BOLD DATA FOR A BOLD MOUTHWASH · 2017. 7. 10. · Accessed May 12, 2015. 2. Marcenes W, Kassebaum...

BOLD DATA FOR A BOLD MOUTHWASH:INTEGRAL ROLE OF LISTERINE® MOUTHWASH IN PREVENTIVE DAILY ORAL CARE

A BOLD QUESTION: CAN A MOUTHWASH CHANGE THE WORLD OF ORAL HEALTH?

WHEN

OF PATIENTS ARE WILLING TO USE A MOUTHWASH FOR ENHANCED ORAL HEALTH*—IT CAN.

90%

*Based on self-reported data from a survey of patients in the United States, United Kingdom, Thailand, Brazil and Japan (N=4134).

THE LISTERINE® GOAL: REDEFINING PREVENTION IN DAILY ORAL CARE AND IMPROVING ORAL HEALTH FOR EVERY PATIENT—AT EVERY SITE. BETTER IS BEST.

SECTION ONE:

THE GLOBAL BURDEN OF ORAL DISEASE

61% OF PATIENTS DO NOT KNOW THAT BRUSHING ONLY CLEANS 25% OF THE SURFACE OF THE MOUTH*

SURFACES OF TEETH

SURFACE OF THE MOUTH


1. United States Census Bureau. U.S. and World Population Clock website. www.census.gov/popclock. Accessed May 12, 2015. 2. Marcenes W, Kassebaum NJ, Bernabé E, et al. Global burden of oral conditions in 1990-2010: a systematic analysis. J Dent Res. 2013;92(7):592-597.

Untreated oral disease is a worldwide issue affecting more than half of the populationTOTAL WORLD POPULATION

BILLION AFFECTEDwhich represents more than half of the world population2

3.9

7.3BILLION1

GINGIVITIS IS PREVALENT AT ALL AGES1

Chronic gingivitis affects a large percentage of the world’s population1

1. Coventry J, Griffiths G, Scully C, Tonetti M. Periodontal disease. Brit Med J. 2000;321(7252):36-39.

FACT:

OVER 90%of the world population have chronic gingivitis to some degree

Severe periodontitis is the 6th-most-prevalent oral disease worldwide1

1. Marcenes W, Kassebaum NJ, Bernabé E, et al. Global burden of oral conditions in 1990-2010: a systematic analysis. J Dent Res. 2013;92(7):592-597.2. Petersen PE, Bourgeois D, Ogawa H, et al. The global burden of oral diseases and risks to oral health. Bull World Health Organ. 2005;83(9):661-669.3. Albandar JM, Brown LJ, Loe H. Clinical features of early-onset periodontitis. J Am Dent Assoc. 1997;128(10):1393-1399.

2%of youths are affected worldwide2,3

5 –20%of adults are affected worldwide2

SECTION TWO:

A BOLD GOAL: REDEFINING PREVENTION IN DAILY ORAL CARE

76% OF PATIENTS ARE WILLING TO ADD ANOTHER STEP TO THEIR ORAL CARE ROUTINE FOR A BETTER CHECKUP*76%


Inadequate oral hygiene leads to biofilm buildup1-5

1. Marsh PD. Are dental diseases examples of ecological catastrophes? Microbiology. 2003;149(pt 2):279‐294.2. Do T, Devine D, Marsh PD. Oral biofilms: molecular analysis, challenges, and future prospects in dental diagnostics. Clin Cosmet Investig Dent. 2013;5:11‐19.3. Gurenlian JR. The role of dental plaque biofilm in oral health. J Dent Hyg. 2007;81(5):1‐11.4. Marsh PD. Dental plaque as a biofilm: the significance of pH in health and caries. Compend Contin Educ Dent. 2009;30(2):76‐87.5. Marsh PD. Contemporary perspective on plaque control. Br Dent J. 2012;212(12):601‐606.6. Costerton JW, Lewandowski Z, Caldwell DE, Korber DR, Lappin-Scott HM. Microbial biofilms. Annu Rev Microbiol. 1995;49:711-745.

THIS INCREASES THE RISK FOR DENTAL CARIES AND PERIODONTAL DISEASES, SUCH AS GINGIVITIS.6

Both dental caries and periodontal diseases are diseases resulting from continued dental plaque biofilm accumulation, which can lead to a more mature biofilm. This process represents a shift in the balance of the resident microorganisms to a more pathogenic biofilm due to changes in the oral microenvironment.1-5

Maintaining the oral microflora at levels compatible with health will retain the beneficial properties of the resident oral microflora while minimizing the risk of disease.5

Dental Caries Gingival Inflammation Periodontitis

A healthy mouth requires controlling oral biofilms1-5

*Depending on plaque index used.

