CURRICULUM VITAE

Srinivasan ThyagaRajan

PERSONAL INFORMATION

Date of Birth: May 25, 1964

Marital Status: Married, Two children

Address: 127/8 F4, First Main Road, Alwarthirunagar Annexe, Chennai 600087

Telephone: 9940201794

E-mail: sri_thyagarajan@hotmail.com

EDUCATION Madras Veterinary College

Madras, India. Veterinary Science B. V. Sc. 1981-1987

Kansas State University, KS, U.S.A. Physiology Ph. D. 1988-1993

(Neuroendocrinology)

PREVIOUS POSITIONS AND APPOINTMENTS

6/1988-9/1993 Graduate Research Assistant with Teaching Responsibilities, Dept. of

Anatomy and Physiology, College of Veterinary Medicine, Kansas State

University, KS, U. S. A.

10/1993-1/1997 Postdoctoral fellow, Dept. of Neurobiology and Anatomy, School of

Medicine and Dentistry, University of Rochester, NY, U. S. A.

2/1997-6/1998 Research Assistant Professor, Dept. of Neurobiology and Anatomy,

University of Rochester, NY, U. S. A.

7/1998-6/2001 Assistant Professor, Dept. of Pathology and Human Anatomy,

Center for Neuroimmunology, School of Medicine,

Loma Linda University, CA, U. S. A.

7/2001-8/2003 Assistant Adjunct Professor, Dept. of Anatomy and Neurobiology,

Susan Samueli Center for Complementary and Alternative Medicine,

College of Medicine, University of California, Irvine, CA, U. S. A.

9/2003-7/2006 Associate Research Professor, Division of Human Anatomy, Dept. of

Pathology and Human Anatomy, School of Medicine, Loma Linda

University, Loma Linda, CA, U. S. A.

8/2006-6/2008 Adjunct Associate Research Professor, Division of Human Anatomy,

Dept. of Pathology and Human Anat., School of Medicine, Loma Linda

University, Loma Linda, CA, U. S. A.

1/2007-1/2008 Interim Head of the Department, Department of Biotechnology

(~6 months) SRM University, Kattankulathur 603 203, Kanchipuram District, Tamil

Nadu, INDIA

07/2010-2013 Honorary Consul General of Michigan State University, MI, USA

for India representing College of Veterinary Medicine, MSU

07/2011-2013 Adjunct Associate Professor, Department of Pathobiology and

Diagnostic Investigation, Michigan State University, MI, USA

12/2012-05/2019 Head, Department of Biotechnology, School of Bioengineering, SRM

IST, India

10/2006-05/2019 Professor, Department of Biotechnology, SRM IST, India

2

HONORS 1983-1987 Recipient of Tamil Nadu Agricultural University Merit Scholarship

Award, Madras Veterinary College, India.

1987 Gold Medals and Books (Physiology), Madras Veterinary College, India.

1993 Sigma Xi Travel Award, Kansas State University, KS, U. S. A.

MEMBERSHIP IN PROFESSIONAL SOCIETIES

Indian Academy of Neuroscience, 2007-present

Society for Neuroscience, 1991- 2016

The Endocrine Society, 1992-2002

Psychoneuroimmunology Research Society, 2000-2004

The Gerontological Society of America1991-1993

Sigma Xi 1993

Society of Phi Zeta 1991-1993

UNIVERSITY AND DEPARTMENTAL COMMITTEES AT SRM UNIVERSITY, INDIA

Development of curriculum and syllabi for B. Tech. (Biotech.) course for 2007-2010

B. Tech. (Biotech.) Immunology Project Coordinator, Dept. Biotechnology, 2008, 2009.

B. Tech. (Biotech.) Medical Biotechnology Project Coordinator, Dept. Biotechnology, 2010

M. Tech. (Biotech.) Research Project Coordinator, Dept. Biotechnology, 2007-08.

Associate Superintendent, Exam Cell. Supervision of University examinations. 2007-08.

Organizing Secretary, Recent Advances in Bioengineering, SRM IST, February 7-9,

2008. International workshop and conferences by the six departments of the School of

Bioengineering with delegates over 2000.

Organized the inauguration of Biotechnology Student Association with 3 eminent speakers and

arranged 9 seminars given by entrepreneurs, industrialists, and scientists. 2009-10

Local Sectional Secretary: Animal, Veterinary, and Fishery Sciences, Indian Science Congress

Association Meeting, SRM University, January 3-7, 2011.

Organized an one-day workshop on Innovative Methodologies in Teaching of Life Science and

Biomedical Science Laboratory Courses in collaboration with Mahatma Gandhi-

Doerenkamp Center (MGDC) for Alternatives to Use of Animals in Life Science

Education, Bharathidasan University, Tiruchy at SRM University, February 26, 2011.

Organized the inauguration of Biotechnology Student Association with 2 eminent speakers and

arranged 3 seminars given by clinician, industrialist, and scientist. 2011-12

Development of curriculum and syllabi for B. Tech. and M. Tech. (Biotech.) courses-2013

Regulations

Development of curriculum and syllabi for B. Tech. and M. Tech. (Biotech.) courses-2015

Regulations

Development of curriculum and syllabi for B. Tech. (Biotech.) course-2018 Regulations

PARTICIPATION IN ACADEMIC AND RESEARCH REVIEW COMMITTEES

The Wellcome Trust, U. K.; Ad hoc reviewer, 2000.

Member, Board of Studies of Basic Sciences Faculty, Tamil Nadu Veterinary and Animal

Sciences University, 2009-2012.

Head, Pharmacology and Clinical Sciences Research Program, World Noni Research

Foundation, Chennai, April 2013-present

3

Reviewer of grants under SPARSH (Social Innovation Programme for Products Affordable &

Relevant to Societal Health), Biotechnology Industry Research Assistance Council

(BIRAC), DBT. September 8, 2016

Reviewer of grants, DST. 2015, 2016

Executive Council Member, National Academy of Biological Sciences, India. September 2016-

present

MANUSCRIPT REVIEW FOR JOURNALS

Neuroimmunomodulation

International Journal of Psychology

Brain Behavior and Immunity

Brain Research

Neurobiology of Aging

Journal of Pharmacology and Experimental Therapeutics

Journal of Neuroimmunology

Endocrine

Proceedings of Indian National Science Academy- B

Pharmacological Research

Endocrinology

Oncology Research International

AGE

Psychiatry Research

Neuroscience Letters

BioMed Research International

Experimental Biology and Medicine

Drug and Chemical Toxicology

American Journal of Physiology-Endocrinology and Metabolism

Molecular Psychiatry

International Immunopharmacology

EDUCATIONAL CONTRIBUTIONS

Graduate Education

Gross Anatomy (Medical, Dental, and Veterinary)

Veterinary Gross Anatomy I (AP 700, 6 credit hours), Kansas State University, KS.

Fall Semester, 1991 and 1992: Laboratory Instructor. Contact hours: 250

hours/semester.

Medical Gross Anatomy (ANAT 511), Loma Linda University, CA. Fall and Winter

Quarter, 1999. Laboratory instruction to medical students.

Human Gross Anatomy (Medicine 500), University of California, Irvine, College of Medicine.

2002-2003. Lectures and laboratory instruction to medical students.

Medical Gross Anatomy (ANAT 521-524), Loma Linda University, CA. 2005-2006.

Laboratory instruction and review of Anatomy to first-year medical students.

Human Anatomy for Dentists (ANAT 509) Loma Linda University, CA. Spring Quarter, 2006.

Laboratory instruction on head and neck to first year dental students.

Neuroscience

Neuroscience (ANAT 537), Loma Linda University, CA. Spring Quarter, 2006. Lecture on

4

Hypothalamus, neural pathways, and functions to medical students.

Psychoneuroimmunology involving Behavior, Neuroscience, Endocrinology, and Immunology

Mind-Body interactions and health outcomes (HPRO 515), Loma Linda University, CA.

