BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those...
-
Upload
charlotte-hicks -
Category
Documents
-
view
215 -
download
1
Transcript of BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those...
![Page 1: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/1.jpg)
![Page 2: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/2.jpg)
BRONCHIOLITIS
![Page 3: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/3.jpg)
EPIDEMIOLOGYAnnual incidence is 11.4% in children younger than 1
year and 6% in those aged 1-2 years.Incidence peaks in those aged 2-8 months95% have serologic evidence of past (RSV).; presence
of antibodies to RSV does not confer immunity.Incidence of bronchiolitis winter months in
temperate climates and during the rainy season in tropical climates.
Hospitalization -2% of cases under 6 monthsMortality rate is 1-2% of all hospitalized patients and
3-4% for patients with underlying cardiac or pulmonary disease.
![Page 4: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/4.jpg)
EPIDEMIOLOGY
Accounts for 60% of all lower respiratory tract illness in the first year of life!
![Page 5: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/5.jpg)
Bronchiolitisyoung infants, aged 2-24 months.viral infection of the small airways (bronchioles). increased mucus secretion, cell death followed by
a peribronchiolar lymphocytic infiltrate and submucosal edema
debris and edema produce narrowing and obstruction of small airways.
decreased ventilation in the lung causes ventilation/perfusion mismatching and hypoxia.
in expiratory phase of respiration, further dynamic narrowing of the airways produces disproportionate airflow decrease and resultant air trapping.
![Page 6: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/6.jpg)
Pathophysiology
The virus spreads from the upper respiratory tract to the medium and small bronchi and bronchioles, causing epithelial necrosis and initiating an inflammatory response.
The developing edema and exudate result in partial obstruction, which is most pronounced on expiration and leads to alveolar air trapping.
Complete obstruction and absorption of the trapped air may lead to multiple areas of atelectasis
![Page 7: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/7.jpg)
lung hyperinflation with a flattened diaphragm and bilateral atelectasis in the right apical and left basal regions
![Page 8: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/8.jpg)
RISK FACTORS OF SEVERITYPrematurityLow birth weightAge less than 6-12 weeksChronic pulmonary diseaseHemodynamically significant cardiac diseaseImmunodeficiencyNeurologic diseaseAnatomical defects of the airwaysOlder siblingsConcurrent birth siblingsPassive smoke exposureHousehold crowdingHigh altitude
![Page 9: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/9.jpg)
ETIOLOGYTypically caused by viruses
RSV-most commonParainfluenzaHuman MetapneumovirusInfluenzaRhinovirusCoronavirusHuman bocavirus
Occasionally associated with Mycoplasma pneumonia infection
![Page 10: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/10.jpg)
ClinicsEarly symptoms are those of a viral URTI, including
rhinorrhea, cough, and sometimes low-grade fever.
paroxysmal cough and dyspnea develop within 1-2 days.Fever Increased work of breathing Wheezing Cyanosis Grunting Noisy breathing Vomiting, especially post-tussive Irritability Poor feeding or anorexia
![Page 11: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/11.jpg)
ClinicsPhysicalTachypnea, over 50-60 breaths per minute (most
common)Tachycardia Fever, usually in the range of 38.5-39°C Mild conjunctivitis, otitis, pharyngitisDiffuse expiratory wheezing Nasal flaring Intercostal retractions Cyanosis Inspiratory crackles Apnea, especially in infants younger than 6 weeks Palpable liver and spleen from hyperinflation of the
lungs and consequent depression of the diaphragm
![Page 12: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/12.jpg)
DIFFERENTIAL DGAsthmaGastric reflux with aspiration of gastric contents
also may cause the clinical picture of bronchiolitis; multiple episodes in an infant may be clues to this diagnosis.BronchitisCongestive Heart Failure and Pulmonary EdemaMycoplasmaApneaPneumonia
Cystic fibrosisVascular ringLobar emphysemaForeign bodyCardiac diseaseRefluxAspiration
![Page 13: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/13.jpg)
LABORATORY AND IMAGISTICSComplete blood count (CBC) with white blood cell
(WBC) count within normal limits. 2/3 of the children have WBC counts of 10,000 to 15,000/μL. Most have 50 to 75% lymphocytes
Serum chemistries may be affected in dehydration. Arterial blood gases (ABG) in severely ill patients,
with mechanical ventilation.Chest radiographs should include anterior-posterior
(AP) and lateral views. Hyperinflation and patchy infiltrates ;these
findings are nonspecific and may be observed in asthma, viral or atypical pneumonia, and aspiration.
