Clemson University, South Carolina

Department of AnesthesiologyVice Chair for AcademicsEmail will [email protected] (864-313-7341)

Key Departmental Research Projects• EMR assisted protocol adherence• Genetic link with opioid addiction• Virtual Reality’s role in reducing anxiety and pain during procedures

Department Research Interests

Interested in collaborating with:

The department has several areas of interest reflected by our current projects:

How to more consistently implement evidence-based medicine

Reducing persistent use of opioids for patients undergoing surgery; predicting patients at risk of addiction.

Using virtual reality, or other distraction techniques, for patients not under general anesthesia during procedures to decrease anxiety and pain.

Industrial engineering, geneticists, software engineering, decision support experts, anyone else!

Department of Emergency MedicineRonald G. Pirrallo, MD, MHSA, Vice Chair for Academic AffairsEmail: [email protected]: 864-361-6815

Key Departmental Research Projects• Public health disease surveillance: HIV, Hepatitis C, Diabetes• Opioid recovery coaching and medical assisted therapy initiation• Shift work affects on faculty fertility and sleep hygiene• Work demands and meaningful work experiences as predictors of fatigue, stress and performance• Impact of the ED built environment on interruptions during patient handovers



PhilosophyAcademic relationships yield academic productivity

All are welcome

Community Health Education Operations Wellness

Roadway safety UME Efficiency Profession burnout

Disease surveillance GME Patient satisfaction Gender specific

Opioid use Simulation Design Physician motivation

Behavior health Teamwork Modeling Performance

Department of Family MedicineVice Chair for AcademicsPhyllis D. MacGilvray, MD, FAAFPVice Chair for Academics(910)650-2819

Key Departmental Research ProjectsImplementation of Group Medical Visits for Type 2 Diabetes Mellitus at a Community -Based Primary Care Clinic

PIs : Shannon Stark Taylor, PhD& John Emerson, MDDesign and Implementation of a Multi-disciplinary Diabetes Focused Clinic within a Primary Care Center to Support Patient Self-efficacy and Improve Diabetes Outcomes in an Uncontrolled Diabetic Patient Population

PIs : John F. Emerson, MD & Shannon Stark Taylor, PhD2019 Transformative Seed Grant

Development of a Virtual Reality Experience to Enhance Empathy in Pre-Clinical Medical StudentsPIs : Shannon Stark Taylor and Ann Blair Kennedy, PhD

The Impact of Remote Telepresence on Interprofessional Healthcare Team Collaboration and SatisfactionPI: Kenneth Becker, MD

2019 Enhancing the Practice of Medicine Seed GrantExamining the relationship between burnout, teaching, and meaning in the clinical learning environment: a mixed-methods study

PIs : Mol ly Benedum, MD and Ann Blair Kennedy, PhD ; co -investigator Shannon Stark Taylor, PhDThe Clinic of Tomorrow: Creating Patient Centered Clinical Experience Utilizing Novel Technology and Communication

PIs : Stephen Carek, MD and Ann Blair Kennedy , PhD

Rural Communities Opioid Response Planning Grant (RCORP) “Piloting a Collaborative Care Behavioral Health Model in a Rural FM Residency“ Rural Innovations Cooperative

Agreement with South Carolina Center for Rural and Primary Health (SCCRPH) to pi lot a Col laborative Care Behavioral Health Curricular model in our new FM res idency, May 2019.

PIs : Aaron Zeller, MD and Kati Beben, MD

Additional projects:• Zeller, Ewing, Asif. “Prevalence of Clinic First Curricula: A Survey of AFMRD Members” published in Family Medicine April 2019• Zeller, Beben. “The Secret Sauce: Cultivating a Healthy Clinic Culture Using Commitments to Conscious Leadership”• Beben, Zeller. “Recruiting and Retaining Quality Faculty and Staff for a New Family Medicine Residency Site”• Edenfield KM, Reifsteck F, Carek S, et al. Echocardiographic measurements of left ventricular end-diastolic diameter and interventricular septal

diameter in collegiate football athletes at preparticipation evaluation referenced to body surface area. BMJ Open Sport Exerc Med. 2019;5(1)• Reifsteck F, Clugston JR, Carek S, et al. Echocardiographic measurements of aortic root diameter (ARD) in collegiate football Athletes at pre-

participation evaluation. BMJ Open Sport Exerc Med. 2019;5(1) Smith D, Sadler P, Benedum M. Febrile Seizures: Risks, Evaluation, and Prognosis.Amer Fam Phys. 2019 Apr 1;99(7):445-450.