Fall Quarter, 1999 and 2000. Lectures on Psychoneuroimmunology and Cancer.

Immune system: Public health applications (HPRO 575), Loma Linda University, CA.

Fall Quarter, 2003 and 2004. Lectures on neuroendocrine-immune basis for cancer

pathogenesis and psychosocial influences on cancer pathogenesis and therapy.

Immunology for Pharmacy Students (RXPS 571), Loma Linda University, CA. Winter

Quarter, 2005 and 2006. Lectures on interactions between the nervous, endocrine, and

immune systems and immunopharmacology.

Cellular Mechanism and Integrated Systems II (IBGS 512 & 513), Loma Linda University,

CA. Winter and Spring Quarters, 2006. Lectures on Neuro-Endocrine-Immune

Interaction and its role in diseases to graduate students.

Graduate course in Psychoneuroimmunology (ANAT 557), Loma Linda University, CA.

Spring Quarter, 2006. As a Co-Director of the course assisted in developing the course

and lecture material, selection of peer-reviewed manuscripts for group

discussion, and grading of the students. Lectures and moderating group discussions on

a variety of topics in psychoneuroimmunology to graduate students.

Biotechnology, Genetic Engineering, and Bioinformatics at SRM University, INDIA

Immunology Laboratory (BT 208), Even semester 2006-07.Immunology lab training to II year

B. Tech. (Biotechnology).

Immunology BT 207: Odd semester 2007-08, II year B. Tech. (Biotech.).

BI 356: Even Semester 2008-09, III year B. Tech. (Bioinfo.).

BT0205: Course Coordinator, Odd Semesters 2008-09, 2009-10, 2010-11, 2011-

12, 2012-13, 2013-14II year B. Tech. (Gen. Eng. and Biotech.).

BT1010/15BT205: Odd semesters 2014-15, 2015-16, 2017-18, 2018-19

Seminar: BT 504, Even semester 2006-07.I year M. Tech. (Biotech.).

BT 509, Odd semester, 2007-08, I year M. Tech. (Biotech.).

Signal transduction and cell signaling (BT 560), Even semester 2006-07.I year M. Tech.

(Biotech.).

Cancer Biology BT0615: Odd semester 2009-10. II Year M. Tech. (Biotech.).

BT0325: Odd Semester 2010-11, 2011-12, 2012-13, 2013-14, 2014-15. III Year

B. Tech. (Biotech.).

BI0358:Even Semester 2009-10, 2010-11. III Year B. Tech. (Bioinfo.)

BT1051:Odd semester 2015-16

Cell culture and Hybridoma technology (GN 304), Even semesters 2006-07. 2007-08.2008-09

Lectures to III year B. Tech. (Genetic Engineering).

Immunotechnology BT 455:Odd semester, 2007-08, 2008-09, 2009-10. IV year B. Tech.

(Biotech.).

BT 558: Even semester, 2007-08, I year M. Tech. (Biotech.).

Biology for Engineers (GE 0102), Even semester, 2007-08, I year B. Tech. (ICE).

Course Coordinator, Even semester, 2009-2010, 2010-11, 2011-12 and taught I year B.

Tech. (FPE).

Biochemistry BT0102: Course Coordinator, Even Semester, 2010-11, 2011-12, 2012-13. I

Year B. Tech. (Biotech.).

BT1004: Even Semester, 2013-14, 2014-15

5

Cell Biology BT0104: Course Coordinator, Even Semester, 2011-12, 2012-13. I Year B.

Tech. (Biotech.).

BT1003/15BT201: Even Semester, 2013-14, 2014-15, 2016-17, 2017-18,

Human Physiology and Health BT1002: Even Semester, 2013-14, 2014-15, 2015-16

Neurobiology BT1021: Odd Semester, 2015-16

Cellular and Molecular Neuroscience BT1072/15BT211E: Even semester, 2015-16,

2016-17, 2017-18, 2018-19

Developmental Biology 15BT207E: Odd semester, 2018-19

Training of Undergraduate and Graduate Students University of Rochester, NY.

Undergraduate students: Valerie Levy (1994-1995)

J. Cory Kalvass (1996-1997).

Loma Linda University, CA.

Summer Research Scholars

(2nd year medical students): R. Kerr (June-August, 1998)

Brian Teruya (June-August, 1999)

University of California Irvine, CA.

Minority Biomedical Research

Support Program & Biol. 199: Danielle Campbell, July-December, 2002,

Biol 199: Catherine Lajoie, July-December, 2002,

Loma Linda University, CA.

Minority Summer Student: Paola Garcia, June-August, 2005

M.S. thesis committee member: Schari Flowers, 2004-2006

Guidance to Graduate students: Jeff Carter, Brooke Millar, Sam Perez, and

Dorian Silva, 2003-2006

SRM IST, Kattankulathur, INDIA

B. Tech. (Biotech.) Students: Harini Krishnan; 2009-2011

Miti Mishra and Ranvijay Singh; 2010-2014

S. Gopinath; 2011-2013

R. Karthik Ramakrishnan and Vishak Raman;

2012-2013

Soha Chhaya, Sushrut Shitoot, T. C. ThyagaRajan,

2013-2014

Shaili Gour, T. Kannan, Mantavya Patel, M. M.

Hariharan, V. Prasanna, 2013-16

M. Tech. (Biotech.) Students: Biswa Behera and Vikram Sabapathy;.2005-07.

Ramyapriya, Sam Masih, and Mohd. Zeeshan;

2007-09

A. Sindhu and Preetam Bala; 2009-10

Utsav Sharma and Varun Sharma; 2010-2011

Uday Pratap and Aparna Mohanty; 2011-2012

Anushree Patil, Prathamesh Kale, and Himanshu

Sharma; 2012-2013

6

Anurupa Bhattacharya (External), 2014

Rahul Nair, 2014-2015

Ph. D. (Biotech.) Full-time: Hannah Priyanka 2009-2014

Uday P. Pratap 2012-2017

Hima, L. 2013-

R. Vasantharekha 2012-2018

PAST GRANT SUPPORT

U. S. A.

Somerset Pharmaceuticals Inc., Desmethylselegiline in an in vivo model of neuronal

degeneration and altered immune responses. 9/15/95-6/30/98. Co-P. I. (David L. Felten,

P. I.), 100% effort. $224,000 (TC).

U. S. Army Medical Research and Materiel Command Breast Cancer Research Program, Grant

DAMD17-96-1-6214, “Deprenyl and Protection against Mammary tumors.” 1996-1999.

Co-P. I. (David L. Felten, P. I.), 85% effort. $601,310 (TC)

Intramural Grant, Loma Linda University, “Sympathetic Noradrenergic Neuronal Modulation

of Th1Vs Th2 Cytokines in Aging: Effects of Deprenyl Treatment.” 2000-2001. P. I.

$6,000.

The Japan Foundation for Aging and Health: Japan-U. S. Cooperative Research Program for

Longevity Sciences. “Desmethyldeprenyl and Neural-Immune Interactions.” 1/1/01-

12/31/01. P. I. $5,000.

Intramural Grant, Loma Linda University, “Estrogen and Reproductive Aging.” 2003-2005.

P. I. $50,000.

India

SRM University. “Estrogen: A Neuroprotective or Proinflammatory Hormone?” August 2009-

July 2010. P. I. Harini Krishnan, II B. Tech. (Biotech.), Co-I. Rs. 0.65 Lakhs.

Department of Science and Technology, Government of India. “Modulation of Neural-Immune

Signaling by Estrogen in Reproductive Aging.” March 2008-February 2011. P. I. F.

NO. SR/SO/HS-46/2007. Rs. 37.44 Lakhs.

World Noni Research Foundation, Chennai. “Physiological significance of Noni

phytochemicals on the Neuro-Endocrine-Immune system.” 2010-2012. P. I. Order

No.: FFEP-CRP-O8-O02. Rs. 10.00 Lakhs.

