, F., Greis, K.D., Sun, Y., Keogh, T.W., Bodine, S.C., and Anderson, N.L.

Proteomic analysis of rat soleus muscle and tibialis muscle following immobilization. J. Chromatography B Analyt Technol Biomed Life Sci 769: 323-332, 2002.

49. Reynolds, T.H., Bodine, S.C., and Lawrence, J.C. Control of Ser2448 phosphorylation in the

mammalian target of rapamycin by insulin, amino acids, and skeletal muscle loading. J. Biol. Chem. 277: 17657-17662, 2002.

50. Lewis, M.I., Bodine, S.C., Kamangar, N., Xu, X., Da, X., and Fournier, M. Effect of severe

short-term malnutrition on diaphragm muscle signal transduction pathways influencing protein turnover. J. Appl. Physiol. 100: 1799-806, 2006. Epub 2006 Feb 16.

51. Bodine, S.C. mTOR signaling and molecular adaptations to resistance exercise. Med Sci

Sports Exerc. 38:1950-1957, 2006. 52. Baar, K., Nader, G. and Bodine, S.C. Resistance exercise, muscle loading/unloading and the

control of muscle mass. Essays in Biochemistry. 38:1950-1957, 2006. 53. Kline, W.O., Panaro, F.J., Yang, H., and Bodine, S.C. Rapamycin inhibits the growth and

muscle sparing effects of clenbuterol. J. Appl. Physiol. 102: 740-741, 2007. 54. Cohen, T.J., Wadell, D.S., Barrientos, T., Lu, Z., Feng, G., Cox, G., Bodine S.C., Yao, T-P.

The histone deacetylase DHAC4 connects neural activity to muscle transcriptional reprogramming. J. Biol. Chem. 282: 33752-9, 2007. Epub 2007 Sept 16.

55. Spangenburg EE, Le Roth, D., Ward, CW., and Bodine SC. A functional insulin-like growth

factor receptor is not necessary for load-induced skeletal muscle hypertrophy. J. Physiol. 586: 283-291, 2008.

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56. Bodine, S.C. In response to Point:Counterpoint: Satellite cell addition is/is not obligatory for

skeletal muscle hypertrophy. J. Appl. Physiol. 103: 1105-1106, 2007. 57. Waddel, D.S., Baehr, L.M., van den Brandt, J., Johsen, S.A., Reichardt, H.M., Furlow, J.D.,

and Bodine, S.C. The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy associated MuRF1 gene. Am. J. Physiol Endorinol Metabol 295: E785-E797, 2008.

58. Hwee, D. T. and Bodine, S.C. Age-related deficit in load-induced skeletal muscle growth. J.

Gerontology A Biol Sci Med Sci 64: 618-6128, 2009. 59. Sitnick, M., Bodine, S.C. and Rutledge, J.C. Chronic high fat feeding attenuates load-induced

hypertrophy in mice. J. Physiology London 587: 5753-5765, 2009. 60. Hwee, D.T., Gomes, A.V., and Bodine S.C. Cardiac proteasome activity in Muscle Ring

Finger-1 null mice at rest and following synthetic glucocorticoid treatment. Amer. J. Physiol Endo Metab 301: E967-977, 2011.

61. Baehr, L.M., Furlow, J.D., and Bodine, S.C. Muscle Sparing in Muscle Ring Finger-1 Null

Mice: Response to Synthetic Glucocorticoid. Journal of Physiology (Lond). 589: 4759-4776, 2011.

62. Bodine, S.C. and Baar, K. Analysis of Muscle Hypertrophy in Models of Skeletal Muscle

Overload. Methods Molecular Biology 798: 213-229, 2012. 63. Files, D.C. D’Alessio, FR, Johnston, LF, Kesari, P, Aggarwal, NR, Garibaldi, BT, Mock, JR,

Simmers JL, Degorordo A, Murdoch, J, Willis MS, Patterson C, Tanskersley, CG, Messi, ML, Liu, C, Delbano, O, Furlow, JD, Bodine, SC, Cohn, RD, King, LS, and Crow, MT. A Critical Role for Muscle Ring Finger-1 in Acute Lung Injury-Associated Skeletal Muscle Wasting. Am J Respir Crit Care Med 185: 825-834, 2012 (Epub 2012 Feb 3].