• Brooks C, Nguyen T, Hinton S. Happy As A LARC: Improving Contraception Counseling in the Primary Care Setting. Quality improv ement project. Presented at the annual meeting of the South Carolina chapter of the American Academy of Pediatrics, Asheville, NC, August, 2019.

• Zeller, Beben. Rural Communities Opioid Response Planning Grant (RCORP) – Formation of Oconee County Opioid Response Taskforce (OCORT), 2018-2019

• Zeller, Beben. RCORP Community Attitudes Survey, July 2019. 361 responses, working on manuscript.• Zeller, Asif, Beben, Patterson. Identifying and Overcoming Barriers to Development of High-Functioning Primary Care Residency Clinics”, a

Roundtable Event, hosted on August 15, 2019 in Greenville, SC. 6 invited thought leaders, 24 registered attendees from around the Southeast. Funded by a Rural Health Initiatives grant from the South Carolina DHHS.

• Emerson. Ambulatory Community Fac Development Needs Assessment. Presented results of the survey that a workgroup through the M3/M4 subcommittee completed evaluating needs of the community faculty.

• Emerson. ABFM/STFM Preceptor Performance Improvement Pilot Program. Lessons Learned from 4 Undergraduate Medical Education Pilot Sites-Panel presentation describing the initial results and lessons learned from 4 UME sites that implemented the pilot.

Presentations from faculty, fellows, residents, and students at the following: AAFP FMX, STFM, SCAFP, AFMRD, ACSM, AMSSM & S EACSM .

Departmental Interests/Interested In Collaborating With:

Lifestyle Medicine/Primary Care Patient-Centered Medical Home Medical EducationIncorporating exercise in medical education Use of team-care and rates of provider burnout UME/GME continuumLifestyle Medicine Residency Curricula Care delivery and coordination for chronic disease – DM Primary care recruitmentSports Medicine Rural Health Burnout preventionCardiac disease in athletes Opioid response planning – OCORT Learner-focused evaluationHead injury and concussion in athletes Collaborative care behavioral health Community preceptor optimizationPreparticipaton exams

Department of Hematology and OncologyVice Chair for Academics: W. Jeff Edenfield, MDEmail : [email protected]: (864) 455-3600

Key Departmental Research Projects

• Biorepository Data Mining – tissue and genomic data

• Pharmacogenomics Seed Grant

• Investigator Initiated clinical trial using immunotherapy in patients with rare

malignancies.



Molecular and genetic epidemiology – assessing the genetic and environmental causes of cancer.

Molecular pathology – developing molecular based classification and diagnostic procedures for malignancies.

Pharmacogenomics and proteomics – understanding genotype and/or phenotype and response to therapy.

Academic partners interested in above research.

Partners with basic science capabilities to study these areas of research.

Department of MedicineVice Chair for Academics: Alain Litwin, MD, MPHEmail: [email protected]: 864-430-0911

Key Departmental Research Projects• Diabetes: impact health of practices/neighborhoods/communities via collaborative team efforts• Cardiology: MI, CHF, antianginals, antiarrhythmics, cardiogenic shock, and ablation – 26 trials• Neurology: treatment of movement disorders, multiple sclerosis, epilepsy, and stroke – 12 trials in 2019• Gastroenterology/Hepatology: treatment of fatty liver disease & non-alcoholic steatohepatitis (NASH)• Endocrinology: prevention and treatment of type 1 and type 2 diabetes mellitus• Infectious Diseases: management of infections, developing antibiotics, & integrated addiction care• Addiction Research Center: Prevention, Education, Treatment/Recovery, Research, Policy, & Data Cores• Geriatrics: Memory Health Program and Medical Legal Partnerships


Interested in collaborating with investigators, clinical leaders, policy makers, & entrepreneurs:

-Dissemination of research findings via social media-Developing mHealth technology & smart phone apps – SBIR/STTR-Machine learning & artificial intelligence-Implementation science and health systems science-Qualitative research methods -Research transforming policy, health care delivery, & quadruple aim

RCT – Inpatient Recovery Coaches improve addiction.

Aligning diabetes resources within Prisma Health, HSC, and community using interdisciplinary teams.

JAMA: RCT - algorithm-informed antibiotic management vs. usual care is as effective & safe.

3213

FI…N…

Non-alcoholic Fatty Liver Disease (NAFLD) is a global epidemic. Prisma Health has 50,000 – 100,000 people with obesity & diabetes at risk. New drugs are being developed to prevent cirrhosis and liver cancer.

