ChemInform Abstract: Rhodium-Catalyzed C—H Activation and Conjugate Addition under Mild...
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ChemInform 2012, 43, issue 12 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Pyridine derivatives R 0380 DOI: 10.1002/chin.201212143 Rhodium-Catalyzed C—H Activation and Conjugate Addition under Mild Con- ditions. — Phenylpyridine analogues (I), (IV), and (VI) smoothly react with cyclohex- enone (II) to produce the corresponding conjugate addition product, regardless of the electronic nature of the substituents. Other nitrogen-containing heterocyclic substitu- ents can also act as directing group, cf.(VIII). Finally, the substrate scope of the Michael acceptor in this C—H activation and conjugate addition process is explored, cf.(XI). The current process does not require pre-generation of a stoichiometric quantity of or- ganometallic reagents. Besides the wide range of functional groups air and water are tolerated as well. — (YANG, L.; CORREIA, C. A.; LI*, C.-J.; Org. Biomol. Chem. 9 (2011) 20, 7176-7179, http://dx.doi.org/10.1039/c1ob05993a ; Dep. Chem., McGill Univ., Montreal, Que. H3A 2K6, Can.; Eng.) — H. Hoennerscheid 12- 143
Transcript of ChemInform Abstract: Rhodium-Catalyzed C—H Activation and Conjugate Addition under Mild...
Pyridine derivativesR 0380 DOI: 10.1002/chin.201212143
Rhodium-Catalyzed C—H Activation and Conjugate Addition under Mild Con-ditions. — Phenylpyridine analogues (I), (IV), and (VI) smoothly react with cyclohex-enone (II) to produce the corresponding conjugate addition product, regardless of the electronic nature of the substituents. Other nitrogen-containing heterocyclic substitu-ents can also act as directing group, cf.(VIII). Finally, the substrate scope of the Michael acceptor in this C—H activation and conjugate addition process is explored, cf.(XI). The current process does not require pre-generation of a stoichiometric quantity of or-ganometallic reagents. Besides the wide range of functional groups air and water are tolerated as well. — (YANG, L.; CORREIA, C. A.; LI*, C.-J.; Org. Biomol. Chem. 9 (2011) 20, 7176-7179, http://dx.doi.org/10.1039/c1ob05993a ; Dep. Chem., McGill Univ., Montreal, Que. H3A 2K6, Can.; Eng.) — H. Hoennerscheid
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ChemInform 2012, 43, issue 12 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
ChemInform 2012, 43, issue 12 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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