Focal atelectasis Air trapping Flattened diaphragm Increased anteroposterior diameter
![Page 14: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/14.jpg)
![Page 15: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/15.jpg)
![Page 16: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/16.jpg)
RSV rapid antigen testing done on a nasal swab or washing is diagnostic but not generally necessary; it may be reserved for patients with illness severe enough to require hospitalization.
A positive culture or direct fluorescent antibody test result can confirm the diagnosis of RSV infection
![Page 17: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/17.jpg)
COURSEDepends on co-morbiditiesUsually self-limitedSymptoms may last for weeks but
generally back to baseline by 28 daysIn infants > 6 months, average
hospitalization stays are 3-4 days, symptoms improve over 2-5 days but wheezing often persists for over a week
Disruption in feeding and sleeping patterns may persist for 2-4 weeks
![Page 18: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/18.jpg)
Prognosis
Prognosis is excellent. Most children recover in 3 to 5 days without
sequelae, although wheezing and cough may continue for 2 to 4 wk.
Mortality is < 1% when medical care is adequate. Bronchiolitis has been identified as a risk factor for asthma, but the association is controversial and the incidence seems to decrease as children age.
![Page 19: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/19.jpg)
TreatmentSupportive therapyO2 supplementation as neededIV hydration as neededIndications for hospitalization include accelerating respiratory distress, ill appearance (eg, cyanosis, lethargy, fatigue), apnea by history, hypoxemiainadequate oral intake. children with underlying disorders such as cardiac
disease, immunodeficiency, or bronchopulmonary dysplasia, which put them at high risk of severe or complicated disease, also should be considered candidates for hospitalization
![Page 20: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/20.jpg)
In hospitalized children, 30 to 40% O2 by tent or face mask is usually sufficient to maintain O2 saturation > 90%.
Endotracheal intubation is indicated for severe recurrent apnea, hypoxemia unresponsive to O2 therapy, or CO2 retention or if the child cannot clear bronchial secretions.
Hydration maintained with frequent small feedings of clear liquids. For sicker children, fluids should be given IV initially, and the level of hydration should be monitored by urine output and specific gravity and by serum electrolyte determinations.
There is little evidence that systemic corticosteroids are beneficial
![Page 21: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/21.jpg)
Antibiotics should be withheld unless a secondary bacterial infection (a rare sequela) occurs.
Bronchodilators are not uniformly effective some children may respond with short-term improvement. This is particularly true of infants who have wheezed previously. RIBAVIRINactive in vitro against RSV, influenza, and measles, is toxic
RSV immune globulin has been triedPrevention of RSV infection by passive
immunoprophylaxis with monoclonal antibody to RSV ( palivizumab ) SYNAGIS decreases the frequency of hospitalization but is costly and is indicated primarily in high-risk infants
![Page 22: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/22.jpg)
RESPIRATORY PHYSIOTHERAPYNEBULISATIONS WITH: Epinephrine:
0.01 mL (ie, 0.01 mL/kg of 1:1000 solution [1 mg/mL]) SC q15-20min, not to exceed 0.3 mL/doseRacemic epinephrine:<2 years: 0.25 mL of 2.25% solution via nebulizer diluted in 3 mL NS>2 years: 0.5 mL of 2.25% solution via nebulizer diluted in 3 mL NS
ALBUTEROL, VENTOLINE 90 mcg; 4-8 inhalations q 20min up to 4 h, then q 1-4h prn; use with a spacer device
![Page 23: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/23.jpg)
NONSTANDARD THERAPIESHeliox
Mixture of helium and oxygen that creates less turbulent flow in airways to decrease work of breathing
Only small benefit in limited patientsAnti-RSV preparations RSV-IGIV or
PalivizumabNo improvement in outcomes
SurfactantMay decrease duration of mechanical
ventilation or ICU stay
![Page 24: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/24.jpg)
COMPLICATIONSHighest in high-risk childrenApnea
Most in youngest children or those with previous apnea
Respiratory failureAround 15% overall
Secondary bacterial infectionUncommon, about 1%, most in children
requiring intubation
![Page 25: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/25.jpg)
PNEUMONIA
![Page 26: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/26.jpg)
•The WHO Child Health Epidemiology Reference Group estimated an annual incidence of 150.7 million new cases, of which 11-20 million (7-13%) are severe enough to require hospital admission.
