Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 69 Immunosuppressants.
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 82 Drugs for Weight Loss.
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Transcript of Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc. Chapter 82 Drugs for Weight Loss.
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Chapter 82
Drugs for Weight Loss
2Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Obesity
May be associated with hypertension, coronary heart disease, stroke, type 2 diabetes, gallbladder disease, kidney stones, osteoarthritis, sleep apnea, dementia, and certain cancers, although underweight or normal-weight patients also suffer from these conditions
3Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Assessment of Obesity-Related Health Risk
Assessment: obesity1. Degree of obesity
Body mass index (BMI)
2. Pattern of fat distribution Waist circumference
3. Presence of risk factors Coronary heart disease, diabetes, hypertension Other atherosclerotic diseases, sleep apnea
4Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Overview of Obesity Treatment
Who might want to be treated? Body mass index (BMI) of 30 or more BMI of 25 to 25.9 plus two risk factors Weight circumference (WC) greater than 40
inches (in men) or greater than 35 inches (in women) plus two risk factors
Treatment goals
5Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Treatment Modalities
Nutritious diet Exercise Behavior modification Drug therapy Bariatric therapy
6Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Weight-Loss Drug
Only weight-loss drug currently approved for long-term use: Orlistat (Xenical, Alli)
7Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Sibutramine (Meridia)
Withdrawn in 2010 because of risk of stroke and myocardial infarction
Additional adverse effects included: Headache Dry mouth Constipation Elevated heart rate Insomnia Elevated blood pressure Nervousness and anxiety
8Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Orlistat (Xenical, Alli)
Acts in the GI tract to reduce absorption of fat Adverse effects
GI effects Fecal incontinence Fecal urgency Oily spotting Oily stools
Can be reduced somewhat with decreased fat intake and psyllium
Reduced absorption of fat-soluble vitamins Take vitamin supplement: 2-hour window
Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Orlistat (Xenical, Alli)
● Cautions Vitamin K deficiency can intensify effects
of warfarin Associated with severe liver damage May cause hypothyroidism in patients
taking levothyroxine
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10Copyright © 2013, 2010 by Saunders, an imprint of Elsevier Inc.
Miscellaneous Appetite Suppressants
Sympathomimetic amines Nonamphetamines Amphetamines
Bupropion Fluoxetine Topiramate and zonisamide