ChemInform Abstract: Stereoselective RhI-Catalyzed Tandem Conjugate Addition of Boronic...
2
2008 Indan derivatives Q 1050 Stereoselective Rh I -Catalyzed Tandem Conjugate Addition of Boronic Acids—Michael Cyclization. — The process affords 1,2,3-trisubstituted indans, which represent interesting pharmaceutical scaffolds, in a regio- and diastereoselective manner. The diastereoselectivity is dependent on the substitution pattern of the starting diketones. The presence of an ester moiety [cf. (XI)] leads to a complex mixture. Di- ester products, however, are available by oxidation of (VI). — (NAVARRO, C.; CSAKY*, A. G.; Org. Lett. 10 (2008) 2, 217-219; Dep. Quim. Org., Fac. Quim., Univ. Complutense, E-28040 Madrid, Spain; Eng.) — R. Simon 26- 098
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Transcript of ChemInform Abstract: Stereoselective RhI-Catalyzed Tandem Conjugate Addition of Boronic...
2008
Indan derivativesQ 1050 Stereoselective RhI-Catalyzed Tandem Conjugate Addition of Boronic
Acids—Michael Cyclization. — The process affords 1,2,3-trisubstituted indans, which represent interesting pharmaceutical scaffolds, in a regio- and diastereoselective manner. The diastereoselectivity is dependent on the substitution pattern of the starting diketones. The presence of an ester moiety [cf. (XI)] leads to a complex mixture. Di-ester products, however, are available by oxidation of (VI). — (NAVARRO, C.; CSAKY*, A. G.; Org. Lett. 10 (2008) 2, 217-219; Dep. Quim. Org., Fac. Quim., Univ. Complutense, E-28040 Madrid, Spain; Eng.) — R. Simon
26- 098
2008