95% of all episodes of clinical pneumonia in young children worldwide occur in developing countries
![Page 27: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/27.jpg)
PATHOPHISIOLOGYInflammation of the alveolar space and may
compromise air exchange. Often complicating other lower respiratory
infections such as bronchiolitis or laryngotracheobronchitis, pneumonia may also occur via hematogenous spread or aspiration.
Most commonly, this inflammation is the result of invasion by bacteria, viruses, or fungi, but it can occur as a result of chemical injury or may follow direct lung injury
![Page 28: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/28.jpg)
PATHOLOGYBronchopneumonia is a patchy consolidation
involving one or more lobes. The neutrophilic exudate is centered in bronchi and bronchioles, with centrifugal spread to the adjacent alveoli.
In interstitial pneumonia, patchy or diffuse inflammation involving the interstitium is characterized by infiltration of lymphocytes and macrophages. The alveoli do not contain a significant exudate
Bacterial superinfection of viral pneumonia can also produce a mixed pattern of interstitial and alveolar airspace inflammation.
![Page 29: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/29.jpg)
Four stages of lobar pneumonia 1.In the first stage, within 24 hours of infection,
microscopically by vascular congestion and alveolar edema. Many bacteria and few neutrophils are present.
2.The stage of red hepatization (2-3 d) similar to the consistency of liver: presence of many erythrocytes, neutrophils, desquamated epithelial cells, and fibrin within the alveoli.
3.In the stage of gray hepatization (2-3 d), the lung is gray-brown to yellow because of fibrinopurulent exudate, disintegration of red cells, and hemosiderin.
4.The final stage of resolution :resorption and restoration of the pulmonary architecture. Fibrinous inflammation may extend into the pleural space, causing a rub heard by auscultation, (resolution or to organization and pleural adhesions)
![Page 30: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/30.jpg)
ETIOLOGYBacteria accounted for 60%, of which 73% were
due to Streptococcus pneumoniae; Mycoplasma pneumoniae and Chlamydia pneumoniae were detected in 14% and 9%, respectively.
S pneumoniae, S aureus H influenzae are by far the most common bacterial pathogen in 1-3 years age group
EnterococciNewborns: group B Streptococcus, gram-negative
rods (E.coli, Klebsiella pneumoniae), Lysteria monocytogenes
Chlamydia trachomatis, U urealyticum, Mycoplasma hominis, Treponema pallidum Toxoplasma gondi
![Page 31: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/31.jpg)
Viruses that cause acute pneumoniaViruses that cause acute pneumoniaadenovirusadenovirus
coronaviruscoronavirus
influenza A and B virusesinfluenza A and B viruses
parainfluenza virusparainfluenza virus
respiratory syncytial virusrespiratory syncytial virus
coxsackievirus A21coxsackievirus A21
rhinovirusrhinovirus
![Page 32: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/32.jpg)
BACTERIA THAT CAUSE PNEUMONIAGRAM POSITIVE COCCI 1.Streptococcus Pneumoniae the most common 2. Streptococcus Pyogenes 3. Streptococcus Agalactiae
![Page 33: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/33.jpg)
ETIOLOGY OF BACTERIAL PNEUMONIAS- Pneumoniae generally resides in the
nasopharynx and is carried asymptomatic in approximately 50% of healthy individuals. A strong association exists with viral illnesses, such as influenza. Viral infections increase Pneumococcal attachment to the receptors on activated respiratory epithelium. Once aerosolized SP go from the nasopharynx to the alveolus,
Pneumococci infect type II alveolar cells,multiply in the alveolus and invade alveolar epithelium. Pneumococci spread from alveolus to alveolus through the pores of Kohn, thereby producing inflammation and consolidation along lobar compartments
![Page 34: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/34.jpg)
Patients with pneumococcal pneumonia may produce bloody or rust-colored sputum
Streptococcus agalactiae is a commensal organism in the genital tract and it can cause pneumonia in newborns which inhale fluid containing the bacteria during its journey down the birth canal and develops pneumonia soon after birth.
Staphylococcus aureus is gram positive organism,affecting children and old people. as well as extreme ages.it can produce thin walled air filled cavities ("pneumatoceles")
Staphylococcal pneumonia is diagnosed by finding typical clusters of Gram-positive cocci by microscopy and subsequently a growth of Staphylococcus aureus in a purulent sputum that often appears creamy and bloodstained.