Department of Biotechnology, Government of India. “Neuroendocrine-Immune Interactions in

Mammary Tumorigenesis.” 2009-2012. P. I. Order No.: BT/PR9199/Med/30/12/2007.

Rs. 40.25 Lakhs.

Ministry of Agriculture, GoI, Coconut Development Board, Kerala. “Health benefits of dietary

intake of Virgin coconut oil on neural-immune network.” 2014-2016. P. I.

F.No.1345/2013 Tech. Rs. 26.29 Lakhs

INVITED SPEAKER 1. Aging: Hypothalamic catecholamines and neuroendocrine functions. Department of

Neurobiology and Anatomy, University of Rochester School of Medicine, Rochester, New

York, June 18. 1993.

7

2. First International Conference on Immunology and Aging: In a symposium titled Neuro-

Endocrine-Immune System Interaction. National Institutes of Health Campus, Bethesda, MD.

June 16-19, 1996.

3. In Vivo Neuroimmunology and L-deprenyl effect on brain catecholamines/serotonin. Somerset

Pharmaceuticals, Tampa, FL. October 21, 1996.

4. Anti-tumor effect of deprenyl in rats with carcinogen-induced mammary tumors. 1st Annual

University of Rochester Cancer Center Scientific Symposium, Genesee County Museum,

Mumford, NY. November 4, 1996.

5. Sympathetic modulation of immunity in aging. Twenty-first International Symposium on Brain

and the Bio-defense System. Division of Brain Sciences, The Taniguchi Foundation, Kyoto,

Japan. January 19-22, 1998.

6. L-deprenyl-induced inhibition of mammary tumor growth is associated with altered neural

activity and immune function in rats. Era of Hope Meeting, Department of Defense Breast

Cancer Research Program, Atlanta. June 8-11, 2000.

7. Modulation of neuroendocrine-immune signaling by deprenyl and desmethyldeprenyl in aging

and breast cancer. Fifth International National Institute for Longevity Sciences Workshop,

Interventions: Part III, Obu-shi, Aichi, Japan, November 30-December 1, 2000. Co-Chairman

of the scientific session: Antioxidants I.

8. Sprouting of noradrenergic nerve fibers, immune modulation and protection from mammary

tumors. Symposium: Sympathetic nervous system modulation of immune function: role in

immune function abnormalities in the elderly, in cancer, and in autoimmune disease. Annual

meeting of the Psychoneuroimmunology Research Society, Utrecht, The Netherlands, May 19,

2001.

9. Neuroendocrine regulation of immune reactivity: Effects of propargylamines in aging and

breast cancer. Department of Anatomy and Neurobiology, University of California, Irvine.

May 25, 2001 10. Neural Influences on Immune Reactivity in Reproductive Aging. Biomedical Research

Seminar, Loma Linda University, CA. April 22, 2004 11. Communications between the Neuroendocrine System and Immune System in Aging and

Mammary Cancer. School of Biotechnology, SRM University, Kattankulathur, India. November 4, 2006.

12. Neuroimmunomodulation of splenic sympathetic noradrenergic (NA) nerve fibers by estrogen in rats. Silver Jubilee Conference of Indian Academy of Neurosciences, Varanasi, India. November 23, 2007.

13. Fundamental Concepts of Neural-immune Interactions in Health and Disease: Implications in Infectious Diseases and AIDS. NIPER, Chandigarh, India. December 11-13, 2008.

14. Female Reproductive Aging and Mammary Cancer: Involvement of Neural-immune Interactions. Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, MI, USA. March 18, 2010.

15. Current Status in Cancer Biology. Department of Biotechnology, Rajalakshmi Engineering College, Thandalam, Chennai. February 27, 2012

16. Pharmacological Properties and Clinical Applications of Morinda citrifolia. Noni Search 2014; Ninth national symposium “Noni for Everyone,” Goa. September 27, 2014

17. A conundrum: Does immune system operate in isolation or regulated by neuroendocrine system? Immunocon-2014, Madurai Kamaraj University, Madurai. December 13, 2014

18. Neuroendocrine-Immune system and Homeostasis and Neuroendocrine-Immune interactions in Aging and Age- related diseases. Academies’ Lecture Workshop, Vels University, Chennai. March 12, 2015

19. Medicinal plants in the treatment of cancer and neurodegenerative diseases. Second World Noni Congress: Noni and Medicinal plants for Inclusive Growth and Wellness. SRM University. March 20, 2016

8

20. Reproductive Aging: Key neural-immune interactions during early middle age in brain and lymphoid organs. Symposium on Neural Functions of Aging Brain organized by ICUBR & SSH and RGCB, Thiruvananthapuram, September 28, 2016.

PUBLICATIONS

1. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1 stimulates the

release of dopamine and dihydroxyphenylacetic acid from the hypothalamus in vivo. Life Sci.

48:925-930, 1991.

2. ThyagaRajan, S., Meites, J. and Quadri, S. K. Underfeeding-induced suppression of

mammary tumors: counteraction by estrogen and haloperidol. Proc. Soc. Exp. Biol. Med.,

203:236-242, 1993.

3. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1ß increases

5-hydroxyindoleacetic acid release in the hypothalamus in vivo. Brain Res. Bull., 31:745-748,

1993.

4. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Correlations of catecholamine

release in the medial preoptic area with proestrous surges of luteinizing hormone and prolactin:

effects of aging. Endocrinology 135:119-126, 1994.

5. ThyagaRajan, S., Meites, J. and Quadri, S. K. Deprenyl treatment reinitiates estrous cycles,

reduces serum prolactin and decreases the incidence of mammary and pituitary tumors in old

acyclic rats. Endocrinology 136:1103-1110, 1995.

6. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Cyclic changes in the release of

norepinephrine and dopamine in the medial basal hypothalamus: effects of aging. Brain Res.,

689:122-128, 1995.

7. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Cyclic and age-related changes in

norepinephrine concentrations in the medial preoptic area and arcuate nucleus. Brain Res.

Bull., 38:561-564, 1995.

8. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Tyrosine hydroxylase and DOPA

decarboxylase activities in the medial preoptic area and arcuate nucleus during the estrous

cycle: effects of aging. Brain Res. Bull., 42:265-271, 1997.

9. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Anti-tumor effect of L-deprenyl in rats with

carcinogen-induced mammary tumors. Cancer Letters 123:177-183, 1998.

10. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Restoration of sympathetic noradrenergic

nerve fibers in the spleen by low doses of L-deprenyl treatment in young sympathectomized

and old Fischer 344 rats. J. Neuroimmunol., 81:144-157, 1998.

11. ThyagaRajan, S., Madden, K.S., Kalvass, J. C., Dimitrova, S., Felten, S. Y. and Felten, D. L.

L-deprenyl-induced increase in IL-2 and NK cell activity accompanies restoration of

noradrenergic nerve fibers in the spleens of old F344 rats. J. Neuroimmunol., 92:9-21, 1998.

9

12. ThyagaRajan, S., Stevens, S. Y. and Felten, D. L. Region-specific alterations in the

concentrations of catecholamines and indoleamines in the brains of young and old F344 rats

after L-deprenyl treatment. Brain Res. Bull., 48:513-520, 1999.

13. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Effects of L-deprenyl

treatment on noradrenergic innervation and immune reactivity in lymphoid organs of young

F344 rats. J. Neuroimmunol., 96:57-65, 1999.

14. ThyagaRajan, S. and Quadri, S. K. L-deprenyl inhibits tumor growth, reduces serum

prolactin, and suppresses brain monoamine metabolism in rats with carcinogen-induced

mammary tumors. Endocrine, 10:225-232, 1999.

15. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Inhibition of tumor growth

by L-deprenyl involves neural-immune interactions in rats with spontaneously developing

mammary tumors. Anticancer Res., 19:5023-5028, 1999.