64. Watson, ML, Baehr, LM, Reichardt, HM, Tuckermann, JP, Bodine, SC and Furlow JD. Muscle

Specific Deletion of the Glucocorticoid receptor Prevents Synthetic Glucocorticoid Induced Skeletal Muscle Atrophy. Amer. J. Physiol: Endo Metab, 302: E1210-1220, 2012.

65. Xuhui, L, Joshi, SK, Samagh, SP, Dang, Y, Larn, D, Laron, D, Lovett, DH, Bodine, SC, Kim,

HT, and Beeley, BT. Evaluating Akt/mTOR signaling activity in supraspinatus muscle atrophy after massive rotator cuff tear in the rat model. J. Ortho Research, 2012 Feb 29 (Epub ahead of print).

66. Gomes, A.V. Waddell, D.S., Siu, R., Stein, M., Dewey, S., Furlow, J.D., and Bodine, S.C.

Upregulation of Proteasome Activity in Muscle Ring Finger-1 Null Mice Following Denervation. FASEB J Jul; 26(7) 2986-2999, 2012 (Epub 2012 April 16).

67. Bodine, S.C. What does the transcriptome signature of resistance exercise tell us about

aging and skeletal muscle adaptation? J Appl Physiol. 112: 1621-1622, 2012. 68. Joshi, S.K., Liu, X. Samagh, S.P., Lovett, D.H., Bodine, S.C., Kim, H.T., and Feeley, B.T.

mTOR regulates fatty infiltration through SREBP-1 and PPARγ after massive rotator cuff tears in rats. J. Orthopedic Research, 31(5):724-30, 2013. Epub 2012 Dec 13.2012

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69. Bodine, S.C. Hibernation: The search for treatments to prevent disuse-induced skeletal muscle atrophy. Invited Commentary/ Mini Review: Experimental Neurology, 248: 129-135, 2013.

70. Bodine, S.C. Disuse-Induced Muscle Wasting. Invited Review: International J. Biochem Cell

Biol. 45: 2200-2208, 2013. 71. Hwee, DT, Baehr, LM, Philp, A., Baar, K and Bodine, SC. Maintenance of muscle mass and

load-induced growth in Muscle Ring Finger 1 null mice with aging. Aging Cell 13: 92-101, 2014 (accepted August 9, 2013).

72. Furlow, JD, Watson, ML, Waddell, DS, Neff, E., Baehr, LM, Ross, AP and Bodine, SC

Altered gene expression patterns in muscle ring finger 1 null mice during denervation and dexamethasone-induced muscle atrophy. Physiol Genomics 45: 1168-1185, 2013.

73. Baehr, LM, Tunzi, M. and Bodine, SC. Muscle hypertrophy is associated with increases in

proteasome activity that is independent of MuRF1 and MAFbx expression. Frontiers in Striated Muscle Physiology 2014 Feb 21;5:69. doi: 10.3389/fphys.2014.00069

74. Hamilton, DL, Philp, A., MacKenzie, MG., Patton, A., Towler, MC., Gallagher, IJ, Bodine, SC

and Baar, K. Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. Amer. J. Physiol: Endocrinol. Metab. 307: E365-373, 2014

75. Bodine, SC and Baehr, LM. Invited Review, Skeletal Muscle Atrophy and the Role of the E3

Ubiquitin Ligases, MuRF1 and MAFbx/Atrogin-1. Amer. J. Physiol: Endo Metab 307: E469-484, 2014

76. Reid, MB, Judge, AR, and Bodine, S.C. CrossTalk opposing view: The dominant mechanism

causing disuse muscle atrophy is proteolysis. J. Physiol. 592: 5345-5347, 2014. 77. Zhang, Q, Joshi, SK, Lovett, D., Zhang, Bodine, S, Kim, HT, Liu, X. Matrix metalloproteinase-

2 plays a critical role in overload induced skeletal muscle hypertrophy. Muscle Ligaments Tendons J. 4: 446-54, 2015.