1. Marsh PD. Are dental diseases examples of ecological catastrophes? Microbiology. 2003;149(pt 2):279‐294.2. Do T, Devine D, Marsh PD. Oral biofilms: molecular analysis, challenges, and future prospects in dental diagnostics. Clin Cosmet Investig Dent. 2013;5:11‐19.3. Gurenlian JR. The role of dental plaque biofilm in oral health. J Dent Hyg. 2007;81(5):1‐11.4. Marsh PD. Dental plaque as a biofilm: the significance of pH in health and caries. Compend Contin Educ Dent. 2009;30(2):76‐87.5. Marsh PD. Contemporary perspective on plaque control. Br Dent J. 2012;212(12):601‐606.6. Marsh PD. Dental plaque. In: Marsh PD, Martin MV, ed. Oral Microbiology. 5th ed. New York, NY: Churchill Livingstone Elsevier; 2009:74-102.7. Slot DE, Wiggelinkhuizen L, Rosema NA, et al. The efficacy of manual toothbrushes following a brushing exercise: a systematic review. Int J Dent Hyg. 2012;10(30):187-197.

PLAQUE BIOFILM COLONIZATION

BEGINS TO APPEAR WITHIN MINUTES—DOUBLES EVERY 1-2 HOURS IN EARLY STAGES6

WITHIN DAYS, MICROBES FORM A COMPLEX 3D COLONY THAT COULD CONTAIN MORE THAN 25 DISTINCT SPECIES PER SITE 6

30 53%OF PLAQUE7

Changes in diet or lifestyle can alter the balance of the mircoflora, increasing bacteria

RESEARCH REVEALS BRUSHING ALONE ONLY REMOVES APPROXIMATELY*

RINSING WITH LISTERINE® IS NOT TECHNIQUE-SENSITIVE: IT REACHES EVERY SITE IN THE MOUTH FOR EVERY PATIENT, REDUCING PLAQUE BIOFILM IN AREAS THAT PATIENTS MAY NOT ADEQUATELY CLEAN

BRUSH, FLOSS, RINSE: the optimal method for biofilm management1

While brushing and flossing are the best form of mechanical biofilm management, clinical data demonstrate the additive benefit of mouthwashes, including LISTERINE®, as a method for better antimicrobial biofilm control.1

BRUSH FLOSS RINSE

1. Boyle P, Koechlin A, Autier P. Mouthwash use and the prevention of plaque, gingivitis and caries. Oral Dis. 2014;20(suppl 1):1‐68.

SECTION THREE: A BOLD GOAL DEMANDS A LANDMARK ANALYSIS

86% OF PATIENTS PREFER A PRODUCT SUPPORTED BY CLINICAL EVIDENCE,* AND 4 DECADES’ WORTH OF LISTERINE® DATA MAKE IT CLEAR WHY.

4 DECADESOF DATA


Landmark, peer-reviewed analysis adds clinical relevance to your everyday practice

LANDMARK , PEER-REVIEWED ANALYSIS ON THE ADDITIVE BENEFITS OF LISTERINE®

1 2 3Results reported in sites healthy and plaque-free—allows dental practitioners to easily set targets for their practice, as opposed to whole-mouth plaque/gingivitis reductions

This analysis reviewed data on the additive benefits of LISTERINE®: randomized, observer-blinded, placebo-controlled studies, including both published and unpublished data (with both favorable and unfavorable results)

Evidence representative of a larger-than-usual population

– N>5000 subjects; single studies have an average of 163 subjects

The most robust collection of clinical data of its kind RESEARCH ACROSS

UNITED STATES, CANADA AND BRAZIL

LANDMARK ANALYSIS Enabled broader, more clinically relevant conclusions, bringing us 1 step closer to the goal of improved oral health worldwide1

COUNTRIES:

Over 5000 patients

29 studies of6 months’ duration

29

4 decadesof data

500,000+sites

Analysis compared the results of 2 treatment groups

CONTROL GROUP MECHANICAL METHODS (MM) ALONE

EXPERIMENTAL GROUPMM + LISTERINE®

* In only 2 studies daily flossing was required in mechanical regimen. In all others use of an interdental cleaning device was allowed to continue if it had been part of the subject’s usual oral care regimen.

