Common Name: SAFETEX CYTOLOGY FIXATIVE … Name: SAFETEX CYTOLOGY FIXATIVE FSPI Manufacturer: ANDWIN...

Common Name: SAFETEX CYTOLOGY FIXATIVE FSPI Manufacturer: ANDWIN SCIENTIFIC

Revision: (No Data Listed)

MATERIAL SAFETY DATA SHEET 1. IDENTIFICATION PRODUCT NAME: SAFETEX CYTOLOGY FIXATIVE FSP1 ANDWIN SCIENTIFIC 6636 VARIEL AVE CANOGA PARK, CA 91303 (818) 999-2828 IN CASE OF EMERGENCY CONTACT ANDWIN AT (800) 497-3113 CHEMICAL NAME: SOLUTION OF: 95% ISOPROPANOL 3% DISTILLED WATER 2% POLYETHYLENE GLYCOL 1450 FORMULA: 95% (CH3)2CHOH 3% H2O 2% HO-(CH2CH2O)n-H MOLECULAR WEIGHT: 1510.10 SYNONYMS: 95% 2-PROPANOL,SEC-PROPYL ALCOHOL, ISOPROPANOL 3% DISTILLED WATER 2% POLYETHYLENE GLYCOL 1450 CAS# AND NAME: 95% ISOPROPYL ALCOHOL (67-63-0) 3% DISTILLED WATER (007732-18-5) 2% POLY(OXY-1,2-ETHANEDIYL), A-HYDRO-W-HYDROXY- 2. PHYSICAL DATA BOILING POINT: 86 DEGREES C (187 DEGREES F) SPECIFIC GRAVITY (H2O=1): 0.79 FREEZING POINT: -85C (-121F) VAPOR PRESSURE AT 20 DEG. C: 30 MMHG (ESTIMATED BASED ON ISOPROPYL ALCOHOL) VAPOR DENSITY (AIR =1): 2.0 (ESTIMATED BASED ON ISOPROPYL ALCOHOL) EVAPORATION RATE (BUTYL ACETATE =1): 2.5 (ESTIMATED BASED ON ISOPROPYL ALCOHOL) SOLUBILITY IN WATER BY WT.: INFINITIVE IN WATER

APPEARANCE: CLEAR, COLORLESS LIQUID ODOR: RUBBING ALCOHOL PHYSICAL STATE: LIQUID PRECAUTIONARY MEASURES WARNING! FLAMMABLE LIQUID, HARMFUL IF SWALLOWED OR INHALED, AFFECTS CENTRAL NERVOUS SYSTEM, CAUSES IRRITATION. KEEP AWAY FROM HEAT, SPARKS AND FLAME. KEEP CONTAINER CLOSED. USE WITH ADEQUATE VENTILATION. AVOID BREATHING VAPOR. WASH THOROUGHLY AFTER HANDLING. AVOID CONTACT WITH EYES, SKIN AND CLOTHING. EMERGENCY FIRST AID IF SWALLOWED, GIVE WATER TO DRINK. INDUCE VOMITING IF MEDICAL HELP IS NOT IMMEDIATELY AVAILABLE. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. IF INHALED, REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. IN CASE OF CONTACT, IMMEDIATELY FLUSH SKIN OR EYES WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES. IN ALL CASES CALL A PHYSICIAN. SEE SECTION 6. DOT HAZARD CLASS: FLAMMABLE LIQUID NFPA RATINGS: HEALTH: 1 FLAMMABILITY: 3 REACTIVITY: 0 FIRE AND EXPLOSION: FLAMMABLE LIQUID FLASH POINT: 12 c (53F),(CLOSED CUP). AUTO IGNITION TEMPERATURE: 399 C (750F). FLAMMABLE LIMITS IN AIR,% BY VOLUME: LEL: 2.0; EUL: 12.0 SECTION 3 EXPLOSION: ABOVE FLASH POINT, VAPOR-AIR MIXTURES ARE EXPLOSIVE WITHIN FLAMMABLE LIMITS NOTED ABOVE. CONTACT WITH STRONG OXIDIZERS MAY CAUSE FIRE OR EXPLOSION. FIRE EXTINGUISHING: MEDIA: WATER SPRAY, DRY CHEMICAL, ALCOHOL FOAM, OR CARBON DIOXIDE. WATER SPRAY MAY BE USED TO KEEP FIRE EXPOSED CONTAINERS COOL. SPECIAL INFORMATION: IN THE EVENT OF A FIRE, WEAR FULL PROTECTIVE CLOTHING AND NIOSH-APPROVED SELF-CONTAINED BREATHING APPARATUS WITH FULL FACE PIECE OPERATED IN THE PRESSURE DEMAND OR OTHER POSITIVE PRESSURE MADE. WATER MAY BE USED TO FLUSH SPILLS AWAY FROM EXPOSURES AND TO DILUTE SPILLS TO NON-FLAMMABLE MIXTURES. VAPORS CAN FLOW ALONG SURFACES TO DISTANT IGNITION SOURCE AND FLASH BACK.

