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Biodata Name : Dr. PRADIP PAIK

(Associate Professor)

School of Biomedical Engineering

Indian Institute of Technology (IIT)-BHU, Varanasi

Varanasi 221005, UP, India

Phone:, +91-8500109932 (M)

E-mail:paik.bme@iitbhu.ac.in, ppse@uohyd.ernet.in, pradip.paik@gmail.com,

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Associate Professor (in Lean)

Department of Materials Technology & Nanoscience and Nanotechnology

School of Engineering Sciences and Technology

University of Hyderabad, Hyderabad, Telangana, India

Phone: +91-(040)-23134457 (UoH-office), +91-8500109932 (M)

E-mail:ppse@uohyd.ernet.in, pradip.paik@gmail.com,

Academic Qualification:

Ph.D. Department of Materials Science, Indian Institute of Technology Kanpur (IITK), India, 2008. Ph.D. Dissertation: “Synthesis and characterization of nanopolymers: polyethylene, polypropylene and polystyrene”. Supervisor: Prof. Kamal Krishna Kar.

M. Tech. Materials Science, Indian Institute of Technology Kanpur (IITK), India, 2003. Dissertation: Nano polymers synthesis and characterization. Supervisor: Prof. Kamal Krishna Kar. (Results: 1st division)

B. Tech. Chemical Technology, University of Calcutta, India, 2001, Dissertation: Synthesis and Characterization of Oxychloride bonded Refractory Materials. Supervisors: Prof. N. K. Mitra and Prof. T. K. Parya, (Results: 1st division)

Research Experiences:

1. B. Tech. Dissertation, 6 months (January, 2001-June, 2001), University of Calcutta, India

2. M. Tech. Dissertation, 14 months (January, 2002-February, 2003), IIT Kanpur, India

3. Ph.D. Dissertation, 5 years, April, (2003-Nov, 2007), IIT Kanpur, India

4. Research Scientist, 3 months, (Dec, 2007-February, 2008), IIT Kanpur, India

5. Post doctoral experience: 2 years & 10 months, (March, 2008-Dec, 2010), Bar-Ilan University, Israel and NUS

Singapore

6. Independent research group from Dec 2010-till date, University of Hyderabad, India

Key research areas: Materials for Health Care and Therapeutic Applications

Nanomedicines, Bio-Polymers and Soft Bio-materials, Functional-Core-shell materials and Mesoporous materials for Nanobiotechnology and therapeutics,

Nanocomposites, Hybrid nanomaterials and nanocapsules design and synthesis for drug and gene delivery,

Designing of Carriers for drugs/cargoes for cancer treatment (Lungs and Breast), vaccination, etc.

Health Care: Cancer therapy, Nano-Vaccination, Nano-Immunology, Tissue Engineering, Antibacterial Effects, ..

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Research Guidance:

Ph.D.: Degree Awarded: 4

Thesis Submitted: 2 (awaiting for award) + 1 (Synopsis Submission)

On-going: 4

M. Tech.: Degree Awarded: 11

M.Sc./M. Pharm: Degree Awarded: 2

Total Publications:

Patents: 11 (filled) + 3 (pending) Research Paper: 51 + 5, (International Peer reviewed Journals), Conferences/ Proceedings: 58, Abstract: 6, Poster: 27, Book: 1, Book Chapters: 4, Invited Talk: 37 Paper Communicated: 5, Manuscript under Preparation: 8 (eight)

Professional Appointment:

15th Nov, 2017-till date, Associate Professor, School of Biomedical Engineering, Indian Institute of Technology (IIT) (BHU), Varansi

09th Feb, 2017-till date Associate Professor, School of Engineering Sciences and Technology, University of Hyderabad (Central University)

23rd Dec 2010-08th Feb, 2017, Assistant Professor, School of Engineering Sciences and Technology, University of Hyderabad (Central University), since December 2010.

2010-June-Dec 2010, Post Doctoral Research Fellow, National University of Singapore (NUS), Singapore, Lab: Cellular and Molecular Bioengineering, Division of Bioengineering. Group: Prof. Zhang, Yong. Research Areas: Novel Mesoporous Polymer Nanocapsules for Sustained Drug and Gene Delivery.