58 % reduction at

1 year

CHAMPION and CardioMEMs trials: reduced hospitalizations, readmissions and costs; and increased quality of l ife.

New subcutaneous pump & new levodopa formulation for the treatment of Parkinson’s Disease.

Immune therapy can delay onset of clinical diabetes.

PCORI: RCT - Patient Navigation vs. Directly Observed Therapy in HCV-infected people who inject drugs.

Department of Obstetrics & GynecologyPaul B. Miller, MD, Vice Chair for [email protected](864) 455-5890

Key Departmental Research Projects• CRaDle—Centering and Racial Disparities• PIINC—Psychosocial Intervention, Maternal Inflammation, and Birth Outcomes

• MOMPOD—Medical Optimization & Management of Pregnancies with Overt Type 2 Diabetes

• MFMU—Maternal Fetal Medicine Unit (4 studies)• EQUINOX—Safety and Efficacy of Elagolix (Orilissa) in Combination with

Estradiol/Norethindrone

• Utilization of Ovarian Inflammation Markers• Outpatient Cervical Ripening (prospective resident research)• NOMO—Non-Opioid Multimodal Pain Regimen in Urogynecologic Surgery (prospective

resident research)



• Group prenatal care and the risk for preterm birth• Optimizing medical therapy for women with endometriosis• Optimizing outcomes for women with a short cervix at midgestation• Reducing blood loss-related morbidity for women with cesarean delivery• Improved management of gestational diabetes• Improving the patient experience with labor induction• Decreasing post-operative dependence on opioid analgesia

• Biostatistics• Data mining from EMR• Health outcomes

Department of Orthopaedic SurgeryThomas B. Pace, MD, Vice Chair for [email protected]

Key Departmental Research Projects• Aqueous-PREP: A Pragmatic Randomized trial Evaluating Pre-operative aqueous antiseptic skin solutions

in open fractures • Treatment of Pediatric Mid-shaft Clavicle Fractures: A Prospective, Observational Study• Prospective Observational Study of Individuals with Multiligamentous Knee Injuries



• Comparative Effectiveness (SC Center for Effectiveness Research in Orthopaedics)• Clinical and Patient-Reported Outcomes• Biomechanics/Biomaterials• Prospective Randomized Clinical Trials in trauma, hand, sports, shoulder and elbow, and joint

replacement• Facilitation of industry sponsored-collaboration across HSC partners• Develop collaborative research processes to improve translational research

• Continue to collaborate with HSC Partners• Continue to collaborate with SC-TRIMH

Department of PathologyVice Chair for Academics: Jenny Knight, MDEmail: [email protected]: 864-455-7735

Key Departmental Research ProjectsIn 2018-2019Abernathy K, Fiester S, Fulcher JW. Miliary pattern MRSA sepsis following clandestine intravenous infusion. Forensic Sci Med Pathology 2019; doi: 10.1007/s12024-018-0077-5

Merchant K, Schammel C, Fulcher J. Acute Methamphetamine-Induced Hepatic and Pancreatic Ischemia. Am J Forensic Med Path 2019; accepted (waiting on final proofs)

Schammel JA, Schammel CMG, Schammel DP, Trocha SD. Utilization of a nasal trumpet for successful drainage of a biliary cystadenoma to eliminate the possibility of leakage World J Med Surg Case Reports 2019;8:1-6.

Lauren Pinckney, MD; Justin Collins, BS; Christine M.G. Schammel, PhD; Matt Gevaert, PhD; David P. Schammel, MD; W. Jeffrey Edenfield, MD; Jeffrey Elder, MD; Larry E. Puls, MD. Mutational Analysis of Selected High-Grade Malignancies in a Premenopausal Gynecologic Cancer Population: A Potential for Targeted Therapies? Applied Cancer Research 2018 38:13

Aun JA, Patel HS, Patel KK, Cashman J, Bailey E. Perplexing Rash: Challenges to Diagnosis and Management of Mycosis Fungoides. J Am Ostepopath Assoc 2018; 118 (7):472-478.

Schammel D Unexplained Recurrent Pregnancy Loss and Unexplained Infertility: Twins in Disguise Hum Reprod Open (accepted)

Pahlavanzadeh M, Lucas T, Schammel C, Massey P, Hakimi R. Mechanical Mitral Valve Replacement Without Anticoagulation: A Case Report. Curr Neurobiol 2019;10(3):130-133.