SECTION 4 REACTIVITY DATA: STABLE UNDER ORDINARY CONDITIONS OF USE AND STORAGE. HEAT AND SUNLIGHT CAN CONTRIBUTE TO INSTABILITY. HAZARDOUS-DECOMPOSITION PRODUCTS: TOXIC GASES AND VAPORS SUCH AS CARBON MONOXIDE MAY BE RELEASED IN A FIRE INVOLVING ISOPROPYL ALCOHOL. HAZARDOUS POLYMERIZATION: WILL NOT OCCUR. INCOMPATIBILITIES: HEAT, FLAME STRONG OXIDIZERS, ACETALDEHYDE, CHLORINE, ETHYLENE OXIDE, HYDROGEN-PALLADIUM COMBINATION, HYDROGEN PEROXIDE-SULFURIC ACID COMBINATION, POTASSIUM TERT-BUTOXIDE, HYPOCHLOROUS ACID, ISOCYANATES, NITROFORM, PHOSGENE, OLEUM AND PERCHLORIC ACID. SECTION 5 LEAK/SPILL DISPOSAL INFORMATION: REMOVE ALL SOURCES OF IGNITION. VENTILATE AREA OF LEAK OR SPILL. CLEAN-UP PERSONNEL REQUIRE PROTECTIVE CLOTHING AND RESPIRATORY PROTECTION FROM VAPORS. SMALL SPILLS MAY BE ABSORBED ON PAPER TOWELS AND EVAPORATED IN A FUME HOOD. ALLOW ENOUGH TIME FOR FUMES TO CLEAR HOOD, THEN IGNITE PAPER IN A SUITABLE LOCATION AWAY FROM COMBUSTIBLE MATERIALS. CONTAIN AND RECOVER LIQUID FOR RECLAMATION WHEN POSSIBLE. LARGER SPILLS AND LOT SIZES CAN BE COLLECTED AS HAZARDOUS WASTE AND ATOMIZED IN A SUITABLE RCRA APPROVED COMBUSTION CHAMBER, OR ABSORBED WITH VERMICULITE, DRY SAND, EARTH OR SIMILAR MATERIAL FOR DISPOSAL AS HAZARDOUS WASTE IN A RCRA APPROVED FACILITY. ENSURE COMPLIANCE WITH LOCAL, STATE AND FEDERAL REGULATIONS. SECTION 6 HEALTH HAZARD INFORMATION: A. EXPOSURE/HEALTH EFFECTS INHALATION: MAY CAUSE IRRITATION OF THE NOSE AND THROAT. EXPOSURE TO HIGH CONCENTRATIONS HAS A NARCOTIC EFFECT, PRODUCING SYMPTOMS OF DROWSINESS, HEADACHE, STAGGERING, UNCONSCIOUSNESS AND POSSIBLY DEATH. INGESTION: MAY CAUSE DROWSINESS, UNCONSCIOUSNESS, AND DEATH. GASTROINTESTINAL PAIN, CRAMPS, NAUSEA, VOMITING, AND DIARRHEA MAY ALSO RESULT. THE SINGLE LETHAL DOSE FOR HUMAN ADULT=ABOUT 250 mls (SAX SIXTH EDITION). SKIN CONTACT: HAS A DEFATTING ACTION OF THE SKIN THAT CAN CAUSE IRRITATION. MAY CAUSE IRRITATION WITH A STINGING EFFECT AND BURNING SENSATION. EYE CONTACT: VAPORS MAY IRRITATE THE EYES. SPLASHES MAY CAUSE SEVERE IRRITATION, DRYING, CRACKING, OR CONTACT DERMATITIS MAY DEVELOP. CHRONIC EXPOSURE: PROLONGED CONTACT WITH SKIN MAY CAUSE MILD IRRITATION,