2562

2544

PATIENTS

PATIENTS

Site-wise analysis: evaluates efficacy at multiple sites per tooth across the entire mouth

F = facial.L = lingual.Mid = middle when referring to tooth (plaque site) but mid = midline for healthy gum sites.D = distal.Mes = mesial.

PLAQUEINDEX

SITES PER TOOTH

F-DF-MIDF-MES

L-DL-MIDL-MES

# OF TOOTH F (2 F)# OF TOOTH L (2 L)POINTS IN BETWEEN TEETH (2-3 F); (2-3 L)

6

MODIFIEDGINGIVALINDEX

SITES PER TOOTH4

Plaque-free sites provide more clinically relevant measurements

PLAQUE INDEX (PI) SCORE

Plaque-free sites were identified as those with small pieces of plaque (1) or no plaque (0), based on the PI score.

NO PLAQUE

PLAQUE FREE PLAQUE BUILDUP

SMALLPIECES

THINBAND

MEDIUMBAND

LARGEBAND

2/3 OR MORECOVERED

0 1 2 3 4 5

Healthy sites provide more clinically relevant measurements

MODIFIED GINGIVAL INDEX (MGI) SCORE

0 1 2 3 4

NO INFLAMMATION

HEALTHY UNHEALTHY

MILDINFLAMMATION

MILDINFLAMMATION

MODERATEINFLAMMATION

SEVEREINFLAMMATION

Healthy sites were those with mild (1) to no (0) inflammation, based on the MGI scores.

section four:BOLD RESULTS DEMONSTRATE MORE PLAQUE-FREE SITES ARE ACHIEVABLE WITH LISTERINE*

ONLY HALF OF ALL PATIENTS KNOW THAT PLAQUE BACTERIA REPOPULATE ON TEETH WITHIN MINUTES AFTER BRUSHING.†

Half

*vs. MM alone.†Based on self-reported data from a survey of patients in the United States, United Kingdom, Thailand, Brazil and Japan (N=4134).

BOLD FACT: LISTERINEUSERS WERE MORE LIKELY TO HAVE A CLEANER, HEALTHIER MOUTH VS. MM ALONE

1. Araujo M, Charles C, Weinstein R, et al. Meta-analysis of the effect of an essential oil-containing mouthrinse on gingivitis and plaque. J Am Dent Assoc. Manuscript ID: 539-14. RI.

2. Based on a meta-analysis in Araujo et al and/or post-hoc study analyses.

MORE PLAQUE-FREE SITES AT 6 MONTHS VS. MM ALONE1,2

5xNEARLY

Patients who added LISTERINE® to their daily oral health regimen had

0

20

40

60

80

100

100

80

60

40

20

0

PATIENTS USING MECHANICAL METHODS ALONE

PERCENTAGEOF PATIENTS

PLAQUE-FREEAT EACH SITE

2 3 4 5 6 7 98 10 11 12 13 14 15

31 30 29 28 27 26 2425 23 22 21 20 19 18

Could your patients have more plaque-free sites?


At 6 months (PI scores 0, 1) 17 studies (6 surfaces) Mechanical methods only

RESULTS BY TOOTH NUMBER AND LOCATION

2 3 4 5 6 7 98 10 11 12 13 14 15

31 30 29 28 27 26 2425 23 22 21 20 19 18

PATIENTS WHO ADDED LISTERINE® TO MECHANICAL METHODS

0

20

40

60

80

100

100

80

60

40

20

0

PERCENTAGEOF PATIENTS

PLAQUE-FREEAT EACH SITE

At 6 months (PI scores 0, 1) 17 studies (6 surfaces)


Mechanical methods + LISTERINE®Mechanical methods only

More LISTERINE users had more plaque-free sites— even in the hardest-to-reach areas of the mouth

RESULTS BY TOOTH NUMBER AND LOCATION

A BOLD GOAL: MORE PLAQUE-FREE SITES FOR EVERY PATIENT — AT EVERY SITE



WHEN THEY ADDED LISTERINE® TO THEIR DAILY ORAL CARE ROUTINE THAN THOSE USING MECHANICAL METHODS ALONE AT 6 MONTHS

BOLD RESULTS:11x

11X MORE PATIENTS MET THE GOAL OF 75% PLAQUE-FREE SITES in the Listerine group than those using mechanical methods alone at 6 months

