Tutorial Muza Medeli Gp120 Por Cristopher Pacheco, La Serena, Chile
ChemInform Abstract: Synthesis of an N-Glucoasparagine Analogue as a Building Block for a V3-Loop...
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1999 carbohydrates carbohydrates U 0500 16 - 205 Synthesis of an N-Glucoasparagine Analogue as a Building Block for a V3-Loop Glycopeptide from GP120 of HIV-I. — Building block (IV) possesses a new amide linkage between the amino function of the carbohydrate moiety and the side chain of the amino acid which ensures an im- proved stability towards enzymes, acids, and bases. Modified glycopeptides are prepared using (IV) as building block and solid-phase support. The glycosylated V3-loop peptides exhibit no inhibitory effects. — (SCHAEFER, ANDREAS; KLICH, GUNTHER; SCHREIBER, MICHAEL; PAULSEN, HANS; THIEM, JOACHIM; Carbohydr. Res. 313 (1998) 2, 107-116; Inst. Org. Chem., Univ. Hamburg, D-20146 Hamburg, Germany; EN) 1
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Transcript of ChemInform Abstract: Synthesis of an N-Glucoasparagine Analogue as a Building Block for a V3-Loop...
1999 carbohydrates
carbohydratesU 0500
16 - 205Synthesis of an N-Glucoasparagine Analogue as a Building Blockfor a V3-Loop Glycopeptide from GP120 of HIV-I. — Buildingblock (IV) possesses a new amide linkage between the amino function of thecarbohydrate moiety and the side chain of the amino acid which ensures an im-proved stability towards enzymes, acids, and bases. Modified glycopeptides areprepared using (IV) as building block and solid-phase support. The glycosylatedV3-loop peptides exhibit no inhibitory effects. — (SCHAEFER, ANDREAS;KLICH, GUNTHER; SCHREIBER, MICHAEL; PAULSEN, HANS; THIEM,JOACHIM; Carbohydr. Res. 313 (1998) 2, 107-116; Inst. Org. Chem., Univ.Hamburg, D-20146 Hamburg, Germany; EN)
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