![Page 35: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/35.jpg)
Staphylococcal pneumonia and bronchopneumonia ( cont’)
Commonly following influenza in debilitated patients and in those with cystic fibrosis.
Abcess formation is very common.The abcesses are thin walled,multiple and
commonly bilateral giving rise to patchy bronchopneumonia.
![Page 36: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/36.jpg)
Some strains of staphylococcal bacteria produce toxins (poisons) when they grow and reproduce on food.
Contaminated food with staphylococcal bacteria and these toxins can cause staphylococcal food poisoning. The toxins can also cause scalded skin syndrome and, very
occasionally, toxic shock syndrome
![Page 37: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/37.jpg)
Bacteria gram positive rods1. Bacillus anthracis
2. Nocardia sp3. Actinomyces sp. Bacteria Gram Negative cocci1. Neisseria meningitidis2. Moraxella catarrhalis Bacteria gram negative rods1. Klebsiella pneumoniae
![Page 38: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/38.jpg)
Bacillus anthracis is Anthrax or Wool-Sorters disease Associated with wool sorting, with animal handlers, and veterinarians,produces eschar
Nocardia sp Beaded filamentous rod shaped bacteria,
Pleura and chest wall involvmentActinomyces sp. Beaded filamentous rod shaped bacteria,
causing rib destruction, cutaneous sinuses, cavitation, spreads to pleura and chest wall.
![Page 39: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/39.jpg)
Neisseria meningitidis (meningococci) cause epidemics in schools,adolescents .
Klebsiella pneumoniae produces Current Jelly sputum, more commonly seen in patients with cronic cardiopulmonary ilness, immunocompromised. Also called (friedlanders bacillus)
Severe form of pneumonia with high mortalityUpper lobes being most affected with massive
lobar consolidationSputum is jelly like and blood stained producing
(current jelly sputum).
![Page 40: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/40.jpg)
2.Pseudomonas aeruginosa produces green sputum, abscess formation, Common cause of pneumonia in cystic fibrosis and those with severely compromised respiratory defenses.
3. Acinetobacter sp. often found on respiratory therapy equipment and on human skin
very difficult to treat due to multiple drug resistance.4. Burkholderia pseudomallei exposure with
contaminated soil5. Francisella tularensis ,Tularemia Infection is
via tick bite or contact with contaminated rabbits.
6. Hemophilus influenzae more commonly seen in patients with COPD, alcoholics, and the elderly.
7. Bordetella pertussis Whooping cough
![Page 41: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/41.jpg)
ANAEROBIC BACTERIA•Bacteroides •Fusobacterium •Porphyromonas •Prevotella•Actinomyces •Bifidobacterium •Clostridium •Peptostreptococcus •Propionibacterium
![Page 42: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/42.jpg)
Gram-Negative BacteriaE-coli, Salmonella, Pseudomonas, Moraxella,
Helicobacter, Stenotrophomonas, Legionella,Along with the above mentioned bacteria,
there are several other type of Gram-Negative bacteria such as Hemophilus influenzae (also known as Bacillus influenzae), Neisseria Meningitidis, Moraxella Catarrhalis, Neisseria Gonorrhoeae, Acinetobacter Baumanii (which comes under Nosocomical Gram-Negative bacteria group).
![Page 43: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/43.jpg)
Fungal PneumoniaEndemic fungi
HistoplasmosisBlastomycosisCryptococcosisSporotrichosis - primarily a lymphocutaneous disease,
but can involve the lungs as well AspergillusCandidaCoccidiodomycosisHistoplasmosis All Chickens, bats, river valleys Coccidioidomycos All California, Southwest USA
![Page 44: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/44.jpg)
Coccidioides immitis: Pneumonia may develop after travel to the southwestern United States and after exposure to a wind or rain storm in an endemic area.
Blastomyces dermatitidis: Patients may have traveled to the midwestern United States or the Canadian Shield.
![Page 45: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/45.jpg)
Protozoal PneumoniaParasites causing pneumonia are 1.Toxoplasma gondii 2.Strongyloides stercoralis 3.Ascariasis. 4.Cryptosporidia 5.Hookworms A variety of parasites can affect the lungs. These
parasites enter the body through the skin or by being swallowed, they travel to the lungs, usually through the blood. The eosinophils, responds hihgy to parasite infection. Eosinophils in the lungs can lead to eosinophilic pneumonia.