16. ThyagaRajan, S. and Quadri, S. K. L-deprenyl stimulates the release of catecholamines in the

rat medial basal hypothalamus in vivo. Neurosci. Lett., 270:79-82, 1999.

17. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Restoration of splenic

noradrenergic nerve fibers and immune reactivity in old F344 rats: a comparison between L-

deprenyl and L-desmethyldeprenyl. Int. J. Immunopharmacol., 22:523-536, 2000.

18. ThyagaRajan, S., Madden, K.S., Stevens, S. Y. and Felten, D. L. Anti-tumor effect of L-

deprenyl is associated with enhanced central and peripheral neurotransmission and immune

function in rats with carcinogen-induced mammary tumors. J. Neuroimmunol., 109:95-104,

2000.

19. Bellinger, D. L., Stevens, S. Y., ThyagaRajan, S., Lorton, D., and Madden, K.S. Aging and

sympathetic modulation of immune function in Fischer 344 rats: Effects of chemical

sympathectomy on primary antibody response. J. Neuroimmunol., 165: 21-32, 2005.

20. Bellinger, D. L., Silva, D., Millar, B. A., Molinaro, C., Ghamsary, M., Carter, J., Perez, S.,

Lorton, D., Lubahn, C., Araujoa, G. and ThyagaRajan, S. Sympathetic nervous system and

lymphocyte proliferation in the Fischer 344 rat spleen: a longitudinal study.

Neuroimmunomodulation, 15(4-6):260-271, 2008

21. Perez, S., Silva,D., Millar, B., A.,Molinaro, C., Carter, J., Bassett, K., Lorton, D., Garcia, P.,

Tan, L., Lubahn, C., ThyagaRajan, S. and Bellinger, D. L. Sympathetic innervation of the

spleen in male Brown Norway rats: A longitudinal aging study. Brain Res.,1302:106-117,

2009.

22. ThyagaRajan, S., Madden, K.S., Teruya, B., Stevens, S. Y., Felten, D. L. and Bellinger, D. L.

Age-associated alterations in sympathetic noradrenergic innervation of primary and secondary

lymphoid organs in female Fischer 344 rats. J. Neuroimmunol., 233:54-64, 2011.

23. Perez, S., Kozic, B., Molinaro, C., ThyagaRajan, S., Ghamsary, M., Lubahn, C., Lorton, D.

and Bellinger, D. L. Chronically lowering sympathetic activity protects sympathetic nerves in

spleens from aging F344 rats. J. Neuroimmunol., 247:38-51, 2012

10

24. Priyanka, H.P., Bala, P., Ankisettipalle, S. and ThyagaRajan, S. Bacopa monnieri and L-

deprenyl differentially enhance the activities of antioxidant enzymes and the expression of

tyrosine hydroxylase and nerve growth factor via ERK 1/2 and NF-B pathways in the spleen

of female Wistar rats. Neurochem. Res., 38:141-152, 2013.

25. ThyagaRajan, S.,Madden, K.S., Boehm, G. W., Stevens, S. Y., Felten, D. L. and Bellinger, D.

L. L-deprenyl reverses age-associated decline in splenic norepinephrine, IL-2 and IFN-

production in old female F344 rats. Neuroimmunomodulation,20:72-78, 2013.

26. ThyagaRajan, S.,Tran, L., Molinaro, C. A., Gridley, D. S., Felten, D. L. and Bellinger, D. L.

Prevention of mammary tumor development through neuroimmunomodulation in the spleen

and lymph nodes of old female Sprague-Dawley rats by L-deprenyl.

Neuroimmunomodulation20:141-151, 2013.

27. Priyanka H., Singh, R. V., Mishra, M., and ThyagaRajan, S. Diverse age-related effects of

Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities,

and intracellular targets in splenocytes of F344 male rats. Int. Immunopharmacol. 15:260-274,

2013.

28. Priyanka H., Sharma, U., Gopinath, S., Sharma, V., Hima, L., and ThyagaRajan, S. Menstrual

cycle and reproductive aging alters immune reactivity, NGF expression, antioxidant enzyme

activities, and intracellular signaling pathways in the peripheral blood mononuclear cells of

healthy women. Brain Behav. Immun. 32, 131–143, 2013

29. Priyanka H., Krishnan, H. C., Singh, R. V., Hima, L., and ThyagaRajan, S. Estrogen

modulates in vitro T cell responses in a concentration- and receptor dependent manner: effects

on intracellular molecular targets and antioxidant enzymes. Mol. Immunol. 56(4):328–339,

2013.

30. Priyanka, H.P. and ThyagaRajan, S. Selective modulation of lymphoproliferation and

cytokine production via intracellular signaling targets by 1- and 2-adrenoceptors and

estrogen in splenocytes. Int. Immunopharmacol.17:774–784, 2013.

31. Kale, P., Mohanty, A., Patil, A., Mishra, M., Pratap, U.P., Priyanka, H.P. and ThyagaRajan, S.

Estrogen modulates neural–immune interactions through intracellular signaling pathways and

antioxidant enzyme activity in the spleen of middle-aged ovariectomized female rats. J.

Neuroimmunol. 267:7-15, 2014.

32. Priyanka, H.P., Singh, R.V., Pratap, U.P. and ThyagaRajan, S. Estrogen modulates β(2)-

adrenoceptor-induced cell-mediated and inflammatory immune responses through ER-α

involving distinct intracellular signaling pathways, antioxidant enzymes, and nitric oxide. Cell

Immunol. 292:1-8, 2014.

33. Pratap, U.P., Anand, K., Yasmine, F., Hima, L., Priyanka, H.P., ThyagaRajan, S.

Phytochemicals in Morinda citrifolia fruit selectively modulate age-associated immunity and

antioxidant enzyme activities through ERK pathway in splenic lymphocytes of male F344 rats.

J Recept Signal Transduct Res. 2015 Oct 8:1-13.

11

34 Pratap, U.P., Sharma, H.R., Mohanty, A., Kale, P., Gopinath, S., Hima, L., Priyanka, H.P.,

ThyagaRajan, S. Estrogen upregulates inflammatory signals through NF-κB, IFN-γ, and nitric

oxide via Akt/mTOR pathway in the lymph node lymphocytes of middle-aged female rats. Int

Immunopharmacol. 29(2):591-598, 2015

35. Pratap, U.P., Patil, A., Sharma, H.R., Hima, L., Chockalingam, R., Hariharan, M. M., Shitoot,

S., Priyanka, H.P., ThyagaRajan, S. Estrogen-induced neuroprotective and anti-inflammatory

effects are dependent on the brain areas of middle-aged female rats. Brain Res. Bull. 124:238-

253 2016.

36. Pratap, U.P., Hima, L., Priyanka, H.P., ThyagaRajan, S. Noni (Morinda citrifolia L.) fruit

juice reverses age-related decline in neural-immune interactions in the spleens of old F344 rats.

J. Ethnopharmacol. 198:363-371, 2017

37. Vasantharekha, R., Priyanka, H.P., Swarnalingam, T., Srinivasan, A.V., ThyagaRajan, S.

Interrelationship between Mini-Mental State Examination scores and biochemical parameters

in patients with mild cognitive impairment and Alzheimer's disease. Geriatr Gerontol Int.

17(10):1737-1745, 2017

38. Ravichandran, K. A., Karrunanithi, S., Hima, L., Pratap, U.P., Priyanka, H.P., ThyagaRajan,

S. Estrogen differentially regulates the expression of tyrosine hydroxylase and nerve growth

factor through free radical generation in the thymus and mesenteric lymph nodes of middle‐aged ovariectomized female Sprague–Dawley rats. Clin. Exp. Neuroimmunol. 8: 341-350,

2017.

39. Pratap, U.P., Priyanka, H.P., Ramanathan, K.R., Raman, V., Hima, L., ThyagaRajan, S. Noni

(Morinda citrifolia L.) fruit juice delays immunosenescence in the lymphocytes in lymph nodes

of old F344 rats. J Integr Med. 16(3):199-207, 2018.