DRYING, CRACKING, OR CONTACT DERMATITIS MAY DEVELOP. AGGRAVATION OF PRE-EXISTING CONDITIONS: PERSONS WITH PRE-EXISTING SKIN DISORDERS OR EYE PROBLEMS OR IMPAIRED RESPIRATORY FUNCTION MAY BE MORE SUSCEPTIBLE TO THE EFFECTS OF THE SUBSTANCE. B. FIRST AID INHALATION: REMOVE TO FRESH AIR. IF NOT BREATHING, GIVE ARTIFICIAL RESPIRATION. IF BREATHING IS DIFFICULT, GIVE OXYGEN. CALL A PHYSICIAN. INGESTION: GIVE WATER TO DRINK. INDUCE VOMITING IF MEDICAL HELP IS NOT IMMEDIATELY AVAILABLE. NEVER GIVE ANYTHING BY MOUTH TO AN UNCONSCIOUS PERSON. GET MEDICAL ATTENTION IMMEDIATELY. SKIN EXPOSURE: REMOVE ANY CONTAMINATED CLOTHING. WASH SKIN WITH SOAP OR MILD DETERGENT AND WATER FOR AT LEAST 15 MINUTES. GET MEDICAL ATTENTION IF IRRITATION DEVELOPS OR PERSISTS. EYE EXPOSURE: WASH EYES WITH PLENTY OF WATER FOR AT LEAST 15 MINUTES, LIFTING LOWER AND UPPER EYELIDS OCCASIONALLY. GET MEDICAL ATTENTION IMMEDIATELY. C. TOXICITY: (RTECS, 1986) ORAL RAT LD50: 5840 MG/KG. SKIN RABBIT LD50: 13 GM/KG. INHALATION RAT LC50: 16000 PPM/8H. MUTATION REFERENCES CITED AQUATIC TOXICITY RATING. TLM96: 1000-10 PPM SECTION 7 OCCUPATIONAL CONTROL MEASURES AIRBORNE EXPOSURE LIMITS:-OSHA PERMISSIBLE EXPOSURE LIMIT(PEL): 400 PPM (TWA), 500 PPM (STEL)-ACGIH THRESHOLD LIMIT VALVE(TLV): 400 PPM (TWA), 500 PPM (STEL) VENTILATION SYSTEM: A SYSTEM OF LOCAL AND/OR GENERAL EXHAUST IS RECOMMENDED TO KEEP EMPLOYEE EXPOSURES BELOW THE AIRBORNE EXPOSURE LIMITS. LOCAL EXHAUST VENTILATION IS GENERALLY PREFERRED BECAUSE IT CAN SOURCE, PREVENTING DISPERSION OF IT INTO THE GENERAL WORK AREA. PLEASE REFER TO THE ACGIH DOCUMENT, "INDUSTRIAL VENTILATION A MANUAL OF RECOMMENDED PRACTICES", MOST RECENT EDITION, FOR DETAILS. PERSONAL RESPIRATORS: IF THE TLV IS EXCEEDED A FULL FACE PIECE CHEMICAL (NIOSH APPROVED) CARTRIDGE RESPIRATOR MAY BE WORN, IN GENERAL, UP TO THE MAXIMUM USE CONCENTRATION SPECIFIED BY THE RESPIRATOR