78. Khodabukus A, Baehr LM, Bodine SC, Baar, K. Role of contraction duration in inducing fast-

to-slow contractile and metabolic protein and functional changes in engineered muscle. J. Cell Physiol. 2015 Apr 9 [Epub ahead of print].

79. Neufer PD, Bamman MM, Muoio DM, Bouchard C, Cooper DM, Goodpaster BH, Booth FW,

Kohrt WM, Gerszten RE, Mattson MP, Hepple RT, Kraus WE, Reid MB, Bodine SC, Jakicic JM, Fleg JL, Williams JP, Joseph L, Evans M, Maruvada P, Rodgers M, Roary M, Boyce AT, Drugan JK, Koenig JI, Ingraham RH, Krotoski D, Garcia-Cazarin M, McGowan JA, Laughlin MR. Understanding the Cellular and Molecular Mechanisms of Physical Activity-Induced Health Benefits. Cell Metab. 2015 Jun 9. pii: S1550-4131(15)00223-5. doi: 10.1016/j.cmet.2015.05.011. [Epub ahead of print] Review.

80. Gilda JE, Rajeshwary G, Cheah, JX, West, TM, Bodine SC, and Gomes, AV. Western blotting

inaccuracies with unverified antibodies: need for a western blotting minimal reporting standard (WBMRS). PLOS One Aug 19; 10(8):e013539, 2015

81. West EDW, Baehr LM, Marcotte GR, Chason CM, Tolento, L., Gomes AV, Bodine SC, and

Baar K. Acute resistance exercise activates rapamycin-sensitive and insensitive mechanisms

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that control translational activity and capacity in skeletal muscle. J. Physiology 594: 453-468, 2015.

82. Baehr LM, West DWD, Marcotte G, Marshall AG, DeSousa, LG, , Baar K, and Bodine SC.

Age-related deficits in skeletal muscle recovery following disuse atrophy are associated with neuromuscular junction instability and ER stress, not impaired protein synthesis. Aging,8: 127-146, 2016.

83. Anderson MJ, Diok S, Baehr LM, Baar K, Bodine SC, and Christiansen BA. Contribution of

mechanical loading to trabecular bone loss following non-invasive knee injury in mice. Journal of Orthopedic Research, Jan 30. doi: 10.1002/jor.23178. [Epub ahead of print]

84. Hughes DC, Marshall AG, West DWD, Baehr LM, Saleh PM, Bodine SC, and Baar, K. Age-

related differences in cytoskeleton proteins: impact on force transfer and the susceptibility to injury. J. Gerontology A Biol Sci Med Sci. 2016 Jul 5 pii:glw109 [Epub ahead of press]

85. Atherton PJ, Greenhaff PL, Phillips SM, Bodine SC, Adamas SC, and Lang CH. Control of

skeletal muscle atrophy in response to disuse: clinical/preclinical contentions and fallacies of evidence. AJP: Endo Metab. 311: E594-604, 2016.

Submitted 1. Baehr LM, West DWD, Marcotte GR, Baar K., and Bodine SC. Muscle-specific and age-related

changes in protein synthesis and protein degradation in response to hindlimb unloading in rats. 2. Hughes DC, Marcotte GR, Baehr LM, West DWD, Marshall AG, Davidyan A., Bodine SC, and

Baar K. Alterations in the muscle force transfer apparatus in aged rats during unloading and reloading.

BOOK CHAPTERS (reviewed) 1. Bodine, S.C. and Botte, M.J. Muscle Spasticity. In: Orthopaedic Rehabilitation , V.L. Nickel

and M.J Botte (eds) Churchill Livingstone, pp. 295-308, 1991. 2. Botte, M.J., Bodine, S.C., Dulbecco, F.L. and Abrams, R.A. Nerve Repair in the Lower

Extremity. In: Current Therapy in the Foot and Ankle. M.S. Myerson (ed), Mosby-YearBook, 1992.

3. Bodine, S.C. and Lieber, R. L. Peripheral Nerve Physiology, Anatomy and Pathology. In:

Orthopaedic Science S.R. Simon (ed), American Academy of Orthopaedic Surgeons, Illinois 1994, pp. 325-396.