![Page 46: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/46.jpg)
Rickettsial PneumoniaTyphus fevers (epidemic and endemic)Rocky mountain spotted fever,scrub
typhus, rickettsialpox
Louse-borneflea-borne through rats and mouse fleas
![Page 47: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/47.jpg)
Rickettsial PneumoniaQ fever ranging from multiple segmental
opacities to pleural effusion, lobar consolidation, or linear atelectasis.
Hepatosplenomegaly is a common finding; it usually is accompanied with elevation of liver enzymes
Rickettsia pneumonia cannot be distinguished clinically, radiologically, or histologically from atypical pneumonia.
![Page 48: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/48.jpg)
ATYPICAL BACTERIAThese are the bacteria's that will be called as atypical bacteria
and causing also atypical pneumonias like other viral agents etc.and constitute following organisms
Legionella Mycoplasma pneumoniae Chlamydia trachomatis an afebrile pneumonia,
usually seen in 2 wk to 6 months of ageChlamydia psittaci Chlamydia pneumoniae , Chlamydia trachomatisThis is a sexually transmitted disease that may also cause
pneumonia and bronchitis. It usually is a subacute infection of early infancy producing a sudden cough and eosinophilia without fever that lasts from 1-3 weeks, but it may occur in adults too.
![Page 49: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/49.jpg)
Etiology of Pneumonia inHospitalized Children
– Streptococcus pneumoniae 73% – Mycoplasma pneumoniae 23%– Chlamydia pneumoniae 13%– Mycobacterium tuberculosis 2%
![Page 50: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/50.jpg)
Features of viral PneumoniaStrikes primarily in the fall and winter and tends to be more serious in people
with cardiovascular or lung disease.
Usually starts with a dry (nonproductive) cough fever ,headache, sore throat,dry cough, malaise,running nose,common cold, aches and pains precedes several days before viral pneumonia ;
In viral pneumonia onset is less abrupt Leucocyte count is usually normal or low • On x ray may show features of interstitial or of atypical pneumonia
• Course is mild and self limiting and resolves by 7-10 days time
Diagnosis confirmed by isolation of virus and serological tests
![Page 51: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/51.jpg)
Features of Bacterial PneumoniaOnset is often suddenHigh grade feverRigors and chillsSputum is rusty coloured or blood stained
![Page 52: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/52.jpg)
CLINICS Neonates
The infant may present with tachypnea; grunting, flaring, and retractions; lethargy; poor feeding; or irritability. Fever may not be present in newborns; however, hypothermia and temperature instability may be observed.
Cyanosis may be present in severe cases. Nonspecific complaints, such as irritability or poor
feeding, may be the presenting symptoms. Cough may be absent in the newborn period. Early-onset group B streptococci infection usually
presents via ascending perinatal infection as sepsis or pneumonia within the first 24 hours of life. Chlamydia trachomatis pneumonia should be considered in infants aged 2-4 weeks and is often associated with conjunctivitis.
![Page 53: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/53.jpg)
Infants After the first month of life, cough is the most
common presenting symptom. Infants may have a history of antecedent upper
respiratory symptoms. Depending upon the degree of illness,
tachypnea, grunting, and retractions may be noted. Vomiting, poor feeding, and irritability are also common.
Infants with bacterial pneumonia often are febrile, but those with viral pneumonia or pneumonia caused by atypical organisms may have a low-grade fever or may be afebrile. The child's caretakers may complain that the child is wheezing or has noisy breathing.
![Page 54: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/54.jpg)
Toddlers and preschool children
A history of antecedent upper respiratory illness is common.
Cough is the most common presenting symptom. Vomiting, particularly post-tussive emesis, may
be present. Chest pain may be observed with inflammation of or near the pleura. Abdominal pain or tenderness is often seen in children with lower lobe pneumonia and replaces chest pain!
The presence and degree of fever is dependent upon the organism involved.
![Page 55: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/55.jpg)
Older children and adolescents
Atypical organisms, such as Mycoplasma, are more common in this age group.
In addition to the symptoms observed in younger children, adolescents may have other constitutional symptoms, such as headache, pleuritic chest pain, and vague abdominal pain. Vomiting, diarrhea, pharyngitis, and otalgia/otitis are other common symptoms.