2008-10 Post Doctoral Fellow, Institute for Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University, Israel. Group: Prof. Aharon Gedanken, and Prof. Yitzhak Mastai. 'Israel Science Foundation' project, from 2008-2010. Research Areas: Imprinting Chirality in Mesoporous Structures and its Application in Chiral Resolution, Separation of Amino Acids and loading of Chiral drugs.

2007 -08 Project Scientist: IIT Kanpur. Project Title: Nanocomposites. 2003-08 Appointed as a Teaching Assistant at IIT Kanpur for SEM, DSC, DTA/TGA and DMA (DMTA) Experiments for

M.Tech. Students. Editorial Board:

Editor: Special Issue on Nanomedicine: Nanotechnology, Biology and Medicine, June 2017

Editorial Board members: Journal of Engineering Technology (JET) (2014 onwards) Guest Editor : The Scientific World Journal, for the special issue: Functional Nanomaterials and Their

Applications

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Academic Honors and Awards:

2016-17 Associate Fellow in Engineering Sciences, Telangana Academy of Sciences,

2015 Paper accepted for the India International Science Festival- Young Scientists’ Meet Department of Science and Technology, Government of India –Dec 4-8, 2015, Paper Code: Mater80. Expenditure (travel, registration, accommodation etc awarded)-Student name: Mr. Chander

2015 Visiting Scientist, Institute for Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan University,

Israel. (2 Months)

2014 Best oral presentation award (first) (Ms. Alka Pareek, Ph.D. scholar), International Conference on Environment and

Energy (ICEE-2014), December 15th -17th 2014, JNTU, Hyderabad, (Authors name: Alka Pareek, Dr. Pradip Paik, Dr.

P.H. Borse), Paper name: Electrochemical characterization of Ag loaded nano-titania modified CdS /polysulphide

electrolyte interface.

2014 Student Awarded (Ms. Alka Pareek, Ph.D. scholar) Best paper presentation award, by Electrochemical Society, India

2013 Student awarded: Mr. Vijay Bhooshan Kumar (M.Tech. fellow) awarded Best Thesis Award for his M. Tech.

dissertation by INAE, India.

2012 Visiting Scientist/Faculty, Institute for Nanotechnology and Advanced Materials, Department of Chemistry, Bar-Ilan

University, Israel (December 2012, for 1 month), worked on mesoporous materials for Drug and gene delivery

2011 Swarnaya Jayanty Endowment Fellowship, Indian Institute of Metal, August 2011

2011 ‘SERC Fast Track project for Young Scientists in Engineering Science’, Department of Science & Technology,

India, August 2011

2007 'Young Scientist Award’ by Indian Science Congress Association (ISCA) in Materials Science, and

Nanoscience and Nanotechnology, for the year of 2007-2008

2001 Qualified Graduate Aptitude Test for Engineers (GATE), Engineering Science. AIR: 127

Session Chairs:

1. UGC sponsored Short term Course on “Bio-Nanotechnology”, JNTU, Hyderabad, 12-27/9/2014

2. 26th European Conference on Biomaterials, University of Liverpool, Liverpool, 31st August – 3rd September 2014

3. International Conference on Advanced Polymeric Materials (ICAPM 2013), October 2013, Mahatmagandgi University, Kottayam.

4. International Conference on Nanomaterials and Nanotechnology’ (ICNANO2011), 18-21st December, 2011 at

University of Delhi, Delhi, India.

Travel Grants Awarded:

2014 Centre for International Co-operation Science (CICS) (INSA-CSIR DAE/BRNS-CICS Travel Fellowship Scheme for

ESB 2014, 31st August-3rd Sept 2014 (partial) –Liverpool, UK, By ICMR

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2014 Travel grant by Indian Council for Medical Research (ICMR), New Delhi for ESB 2014, 31st August-3rd Sept 2014,

Liverpool, UK

2011 Swarnaya Jayanti Endowment Fellowship, Indian Institute of Metal, August 2011, (Canada)

2011 ‘DST International Travel Grant for Young Scientist’ for conference, July 2011, Canada

2006 CSIR Travel Grant for attending conference in USA

2006 PerkinElmer Travel support (partial) for attending conference in USA

Postdoctoral Research Awards:

2010 Research Fellow, NUS Singapore, Division of Bio-engineering, June to Dec 2010

2008-10 'Post-Doctoral Fellowship' in an 'Israel Science Foundation (ISF)' project in Israel, 2008-10

Research Papers Awards:

2007 Research paper cash award, Twice, by 'Department of Resource Planning and Generation (DRPG)', at IIT

Kanpur, April and November, 2007

Fellowship Awarded:

2003-08 Scholarship of “Ministry of Human Resource and Development (MHRD)” for Ph.D.