Hakimi R, Pahlavanzadeh M, Barrera J, Schammel C, Morris S, Sivakumar S. Elective proctocolectomy to facilitate treatment of Cerebral Venous Thrombosis (CVT) in Ulcerative Colitis (UC) complicated by gastrointestinal hemorrhage: a case report. Curr Neurobiol 2019;10(2):79-83

Differential Expression of KRAS and SIRT1 in Ovarian Cancers with and without Endometriosis. Reproductive Science RSCI-19-049.R2. accepted (waiting on final proofs)

Montes de Oca MK, Nye A, Porter C, Collins J, Satterfield C, Schammel CMG, Trocha S. Head and Neck Cancer PEG Site Metastases: association with PEG placement method doi.org/10.1002/hed.25564

William R. Lorenz, Allison B. Frederick, Christine Schammel, William D. Bolton, James E. Stephenson, Sharon Ben-Or Robotic Excision of Intralobar Pulmonary Sequestration. Annals of Robotic Surgery; Published 25 Jan, 2018. http://www.remedypublications.com/annals-of-robotic-surgery/

Anthony Nye, Justin D Collins, Caroline L Porter, Mary Montes de Oca, Kathryn George, Colin G Stafford, Christine MG Schammel, Samuel Horton, Steven D Trocha. Predictive Genetic Profiles for Regional Lymph Node Metastasis in Primary Cutaneous Melanoma: A Case Matched Pilot Study . Melanoma Research. 28(6):555-561, December 2018. Doi: 10.1097/CMR.0000000000000000499

Krishna YT, Schammel JA, Schammel C, Schammel DP, Young AM, Trocha SD. The Great Imposture: Eosinophilic Cholangitis. Surgical Case Reports 2018; 1(3):2-9; doi10.31487/j.SCR.2018.03.013

Barrera J, Corso O, Schammel C, Devane M. Microwave ablation of a gallbladder remnant following partial cholecystectomy. JVIR accepted doi: 10.1016/j.jvir.2019.07.022



• Mentoring of medical students through research projects• Research through interdepartmental collaboration• Subspecialty pathology expertise in…

• Hematopathology• Dermatopathology• GI and liver• Breast and GYN

We’d like to continue our relationship with students from all of our partners.We will continue to work with our Prisma colleagues having worked with Surgery, Radiology, NICU, Internal Medicine, Emergency, Neurosurgery, PM&R, Neurology, Oncology, and Biomedical Sciences faculty.

• GU• Cytopathology• Blood banking and transfusion• Bone and soft tissue

• Pediatric pathology• Forensic pathology• Clinical chemistry• Microbiology

Department of PediatricsVice Chair for Academics: Jonathan Markowitz, MD Email: [email protected]: 864-454-5225

Key Departmental Research Projects• Maintenance of Abstinence in Newborns (MAiN) program• Epidemiology and treatment of eosinophilic esophagitis in children, adolescents, and young adults• Neurotherapeutics and neurofeedback in autistic spectrum disorders• Immigrant and refugee health in Greenville



• Diabetes• Cystic fibrosis• Asthma• Autistic spectrum disorders• Infection prevention• Travel medicine• International adoption• Eosinophilic esophagitis• Inflammatory bowel disease• Hypertension• Chronic kidney disease

• Insomnia• Sleep apnea• Narcolepsy• Telehealth• Opioid use• Muscular dystrophy• Epilepsy• Congenital heart disease• Medical decision making

support• Sickle cell disease

• Aplastic anemia• Global health• Adolescent/young adult

oncology• Health resource allocation• Palliative care/supportive care

services• Population/community health• Access to care• Transition of care

• Biomedical sciences• School of public health• Cancer institute• Biomedical engineering• Community health• Nursing• Adult specialist counterparts• Telemedicine• Microbiology and biomarkers• Mobile technology and social media• Computer science (big data, computer animation)

Department of Psychiatry & Behavioral MedicineVice Chair for Academics (Interim) Karen Lommel, DO, MHA, MSEmail: [email protected]: 864-455-4238 (o) 864-293-5503 (m)

Key Departmental Research Projects• SAMSHA grant for Mental Health First Aid• Collaborative Care Projects (M3 and Mind-I)• Virtual Reality Crisis Intervention Training – Medical Students, EMS and Emergency Medicine Providers• Vagal Nerve Anatomy and Depression Connection with vascular surgery• HRSA Grant with Bradshaw Institute (Mental Health Navigator)• HRSA Sexual Assault Nursing Project with College of Nursing