4. Edgerton, V.R., Bodine, S., Roy, R.R., Ishihara, A., and Hodgson, J.A. Neuromuscular

Adaptation. In: Handbook of Physiology: Integration of Motor, Circulatory and Metabolic Control During Exercise. Section A: Neural Control of Movement. Edited by: L.B. Rowell, J.T. Shephard. American Physiological Society, Oxford University Press, 1996, pp. 54-88.

5. Bodine SC and Furlow JD. Glucocorticoids and Skeletal Muscle. Adv Exp Med Biol 872:

145-76, 2015.

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Other Media:

1. Bodine, S.C. Successfully making Transitions Between Academia and Industry. Physiologist, April 2011; www.the-aps.org/career/mentor

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INVITED PRESENTATIONS (since 2002) October 2, 2003 UCLA Molecular Biology Institute and ACCESS Graduate Program

Seminar Series: “Unraveling the mechanisms responsible for muscle atrophy”.

February 24, 2004 Pfizer Global Research and Development; Division of Cardiovascular

and Metabolic Diseases ; “Regulation of skeletal muscle size: balancing synthesis and degradation pathways”.

November 30, 2005 The Pennsylvania State University Medical School, Department of

Cellular and Molecular Physiology. Role of AKT-mediated Signaling Pathways in Skeletal Muscle Growth in Young and Old Rats.

June 3, 2005 American College of Sports Medicine; mTOR Signaling and the

Molecular Adaptation to Resistance Exercise. Symposium speaker. November 3, 2006 UC Davis Biotechnology Program Transitioning From Industry to Academia November 30, 2006 University of Virginia, School of Medicine, Department of

Pharmacology. Regulation of MuRF1/MAFbx Expression in Skeletal Muscle and the Role of Akt Signaling.

December 12, 2008 Bispebjerg Symposium on Skeletal Muscle Atrophy: Mechanical and

molecular adaptations to ageing and disease. Invited Speaker: The Role of Ubiquitin Ligases in the Regulation of Muscle Atrophy. Copenhagen, Denmark

January 21, 2009 University of Florida, Grant Writing Seminar. Invited Speaker. “Writing

Your First RO1”, Gainesville, Florida. January 22, 2009 University of Florida, Symposium on Advances in Skeletal Muscle

Biology in Health and Disease. Invited Speaker. The Role of MuRF1 in Skeletal muscle Atrophy.

April 28, 2010 Experimental Biology 2010 Annual Meeting; Invited Speaker,

Symposium, To Exercise or Not to Exercise: Can We Replace Physical Activity With a Pill?, “Decreased muscle wasting and enhanced muscle function with E3 ligase inhibitors.” , Anaheim, CA.

January 17, 2011 Uppsala University, Department of Clinical Neurophysiology. Invited

Speaker, “The Role of the E3 Ubiquitin Ligases, MuRF1 and MAFbx, in Skeletal Muscle Atrophy”.

April 25, 2011 Endocrine Grand Round, Department of Endocrinology, Boston

University School of Medicine. Invited Speaker, “The Role of the E3 Ubiquitin Ligases, MuRF1 and MAFbx, in Glucocorticoid-Induced Muscle Atrophy”.

April 26, 2011 Pepper Center Seminar Series, Boston Claude Pepper Older

Americans Independence Center, Boston University. Invited Speaker

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“Signaling Pathways Involved in Skeletal Muscle Atrophy and Hypertrophy”.

February 22, 2012 University of Florida, Department of Physical Therapy Seminar Series,

Invited Speaker MuRF1 and its Role in Age-Related Muscle Loss. February 22, 2012 University of Florida, Grant Workshop, Invited Speaker and panel

discussant, Interpreting and Addressing Reviewer Comments. February 23, 2012 University of Florida, Symposium on Advances in Skeletal Muscle

Biology in Health and Disease. Invited Speaker. Ten Years After, Muscle Sparing in the MuRF1 KO Mouse.

April 25, 2012 Experimental Biology 2012 Annual Meeting; Invited Speaker,

Symposium, Anabolic Resistance to Exercise with Aging or Disease, Anabolic Resistance to Exercise in Animal Models of Obesity and Aging, San Diego, CA

May 22, 2012 University of Iowa, Department of Molecular Physiology and Biophysics

Seminar Series, Invited Speaker, “The Role of the E3 Ubiquitin Ligases, MuRF1 and MAFbx, in Skeletal Muscle Atrophy and Aging.