MORE PATIENTS ACHIEVED 75% PLAQUE-FREE SITESWHEN THEY ADDED LISTERINE® TO THEIRDAILY ORAL CARE ROUTINE THAN THOSE USINGMECHANICAL METHODS ALONE AT 6 MONTHS1,2

SECTION FIVE:BOLD RESULTS DEMONSTRATE MORE HEALTHY GINGIVAL SITES ARE ACHIEVABLE WITH LISTERINE*

OF PATIENTS KNOW THAT GINGIVITIS CAN LEAD TO TOOTH LOSS, BUT DO THEY KNOW HOW TO PREVENT IT?†

87%

*vs. MM alone.†Based on self-reported data from a survey of patients in the United States, United Kingdom, Thailand, Brazil and Japan (N=4134).

BOLD FACT: LISTERINEUSERS WERE MORE LIKELY TO HAVE A CLEANER, HEALTHIER MOUTH VS. MM ALONE

MORE HEALTHY GINGIVAL SITES AT 6 MONTHS VS. MM ALONE1,2

2xOVER



Patients who added LISTERINE® to their daily oral health regimen had


At 6 months (MGI scores 0, 1) 27 studies (4 surfaces) Mechanical methods only

2 3 4 5 6 7 8 9 10 11 12 13 14 15

31 30 29 28 27 26 25 24 23 22 21 20 19 18

LF

LF

PERCENTAGE OF PATIENTS

GINGIVITIS-FREE AT EACH SITE

0

20

40

60

80

100

100

80

60

40

20

0

PATIENTS USING MECHANICAL METHODS ALONE

Could your patients have more healthy gingival sites?

RESULTS BY TOOTH NUMBER AND LOCATION1

LISTERINE users had more healthy sites— even in the hardest-to-reach areas of the mouth


Mechanical methods + LISTERINE®Mechanical methods only

2 3 4 5 6 7 8 9 10 11 12 13 14 15

31 30 29 28 27 26 25 24 23 22 21 20 19 18

LF

LF

PATIENTS WHO ADDED LISTERINE® TO MECHANICAL METHODS

PERCENTAGE OF PATIENTS

GINGIVITIS-FREE AT EACH SITE

0

20

40

60

80

100

100

80

60

40

20

0

RESULTS BY TOOTH NUMBER AND LOCATION1

At 6 months (MGI scores 0, 1) 27 studies (4 surfaces)

3xMORE PATIENTS ACHIEVED

HEALTHY SITES WHEN THEY ADDED LISTERINE®

to their daily oral care regimen than those using mechanical methods alone at 6 months1,2

75%

A BOLD GOAL: MORE HEALTHY GINGIVAL SITES FOR EVERY PATIENT—AT EVERY SITE



SECTION SIX:

WHY RECOMMEND LISTERINE MOUTHWASH?

OF PATIENTS ARE WILLING TO USE A MOUTHWASH FOR ENHANCED ORAL HEALTH.* THIS BOLD EVIDENCE MAKES THE RECOMMENDATION CLEAR.

90%


LISTERINE penetrates deep into the hardest-to-reach areas of the mouthThe antimicrobial action of the 4 essential oils in LISTERINE® reduces plaque left behind by mechanical methods, deeply penetrating into the bottom layers of the biofilm, breaking down its structure in places that are more difficult for a toothbrush and dental floss to access.1-3 THAT’S BOLD.

• The antimicrobial action comes from the unique fixed combination of 4 essential oils that can be found in natural plant sources: thymol, eucalyptol, methyl salicylate, and menthol

• These 4 essential oils penetrate deep into the plaque biofilm, disrupting bacterial cell walls and inhibiting enzyme activity1,2

LISTERINE® has been proven safe for both daily and long-term use and contributes to the maintenance of healthy oral flora.2-4

1. Foster JS, Pan PC, Kolenbrander PE. Effects of antimicrobial agents on oral biofilms in a saliva-conditioned flowcell. Biofilms. 2001;1:512.

2. Minah GE, DePaola LG, Overholser CD, et al. Effects of 6 months use of an antiseptic mouthrinse on supragingival dental plaque microflora. J Clin Periodontol. 1989;16:347-352.

3. Walker C, Clark W, Wheeler T, Lamm R. Evaluation of microbial shifts in supragingival plaque following long-term use of an oral antiseptic mouthrinse. J Dent Res. 1989;68:412.

4. Swango PA. Regular use of antimicrobial mouthrinses can effectively augment the benefits of oral prophylaxis and oral hygiene instructions at 6‐month recall intervals in reducing the occurrence of dental plaque and gingivitis. J Evid Based Dent Pract. 2012;12(2):87-89.