40. Perez, S.D., Molinaro, C.A., Tan, L., ThyagaRajan, S., Lorton, D., Bellinger, D. L.

Sympathetic neurotransmission in spleens from aging Brown-Norway rats subjected to reduced

sympathetic tone. J Neuroimmunol. 324:1-15, 2018.

Reviews

1. Madden, K. S., ThyagaRajan, S., Bellinger, D. L., Felten, S. Y. and Felten, D. L. Age-

associated alterations in sympathetic neural interactions with the immune system. Dev. Comp.

Immunol., 21:479-486, 1997.

2. Madden, K. S., ThyagaRajan, S. and Felten, D. L. Alterations in sympathetic noradrenergic

innervation in lymphoid organs with age. Ann. N. Y. Acad. Sci., 840:262-268, 1998.

3. ThyagaRajan, S. and Felten, D. L. Modulation of neuroendocrine-immune signaling by L-

deprenyl and L-desmethyldeprenyl in aging and mammary cancer. Mech. Ageing Dev., 123:

1065-1079, 2002.

12

4. Bellinger, D. L., Millar, B. A., Perez, S., Carter, J., Wood, C., ThyagaRajan, S., Molinaro, C.,

Lubahn, C. and Lorton, D. Innervation of lymphoid organs: Clinical implications. Clinical

Neurosci. Res., 6(1-2):3-33, 2006.

5. Bellinger, D. L., Millar, B. A., Perez, S., Carter, J., Wood, C., ThyagaRajan, S., Molinaro, C.,

Lubahn, C. and Lorton, D. Sympathetic modulation of immunity: Relevance to disease. Cell

Immunol., 252:27-56, 2008.

6. ThyagaRajan, S. and Priyanka, H.P. Bidirectional communication between the

neuroendocrine system and the immune system: relevance to health and diseases. Annals of

Neurosci., 19(1):40-46, 2012.

7. ThyagaRajan, S., Priyanka, H.P. and Pundir, U. P. Aging alters sympathetic noradrenergic

innervation and immune reactivity in the lymphoid organs: Strategies to reverse neuro-immune

senescence. Online journal. http://www.brainimmune.com. July 29, 2012

8. ThyagaRajan, S., Hima, L., Pratap, U.P., Priyanka, H.P., Vasantharekha, R. Estrogen-induced

neuroimmunomodulation as facilitator of and barrier to reproductive aging in brain and

lymphoid organs. J. Chem. Neuroanat. 2019 Jan;95:6-12, 2019.

Book Chapters

1. ThyagaRajan, S., Madden, K.S., Bellinger, D. L., Felten, S. Y. and Felten, D. L. Sympathetic

modulation of immunity in aging. In: Brain and Biodefence, Oomura, Y. and Hori, T. (Eds.),

Japan Scientific Societies Press, Tokyo and Karger, Switzerland, 27-38, 1998.

2. Bellinger, D. L., Madden, K.S., Lorton, D., ThyagaRajan, S. and Felten, D. L. Age-related

alterations in neural-immune interactions and neural strategies in immunosenescence. In:

Psychoneuroimmunology, Ader, R., Felten, D. L. and Cohen N. (Eds.), Academic Press, New

York, Third Edition, Volume 1, 241-286, 2001.

3. Bellinger, D. L., ThyagaRajan, S., Lorton, D., Madden, K.S., Tran, L. and Felten, D. L.

Psychoimmunology Today - Mechanisms Mediating the Effects of Psychological Status on the

Immune System. In: The Psychoimmunology of Cancer, Lewis, C. E., Barraclough, J., and

O’Brien, R. (Eds.), Second Edition, Oxford University Press, Oxford, 4-99, 2002.

4. Bellinger, D. L., ThyagaRajan, S.,Damjanovic, A. K., Millar, B., Lubahn, C. and Lorton, D. An

Overview of Neural-Immune Communication in Development, Adulthood, and Aging. In:

Immunotoxicology and Immunopharmacology, Luebke, R. W., House, R., and Kimber, I. (Eds.),

Third Edition, CRC Press, Florida, 489-507, 2006.

5. ThyagaRajan, S., Arun, M., Masih, S., Ramyapriya, M. and Mohammed, Z. Fundamental

Concepts of Neural-immune Interactions in Health and Disease: Implications in Infectious

Diseases and AIDS. In: Proceedings of the International Conference on Biotechnological

Approaches to Neuroimmunomodulation and Infectious Diseases, Singh, P. P. and Donahoe,

R.M. (Eds.), 461-480, 2008.

13

Proceedings of Conferences 1. Priyanka, H., Pundir, U., Mohanty, A., Singh, R., Hima, L., ThyagaRajan, S. In vitro effects

of Noni fruit juice on the age-related modulation of proliferation of lymphocytes, IFN

production, and antioxidant enzyme activities in the splenic lymphocytes of F344 rats. In:

Proceedings of Noni Search 2011; Sixth national symposium “Noni-A panacea for wellness,

Rethinam, P. and Marimuthu, T. (Eds.), 54-68, 2011.

2. Pundir, U.P., Priyanka, H.P., Yasmine, F., Mohanty, A., Singh, R., Mishra, M., Hima, L.,

ThyagaRajan, S. In vitro effects of Noni fruit juice on the age-related modulation of

proliferation of lymphocytes, IFN production, and antioxidant enzyme activities in the draining

lymphocytes of F344 rats. In: Proceedings of Noni Search 2012; Seventh national symposium

“Noni-The tool for wellness, Rethinam, P. and Marimuthu, T. (Eds.), 136-149, 2012.

3. Pratap, U.P., Ramakrishnan, K.R., Raman, V., Patil, A.P., Kale, P.P., Sharma, H.R., Singh,

R.V., Priyanka, H.P., ThyagaRajan, S. In vivo effects of Morinda citrifolia fruit juice on

lymphocytes proliferation, cytokine production, nitric oxide level and intracellular signaling

pathways in spleen and draining lymph nodes isolated from old F344 rats. Proceedings of

Eighth National Symposium, "Noni for Sustainable Wellness," p 184-196, 2013

4. Pratap, U.P., Patel, M., Hima, L., and ThyagaRajan, S. In vivo effects of Divine Noni Gold on

Cholinesterase activities and nitric oxide production in different brain areas of old F344 male

rats. Proceedings of Ninth National Symposium,“ Noni for Everyone”, p. 144-153, 2014.

Books

1. Biology for Engineers. S. ThyagaRajan, N. Selvamurugan, M. P. Rajesh, R. A. Nazeer,

Richard W. Thilagaraj, S. Barathi, and M. K. Jaganthan. Tata McGraw-Hill, New Delhi, 2012.

ISBN-13:978-1-12-143993-1; ISBN-10:1-12-143993-4

Author of Chapters 4 (Molecular machines) and 5 (Nervous system, immune system, and cell

signaling), pp. 126-205.

ABSTRACTS

1. Palazzolo, D. L., ThyagaRajan, S. and Quadri, S. K. Effects of aging on in vitro

catecholamine release. Gerontological Society of America Abstracts 29:93a, 1989.

2. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Changes in norepinephrine and

dopamine contents in the hypothalamus during the afternoon of proestrus. Kansas Academy of

Science Abstracts 9:41, 1990.

3. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin induces the release of

dopamine and its metabolite from the hypothalamus in vivo. Society for Neuroscience

Abstracts 16(2):971, 1990.

4. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on mammary tumors and on brain

neurotransmitters. Kansas Academy of Science Abstracts 10:34, 1991.

5. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Changes in the concentration of

catecholamines and their metabolites in middle-aged animals during the afternoon of proestrus.

Kansas Academy of Science Abstracts 10:23, 1991.

14

6. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. The in vivo release of

catecholamines (CA) from the medial preoptic area (MPA) during the estrous cycle in rats:

effects of aging. Endocrine Society Abstracts 73:1023, 1991.

7. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Age-related changes in

catecholamines released from the medial basal hypothalamus (MBH) of conscious, freely

moving female rats. Third IBRO World Congress of Neuroscience Abstracts 3:228, 1991.

8. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on brain neurotransmitters (NT) in old

male rats. Society for Neuroscience Abstracts 17(1):369, 1991.

9. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Aromatic L-aminoacid

decarboxylase activity in the hypothalamus (HT) during the estrous cycle: effects of aging.

Society for Neuroscience Abstracts 17(1):347, 1991.

10. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on body weight and organ weights in

old female rats. KansasAcademy of Science Abstracts 11:44, 1992.

11. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Release of 5-hydroxyindoleacetic

acid (5-HIAA) from the medial preoptic area (MPA) during different stages of estrous cycle:

effects of aging. Kansas Academy of Science Abstracts 11:30, 1992.

12. ThyagaRajan, S. and Quadri, S. K. Effects of deprenyl on neurotransmitters (NT) in the

medial basal hypothalamus (MBH) and striatum (ST) of old female rats. The FASEB Journal

6:A2034, 1992.

13. ThyagaRajan, S. and Quadri, S. K. Deprenyl stimulates the release of catecholamines and 5-

hydroxyindoleacetic acid from the medial basal hypothalamus in vivo. Endocrine Society

Abstracts 74:431, 1992.

14. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Effects of aging on the monoamine

oxidase activity in the hypothalamus. Ninth International Congress of Endocrinology Abstracts

9:556, 1992.

15. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Interleukin-1ß induces the release of

5-hydroxyindoleacetic acid (5-HIAA) from the hypothalamus in vivo. Society for Neuroscience

Abstracts 18(1):766, 1992.

16. ThyagaRajan, S. and Quadri, S. K. Effects of feed restriction on mammary tumor growth and

hypothalamic neurotransmitters in rats. Society for Neuroscience Abstracts 18 (1):114, 1992.

17. ThyagaRajan, S., MohanKumar, P. S. and Quadri, S. K. Age-related changes in the in vivo

release of 5-hydroxyindoleacetic acid (5-HIAA) from the medial basal hypothalamus (MBH) of

female rats. The Gerontologist 32:218, 1992.

18. MohanKumar, P. S., ThyagaRajan, S. and Quadri, S. K. Tyrosine hydroxylase activity in the

hypothalamus during the estrous cycle: effects of aging. The Gerontologist 32:217, 1992.

15

19. ThyagaRajan, S. and Quadri, S. K. Deprenyl-induced suppression of carcinogen-induced

mammary tumor. growth in rats. Endocrine Society Abstracts 75:528, 1993.

20. Quadri, S. K., MohanKumar, P. S., ThyagaRajan, S., Palazzolo, D. L. and Sakamoto, K. Age-

related changes in hypothalamic monoamines and estrous cycles: effects of dietary restriction.

Endocrine Society Abstracts 77:P1-103, 1995.

21. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Deprenyl inhibits the development of

mammary tumors in rats. Society for Neuroscience Abstracts 21 (3):1629, 1995.

22. Felten, D. L., ThyagaRajan, S. and Felten, S. Y. L-Deprenyl induces recovery of splenic

sympathetic nerves and enhances some immune functions in aged rats. The Gerontologist

35:127, 1995.

23. ThyagaRajan, S., Felten, S. Y. and Felten, D. L. Deprenyl partially restores the age-related

loss of sympathetic noradrenergic innervation in the spleens of F344 rats. Society for

Neuroscience Abstracts 22 (3):1793, 1996.

24. ThyagaRajan, S., Madden, K.S., Kalvass, J. C., Dimitrova, S., Felten, S. Y. and Felten, D. L.

Deprenyl increases IL-2 production, NK cell activity, and partially prevents the age-related loss

of sympathetic noradrenergic innervation in the spleens of F344 rats. Society for Neuroscience

Abstracts 23 (1):718, 1997.

25. ThyagaRajan, S., Madden, K.S., Bellinger, D. L., Felten, S. Y. and Felten, D. L. Age-

associated alterations in norepinephrine concentration in lymphoid organs of female F344 rats.

Research Perspectives in Psychoneuroimmunology VIII. Neuroimmunomodulation 5:50, 1998.

26. Kerr, R., ThyagaRajan, S., Bellinger, D.L., Felten, D.L. Interleukin-2 (IL-2)-induced

activation of c-fos proto-oncogene immunoreactivity in the rat brain. J. Investigative Med.,

47(2):35A, 1999.

27. ThyagaRajan, S., Madden, and Felten, D. L. L-deprenyl-induced inhibition of mammary

tumor growth is associated with altered neural activity and immune function in rats.

Department of Defense Breast Cancer Research Program meeting, Era of Hope, Proceedings,

volume II, 682, 2000.

28. ThyagaRajan, S. and Felten, D. L. L-Deprenyl- and L-desmethyldeprenyl-induced restoration

of splenic noradrenergic nerve fibers and immune functions in old F344 rats. Society for

Neuroscience Abstracts 26 (1):1183, 2000.

29. ThyagaRajan, S. and Felten, D. L. Deprenyl: A modulator of neuroendocrine-immune

interactions in breast cancer. Cancer Detection and Prevention, 24 (Supplement 1): Abstract

216, 2000.

30. ThyagaRajan, S. and Felten, D. L. Modulation of neuroendocrine-immune signaling by

deprenyl and desmethyldeprenyl in aging and breast cancer. 5th International NILS Workshop,

Interventions: Part III, Abstract, 2000.

16

31. ThyagaRajan, S. Effects of L-deprenyl and L-desmethyldeprenyl on neuroendocrine-immune

interactions in aging and breast cancer. Brain Behav. Immun., 15:123, 2001.

32. ThyagaRajan, S., Bellinger, D. L., Nance, D. M., and Karsten, A. H. Estrogen-induced

inhibition of sympathetic noradrenergic (NA) neuronal activity in the spleens of male and female

rats. 11th Annual meeting of the PNIRS at Titisee, Germany, 2004.

33. Bellinger, D. L., Karsten, A.H., Siva, D., Schmidt, E., Molinaro, C., ThyagaRajan, S., Lubahn,

C., and Lorton, D. Age effects on T-lymphocyte function in short and long-lived rats with age-

related differences in sympathetic innervation of the spleen. 11th Annual meeting of the PNIRS,

2004.

34. Karsten A. H. , Bellinger, D. L., Gridley, D. S. and ThyagaRajan, S. Sympathetic modulation

of mammalian prostate cancer. 11th Annual meeting of the PNIRS, 2004.

35. Clarke, C., Karsten, A.H., Gridley, D.S., ThyagaRajan, S., Molinaro, C., Bellinger, D.L.

Sympathetic modulation of mammalian prostate cancer. LLU-NIH Initiative for Minority

Student Development Annual Symposium

36. Bellinger, D. L., Millar, B., Flowers, S., Damjanovic, A. K., Nance, D. M. and ThyagaRajan,

S. Estrogen and immunity: Neuromodulation by splenic sympathetic noradrenergic (NA) nerve

fibers in rats. 12th Annual meeting of the PNIRS at Denver, 2005.

37. Damjanovic, A. K., Carter, J., Gridley, D. S., ThyagaRajan, S., Molinaro, C. and Bellinger, D.

L. Sympathetic Modulation of Mammalian Prostate Cancer. 12th Annual meeting of the

PNIRS at Denver, 2005.

38. Millar, B., Perez, S. D., Carter, J. L., Flowers, S. R., Evelsizer, S., Alberto, S., ThyagaRajan,

S., Molinaro, C. A., Wood, C. and Bellinger, D. L. Aging alters sympathetic response to

immunization with KLH in Fischer 344 rats. Presented at the 13th Annual Meeting of the

Psychoneuroimmunology Research Society May 31 – June 3, 2006 in Miami, Florida.

