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Nama : Albertus SriAgseyogiNIM :201020401011181

BPH-A: A Potentially Useful New

Marker for Benign ProstaticHyperplasia

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BPH CA

PROSTAT

PSA

?

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BPH

BPH (also referred to as Benign Prostatic Hypertrophy) is acondition in which the prostate gland becomes veryenlarged and may cause problems associated withurination

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theory focuses on dihydrotestosterone(DHT), a substance derived from

testosterone in the prostate, which may helpcontrol prostate growth

BPH

Testosteron DHT

5 -Reduktase

M-RNA

GrowthFactor

Proliferasi Sel-Sel

KelenjarProstat

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CA PROSTAT

Prostate cancer is a malignant(cancerous) tumor (growth) thatconsists of cells from the prostate

gland. Generally, the tumor

usually grows slowly andremains confined to the

gland for many years.

During this time, the tumorproduces little or no

symptoms or outward signs

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Immunoassay test underdevelopment By

Beckman Caulter (2005) The test called BPH-A (or BPSA), detects

an isoform ofprostate-specific antigen(PSA) that exists in abnormally high level

in blood of men with enlargement ofProstate Gland.

PSA

(Prostatic-Specific Antigen)

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The rationale for the test is as follows: in its normalphysiological pathway, PSA passes into theseminal plasma, where it promotes sperm motility

by dissolving the seminal coagulum.

When either BPH or prostate cancer exists,significant amounts of PSA leak from the prostate

gland into the bloodstream. The leaked PSA can befound in the blood in a form bound to serumproteins or in an unbound form, also known asfPSA

PSA

(Prostatic-Specific Antigen)

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BPH

Prostatitis

Prostate Biopsy

Recent Ejaculation

Digital Rectal Exam (DRE)Bicycle Riding

Ca Prostat

What Condition mayCause PSA Level

Elevated ?

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Digital Rectal

Exam (DRE)

>10ng/

mL

PROSTATE

ENLARGEME

NT ???

PSA

4

ng/mL

BIOPSICA ???

25%

4-

10ng/m

L

FOLLOW

UP

UnusualProstat/LUMP

Detected /EnlargeProstat

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4/29/12 TransrectalUltrasound

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REFFERENCES B.Cook, Mikolajczyk, Weinzierl, 2005, BPH-A: a

potentially usefull new marker for benignprostatic hyperplasia, USA.

Joana Lins Medical and Cancer Clinic, 2009, Non-

Cancerous Cause of an elevated PSA, accessed 13September 2011,http://prostatecancer.about.com/od/symptomsanddiagno.

NCI, 2009, Prostate-Specific Antigens (PSA) Test,accessed 13 September 2011,http://www.cancer.gov/cancertopics/factsheet/detection/

.

http://prostatecancer.about.com/od/symptomsanddiagnosis/a/psacauses.htmhttp://www.cancer.gov/cancertopics/factsheet/detection/PSAhttp://www.cancer.gov/cancertopics/factsheet/detection/PSAhttp://prostatecancer.about.com/od/symptomsanddiagnosis/a/psacauses.htm

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R Damiano, 2003, Prostate Cancer andProstatic Diseases, accessed 14 September2011, http://www.nature.com/pcan/journal/v6/n3/full/4500671a.htm

.

http://www.nature.com/pcan/journal/v6/n3/full/4500671a.htmlhttp://www.nature.com/pcan/journal/v6/n3/full/4500671a.htmlhttp://www.nature.com/pcan/journal/v6/n3/full/4500671a.htmlhttp://www.nature.com/pcan/journal/v6/n3/full/4500671a.htmlhttp://www.nature.com/pcan/journal/v6/n3/full/4500671a.html

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Results of biopsies accordingto clinical and PSA indications

PtsIndications

CancerDetectionrate (%)

61 (37%) DRE+ PSA >4 39 64

28 (17%) DRE+ PSA4 21 28(R Damiano,2003)

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Chen et al :The addition of biopsy of the anterior TZ,midline PZ and inferior portion of the AH of

the PZ reliably detected cancer in 96% of

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