SUPPLIER. ALTERNATIVELY, A SUPPLIED AIR FULL FACE PIECE RESPIRATOR OR AIRLINED HOOD MAY BE WORN. SKIN PROTECTION: WEAR IMPERVIOUS PROTECTIVE CLOTHING, INCLUDING BOOTS, GLOVES, LAB COAT, APRON OR COVERALLS TO PREVENT SKIN CONTACT. EYE PROTECTION: USE CHEMICAL SAFETY GOGGLES AND/OR A FULL FACE SHIELD WHERE SPLASHING IS POSSIBLE. CONTACT LENSES SHOULD NOT BE WORN WHEN WORKING WITH THIS MATERIAL. MAINTAIN EYE WASH FOUNTAIN AND QUICK-DRENCH FACILITIES IN WORK AREA. SECTION 8 STORAGE AND SPECIAL INFORMATION PROTECT AGAINST PHYSICAL DAMAGE. STORE IN A COOL, DRY WELL-VENTILATED LOCATION, AWAY FROM ANY AREA WHERE THE FIRE HAZARD MAY BE ACUTE. CUTSIDE OF DETACHED STORAGE IS PREFERRED. SEPARATE FROM OXIDIZING MATERIALS. CONTAINERS SHOULD BE BONDED AND GROUNDED FOR TRANSFERS TO AVOID STATIC SPARKS. STORAGE AND USE AREAS SHOULD BE NO SMOKING AREAS. USE NON-SPARKING TYPE TOOLS AND EQUIPMENT. ADDENDUM TO MATERIAL SAFETY DATA SHEET REGULATORY STATUS THIS ADDENDUM MUST NOT BE DETACHED FROM THE MSDS IDENTIFIES SARA 313 SUBSTANCE(S) ANY COPYING OR REDISTRIBUTION OF THE MSDS MUST INCLUDE A COPY OF THIS ADDENDUM. HAZARD CATEGORIES FOR SARA SECTION 311/312 REPORTING ACUTE CHRONIC FIRE PRESSURE REACTIVE X X X PRODUCT OR COMPONENTS SARA SEC. 313 OF PRODUCT: SARA EHS CHEMICALS CERCLA RCRA SEC.302 NAME CHEMICAL SEC.103 SEC. RQ TPQ LIST CATEGORY RQ lbs 261.33 PROPYLENE GLYCOL (0000-57-55-6) NO NO YES NO NO NO ISOPROPYL ALCOHOL (67-63-0) NO NO YES NO NO NO SARA SECTION 302 EHS RQ: REPORTABLE QUANTITY OF EXTREMELY HAZARDOUS SUBSTANCE, LISTED AT 40 CFR 355. SARA SECTION 302 EHS TPQ: THRESHOLD PLANNING QUANTITY OF EXTREMELY HAZARDOUS SUBSTANCE. AN ASTERISK (*) FOLLOWING A THRESHOLD PLANNING QUANTITY SIGNIFIES THAT IF THE MATERIAL IS A SOLID AND HAS A PARTICLE SIZE EQUAL TO OR LARGER THAN 100 MICROMETERS, THE THRESHOLD PLANNING QUANTITY = 10,000 LBS.

SARA SECTION 313 CHEMICALS: TOXIC SUBSTANCES SUBJECT TO ANNUAL RELEASE REPORTING REQUIREMENTS LISTED AT 40 CFR 372.65 CERCLA SEC. 103: COMPREHENSIVE ENVIRONMENTAL RESPONSE, COMPENSATION AND LIABILITY ACT (SUPERFUND) RELEASES TO AIR, LAND OR WATER OF THESE HAZARDOUS SUBSTANCES WHICH EXCEED THE REPORTABLE QUANTITY (RQ) MUST BE REPORTED TO THE NATIONAL RESPONSE CENTER, (800-424-8802) LISTED AT 40 CFR 302.4 RCRA: RESOURCE CONSERVATION AND RECLAMATION ACT. COMMERCIAL CHEMICAL PRODUCT WASTES DESIGNATED AS ACUTE HAZARDS AND TOXIC UNDER 40 CFR 261.33

MSDS – CytoLyt® Solution

CYTYC P/N 85092-001 Rev. I. Page 1 of 6 For distribution by Cytyc US

1. CHEMICAL AND COMPANY IDENTIFICATION

Product Identification:

CytoLyt® Solution

Trade Name/Chemical Family/Synonyms:

Methanol-water solution

Product Description:

A methanol based, buffered preservative solution

Product Use:

A preservative solution to support cells during transport and slide preparation.