39. Perez, S. D., Molinaro, C. A., Vyas, S., Millar, B., Carter, J., Wood, C., ThyagaRajan, S., and

Bellinger, D. L., Chronically reducing sympathetic activity in the spleen during middle age

does not reverse the age-related increase in -AR-stimulated cAMP production in splenocytes.

Presented at the 13th Annual Meeting of the Psychoneurommunology Research Society May

31 – June 3, 2006 in Miami, Florida.

40. Carter, J. L., Damjanovic, A. K., Molinaro, C. A., Vyas, S., Gridley, D. S., ThyagaRajan, S.

and Bellinger, D. L. Sympathetic modulation of mammalian prostate cancer in vitro. Presented

at the 13th Annual Meeting of the Psychoneurommunology Research Society May 31 – June 3,

2006 in Miami, Florida.

41. ThyagaRajan, S. Neuroimmunomodulation of splenic sympathetic noradrenergic (NA) nerve

fibers by estrogen in rats. Annals of Neuroscience, 14:62, 2007

17

42. ThyagaRajan, S.A Union between Biotechnology and Neuroimmunoendocrinology: Its

Implications in Health and Diseases. Proceedings of Recent Advances in Bioengineering, SRM

University. Feb 7-9, 2008

43. ThyagaRajan, S., Arun, M., Masih, S., Ramyapriya, M. and Mohammed, Z. Fundamental

Concepts of Neural-immune Interactions in Health and Disease: Implications in Infectious

Diseases and AIDS. Abstracts of the International Conference on Biotechnological

Approaches to Neuroimmunomodulation and Infectious Diseases, p57, 2008.

44. Priyanka, H.,Bala P, Sindu A, Harini K, and ThyagaRajan, S. In Vitro effects of 17beta-

estradiol alone or in association with adrenergic agents on lymphocytes. 5th Federation of

Asian and Oceanian Neuroscience Societies (FAONS) Congress - 2010 & XXVIII Annual

Meeting of Indian Academy of Neurosciences, Lucknow, India. November 25 - 28,

2010.Annals of Neuroscience, 17: p90.

45. Harini K, Priyanka P H, Preetam B, Sindhu A, and ThyagaRajan S. In vivo effects of 17β-

estradiol on the Antioxidant enzyme activities in the Peripheral organs and Brain Areas in

female Wistar rats.5th Federation of Asian and Oceanian Neuroscience Societies (FAONS)

Congress - 2010 & XXVIII Annual Meeting of Indian Academy of Neurosciences, Lucknow,

India. November 25 - 28, 2010. Annals of Neuroscience, 17: p99.

46. Bala P, Sindu A, Priyanka H, Harini K, and ThyagaRajan, S. Modulation of antioxidant

enzyme activity by Bacopa monnieraand L-deprenyl in the lymphoid organs and brain areas of

female Wistar rats: A comparative study. 5th Federation of Asian and Oceanian Neuroscience

Societies (FAONS) Congress - 2010 & XXVIII Annual Meeting of Indian Academy of

Neurosciences, Lucknow, India. November 25 - 28, 2010. Annals of Neuroscience, 17: p94.

47. Priyanka H., Sharma, U., Sharma, V., and ThyagaRajan, S. Co-incubation of 17 beta-

estradiol with splenic lymphocytes: Effects on lymphocyte functions and modulation by

adrenergic receptor agonists. Society for Neuroscience Abstracts 390.06/VV28, 2011.

48. Sharma, U., Sharma, V., Priyanka H., and ThyagaRajan, S. Alterations in cytokine

production and antioxidant enzyme levels in reproductive aging in Indian women. Society for

Neuroscience Abstracts 926.12/VV77, 2011.

49. Patil, A.P., Sharma, H., Mishra, M., Pundir, U. P., Priyanka H., and ThyagaRajan, S. In vivo

effects of 17β-estradiol on the antioxidant enzyme activities in brain areas of Sprague-Dawley

female rats. Annals of Neurosciences. Vol 19, pp. 39, 2012

50. Priyanka H., Pundir, U. P., and ThyagaRajan, S. In vitro effects of 17β-estradiol on splenic

lymphocytes on Sprague-Dawley rats are mediated by suppression of NO production: effects

on modulation of lymphocyte function by adrenergic agonists and antagonists. Annals of

Neurosciences. Vol 19, pp. 50, 2012

51. Sharma, H., Mohanty, A., Kale, P.P., Raman, V., Pundir, U. P., Priyanka H., and

ThyagaRajan, S. Alterations in antioxidant enzyme activities and immunity by estrogen in the

draining lymph nodes of female Sprague-Dawley rats. Annals of Neurosciences. Vol 19, pp.

52, 2012.

18

52. Ramakrishnan, K.R., Raman, V., Singh, R.V., Kale, P.P., Pundir, U. P., Priyanka H., and

ThyagaRajan, S. Noni fruit juice modulates cytokine production and antioxidant enzyme

activities in draining lymph nodes of old F344 male rats. Annals of Neurosciences. Vol 19, pp.

68, 2012.

53. Mishra, M., Priyanka H., and ThyagaRajan, S. Age-associated in vitro effects of Donepezil on

cytokine levels (IL-2 and IFN-γ) and anti-oxidant enzyme activity in splenic lymphocytes of

Fischer344 rats. Annals of Neurosciences. Vol 19, pp. 59, 2012.

54. Kale, P.P., Mohanty, A., Sharma, H.,Patil, A.P., Ramakrishnan, K.R., Pundir, U. P., Priyanka

H., and ThyagaRajan, S. Effects of estrogen treatment on antioxidant enzyme activity and

immunomodulation in the spleen of middle-aged Sprague-Dawley rats. Annals of

Neurosciences. Vol 19, pp. 67, 2012.

55. Singh, R.V., Priyanka H., and ThyagaRajan, S. In vitro effects of Bacopa monnieri (Brahmi)

on age-dependent proliferation of splenic lymphocytes, modulation of cytokine production and

antioxidant enzyme activities in male F344 rats. Annals of Neurosciences. Vol 19, pp. 70,

2012.

56. Gopinath, S., Hima, L., Sharma, U., Sharma, V., Priyanka H., and ThyagaRajan, S.

Neuroendocrine-immune interactions in female reproductive aging. Annals of Neurosciences.

Vol 19, pp. 72, 2012.

57. Pundir, U. P., Patil, A.P., Gopinath, S., Priyanka H., and ThyagaRajan, S. In vivo effects of

Noni fruit juice on brain antioxidant activities and splenic lymphocyte proliferation, IL-2 and

IFN-γ production in old F344 male rats. Annals of Neurosciences. Vol 19, pp. 83, 2012.

58. Priyanka, H.P., Thiyagaraj, A., Hopper, W., ThyagaRajan, S. In silico modelling and

simulation of neuroendocrine-immune modulation through adrenergic and estrogen receptor-

mediated signals in lymphocytes. Annals of Neurosciences, Vol. 20, p. 66, 2013

59. Vasantharekha, R., Priyanka, H.P., Swarnalingam, T., ThyagaRajan, S. Neuropsychological

Analysis in Indian patients with dementia. Annals of Neurosciences, Vol 20, p. 55, 2013

60. Priyanka, H. P., Pratap, U. P., Hima, L., Vasantharekha, R., Puspharani, A., and ThyagaRajan,

S. Spirituality alters cell-mediated immune functions but not humoral immune functions in Indian

women with metastatic breast cancer. 41st Annual Conference of Indian Immunology Society,

IMMUNOCON-2014. P. 128.

61. Pratap, U. P., Sharma, H., Patil, A., Hima, L., Priyanka, H. P., and ThyagaRajan, S. Estrogen-

induced up regulation of NF-kB is accompanied by an increase in IFN-g and nitric oxide

production via Akt/m-TOR pathways in the lymphocytes draining lymph nodes of middle-aged

female rats. 41st Annual Conference of Indian Immunology Society, IMMUNOCON-2014. P.