2001-02 Scholarship of 'Ministry of Human Resource and Development (MHRD)' for M.Tech.

Other Awards and Recognitions:

1993-95 Jindal Trust Scholarship for HS (10+2) results

1993-95 District Magistrate Scholarship for HS (10+2) results

1992 & 93 Merit certificates: ‘Mathematical Talent Search Examination'

1992, 93 & 94 Merit certificates: ‘Science Talent Search Examination’

Other Academic Honors:

2017 (January) Judge for Avishkar-2016 (Maharashtra State)

2017 Ph.D. thesis Reviewer, AcSIR at CSIR-IICT

Workshop/Conference organizing committee:

1. Organizing Committee, 3rd International Conference on Nanotechnology for Better Living" (NBL -2016), IIT Kanpur and NIT

Srinagar, 25-29 May, 2016.

2. 2nd International Conference on Advances in Mechanical Sciences-2016" which will be held in TKRCET, Hyderabad, Jan 13,

2016 - Jan 14, 2016

3. Advisory committee member, Innovation in Chemical Engineering, 2013, BIT Hyderabad, 15-16 Nov 2013.

4. Organizing Committee, NEMPIQI (National Conference, Hyderabad, October 19-20, 2012)

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Teaching Experience: Course teaching/tough

1. NT408: Nano Bio Technology (M. Tech. & Ph.D.)-4 unit

2. MT/NT-408: Polymer Science –Technology and Advanced Composites (M. Tech. & Ph.D.) – 4 unit

3. NT742: Synthesis and Applications of Nanomaterials (M. Tech. & Ph.D.)-4 unit

4. MT/NT404 & MT/NT 802: Characterization of Materials (M. Tech. & Ph.D.)-4 unit

5. NT-456: Advanced Characterization (M. Tech. & Ph.D.)-2 unit

6. MT414 & NT 414: Laboratory Course (M. Tech. & Ph.D.)-4 units

7. NT415 & MT415: Graduate Seminar (M. Tech. & Ph.D.)-2 units

M. Tech. thesis guidance/completed -Awarded:

1. ‘Core shell Nanostructure of PCL, PCL@SiO2, ZnO-SiO2 and Their Physical Properties and Biomedical Applications- completed by Vijay Bhooshon Kumar (completed on 2012)

2. Towards the Synthesis of ZnO/SiO2-ZnO Nanocapsules for Biomedical Applications, Saranaya Murali, 2012 (April), M. Sc.-Nano.

3. SYNTHESIS AND CHARACTERIZATION OF GRAPHENE OXIDE-SILICA HYBRID NANOCOMPOSITE FOR BIO-APPLICATIONS’, COMPLETED By Santhosh Kumar (Year 2012)

4. Synthesis and Characterization of Porous Micro and Nanocapsules of Block Copolymers as a Potential Vector for Drug Delivery (Awarded, Dec 2013), by Chander A.

5. ‘Studies on the Physical Properties of Conducting Polymer Nanofibers Dispersed Liquidcrystals’, (Awarded April 2014), by Ramesh Manda

6. “Polymeric Hollow Nanocapsule and Mesoporous Silica Nanoparticle as Drug Delivery System” Master of Pharmacy (Pharmaceutics), Department of Biotechnology and Bioinformatics, faculty of Pharmaceutical Sciences, University of Pune, 29-09-2014

7. Nanoformulation of Monodispersed Porous Polymer Nanocapsules for Sustained Drug Delivery , (Awarded, July 2013), by Himadri Medhi

8. “Designing of Mesoporous hollow SiO2-ZnO Nano capsules and It’s Biomedical applications” – Awarded, 2016, Mr.