Manufacturer

Cytyc Corporation 250 Campus Drive Marlborough, Massachusetts 01752 USA Telephone: 800-442-9892

EMERGENCY TELEPHONE NUMBERS: (24 hours a day and 7 days a week)

For Health/Transportation/Chemical Spills (Multilingual capabilities and free calls accepted) Continental United States: (800) 424-9300 Outside of continental United States: +(703) 527-3887

MSDS – CytoLyt ® Solution


2. COMPOSITION/INFORMATION ON INGREDIENTS

Component CAS Registry # Wt. % Methanol 67-56-1 20 – 50 Water 7732-18-5 40 – 70

3. HAZARDS IDENTIFICATION:

EMERGENCY OVERVIEW:

Material is a clear flammable liquid. Inhalation of vapors may cause nonspecific discomfort (nausea, weakness), drowsiness with anesthetic effects and possible blindness. Swallowing as little as 10 ounces (296 ml) may cause blindness and in extreme cases death.

Potential Health Effects.

Inhalation:

May cause depression of central nervous system resulting in nausea, weakness, drowsiness and possibly blindness.

Eye Contact:

May cause transient irritation.

Skin Contact:

May cause irritation and/or dermatitis. Material may be absorbed through the skin resulting in effects similar to ingestion or inhalation.

Ingestion:

May cause intoxication, Central nervous system depression, nausea, and dizziness. May damage liver, kidneys and nervous system. May cause blindness and/or death.

Target Organs:

Liver, kidneys, and central nervous system.



Medical Conditions Aggravated by Exposure:

Individuals with preexisting diseases of the retina (eyes) or liver may have increased susceptibility to toxicity at lower levels of successive exposure (repeated exposures).

Chronic:

Liquid and vapor can penetrate skin and mucous membranes. May cause chronic liver, kidney or nervous system disorders.

4. FIRST AID MEASURES: Inhalation:

Remove patient to fresh air. If symptoms of intoxication or vision problems are apparent, get immediate medical aid.

Eye Contact:

Immediately flush with clean water for at least 15 minutes. Get medical aid.

Skin Contact:

Remove contaminated clothing and shoes. Flush affected area with copious amounts of water. If irritation or other symptoms are present, get immediate medical assistance.

Ingestion:

Do Not Induce Vomiting. Give one or two glasses of water and get immediate medical aid.

Notes to Physician:

Treat for CNS depression and possible renal failure.

5. FIRE FIGHTING MEASURES:

Flashpoint and Method:

109ºF (42.7ºC) Closed cup

Autoignition Temperature:

725ºF (385ºC) (based on methanol component)

Flammable Limits:

LEL-6.7 UEL-36 (based on methanol component)

General Hazard:

Flammable material. Heated material may form toxic and/or explosive vapors.

Fire Fighting Instructions:

Wear full turnout gear with self-contained breathing apparatus. If material is not involved in fire, attempt to cool with water or remove from area. FLAME INVISIBLE IN DAYLIGHT.

Fire Fighting Equipment:

Wear full turnout gear with self-contained breathing apparatus.

Extinguishing Media:

Foam – Yes Alcohol Foam – Yes C02 – Yes Dry Chemical – Yes Water – Yes Other – Water Fog

Hazardous Combustion Products:

Carbon Monoxide and Carbon Dioxide

NFPA Hazard Rating: (National Fire Protection Association)

Health – 1 Flammability – 2 Reactivity – 0 Special Information – None

0=Insignificant 1=Slight 2=Moderate 3=High 4=Extreme U=Unknown *=No Information

Special Information:

None



6. ACCIDENTAL RELEASE MEASURES:

Land Spill

Prevent runoff from entering waterways. Dyke large spills with clay. Absorb small spills with clay or kitty litter. For spills in excess of 50 gallons, contact licensed HAZWOPER responders.

Water Spill:

Follow local, state and Federal guidelines and regulations.

Follow Local, State and Federal Guidelines for all spills.

7. HANDLING AND STORAGE: Handling:

KEEP OUT OF THE REACH OF CHILDREN. Wear recommended personal protective equipment and avoid contact with skin and eyes.

Storage:

Store away from excessive heat and sources of ignition. Keep containers closed and protect from damage. Storage Temperatures: Without cytologic sample: 59 – 86 ºF (15 – 30ºC)

8. EXPOSURE CONTROLS / PERSONAL PROTECTIVE EQUIPMENT:

Engineering Controls:

Supply exhaust and/or ventilation to keep vapor levels below threshold limit value.

Respirator:

Where engineering controls are not adequate, use approved NIOSH respirators or supplied air respirators.

Protective Clothing:

Chemically resistant gloves and eye protection.