June 1, 2012 American College of Sports Medicine, Invited Tutorial Lecture, The

Role of “Atrogenes” in Muscle Atrophy. San Francisco, CA. June 19, 2012 International Biochemistry of Exercise Conference, Invited Speaker,

“Intracellular Signaling and Regulation of Muscle Mass”, Stockholm, Sweden

September 19, 2012 University of California, Berkeley, Department of Nutritional Science

and Toxicology, Invited Speaker, “The Role of the E3 Ubiquitin Ligases, MuRF1 and MAFbx in Skeletal Muscle Atrophy”, Berkeley, California.

November 13, 2012 Baylor School of Medicine, Department of Molecular Physiology and

Biophysicis. Invited Speaker, “ Regulation of Skeletal Muscle Mass by the E3 Ubiquitin Ligases, MuRF1”; Houston, Texas.

January 27, 2014 Keystone Symposia: Growth and Wasting in Heart and Skeletal

Muscle, Invited Speaker, “MuRF1 and the Regulation of Skeletal Muscle Mass”, Santa Fe, New Mexico

March 6, 2014 Advances in Skeletal Muscle Biology in Health and Disease

Conference, Invited Speaker, “Skeletal Muscle Aging and the Development of Anabolic Resistance”, Gainesville, Florida.

March 28, 2014 Institute of Molecular Medicine Seminar Series, Invited Speaker,

“MuRF1 and its Role in the Regulation of Skeletal Muscle Atrophy”, Brown Foundation Institute of Molecular Medicine at University of Texas Heath Science Center, Houston, Texas.

April 30, 2014 Experimental Biology 2014 Annual Meeting, Invited Speaker,

Symposium: The Regulation of Anabolic Signaling in Skeletal Muscle: The Integration of Mechanical, Metabolic and Inflammatory Stimuli,

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“Activation of Growth Pathways in Skeletal Muscle in Normal and Diseased States”, San Diego, CA

May 5, 2014 Distinguished Lecture Series, Invited Speaker; University of Alabama

Birmingham, Center for Exercise Medicine. “ Muscle Ring Finger 1: Regulation of Skeletal Muscle Mass and Metabolism”, Birmingham, Alabama.

September 26, 2014 Health and Exercise Science Seminar Series, Invited Speaker,

Colorado State University “Muscle Ring Finger 1 and the Regulation of Skeletal Muscle Mass”, Fort Collins, CO

November 21, 2014 Invited Speaker, The Ohio State University School of Medicine “

Sarcopenia and the Loss of Muscle Recovery Following Disuse Atrophy”, Columbus, Ohio

January 30, 2015 Invited Speaker, Cytokinetics, Inc. “Sarcopenia and Attenuated

Recovery Following Disuse Atrophy in Old Rats”, South San Francisco, CA

July 20, 2015 Diabetes and Obesity Seminar Series, Invited Speaker, University of

Iowa, “Sarcopenia: What accounts for the attenuated growth of skeletal muscle with aging?” Iowa City, Iowa.

September 22, 2015 EMBO: Molecular Mechanisms of Muscle Growth and Wasting in

Health and Disease Conference, Invited Speaker, “The role of endoplasmic reticulum stress and autophagy in the attenuated recovery of muscle mass following disease in aged rats.” Ascona, Switzerland, September 20-25, 2015

September 28, 2015 Nobel Forum: Bench to Bedside Research on Muscle Wasting:

Mechanisms and Interventions, Invited Speaker, “ Skeletal muscle atrophy, a balance between protein synthesis and degradation”, Karolinska Institute, Stockholm, Sweden, September 28-29, 2015.

January 21, 2016 Advances in Skeletal Muscle Biology in Health and Disease, Invited

Speaker, “ Age-related deficits in skeletal muscle recovery following disuse: role of denervation and impaired proteostasis. University of Florida, Gainesville, Florida, January 20-23, 2016.