![Page 56: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/56.jpg)
PHISICAL EXAMrespiratory distress, hypoxemia, and hypercarbia grunting, flaring, severe tachypnea, and
retractions assessment of oxygen saturation by pulse
oximetry Visual inspection - respiratory effort and count
the respirations – tachypneaAuscultation -crackles or ralesPercussion -identify an area of consolidation.rashes and pharyngitis
![Page 57: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/57.jpg)
IMAGERYThe typical radiological finding is a
homogenous, non-segmental, circumscribed consolidation of lung tissue. The opacities are situated anywhere in the lungs, although they are located most often in the basal segments, and are unifocal or multifocal. An air bronchogram is often seen and is considered to be characteristic of pneumococcal pneumonia. The affected segments of the lung are not reduced in volume. Pleural involvement (pleural effusion) is not usual
![Page 58: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/58.jpg)
![Page 59: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/59.jpg)
CLINICAL FORMS Broncho-PneumoniaCommon cause is staphylococcal infection.Bronchopneumonia is characterized by patchy
exudative consolidation of lung parenchyma due to terminal bronchiolitis with consolidation of peribronchial alveoli.
Bilateral (less often unilateral), patchy consolidation with intervening normal lung tissue.
Lesion is more extensive at the base of the lung and often fuses together resembling lobar pneumonia (confluent bronchopneumonia).
![Page 60: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/60.jpg)
Transverse thin-section CT scan at the level of the carina in a patient with measles infection shows multiple centrilobular nodules (arrowhead) and bilateral areas of lobular consolidation (arrows).
Franquet T Radiology 2011;260:18-39
©2011 by Radiological Society of North America
![Page 61: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/61.jpg)
![Page 62: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/62.jpg)
![Page 63: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/63.jpg)
Staphylococcal Pneumonia inChildren
• Pneumonia caused by S. aureus associated with high
rate of complications (e.g., pleural effusion orempyema in 55-80%; pneumothorax,pyopneumothorax, and pneumatoceles
frequently observed)• Very high mortality rates reported in
primarystaphylococcal pneumonia
![Page 64: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/64.jpg)
CLINICSTOXIC SYMPTOMS:Toxic shock syndrome is caused by toxins
secreted by Staph aureus. Toxic shock syndrome is characterized by the sudden onset of high fever, vomiting, diarrhea, and muscle aches, followed by low blood pressure which can lead to shock and death. There may be a rash with peeling of skin.
![Page 65: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/65.jpg)
FUNCTIONAL:DyspneaChest discomfortPleuritic painChest splintingCough productive of purulent or blood-tinged
sputumTachypneaTachycardia
In advanced cases you may see:CyanosisConfusion Pain referral to the abdominal region due to
diaphragmatic inflammation
![Page 66: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/66.jpg)
PHYSICAL SIGNSrespiratory distress, hypoxemia, and hypercarbia grunting, flaring, severe tachypnea, and
retractions assessment of oxygen saturation by pulse
oximetry Visual inspection - respiratory effort and count
the respirations – tachypneaAuscultation -crackles or ralesPercussion -identify an area of consolidation.rashes and pharyngitis
![Page 67: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/67.jpg)
IMAGERYINTERSTITIALCONDENSATIONSCONFLUATIONPROGRESSION TO ABCESS, EMPIEMARestitutio ad integrum or pneumatocelae
![Page 68: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/68.jpg)
Gram negative infections
Gram negative infections are caused by Klebsiella pneumoniae, Escherichia coli, Pseudomonas aeruginosa, Haemophilus influenzae, and Proteus.
The radiological picture is identical, and it is not possible to differentiate between bacteria.
Gram negative lung infections are seen in chronically ill patients , chronic lung diseases, diabetes, or different types of cancer.
Aspiration to the respiratory tract is the commonest single cause of Gram negative pneumonia.
Opacities caused by Gram negative bacteria are usually localized in the basal lung segments. It is not possible to differentiate these opacities from those caused by staphylococcus aureus.
Complications such as empyema and lung abscess are frequently seen
![Page 69: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/69.jpg)
Atypical or Interstitial or viral PneumoniaCausesMycoplasmaLegionellaChlamydiaPneumocystis carinni. CoxiellaFungi Histoplasma capsulatum (histoplasmosis) Coccidioides immitis (coccidioidomycosis
![Page 70: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/70.jpg)
Atypical or Interstitial or viral PneumoniaIn atypical pneumonia the x ray finding
usually do not show lobar type of picture but meaning that the affection is restricted to small areas that is interstitial spaces between alveoli, rather than involving a whole lobe. As the disease progresses, however, the look can tend to be lobar pneumonia.