Exposure Limits for Ingredients:

Ingredient OSHA PEL ACGIH TLV®

200 ppm – TWA 200 ppm – TWA 250 ppm – STEL Skin

Methanol TWA – 8 hr STEL – 15 minute

9. PHYSICAL AND CHEMICAL PROPERTIES:

Vapor Pressure mm/Hg: 127 Appearance: clear, thin Specific Gravity (Water=1): 0.97 Physical State: liquid Solubility in Water: complete Vapor Density (Air=1): 1.1 Freezing Point (OF/OC): not established. Percent Volatile by Volume: > 99 Evaporation Rate (BuAc=1): > 1 pH: Not applicable Viscosity: Not determined Odor: Alcohol type odor Boiling Point (OF/OC): 148/64.4



10. STABILITY AND REACTIVITY: General Stability:

Stable

Incompatible Materials And Conditions To Avoid:

Strong oxidizers. (May ignite product)

Hazardous Decomposition Products:

Carbon monoxide and carbon dioxide

Hazardous Polymerization:

Will not occur.

11. TOXICOLOGICAL INFORMATION:

For methanol: Product not tested as a mixture:

Inhalation LC50 Rat: 64000 ppm/4H Oral LD50 Rat: 5628 mg/kg Oral LD50 Mouse: 7300 mg/kg Dermal LD50 Rabbit: 15800 mg/kg

12. ECOLOGICAL INFORMATION:

Material has very low aquatic toxicity. LC50 Pimephales promelas (fathead minnows) 29.4 g/l/96 hr, (28-29 days old) EC50 (30 min) Photobacterium phosphoreum: 51,000-320,000 mg/L:

13. DISPOSAL CONSIDERATION: RCRA Hazardous Waste if Discarded? Yes. If so, RCRA ID number: D001, Ignitable waste.

14. TRANSPORTATION INFORMATION: DOT (Department of Transportation)

US DOT Proper Shipping Name: Flammable liquids, n.o.s. (Methanol) Hazard Class: 3 Identification Number: UN1993 Packing Group: III

15. REGULATORY INFORMATION:

TSCA (Toxic Substances Control Act): All ingredients listed on TSCA inventory. CERCLA:

RQ for methanol – 5,000 lbs. (2,268 kg) No TPQ established for methanol

SARA 311 Status:

Immediate, fire hazard

SARA 313:

Methanol is listed on the 313 Toxic Pollutant reporting list.

State Issues:

Not listed for California Proposition 65



Foreign Chemical Inventories:

All ingredients are listed on the chemical inventories of the following countries: Canada (DSL) Japan European Union Australia

WHMIS Status (Canada):

A controlled product. Classification: B2; D1B; D2A This product has been classified in accordance with hazard criteria of the Controlled Products Regulations and the MSDS contains all the information required by the Controlled Products Regulations.

16. OTHER INFORMATION:

Current Issue Date: April, 2008 Previous Issue Date:

February, 2005

Changes to MSDS:

Corrected CAS number for Water

Other Information:

None

Information Note: Where no corresponding data was contained in manufacturer’s MSDS, additional research is required and available upon request. THE INFORMATION RELATES TO THIS SPECIFIC MATERIAL. IT MAY NOT BE VALID FOR THIS MATERIAL IF USED IN COMBINATION WITH ANY OTHER MATERIALS OR IN ANY PROCESS. IT IS THE USER’S RESPONSIBILITY TO SATISFY ONESELF AS TO THE SUITABILITY AND COMPLETENESS OF THIS INFORMATION FOR HIS OR HER OWN PARTICULAR USE.

MSDS – PreservCyt ® Solution

CYTYC P/N 85093-001 Rev. H. Page 1 of 5 For distribution by Cytyc US

1. CHEMICAL AND COMPANY IDENTIFICATION Product Identification:

PreservCyt® Solution

Trade Name/Chemical Family/Synonyms:

Methanol-water solution

Product Description:

A methanol based, buffered preservative solution

Product Use:

A preservative solution to support cells during transport and slide preparation.