Gopobandhu Panigrahi

9. “Complex nanostructures of Copper (II) Oxide dispersed and immobilized on Silica Template: Structure and antibacterial properties” –

Awarded 2016, MR. Dhiman Bonik

10. Complex Metal and Alloy for Antibacterial Activities--- Ghunta Rajesh –Award due 2017 (July)

Ph.D. Thesis guidance:

1. Virus-polymer Bioconjugation for Drug Delivery-by Koushi Kumar (regular, thesis submitted, awaiting award)

2. Graphene-polymer-functional and Hybrid nanocomposites for Drug delivery – by Santhosh Kumar (regular, submitted,

awaiting award)

3. Amino acid based Polymeric Nanocapsules for Drug Delivery…Chander A. (regular, thesis submitted) Due

submission Oct, 2017

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4. Synthesis of New Bio-Polymers and Their uses in making Nanomedicines by Anil Kumar (regular, thesis work

completed), Submission due, Dec 2017

5. Hydrophobic polymers Nanocapsules for Drug Delivery’, by Himadri Medhi (regular), Submission due, May 2017

6. Meta and Fluorescent Materials for Biomedical Applications …Monami Das Modak (regular)

7. Polymeric Nanocapsules for Drug delivery…….Debasrita Bharatiya (regular)

8. Nanocapsule from Plant Virus for Nanomedicines (regular) ..Monica Pandey (regular)

9. Materials for Breast Cancer Treatment. By Somedutta Maity (regular)

Others:

1. Investigations on stability and efficiency improvement of modified Cd-chalcogenide nanostructure hybrid composite film

for photoelectrochemical H2 generation, by Alka Parek (Awarded)

2. Magnetic properties of amorphous AlPO4-Metal nanocluster composites for the applications in magnetic systems, by

Rajalaxmi Maharana (Awarded)

Research Projects:

Ongoing and Sanctioned: 1. Programming protective humoral responses with Nanoparticle based novel vaccine formulations against Dengue Virus,

sanctioned March 2014 by DBT, (2014-2017) for 3 year, Rs. 64.15 Lakhs (Co-PI), 2. Programming Protective Humoral responses with novel vaccine formulations against Dengue Virus (Co-PI), DST

Nanomission, 2014-2017, 69.15 Lakhs 3. Functional-hollow-porous-biopolymer based Nanoformulations and Interventions of Tuberculosis: concept of

nanomedicine with multiple drugs against MTB, DST Nano mission 2017-2020, ~57.00 Lakhs 4. Neem-seed based Nanocapules and nanomedicine for targeted drug delivery and cancer therapy, (PI), DST-SERB,

2017-2020, 40.33 Lakhs 5. Device fabrication of nanostructured carbon decorated with metal nanoparticle loaded metal doped

monochalocogenides: Performance evaluation with commercially available thermoelectric devices. DST-INPRINT, 2017-2020 (with IIT Kanpur) (Total value 200 Lakhs), co-Investigator

Project Completed:

1. Development of CPMV-block-copolymer Bioconjugate Nanoparticles and Synthesis of Functional Nanocapsules with

High Stability for Medical Applications, Funded by DST(SERC/ET-0162/2011)-3 years, 19.44 Lakhs ( August, 2012-2016). (PI)

2. Silicone Rubber Composites with inorganic fillers for Insulation applications, BHEL, 1 year, 17.15 Lakhs (Consultancy project, Started August, 2013). (PI), (2013-2016)

3. PCL-Poly Amino acid based Nanomedicine for Co-treatment of Cancer and Tuberculosis, UPE-II network project, 3.5 Lakhs (Year 2015-2016)

4. Photosensitive Mesoporous and Core-shell-polymer Nanoparticles Composites for Cancer Treatment, UPE-II, 3 lakhs (2012-2013)

5. Identification of a novel anti-malarial drug target: study of Plasmodium falciparum TopoisomeraseVI, UPE-II, 3 lakhs (2012-13)

6. Start-of-Grant -3 Lakhs, 2011, UOH 7. Silicone Rubber Composites with inorganic fillers for Insulation applications, BHEL, 1 year, 17.15 Lakhs (Consultancy

project, Started August, 2013), (PI), (2013-2014) 8. XIth

Plan budget for research facilities Development: (2011-2014, 125.00 Lakhs, UGC-UOH