There is also absence of leukocytosis.Extrapulmonary symptoms, give some clue
to the causing organism.
![Page 71: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/71.jpg)
Atypical or Interstitial or viral PneumoniaIn atypical pneumonia :x ray chest
infiltration, commonly begins in the perihilar region (where the bronchus begins) and spreads in a wedge- or fan-shaped fashion toward the periphery of the lung field.
Reticular shadows as small linear striations running in all directions on which may be small white nodular appearance.
![Page 72: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/72.jpg)
Transverse thin-section CT scan at the level of the carina in a patient with measles infection shows multiple centrilobular nodules (arrowhead) and bilateral areas of lobular consolidation (arrows).
Franquet T Radiology 2011;260:18-39
©2011 by Radiological Society of North America
![Page 73: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/73.jpg)
![Page 74: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/74.jpg)
Atypical or Interstitial or viral PneumoniaThe most common pathogen of this group is
Mycoplasma pneumoniae. It ranks second only to S. pneumoniae.
onset is usually more insidious. Mycoplasma pneumoniae can be communicated through
close personal contact via respiratory droplets or contact with poultry or birds chicken etc.
EXTRAPULMONARY MANIFESTATIONS:gastrointestinal musculoskeletal dermatologic cardiac neurologic symptoms hematological
![Page 75: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/75.jpg)
Complications of Pneumonia1. Pulmonary fibrosis.2. Bronchiectasis3. Lung abscess4. Empyema5. Bacteremia with abscess in other organs6.ARDS7.Bacteremia8.Collapse of lung9.Hemoptysis
![Page 76: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/76.jpg)
Complications of PneumoniaParapneumonic effusionsSeptic arthritisEndocarditisPericarditisRespiratory failureMental symptoms
![Page 77: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/77.jpg)
Differential Diagnoses
Acute Respiratory Distress SyndromeAsthmaBronchiolitisEmpyema and AbscessBronchitisForeign Body AspirationPertussis
![Page 78: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/78.jpg)
Investigations of PneumoniaTotal and differential countPBFBlood ,urine,sputum culture/sensitivityGram staining/stain for AFBFiberoptic bronchoscopy with bronchial
washing/ brushing /biopsy
![Page 79: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/79.jpg)
Inflamatory tests: ESR, Fg, CRP, alpha 2 globulin
Pulse oximetry Urine latex agglutination test: antigen
detection assays for S pneumoniae Blood and sputum culturesFluid recovered from the pleural space should be
sent for Gram stain and culture, along with pH, glucose, protein, and lactate dehydrogenase (LDH).
![Page 80: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/80.jpg)
IMAGERY
![Page 81: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/81.jpg)
Anteroposterior radiograph of a child with a bacterial pneumonia
![Page 82: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/82.jpg)
![Page 83: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/83.jpg)
parahilar peribronchial infiltrates
hilar adenopathy
![Page 84: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/84.jpg)
![Page 85: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/85.jpg)
History of Empiric Therapy
Bacterial Pneumonia in Children:• Early 1900’s Serum therapy• 1950’s Penicillin, the miracle drug• 1960’s Ampicillin improves Haemophilus
coverage;semisynthetic penicillins (oxacillin,
nafcillin) provide Staph coverage• 1980’s 2nd and 3rd generation
cephalosporins provide excellent coverage for the “usual suspects”
• 2010Are beta-lactams still reliable?
![Page 86: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/86.jpg)
Worldwide Trends inPneumococcal Resistance
![Page 87: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/87.jpg)
ATBAmoxicillin 80 mg/kg/d PO divided 2-3Penicillin 100 ooo units/kg/d iv divided qid or orallyCefuroxime (Zinacef) IV: 150-200 mg/kg/d IV divided q8h Ceftriaxone (Rocephin) 50-75 mg/kg/d IV/IM qd; not to
exceed 1 gCefotaxime (Claforan) 100-200 mg/kg/d IV/IM divided q6-
8h Erythromycin 30-50 mg/kg/d (base and ethylsuccinate) PO divided q6-8h
Clarithromycin 15 mg/kg/d PO divided q12h
![Page 88: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/88.jpg)
carbapenems, fluoroquinolones, aminoglycosides, vancomycin
![Page 89: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/89.jpg)
Methicillin-resistant Staphylococcus aureus, known as MRSA, is a type of Staphylococcus aureus that is resistant to the antibiotic methicillin and other drugs in the same class, including penicillin, amoxicillin, and oxacillin
Therapeutic choice: vancomycin, targocid ( teicoplanin), linezolid ( zyvoxid)
![Page 90: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/90.jpg)
Empiric Therapy of Children with Pneumonia (I)
• Cefotaxime/Ceftriaxone reasonable empirictherapy for pneumococcus, Haemophilus,Moraxella, MSSA• Add macrolide for coverage of Mycoplasmaand Chlamydia in older patients (? ≥ 2-3 yrs)• Add clindamycin or vancomycin in patientswith severe or complicated pneumonia(clindamycin in most cases if low rates of R;vancomycin if life-threatening)
![Page 91: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/91.jpg)
Need to establish specific etiologicdiagnosis when possible (e.g.,thoracentesis, culture, moleculardiagnostics)• Consider aggressive management ofempyema (e.g., video-assistedthoracoscopic surgery: VATS)
![Page 92: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/92.jpg)
Pneumocystis carinii pneumonitis (PCP) is a common opportunistic disease that occurs almost exclusively in persons who have profound immunodeficiency.