April 4, 2016 Experimental Biology 2016 Annual Meeting, Invited Speaker,

Symposium: The Control of Skeletal Muscle Atrophy in Response to Disuse: Clinical/Preclinical Contentions and Fallacies of Evidence., “The regulation of protein metabolism in pre-clinical models of disuse atrophy-now and the future”, San Diego, CA

April 6, 2016 American Physiological Society Minority Travel Fellowship Award

Luncheon; Keynote Speaker: Fostering successful scientific collaborations between academia and industry”; Experimental Biology 2016 Annual Meeting San Diego, CA

November 11, 2016 Huffiness Discussion 6, Invited Speaker, “Skeletal Muscle-the Key to a

Healthy Life”. Huffiness Institute for Sports Medicine and Human

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Performance, Texas A&M, College Station, Texas. December 5, 2016 Invited Seminar Speaker, Virginia Tech, “The Regulation of Protein

Metabolism in Preclinical Models of Disuse and Aging”, Blacksburg, Virginia

January 12, 2017 Invited Seminar Speaker, Department of Physiology, LSU Health

Sciences Center, Sarcopenia and the Attenuated Growth Repsonse, New Orleans, Louisiana.

2017 Invitations: February 20-22, 2017 Division of Nutritional and Environmental Sciences, University of Shizuoka,

JAPAN March 16-17, 2017 Department of Nutrition and Exercise Physiology, University of Missouri School

of Medicine August, 2017 Sao Paulo University BRAZIL

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GRANT SUPPORT ACTIVE VA RR&D Merit, 1I01RX000673-01

Bodine, SC. (PI) 8/17/2012 - 1/31/2017

Mechanisms Involved in Age-Related Loss of Muscle Mass and Growth Response The primary purpose of this grant is to investigate the mechanisms responsible for the age-associated loss of muscle growth capacity. Role: PI National Institute of Health 1 R01 AR070031-01

Bodine, SC., Rutledge, J. (MPI)

4/01/2016 - 3/31/2021

The Role of Intramuscular Lipids in Muscle Anabolic Resistance The overall goal of this proposal is to understand the mechanisms by which a high-fat diet in mice reduces skeletal muscle growth in response to increased loading. Role: Co-PI National Institute of Health U24 DK092993-06

Lloyd, K. (PI)

7/01/2016 – 6/30/2021

Mutant Mouse Phenotyping Center (MMPC) at UC Davis The Center is a comprehensive resource for the phenotypic characterization of mouse models pertaining to the study of diabetes, obesity, and diabetic complications. Its mission is to advance medical and biological research by providing the scientific community with standardized, high quality metabolic and physiologic phenotyping services for researchers utilizing the mouse for diabetes and diabetes-related research. Role: Co-Director of Core

FAPESP-UC Davis SPRINT Program Bodine, Sue C. (MPI) 08/01/2016-7/31/2018 Protein quality control in dysfunctional/atrophic skeletal muscle: role of b2 adenoceptor This is a joint program between FAPESP in Brazil and the University of California Davis to encourage collaboration. Intracellular protein quality control is impaired during muscle wasting. Here, we plan to establish a causal relationship between ß2-adrenoceptor activation and improved protein quality control in skeletal muscle, which could have major implications for the treatment of muscle disorders including aging. Role: US PI; Brazilian PI: Julio Ferreira, Ph.D. National Institute of Health Bodine, Sue C., Baar, K (MPI) 12/15/2016-12/30/2022 1U01AG055133-01 MoTrPAC: Preclinical Animal Study Site Our proposal describes how a University of California Preclinical Animal Study Site (UC PASS) would contribute to the goals of MoTrPAC. Specifically, our proposal outlines the animal studies necessary to elucidate the molecular pathways responsible for the acute and chronic effects of both endurance and resistance exercise, be it on individual organs or through interactions between organs. We outline here how the UC PASS would help the consortium achieve the long-term goal of understanding the mechanisms by which different modes of physical activity impart their health benefits. Role: Co-PI (10%)