Manufacturer

Cytyc Corporation 250 Campus Drive Marlborough, Massachusetts 01752 USA Telephone: 800-442-9892

EMERGENCY TELEPHONE NUMBERS: (24 hours a day and 7 days a week)

For Health/Transportation/Chemical Spills (Multilingual capabilities and free calls accepted) Continental United States: (800) 424-9300 Outside of continental United States: +(703) 527-3887

2. COMPOSITION/INFORMATION ON INGREDIENTS

Component CAS Registry # Wt. % Methanol 67-56-1 30 – 60 Water 7782-13-5 40 – 70

3. HAZARDS IDENTIFICATION:

EMERGENCY OVERVIEW:

Material is a clear flammable liquid. Inhalation of vapors may cause nonspecific discomfort (nausea, weakness), drowsiness with anesthetic effects and possible blindness. Swallowing as little as 4 ounces (118 ml) may cause blindness and in extreme cases death.

Potential Health Effects.

Inhalation:

May cause depression of central nervous system resulting in nausea, weakness, drowsiness and possibly blindness.

Eye Contact:

May cause transient irritation.

Skin Contact:

May cause irritation and/or dermatitis. Material may be absorbed through the skin resulting in effects similar to ingestion or inhalation.

Ingestion:

May cause intoxication, Central nervous system depression, nausea, and dizziness. May damage liver, kidneys and nervous system. May cause blindness and/or death.

Target Organs:

Liver, kidneys, and central nervous system.



Medical Conditions Aggravated by Exposure:

Individuals with preexisting diseases of the retina (eyes) or liver may have increased susceptibility to toxicity at lower levels of successive exposure (repeated exposures).

Chronic:

Liquid and vapor can penetrate skin and mucous membranes. May cause chronic liver, kidney or nervous system disorders.

4. FIRST AID MEASURES:

Inhalation:

Remove patient to fresh air. If symptoms of intoxication or vision problems are apparent, get immediate medical aid.

Eye Contact:

Immediately flush with clean water for at least 15 minutes. Get medical aid.

Skin Contact:

Remove contaminated clothing and shoes. Flush affected area with copious amounts of water. If irritation or other symptoms are present, get immediate medical assistance.

Ingestion:

Do Not Induce Vomiting. Give one or two glasses of water and get immediate medical aid.

Notes to Physician:

Treat for CNS depression and possible renal failure.

5. FIRE FIGHTING MEASURES:

Flashpoint and Method:

80ºF (26.5ºC) Closed cup

Autoignition Temperature:

725ºF (385ºC)

Flammable Limits:

LEL-6.7 UEL-36 (based on methanol component)

General Hazard:

Flammable material. Heated material may form toxic and/or explosive vapors.

Fire Fighting Instructions:

Wear full turnout gear with self-contained breathing apparatus. If material is not involved in fire, attempt to cool with water or remove from area. FLAME INVISIBLE IN DAYLIGHT.

Fire Fighting Equipment:

Wear full turnout gear with self-contained breathing apparatus.

Extinguishing Media:

Foam – Yes Alcohol Foam – Yes C02 – Yes Dry Chemical – Yes Water – Yes Other – Water Fog

Hazardous Combustion Products:

Carbon Monoxide and Carbon Dioxide

NFPA Hazard Rating: (National Fire Protection Association)

Health – 1 Flammability – 3 Reactivity – 0 Special Information – None

0=Insignificant 1=Slight 2=Moderate 3=High 4=Extreme U=Unknown *=No Information

Special Information:

None



6. ACCIDENTAL RELEASE MEASURES:

Land Spill

Prevent runoff from entering waterways. Dyke large spills with clay. Absorb small spills with clay or kitty litter. For spills in excess of 50 gallons, contact licensed HAZWOPER responders.

Water Spill:

Follow local, state and Federal guidelines and regulations.

Follow Local, State, Provincial, and Federal Guidelines for all spills.

7. HANDLING AND STORAGE: Handling:

KEEP OUT OF THE REACH OF CHILDREN. Wear recommended personal protective equipment and avoid contact with skin and eyes.

Storage:

Store away from excessive heat and sources of ignition. Keep containers closed and protect from damage. Storage Temperatures: Without cytologic sample: 59 – 86 ºF (15 – 30ºC) With cytologic samples, for up to three weeks: 39 – 99 ºF (4 – 37ºC)

8. EXPOSURE CONTROLS / PERSONAL PROTECTIVE EQUIPMENT:

Engineering Controls:

Supply exhaust and/or ventilation to keep vapor levels below threshold limit value.