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PATENTS and PUBLICATIONS:

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Patents Applications filled:

14. Biopolymer Hydrogel for tissue engineering thereof (Patent application pending, 2017)

13. Amino acid based polymer capsules for antibacterial and cancer therapy thereof (Patent application pending, 2017

12. Hollow-porous Polymer Nano capsules and formulation for therapeutics of multiple diseases (cancer and MTB) thereof. (Patent application pending, 2017)

11. Poly-N-Acryloyl L-Leucine Methyl Ester Hollow Nanocapsules (pLME) for Drug Delivery & Antibacterial Properties: Method of

Fabrication and uses (Ref: Patent application, October 2017)

10. Up-conversion nanoparticle dot (UCN–dot) of size 3.5 nm & its preparation process thereof. (Ref: TEMP/E-1/21071/2017CHE, dt.: 14/06/2017)

9. Stable up-conversion nanoparticle dendrimer (UCND) & method of making thereof. (Ref:TEMP/E-1/21065/2017CHE, dt.: 14/06/2017)

8. Stable up-conversion nanoparticle super lattice (UCN-SL) & in-situ process for developing thereof (Ref:TEMP/E-1/21071/2017CHE, dt.: 14/06/2017)

7. Green synthesis of biocompatible porous and hollow zinc phosphate nano capsules using cow pea mosaic virus (CPMV)” (Ref: 201641031985, dated: 20th Sept. 2016)

6. “Development of hollow nanoporous yolk shell nanocapsules from neem seed thereof” (Ref: 201641031995, dated: 20th Sept. 2016)

5. “A process for preparation and design of a unique nano porous polymeric capsules of (MeO-PEG-NH)-b-(L-GluA)-PCL thereof” (Ref: 201641031990, dated: 20th Sept. 2016)

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4. A process for preparation of nanoparticles of high molecular weight of polystyrene, Inventers: Kamal Krishna Kar and Pradip Paik, References: 1136/DEL/2013, Date: 17th April, 2013

3. Title: A process for preparation of nanoparticles of high molecular weight of polypropylene, Inventers: Kamal Krishna Kar and Pradip Paik, References: 1135/DEL/2013, Date: 17th April, 2013

2. Kamal K Kar and Pradip Paik ‘A Process for Preparation of micron sized High molecular weight Polymer,’ Indian Pat. Appl. (2006), 94pp; Application: IN 2004-DE2503, 20041216.

1. Kamal K Kar and Pradip Paik ‘High molecular weight Nano sized Polyethylene, Polypropylene and Polystyrene: Controlled Preparation and its Characterization,’ Indian Pat. Appl. (2007), 39pp, Application: IN 2005-DE3161, 20051125.

Book:

1. Synthesis and Characterization of Nanopolymers: Polypropylene, Polyethylene and Polystyrene, by Pradip Paik, ISBN: 978-3-659-29646-8, LAP LAMBERT Academic Publishing GmbH & Co. KG, Heinrich-Böcking-Str. 6-8, 66121, Saarbrücken, Germany (2013)

Book Chapters:

1. “Polystyrene Nanospheres”, in the book “Developments in Nanocomposites”, (accepted, June, 2011), Singapore, Editors: Prof. Kamal K. Kar & Dr. Alma Hodzic, (ISBN : 978-981-08-3711-2) ‘Advanced Polymer Nanoparticles: Synthesis and Applications’, Pradip Paik and V. B. Kumar, (Accepted, 2011)

2. ‘Advanced Polymer Nanoparticles: Synthesis and Applications’, in the book “Developments in Nanocomposites”, (Accepted, October, 2011), Singapore, Editors: Prof. Kamal K. Kar & Dr. Alma Hodzic ISBN : 978-981-08-3711-2, Pradip Paik and V. B. Kumar, (Accepted, 2011)

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3. ‘POLYMERS FOR DRUG DELIVERY SYSTEMS’, in Book “Nanotechnology in Animal Health and Production, Chander A., Koushi Kumar, Himadri Medhi, Pradip Paik, ISBN: 9789351243182, Astral International (P) Ltd. New Delhi, Year 2014

