BIPN 148 Lecture 12. Biochemical Basis of LTP Interaction Between AMPAR, Stargazin, and PSD-95...
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BIPN 148 Lecture 12
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Transcript of BIPN 148 Lecture 12. Biochemical Basis of LTP Interaction Between AMPAR, Stargazin, and PSD-95...
Interaction Between AMPAR, Stargazin, and PSD-95
Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.
Stargazin restores AMPA currents in mutants
(Stargazin-deltaC restores surface expression, but not synaptic targeting)