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PENDING National Institute of Health Adams, Christopher (PI) (12th percentile, Nov 2016) Molecular Pathogenesis of Skeletal Muscle Atrophy. Our research program is focused on molecular mechanisms of skeletal muscle atrophy and the discovery and development of small molecules that could potentially be used to prevent or treat this condition. Role: Co-I (10%) Recently COMPLETED CTSC, Highly Innovative Award 07/01/2015-06/31/2016 NIH #UL1 TR000002 Identification of the mechanisms underlying the adverse effects of androgen deprivation therapy for the treatment of prostate cancer. The primary objective of this project is to elucidate the mechanisms underlying the loss of muscle mass in mice with prostate cancer coupled with androgen deprivation therapy. PI: Sue C. Bodine, Ph.D. Navitor Pharmaceuticals 02/1/2016-08/31/2016 Prevention of Disuse Atrophy The overall goal of this project is to test the effectiveness of novel compounds to prevent muscle atrophy or enhance the growth of muscle following an atrophy-inducing condition. PI: Sue C. Bodine, Ph.D. Completed Funding 8/1/2013-6/30/2014 Center for Molecular and Genetic Imaging Measurement of Changes

in Mass and Quality of Skeletal Muscle. PI: Sue Bodine 12/01/08-11/30/12 NIH R01 Glucocorticoid Control of Gene Expression During Skeletal

Muscle Atrophy. Multi-PIs: Sue Bodine and J. David Furlow 09/01/11-05/01/12 Sirtris, a GSK Company Effects of SirT1 Activators on Muscle Growth

in Obese Mice PI: Sue C. Bodine 07/01/09-09/30/10 ARRA Supplement to RO1DK075801; Glucocorticoid control of gene

expression during skeletal muscle atrophy. Co-PIs: Sue C. Bodine & J. David Furlow

07/01/06-6/30/09 Muscular Dystrophy Association Research Grant Function and Regulation of Muscle E3 Ligases: MuRF1 and MAFbx 7/1/96-9/30/02 Private Industry: Regeneron Pharmaceuticals 8/1/94-7/31/96 NASA/NIH-R2 Neuromuscular Development and Regulation of Myosin Expression

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10/1/93-11/31/97 Veteran’s Administration Merit Grant Nerve Injury: The effects of timing and surgical methods on Recovery. 7/1/93-6/30/96 VA Rehabilitation Research & Development Grant Treatment of Spasticity Using Phenol Nerve Blocks 4/1/91-3/31/95 NASA, NAG2-714 Adaptive Response of Slow and Fast Skeletal Muscle in the Monkey to

Spaceflight. 5/1/90-10/31/93 NASA, NAG2-653 Adaptation of Skeletal Muscle to Spaceflight: Cosmos Rhesus Project. 3/1/92-2/28/94 Orthopedic Research and Educational Foundation Specificity of Reinnervation Following Nerve Repair: A Comparison of Different

Surgical Techniques

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TEACHING Courses of Instruction Human Neuromuscular Anatomy Lab (4 hrs/week) TA: 2 sections/week; Department of

Kinesiology, UCLA Fall 1981, 1982 Introduction to Human Physiology Lecture/Lab (4 hours/wk, 2 hours/wk) TA: 4

sections/week; Department of Kinesiology, UCLA Winter 1982 Neuromuscular and Metabolic Bases Lecture/Lab (3 hours/week, 3 hours/week) TA: 3 of Movement sections/wk Spring 1982 Development of Muscle Specificity Graduate Seminar, 3 hours/week Instructor; Department

of Kinesiology, UCLA Fall 1988 Muscle Physiology and Adaptation Lecture, 4 hrs/week, Instructor; Department of

Kinesiology, UCLA Spring 1989 Applied Neuromuscular Undergraduate Seminar, Instructor, UCSD Physiology Spring 1991, Fall 1991, Winter 1994 Nerve Basic Science Lectures 6 Lectures, Orthopedic Resident Training, Department

of Orthopedics, UCSD, Winter 1991, 1993 Neuromuscular Adaptation Lecture (3 hrs/wk), Instructor, Exercise Biology Major,

UCD, Spring 2006, Winter 2007 Exercise Physiology Lecture (4 hrs/wk), Instructor, Exercise Biology Major,

UCD, Fall 2006-present, Spring 2012-present Exercise Metabolism Lecture (3 hrs/wk), Instructor, Exercise Biology Major,

UCD, Winter 2008 Growth & Development Lecture (3 hrs/wk), Instructor (6 lectures), Exercise