Publications in Peer Reviewed Journals:

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Manuscripts Communicated

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56. Fabrication of High Efficiency CdS photoanodes: Surface modification by polypyrrole and polyaniline layer, (Communicate, 2017)

55. Aminoacid based Biopolymer Hydrogel for tissue engineering, RSC, Communicated (2017) 54. Hollow ZnPO4 nanocapsules and targeted cancer therapy, Communicated, (2017) 53. Plate-like-coral Polymer capsules with dendritic structure and nanoporous channels: targeted delivery vehicle for

anticancer drugs, Communicated, (2017) 52. Himadri Medhi and Pradip Paik, Mesoporous Surface Functionalized Porous Polymer Nanocapsules for Delivery of

Antimalaria Activities, Communicated (2017).

PUBLISHED

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------------------------------------------------ 51. Seed Geometry and Hydrogen Bonding Dependent Plasmonic Tuning of Silver Nanocrystals in Citrate-Hydrazine Matrix

and SERS Spectroscopic Detection of Chromium, RSC Adv., 2017, 7, 45911-45919. (IF: 3.1) 50. Poly N-acryloyl-(L-phenyl alanine methyl ester) hollow nanocapsules facilitate sustained delivery of immunomodulatory

drugs and exhibit adjuvant properties, Nanoscale, 2017,9, 14006-14014 (I.F.: 7.8)

49. ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses, Nanoscale, 2017 (Accepted, August, 2017), 10.1039/C7NR03697C (I.F.: 7.8)

48. Graphene Oxide for Biomedical Applications, J Nanomed. Res, 2017, 5(6): 00136. DOI: 10.15406/jnmr.2017.05.00136, (I.F: waiting)

47. Koushi Kumar, Vasudeva Rao Penugurti, Gila Levi, Yitzhak Mastai, Bramanandam Manavathi and Pradip Paik, Bio-inspired synthesis of Hierarchical Self-Assembled Zinc phosphate nanostructure in presence of Cowpea Mosaic Virus: in vitro cell cycle, proliferation and prospective for tissue regeneration, Biomedical Materials 2017 Aug 8. doi: 10.1088/1748-605X/aa84e9. (I.F: 2.7)

46. Vijay Bhooshon Kumar, Himadri Medhi, Yong Zhang, Pradip Paik, Designing idiosyncratic hmPCL-siRNA Nanoformulated Capsules for Silencing and Cancer Therapy, Nanomedicine: Nanotechnology, Biology, and Medicine 2016, 12(3)579-588. (IF: 6.692)

45. Chander Amgoth, Gangappa Dharmapuri, Arunasree M. Kalle and Pradip Paik, Nanoporous capsules of

block co-polymer of [(MeO-PEG-NH)-b-(L-GluA)]-PCL for control release of anticancer drugs for

therapeutic applications, Nanotechnology 27 (2016) 125101 (12pp). (IF: 3.573)

44. Vijay Bhooshon Kumar, Pradip Paik, Twining ZnO nanoparticles to nanorods with control growth and size-shape dependent interactions with cancer cells: physical properties matter to up-take of cancer cells, Advanced Materials Letters, 7th Dec 2016 (DOI: 10.5185/amlett.2017.6474), (IF: 1.2)

43. Sudip Mukherjee, Bonda Rama Rao, Sreedhar B, Pradip Paik and Chittaranjan Patra, Copper Prussian blue analogue: Investigation into multifunctional activities for biomedical applications, Chem. Commun., 2015,51, 7325-7328.

(IF: 6.567)

42. Koushi Kumar, Arunasree MK. Pradip Paik, CPMV induced synthesis of Hollow-meso porous SiO2 Nanocapsules with excellent performance in Drug delivery, Dalton Trans., 2015,44, 4308-4317. (IF: 4.177)

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41. Vijay Bhooshon Kumar, Aharon Gedanken, Pradip Paik. Facile Synthesis of Self-Assembled Spherical and Mesoporous

Dandelion Capsules of ZnO: Efficient Carrier for DNA and Anti-cancer Drugs, J. Mater. Chem. B, 2014, 2, 3956-3964.