Respirator:

Where engineering controls are not adequate, use approved NIOSH respirators or supplied air respirators.

Protective Clothing:

Chemically resistant gloves and eye protection.

Exposure Limits for Ingredients:

Ingredient OSHA PEL ACGIH TLV® 200 ppm – TWA 200 ppm – TWA

250 ppm – STEL Skin

Canada – Alberta, British Columbia, New Brunswick, Manitoba, Ontario, Quebec, and Yukon

Canada – Saskatchewan

Methanol TWA – 8 hr STEL – 15 minute

200 ppm – TWA 250 ppm – STEL Skin

262 mg/m3 TWA 328 mg/m3 STEL

9. PHYSICAL AND CHEMICAL PROPERTIES:

Vapor Pressure mm/Hg: 127 Appearance: clear, thin Specific Gravity (Water=1): 0.92 Physical State: liquid Solubility in Water: complete Vapor Density (Air=1): 1.1 Freezing Point (OF/OC): not established. Percent Volatile by Volume: > 99 Evaporation Rate (BuAc=1): > 1 pH: Not applicable Viscosity: Not determined Odor: Alcohol type odor Boiling Point (OF/OC): 148/64.5



10. STABILITY AND REACTIVITY:

General Stability:

Stable

Incompatible Materials And Conditions To Avoid:

Strong oxidizers. (May ignite product)

Hazardous Decomposition Products:

Carbon monoxide and carbon dioxide

Hazardous Polymerization:

Will not occur.

11. TOXICOLOGICAL INFORMATION:

For methanol: Product not tested as a mixture:

Inhalation LC50 Rat: 64000 ppm/4H Oral LD50 Rat: 5628 mg/kg Oral LD50 Mouse: 7300 mg/kg Dermal LD50 Rabbit: 15800 mg/kg

12. ECOLOGICAL INFORMATION:

Material has very low aquatic toxicity. LC50 Pimephales promelas (fathead minnows) 29.4 g/l/96 hr, (28-29 days old) EC50 (30 min) Photobacterium phosphoreum: 51,000-320,000 mg/L:

13. DISPOSAL CONSIDERATION: RCRA Hazardous Waste if Discarded? Yes. If so, RCRA ID number: D001, Ignitable waste.

14. TRANSPORTATION INFORMATION: DOT (Department of Transportation)

US DOT Proper Shipping Name: Flammable liquids, n.o.s. (Methanol) Hazard Class: 3 Identification Number: UN1993 Packing Group: III



15. REGULATORY INFORMATION:

TSCA (Toxic Substances Control Act): All ingredients listed on TSCA inventory. CERCLA:

RQ for methanol – 5,000 lbs. (2,268 kg) No TPQ established for methanol

SARA 311 Status:

Immediate, fire hazard

SARA 313:

Methanol is listed on the 313 Toxic Pollutant reporting list.

State Issues:

Not listed for California Proposition 65

Foreign Chemical Inventories:

All ingredients are listed on the chemical inventories of the following countries: Canada (DSL) Japan European Union Australia

WHMIS Status (Canada):

A controlled product. Classification: B2; D1B; D2A This product has been classified in accordance with hazard criteria of the Controlled Products Regulations and the MSDS contains all the information required by the Controlled Products Regulations.

16. OTHER INFORMATION:

Current Issue Date: February, 2005 Previous Issue Date:

July, 2002

Changes to MSDS:

New format and revision of text to improve clarity. Addition of non-US exposure values.

Other Information:

None

Information Note: Where no corresponding data was contained in manufacturer’s MSDS, additional research is required and available upon request. THE INFORMATION RELATES TO THIS SPECIFIC MATERIAL. IT MAY NOT BE VALID FOR THIS MATERIAL IF USED IN COMBINATION WITH ANY OTHER MATERIALS OR IN ANY PROCESS. IT IS THE USER’S RESPONSIBILITY TO SATISFY ONESELF AS TO THE SUITABILITY AND COMPLETENESS OF THIS INFORMATION FOR HIS OR HER OWN PARTICULAR USE.

Common Name: SAFETEX CYTOLOGY FIXATIVE … Name: SAFETEX CYTOLOGY FIXATIVE FSPI Manufacturer: ANDWIN...

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