BIPN 148 Lecture 16

RememberingJennifer Anniston

Activate Visual and Auditory Neurons

Stimulate Hippocampal Neurons

Visual Somatosensory

Olfactory

Auditory

Perirhinal Cortex

Entorhinal Cortex

Dentate GyrusCA3

CA1

Sensory RegionsOf Cortex

Perirhinal/ Entorhinal

Cortex

HippocampalFormation

Get info from cortex to hippocampus

Stimulate hippocampal synapses

Activate Spines

Potentiate Synapses

Activate CaMKII

Phosphorylate AMPA receptors

Phosphorylate GluR1on S831

Insert GluR1 at synapses

Unsilence synapses

Use Stargazin to traffic AMPA-R

Stargazin interacts with AMPA receptors in an intracellular compartment in the cell and promotes their delivery to the cell surface. The carboxyl terminus of stargazin binds specifically to the anchor protein PSD-95 and mediates recruitment of the stargazin-AMPA receptor complex to postsynaptic sites.

Induce gene expression

Use CaMKIV to induce gene expression

CRE SRE zif268

C/EBP krox20

AMPARHOMERBDNFNT-3

Arc

CBP/CREB

CaMKIV + ERK

Elk-1

RSK2

Express new genes

New gene products or

proteins

Signal to

nucleus

New gene products or

proteins

Synaptic Potentiation

Locally generated tag captures new gene product

Synaptictag

NMDAR

Send gene products to synapse

RememberingJennifer Anniston

Activate visual & auditory neurons

Stimulate hippocampal neurons

Change synaptic strengthby inserting AMPA receptorsInduce gene expressionStabilize change in synaptic strengthRecall image with visual cueDon’t confuse with Angelina Jolie