Biology Major, UCD, Spring 2007-2014 Frontiers in Exercise Biology Lecture (2 hrs/wk), Instructor, Exercise Biology Major,

UCD, Spring 2010 INDEPENDENT STUDIES Introduction to Laboratory Research UCSD School of Medicine Undergraduate Independent Research UCSD, UCD Faculty Mentor Research Program UCSD, UCD Minority High School Student Summer UCSD School of Medicine Research Program

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Postdoctoral Fellows Andrea Marshall, Ph.D. May 2014-present STEM Minority Fellowship, Identification of

MuRF1 Substrates Leslie Baehr, Ph.D. Feb 2013-present Skeletal Muscle Aging Daniel West, Ph.D. Feb 2013-July 2015 Skeletal Muscle Aging David S. Waddell, Ph.D. July 2004-2008 NRSA Postdoctoral Fellowship 05/08, Molecular

Physiology, David J. Pierotti, Ph.D. June 1993-June 1996 Neuromuscular Physiology & Adaptation William Turner, MD July 1994-June 1995 Otolaryngology/Head & Neck Surgery Joseph Davey, MD. July 1993-June 1994 Orthopedic Surgery Albert Merati, MD. July 1993-June 1994 Otolaryngology/Head & Neck Surgery R. Scott Meyer, MD. July 1992-June 1993 Orthopedic Surgery Medical Student Research Advisor, UCSD School of Medicine Steven Allsing Medical Student IV Summer 1992, Winter 1993 Alex Moskovitz Medical Student II Summer 1993, Fall 1993 Dan Stillman Medical Student IV Winter 1995 Trainees: Doctorate Degree Arik Davidyan UCD, Molecular & Cellular Integrative Physiology Chair 2015- Pearl Chen UCD, Molecular & Cellular Integrative Physiology Member 2015- Nicholas Aguirre UCD, Molecular & Cellular Integrative Physiology Member 2014- Jackie Levin UCD, Molecular & Cellular Integrative Physiology Member 2014- Colin McCoin UCD, Molecular & Cellular Integrative Physiology Member 2012-15 Tiffany Sarrafian UCD, Comparative Pathology Co-Chair 2012-16 Yana Chen UCD, Nutrition Member 2012-12

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Monica Watson UCD, Molecular & Cellular Integrative Physiology Member 2007-12 Philip Matern UCD, Molecular & Cellular Integrative Physiology Chair 2007-15 Darren Hwee UCD, Molecular & Cellular Integrative Physiology Chair 2007-12 Leslie Baehr UCD, Molecular & Cellular Integrative Physiology Chair 2006-12 Mitch Sitnick UCD, Molecular & Cellular Co-Chair 2007-09 Integrative Physiology Kimberly Huey UCSD, Biomedical Sciences Chair 1995-96 Tina Patel UCSD, Bioengineering member 1995-96 Thomas Burkholder UCSD, Bioengineering member 1994-96 Trainees: Master’s Degree Micah Below UCD, Exercise Science Member 2011-12 Mark Pepin UCD, Bioengineering Member 2011-12 Kari Pollock UCD, Molecular & Cellular Integrative Physiology Member 2008-09 Adam Ross UCD, Molecular & Cellular Integrative Physiology Chair 2008-09 Darren Hwee UCD, Exercise Science Chair 2006-07 Kyle Henderson UCD, Exercise Science Member 2004-05 Jessica Wei UCD, Cell & Developmental Member 2004-05 Biology

Training Grants (mentor):

T32: Training Program in Basic and Translational Cardiovascular Science HHMI IMBS Training Program T32: Pharmacology Training Program: Bench to Bedside T32: Mentored Clinical Research Training Program (MCRTP)

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Visiting Scholars: Luis Gustavo Oliveira de Sousa, Ph.D. Candidate, Sao Paulo University, Brazil FASESP Fellowship, Feb 2014 to March 2015 Takuya Yosida, Ph.D. Assistant Professor, University of Shizuoka, Japan, June 1-August 31, 2016 GRADUATE GROUP MEMBERSHIP Molecular, Cellular and Integrative Physiology Exercise Sciences Biotechnology Emphasis