Thymol Methyl Salicylate

Menthol Eucalyptol

+

4 ESSENTIAL OILS

Compared to patients using mechanical methods alone, those who added LISTERINE® to mechanical methods had

—AND—

MORE PLAQUE-FREE SITESat 6 months5x

NEARLY

MORE HEALTHY GINGIVAL SITESat 6 months2x

OVER

BOLD RESULTS FOR A BOLD GOAL:



A WORLD OF BETTER ORAL HEALTH STARTS WITH A LISTERINE RECOMMENDATION

A BOLD OPPORTUNITY:76% OF PATIENTS ARE WILLING TO ADD ANOTHER STEP TO THEIR DAILY ORAL CARE ROUTINE FOR A BETTER CHECKUP*BOLD EVIDENCE LIKE THIS PROVES THAT BETTER ORAL HEALTH IS NOT ONLY POSSIBLE—BUT ACHIEVABLE. AND IT ALL STARTS WITH YOUR PRACTICE. RECOMMEND ADDING A 30-SECOND RINSE WITH LISTERINE® ANTISEPTIC TWICE A DAY.


THANK YOU.

APPENDIX

LISTERINE is the world’s most clinically researched mouthwash brand: 137 years of heritage examined in more than 50 clinical trials1-5

LISTERINE® IS SAFE FOR BOTH DAILY AND LONG-TERM USE5

• No major side effects5

• No evidence of an increased risk of oral cancer with mouthwashes containing alcohol6 • Does not disrupt the normal balance of oral flora7,8

• No emergence of resistant strains, even with long-term use7,8

• Does not promote significant tooth stain or calculus (tartar) formation9-12

1. Gunsolley JC. A meta‐analysis of six-month studies of antiplaque and antigingivitis agents. J Am Dent Assoc. 2006;137(12):1649-1657.

2. Gunsolley JC. Clinical efficacy of antimicrobial mouthrinses. J Dent. 2010;38(suppl 1):S6-S10.

3. Van Leeuwen MP, Slot DE, Van der Weijden GA. Essential oils compared with respect to plaque and parameters of gingival inflammation: a systematic review. J Periodontol. 2011;82(2):174-194.

4. Swango, PA. Regular use of antimicrobial mouthrinses can effectively augment the benefits of oral prophylaxis and oral hygiene instructions at 6 month recall intervals in reducing the occurrence of dental plaque and gingivitis. J EvidBased Dent Pract. 2012;12(2):87-89.

5. Boyle P, Koechlin A, Autier P. Mouthwash use and the prevention of plaque, gingivitis and caries. Oral Dis. 2014;20(suppl 1):1-68.

6. Gandini S, Negri E, Boffetta P, La Vecchia C, Boyle P. Mouthwash and oral cancer risk: quantitative meta-analysis of epidemiologic studies. Ann Agric Environ Med. 2012;19(2):173-180.

7. Minah GE, DePaola LG, Overholser CD, et al. Effects of 6 months use of an antiseptic mouthrinse on supragingival dental plaque microflora. J Clin Periodontol. 1989;16(6):347-352.

8. Walker C, Clark W, Wheeler T, et al. Evaluation for microbial shifts in supragingival plaque following long-term antiseptic mouthrinse use. J Dent Res. 1989;68:412. Abstract 1845.

9. Overholser CD, Meiller TF, DePola LG, Minah GE, Niehaus C. Comparative effects of 2 chemotherapeutic mouthrinses on the development of supragingival dental plaque and gingivitis. J Clin Periodontol. 1990;17(8):575-579.

10. DePaola LG, Overholser CD, Meiller TF, Minan GE, Niehaus C. Chemotherapeutic inhibition of supragingival dental plaque and gingivitis development. J Clin Periodontol.1989;16(5):311-315.

11. Gordon JM, Lamster IB, Seiger MC. Efficacy of Listerine antiseptic in inhibiting the development of plaque and gingivitis. J Clin Periodontol. 1985;12(8):697-704.

12. Lamster IB, Alfano MC, Seiger MC, Gordon JM. The effect of Listerine antiseptic on reduction of existing plaque and gingivitis. Clin Prev Dent. 1983;5(6):12-16.

BOLD DATA FOR A BOLD MOUTHWASH · 2017. 7. 10. · Accessed May 12, 2015. 2. Marcenes W, Kassebaum...

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