PCP was and still is the most common life-threatening opportunistic infection occurring in patients with HIV disease.
![Page 93: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/93.jpg)
PCP: Clinical FeaturesCough
Usually nonproductive, occasionally whitish sputum.
Dyspnea Fever May be accompanied by night sweats, but
not rigors. Rales
May be present, but are often absent.
![Page 94: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/94.jpg)
Tachypnea and fever Diffuse bilateral alveolar disease can be observed by radiography. Diagnosis requires the identification of P carinii in pulmonary tissue or lower airway fluids. Lung biopsy, inducement of sputum, bronchoalveolar lavage, or needle aspiration of the lung. The Gomori, Giemsa, fluorescence-labelled antibody, or toluidine blue O stains may be used to identify the organism.
![Page 95: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/95.jpg)
![Page 96: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/96.jpg)
PCP: CXR Findings90-95% have pulmonary infiltrates.Combined interstitial & alveolar infiltrates.Predominantly at bases and centrally.Pneumothorax can be present.Lace like appearance.
![Page 97: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/97.jpg)
![Page 98: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/98.jpg)
![Page 99: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/99.jpg)
PA Chest Radiograph
Demonstratesbilateral, perihilar,R > L, ground glassopacities
![Page 100: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/100.jpg)
PA Chest Radiograph
Progressivedisease showingextensive groundglass opacificationwith consolidation
![Page 101: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/101.jpg)
PA Chest Radiograph
Progressivedisease showingextensive groundglass opacificationwith consolidation
![Page 102: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/102.jpg)
Histologic DiagnosisSputum (induced if necessary):
Diagnostic Flexible Bronchoscopy with Bronchoalveolar
lavage to find pnuemocytis carinii in sputum and secretions.
.
![Page 103: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/103.jpg)
Diagnosis continuedGomori methenamine silver (GMS) stain from
BAL specimen showing “crushed ping-pong ball” appearance of cyst wall
![Page 104: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/104.jpg)
Calcofluor white stains the fungal cyst wall for rapid diagnosis
![Page 105: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/105.jpg)
Diagnosis continuedImmunofluorescence showing trophozoites
(arrowheads) and cysts (arrows)
![Page 106: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/106.jpg)
•Four drugs currently available for therapy of P carinii pneumonitis are:
Pentamidine isethionate Trimethoprim-Sulfamethoxazole atovaquonetrimetrevate
Trimethoprim-sulfamethoxazole is preferred because of its low toxicity and greater efficacy.
![Page 107: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/107.jpg)
BACTRIM-DSBactrim DS tablet contains. 160 mg of
trimethoprim and 800 mg of Sulfamethoxazole.
21 days coursePrednisolone 40 mg bid x 5 days, then 40
mg/day x 5 days, then 20 mg/day to completion of treatment
![Page 108: BRONCHIOLITIS EPIDEMIOLOGY Annual incidence is 11.4% in children younger than 1 year and 6% in those aged 1-2 years. Incidence peaks in those aged 2-8.](https://reader038.fdocuments.net/reader038/viewer/2022110210/56649ea75503460f94baa6b9/html5/thumbnails/108.jpg)
Alternative Treatments: TMP 15 mg/kg/day PO + dapsone 100
mg/day x 21 days Pentamidine 4 mg/kg/day IV x 21 days-Atovaquone 750 mg PO bid with meal x
21 days
PCP is the most frequently identified serious in HIV disease