• Women’s Mental Health (Reproductive Psychiatry)• Opioid and Substance Use Disorders with Peer Recovery Coaches• Ketamine Infusion for Treatment-Resistant Depression• Mental Health Stigma• Reactive Attachment in Childhood • Collaborative Care in Primary Care• Crisis Intervention Training Using Virtual Reality

• Clemson and Furman social and behavioral science faculty and students

• Interdisciplinary team for novel approach to patient care

• Clinicians in other specialties - surgical specialties, primary care, emergency medicine, and

radiology

• Pediatric pain management multidisciplinary approach

• Clemson University Architecture + Health (Healthcare Architecture Program)

• Clemson University Industrial Organizational Psychology

• Clemson University College of Behavioral, Social and Health Sciences

• Furman University Institute for Advancement of Community Health

Department of RadiologyMike Devane, MDVice Chair for [email protected]

Key Departmental Research Projects• Lung cancer screening• Hepatic steatosis imaging with ultrasound and hepatic elastography• Renovo TIGER-PAC trial treatment of non resectable pancreatic cancer with intra-arterial therapy



Hepatocellular carcinomaHepatic fibrosis Portal hypertensionLung cancer screeningImaging cost effectiveness

Any project involving radiologic imaging or image based tumor therapy

Department of SurgeryVice Chair for Academics: Alfredo Carbonell, D.O.Email: [email protected]: 864-455-5599

Key Departmental Research Projects• Operating room optimization/efficiency• Real time detection of bacterial load in patient and operating room environments • AV fistula cannulation simulation• Robotic operating room lighting• Fast and Early Detection of Sepsis Using Micro pH Probes• Artificial intelligence interpretation of Focused Abdominal Sonography in Trauma (FAST)• Trauma Level Prediction Models Using Emergency Medical Service Vital Signs• Teamwork and ICU design



• Hernia mesh explant analysis• Vascular aneurysm tissue bank analysis• Vascular aneurysm flow dynamics• Shock and sepsis• Neuroendovascular treatment of stroke and aneurysm• Sperm motility and reproductive health

• Industrial engineering• Biomedical engineering• Computer sciences• Microbiology

Department of Biomedical SciencesRichard L. Hodinka, Ph.D., Department Chair [email protected] Rich Goodwin, Ph.D., Professor & Research Director [email protected]

Key Departmental Research Projects• Apoptotic gene expression in human blastocoel fluid varies with embryo ploidy status and implantation

outcomes • Understanding Immunomodulation with Bacterial Enterotoxins for Development of Novel Vaccine

Adjuvants• Effects of 12-hour Shifts on Fatigue and Performance in EMTs• Does Sleep Protect Memories Against Interference? A Failure to Replicate• Reconstructing the ecology of mammalian faunas using 3D surface anatomy and novel topographic

analyses• The influence of the UofSC School of Medicine Greenville Emergency Medicine Technician Training

Program in student matriculation, board preparation, and career decision• Development of a Virtual Reality Experience to Enhance Empathy in Pre-Clinical Medical Students• Improving Student Outcomes through Supplemental Learning Activities• Virulence mechanisms and drug discovery for the treatment of bacterial pneumonia• Interferon Stimulated Genes in Acute Lung Infection



• Immunology and pathogenesis of multiple myeloma and sarcoidosis; immodulation by Enterotoxins

• Pluripotent adult stem cells and multiple sclerosis

• Antimicrobial properties of human galectin and their role in cancer; biomarkers for endometriosis

• Medical microbiology/infectious diseases; molecular diagnostics, identification and monitoring of viral pathogens; virulence of multidrug-resistant bacterial pathogens; drug discovery

• Functional morphology; paleontology; paleoneurology

• Mechanisms of cardiovascular development and malformation; cell-based therapies

• Patient and stakeholder engagement; behavioral change interventions and integrative medicine

• Medical education research and innovative learning strategies; learning and instructional technology; assessment practices; curriculum design

• Neurology; stroke/telestroke program• Molecular embryology; preimplantation embryo

development; IVF; male factor infertility• Immune responses to respiratory viruses;

host-pathogen interactions• Pharmacology; pharmacokinetics;

pharmacodynamics; toxicology• Health services research• Exercise sciences; Exercise is Medicine Greenville;

improving patient health through exercise• Sleep and memory processing • Diabetic retinopathy

Prisma Health–Upstate• Emergency Department• Department of OB/GYN• Cancer Center • Department of Medicine• Pediatrics

Furman• Department of Biology• Department of

Psychology• Sleep Lab• Community Health

Clemson University, South Carolina

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