CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor...
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![Page 1: CHS Research Facilitation Grant April 3, 2014 Carleton ‘Buck’ Jones, PH.D. Associate Professor of Biomedical Sciences Coordinator, Master of Biomedical.](https://reader035.fdocuments.net/reader035/viewer/2022062516/56649dea5503460f94ae5a0a/html5/thumbnails/1.jpg)
CHS Research Facilitation Grant
April 3, 2014Carleton ‘Buck’ Jones, PH.D.
Associate Professor of Biomedical Sciences
Coordinator, Master of Biomedical Sciences Program
College of Health Sciences
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CHS & ORSPIntramural funds for:
◦Animals and per diem◦Supplies and consumable materials◦Non-capital equipment
Pilot studies to obtain preliminary results
Continuation and/or completion of on-going research projects
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Overview of the application processEligibilityRequired sectionsBudgetTimeline and deadlines
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EligibilityCHS faculty with at least 0.8 FTE
◦May collaborate with other facultyAbility for success and tangible
products◦Publications◦External grant proposals◦Peer-reviewed activities
No remaining Start Up
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Required sections
At least 4, but less than 7 pages◦ Including
references◦12-point font
Cover PageProgram Director
review◦All sections addressed◦Project is consistent with
the faculty member’s scholarly agenda
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Required sectionsProgress Reports & Final Reports
Title◦If continuing grant, keep title
consistentHypothesis or Research QuestionAbstract
The RFG Committee should know what you want to do by reading the Abstract
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Abstract - Shaun Mendel, CRNA, MSN TITLE: Interdisciplinary Simulation: Perceptions of Graduate
Health Science Students. Interprofessional collaboration has been linked to improved
patient care [1]. The unique combination of programs within the College of Health Sciences allows for meaningful surgical simulations between specialties mimicking real professional interactions. The World Health Organization, Institute of Medicine and many diverse healthcare professional organizations in the United States support interprofessional education [2-4]. Simulation training is an ideal method of interprofessional education [5].
One of the barriers to effective interprofessional education and collaboration is the presence of negative preconceptions held by the participants [6].
This study intends to use the revised Interprofessional Education Perceptions Scale [7] to assess student perceptions of their own profession and other professions before and after collaborative simulation exercises between nurse anesthesia, podiatric medicine, and cardiovascular science students.
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Abstract - Kolla Kristjansdottir, Ph.D. TITLE: Identifying the NPM1 interactome in neuroblastoma cells Neuroblastoma, a cancer arising from the sympathetic nervous
system, is the most common extra-cranial solid tumor in children. Our data corroborates a previous study that shows an increase in
NPM1 in high-risk neuroblastoma. NPM1 is a nucleolar protein and participates in a wide range of biological processes including ribosome biogenesis, chromatin remodeling, cell cycle, apoptosis and DNA repair. NPM1 functions in these processes via interaction with different binding partners in some cases by sequestering them in the nucleoli. Of the relatively small number of known NPM1 interactors phosphorylation status often modulates interactor binding.
Here we propose to identify novel NPM1 interactors in neuroblastoma using a Yeast two-hybrid (Y2H) screen followed by confirmation of interactions in neuroblastoma cells.
These pilot studies will identify a pool of NPM1-interactors to study further and generate a neuroblastoma cell line with tagged NPM1 for future mechanistic studies. This work will help elucidate the role of NPM1 and its interactome in neuroblastoma and may identify novel targets for drug therapeutics.
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Required sectionsResearch plan
◦Background & significance What is the context? Why is it important?
◦Hypothesis & specific aims What are you going to accomplish to
rigorously test your hypothesis?
◦Preliminary studies if relevant Look! We can do this!
◦Research design, methods, and statistics Figures are great! Sample size calculations are great!
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Research DesignHypothesis: Soy consumption will improve
endothelial function in diabetics
Sample size calculation using data from literature◦ n = 12
Soy Improves EC Function
ID Patients (n = 12) Collect Information Sample 1
Source:Clinical collaborator
Soy consumption4 weeks
Sample 2
Exclusion criteriaAgeSmoking HxEtOH useCVDHtn.
PrescriptionsType I vs IISun exposureEthnicity, gender, etc.
HbA1cGlucoseSerum insulinEndothelial function by flow mediated dilation
DoseFormulationFood & event log
HbA1cGlucoseSerum insulinEndothelial function by flow mediated dilation
Timeline
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Budget (with justification of items)
Animals and animal care $ 770.40
Surgical supplies and consumables $ 974.96
Histopathology supplies and antibodies $ 2565.00
Quantitative rt-PCR supplies $ 692.00
Total $ 4231.96
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Required sectionsTimeline for project – e.g.
IACUC submission and approval January
Animal surgeries, treatments, and behavioral analysis March – April
Tissue processing, histopathology, and qRT-PCRMay – June
Data analysis and preparation of manuscript April – July
Identification of key personnel Roles and responsibilities of
investigators
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Writing a good proposalImportance/impactResearch planPre-submission reviewProgress reports and final reportsORSP spending policies and
guidelines
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Timeline and deadlineConceptualize and develop
proposalContact resources
May 1st ◦ORSP◦Statistics◦Collaborators
Pre-submission reviewMay 22nd
Submit to Program DirectorMay 29th
Submit to Dean’s OfficeJune 2nd
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Resources for facultyCHS website:http://www.midwestern.edu/chs-deans-office/resources-faculty-and-staff/research-and-scholarship.html
ORSP◦ Seeking external funding◦ Presenting and publishing your work
Forming collaborations◦ Mentored Research◦ Journal Clubs
Various research groups SoTL
◦ Involving studentsResearch Club
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Research ClubA forum for those interested in research to share their
ideas, concerns, and needs... Monthly meetings usually include an informal half-hour
presentation of ongoing research by a faculty member, then discussion of some set of related topics.
Discussion topics have included where to go and from whom to get statistics support, what should be expected of master’s level research students, what kind of equipment needs to be requested through capital budget requests and who would share the equipment, how research ideas can be magnified by collaborations among MWU faculty, what equipment is broken and how long it will take to fix or replace, and so on.
Ellen Tarr and Kathy Lawson are the organizers, and they do a terrific job.
-Dr. Soby’s excellent description
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Research SurveyCHS Dean’s Office will be sending
out a scholarship and research survey for faculty
Please complete
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Questions?
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Sample size calculation
n = s2(Z1-b + Z1-a/2)2 a = 0.05
(m0 – m1)2 b = 0.20
power = 0.8
n number of measurements per group
s variation in the sample
a probability of type I error
b probability of a type II error
m0 – m1 treatment effect
Z values from stats tables
Z0.8 = 0.84
Z0.975 = 1.96
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Real World Example
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Sample size calculation n = s2(Z1-b + Z1-a/2)2 a
= 0.05 (m0 – m1)2 b
= 0.20 power
= 0.8
= (1.7)2(0.84 + 1.96)2
(14.3 – 15.7)2
= 11.56, so 12 per group