Clinical presentation & outcomes of stent thrombosis Spanish registry ESTROFA (n=23,500)

Clinical presentation & outcomes of stent thrombosis

Spanish registry ESTROFA (n=23,500)

J Am Coll Cardiol 2008;51:986–90

13.1%18.8%16%Death3.3%

8.87.6n=1330.66%9.8%

84.2%20.4%81.5%

Late(n=152)

n=128n=216Follow-up 151111.810Time, mo

2.7%1.66%Thrombosis

In-hospital 13%11.6%Death

Presentation 0.3686%83.7%STEMI0.9821%20.5%Shock

0.05692%88%TIMI 0/1Outcomes

6%4.6%Thrombosis

pAcute/Subacute(n=149)

Overall (n=301)

DECREASE Study Design

The patients undergoing successful DES implantation

Triple group (n=1443)

Operator decisions for adding cilostazol

Clinical follow-up at 12 months (Death, MI, or stent thrombosis)

Dual group (n=1656)

Propensity score matching (965 pairs)

Triple antiplatelet group (n=965) Dual antiplatelet group (n=965)

Inverse-Probability-of-Treatment-Weighted (IPTW) for the Entire cohort

Study endpoint

• Death• Myocardial infarction • Stent thrombosis (definite and probable by

ARC)

12-month clinical outcomes

Primary endpoint

Secondary endpoint

• Death or Myocardial infarction• TIMI Major bleeding• TIMI minor bleeding

0.82671.045 (0.703-1.555)0.75041.062 (0.734-1.537)0.81251.039 (0.757-1.426)Minor bleeding

0.27810.683 (0.343-1.360)0.93720.969 (0.443-2.119)0.58300.850 (0.477-1.516)Major bleeding

Bleeding

0.08110.556 (0.287-1.075)0.06650.591 (0.3364-1.037)0.28170.761 (0.464-1.251)Death/MI

0.04960.124 (0.016-0.996)0.00360.136 (0.035-0.521)0.05240.286 (0.081-1.013)Stent thrombosis

0.06650.298 (0.082-1.086)0.00970.233 (0.077-0.703)0.06170.381 (0.138-1.048)MI

0.25840.644(0.300-1.381)0.40620.762 (0.401-1.448)0.79070.925 (0.521 -1.644)Death

Cardiac events

P Value

Hazard Ratio (95% CI)

P Value


P Value


Variables Propensity-matched (965 pairs)

Inverse-probability-of-treatment weighted

Crude

Twelve-month risk of Events after DES Implantation of Triple versus Dual antiplatelet therapy according to analytic methods

Hazard ratios are for the triple group, as compared with the dual group.

0.4711 3.611 0.062 0.474 Death/ Myocardial infarction

NAStent thrombosis

NAMI

0.7441 5.570 0.090 0.709 Death

p-value95%CIHROutcome

Triple therapy beyond 6 month, Triple therapy (n=253) vs. Dual therapy (n=1631)


NANANANAStent thrombosis

0.5841 4.615 0.066 0.553 MI

0.8116 3.776 0.183 0.832 Death




0.0415 0.918 0.013 0.108 Stent thrombosis

0.1295 1.365 0.088 0.346 Myocardial infarction

0.6238 2.403 0.591 1.192 Death



Adjusted Landmark Analysis using IPTW in patients without events at landmark months

Clinical presentation & outcomes of stent thrombosis Spanish registry ESTROFA (n=23,500)

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