104.

62. Hima, L., Priyanka, H. P., Pratap, U. P., Vasantharekha, R., and ThyagaRajan, S. Age-

associated alterations in immunity in healthy Indian men and women. 41st Annual Conference

of Indian Immunology Society, IMMUNOCON-2014. P. 122-123.

19

63. Ramasamy Vasantharekha, Hima, L., Pratap, U. P., Priyanka, H. P., Swarnalingam, T.,

Srinivasan, A. V., and ThyagaRajan, S. Peripheral cell-mediated and humoral immune

dysfunction associated with cognitive impairment and Alzheimer’s disease. 41st Annual

Conference of Indian Immunology Society, IMMUNOCON-2014. P. 123.

64. Priyanka, H.P., Pratap, U.P., Hima, L., Vasantharekha, R., and ThyagaRajan S. (2014)

Correlative assessment of spirituality-induced effects on the neuroendocrine-immune network:

Effects on cell-mediated immune functions in Indian women with metastatic breast cancer.

International Symposium on Translational Neuroscience and XXXII Annual Conference of the

Indian Academy of Neurosciences. p. 114-115.

65. Hima, L., Vasantharekha, R., Shitoot, S., Pratap, U.P., Priyanka, H.P., and ThyagaRajan, S.

(2014) Correlative analysis of proinflammatory markers with Mini-Mental State

Examination(MMSE) Indian patients with Cognitive dysfunction. International Symposium on

Translational Neuroscience and XXXII Annual Conference of the Indian Academy of

Neurosciences. p. 122-123.

66. Patel, M., Hima, L., Pratap, U.P., Kannan, T., Gour, S., Vasantharekha, R., Priyanka, H.P., and

ThyagaRajan, S. (2014) Age-related alterations in LPS-induced proliferation, cytokine

production and antioxidant enzyme activities correlative with serum cortisol in healthy Indian

men. International Symposium on Translational Neuroscience and XXXII Annual Conference

of the Indian Academy of Neurosciences. p.127-128.

67. Nair, R.S., Chhaya, S., Pratap, U.P., Hima, L., Priyanka, H.P., and ThyagaRajan, S. (2014)

Correlative study of the role of spirituality on cancer-associated metabolic reprogramming and

cancer-related fatigue in Indian women with metastatic breast cancer. International Symposium

on Translational Neuroscience and XXXII Annual Conference of the Indian Academy of

Neurosciences. p.. 161.

68. Vasantharekha, R., Priyanka, H.P., Swarnalingam, T., and ThyagaRajan, S. (2014) Correlative

analysis of cognitive dysfunction and expression of amyloid precursor protein in Indian men

and women with Alzheimer’s disease. International Symposium on Translational Neuroscience

and XXXII Annual Conference of the Indian Academy of Neurosciences. p.162-163.

69. Gour, S., Hima, L., Pratap, U.P., Kannan, T., Patel, M., Vasantharekha, R., Priyanka, H.P., and

ThyagaRajan, S. (2014) Age-associated alterations in humoral immune functions and

antioxidant enzyme activities correlative with serum cortisol in the lymphocytes of healthy

Indian women. International Symposium on Translational Neuroscience and XXXII Annual

Conference of the Indian Academy of Neurosciences. p.178.

70. Kannan, T., Pratap, U.P., Hima, L., Gour, S., Patel, M., Nair, R.S., Vasantharekha, R.,

Priyanka, H.P., and ThyagaRajan, S. (2014) Aging alters cell mediated immune functions and

signaling pathways in lymphocytes of healthy Indian men correlative with serum cortisol .

International Symposium on Translational Neuroscience and XXXII Annual Conference of the

Indian Academy of Neurosciences. p..198-199.

71. Pratap, U.P., Patil, A., Kale, P., Hima, L., Singh, R.V., Priyanka, H.P., and ThyagaRajan, S.

(2014) Estrogen modulates intracellular signaling pathways in Medial basal hypothalamus and

20

Striatum of middle-aged ovariectomized female rats. International Symposium on Translational

Neuroscience and XXXII Annual Conference of the Indian Academy of Neurosciences. p.199.

72. Priyanka, H.P., Pratap U.P., Hima L., ThyagaRajan S. (2014) β₂-adrenoceptor stimulation

differentially regulates breast cancer cell survival depending on estrogen receptor (ER) status

through p-ERK. Proceedings of International Conference on Cancer Biology: Molecular

Mechanisms and Novel Therapeutics, “Cancercon 2014, p.119.

73. Hima, L., Patel, M., Shaili, G., Kannan, T., Pratap, U.P., ThyagaRajan, S. (2015). Age-related

alterations in stress hormone, pro-inflammatory cytokines and antioxidant enzymes in healthy

indian men and women. XXXIII Annual Conference of Indian Academy of Neurosciences.

P.136-137.

74. Pratap, U.P., Hima, L., Patil, A., Priyanka, H.P., ThyagaRajan, S. (2015). Effects of 17β-

estradiol on cholinesterase activity and tyrosine hydroxylase expression via p-ERK and p-Akt

pathways in frontal cortex of middle-aged ovariectomized rats. XXXIII Annual Conference of

Indian Academy of Neurosciences. P-124

75. Chockalingam, R.M., Hariharan, M.M., Prasanna, V., Pratap, U.P., Hima, L., ThyagaRajan, S.

(2015). Differential modulation of activities of the metabolic enzymes by 17β-estradiol in the

brain areas of ovariectomized female Sprague-Dawley rats. XXXIII Annual Conference of

Indian Academy of Neurosciences. P-101

76. Ravichandran, K. A., Karrunanithi S., Hima, L., Pratap, U. P., Priyanka, H.P. ThyagaRajan, S.

(2016). Upregulation of neural parameters, molecular mechanisms and antioxidant status

mediated by 17β-estradiol in mesenteric lymph nodes of middle-aged ovariectomized female

Sprague-Dawley rats. Indian Academy of Neurosciences-2016:131.

77. Karrunanithi, S., Ravichandran, K. A., Hima, L., Pratap, U. P., Priyanka, H.P. ThyagaRajan, S.

(2016). Estrogen modulates neural factors, intracellular signalling molecules and antioxidant

status in thymus of middle-aged ovariectomized female Sprague-Dawley rats. Indian Academy

of Neurosciences-2016: 132-133.

78. Popat, D., Talapatra, A., Ravichandran, K. A., Hima, L, and ThyagaRajan, S. (2017). Virgin

coconut oil enhances antioxidant status in the thymus of female wistar rats through cell signaling

molecules. Indian Academy of Neurosciences-2017: P86.

79. Talapatra, A., Popat, D., Ravichandran, K. A., Hima, L, and ThyagaRajan, S. (2017). Virgin

Coconut Oil Enhances Intracellular Signaling Molecules and Antioxidant Enzyme Activities in

Mesenteric Lymph Nodes of Female Wistar Rats. Indian Academy of Neurosciences-2017: P82.

80. Hima, L, Patel, M. N., Kannan, T., Gour, S., Pratap, U. P., Priyanka, H.P., Vasantharekha, R.

and ThyagaRajan, S. Accelerated Age-Associated decline in Neuroendocrine-Immune

Interactions occur in men compared to women through discrete intracellular signaling pathways.

International Conference on Immunology. P.No.79, September 2018.

81. Vasantharekha, R. and ThyagaRajan, S. Interaction of signaling and immune pathways in

Alzheimer’s disease. International Conference on Immunology. P.No.29, September 2018.

21

82. Subramanian, P. A., Thandapani, P., Ananth, S., Vasantharekha, R. and ThyagaRajan, S.

Neuro-immune interactions in obesity. International Conference on Immunology. P.No.77,

September 2018.

83. Kumaraguru, S., Ramesh, A. P., Vasantharekha, R. and ThyagaRajan, S. Neuro-immune

interactions in cancer. International Conference on Immunology. P.No.78, September 2018.