(IF: 4.872)

40. Qasim M, Singh BR, Naqvi AH, Paik P, Das D. Silver nanoparticles embedded mesoporous SiO

nanosphere: an effective anticandidal agent against Candida albicans 077. Nanotechnology. 2015 Jul 17;

26(28):285102. doi: 10.1088/0957-4484/26/28/285102. (IF: 3.787)

39. Vijay Bhooshan Kumar, Madhavi Annamanedi, Muvva Durga Prashad, Kalle M. Arunasree, Yitzhak Mastai, Aharon Gedanken, Pradip Paik, Synthesis of Mesoporous SiO2-ZnO Nanocapsules: Encapsulation of Small Bio-molecules for Drugs and ‘SiOZO-plex’ for Gene Delivery, Journal of Nanoparticle Research, Accepted, 26th July, 2013, 15:1904

(page 1-13) (DOI: 10.1007/s11051-013-1904-y). (IF: 2.278)

38. A. Pareek, P. Paik, and P. H. Borse, Stable Hydrogen Generation from Ni and Co based co-catalysts

supported CdS PEC Cell, Dalton Trans., 2016, 45, 11120-11128., (IF: 4.177)

37. Alka Pareek, H. G. Kim, Pradip Paik and Pramod H. Borse, Ultrathin MoS2-MoO3 nanosheets

functionalized CdS photoanodes for effective charge transfer in a photoelectrochemical (PEC) cell, J. Mater.

Chem. A, Dec 2016, Accepted Manuscript, DOI: 10.1039/C6TA09122A, (IF: 8.252)

36. Pareek, Alka; Kim, Hyun Gyu; Paik, Pradip; Joardar, Joydip; Borse, Pramod, Nano-architecture

based photoelectrochemical water oxidation efficiency enhancement by CdS photoanodes;

Materials Research Express 2016, Accepted. Jan. 2017, (Article reference: MRX-103515) (IF: )

35. K. Santhosh Kumar, Pradip Paik, High Dielectric Constant SiO2 Nanoparticles” Advanced Materials

Proceedings, 1(1), 114-117, 2016, (IF :)

34. K Santhosh Kumar, Srinath Sanyadanam and Pradip Paik, Dangling ultrafine nano silica on graphene

oxide to form hybrid nanocomposite: enhancement of dielectric properties, Materials Research

Express, 055019(1-15), 3(5) 2016. (IF :)

33. Rajalaxmi Maharana, V. V. Bhanu Prasad, Durga Prasad, Koushi Kumar, Neha Hebalkar, Pradip Paik, Subir Roy, Synthesis of high temperature stable carbon coated metal nanoparticles in AlPO4 based matrix in-situ in oxidative

atmosphere, Journal of the American Ceramic Society 2016, 99(1),64-71. (IF: 2.787)

32. K. Santhosh Kumar and Pradip Paik, A New Single/Few-layered Graphene Oxide with a high Dielectric Constant of 106:

Contribution of defects and functional groups, RSC Adv., 2015, 5, 14768-14779. (IF: 3.289 ) 31. Alka Pareek, Pradip Paik and Pramodh H. Borse, Nano-niobia Modification of CdS photoanode for an Efficient and

Stable Photoelectrochemical cell, Langmuir 2014, 30, 15540−15549. (IF: 3.993 )

30. Mohd Qasim, J. Ananthaiah, S. Dhara, P. Paik, and D. Das, Synthesis and Characterization of ultra-fine colloidal silica

nanoparticles, Adv. Sci. Eng. Med. 6, 965-973 (2014). (IF: )

29. M. V. Rasna, K. P. Zuhail, R. Manda, P. Paik, S Dhara, Bistable conductivity and Photothermal Switching of liquid crystal

conducting polymer composites, Phys. Rev. E 89, 052503, 2014. (IF: 2.288)

28. Rajalaxmi Maharana, M. Manivel Raja, V.V. Bhanu Prasad , Pradip Paik, Subir Roy, Synthesis and studies of magnetic

properties of high temperature stable Ni nanoparticles in nearly amorphous AlPO4 matrix in oxidative atmosphere, J.

Mater. Chem. C, 2014, 2, 5142-5148. (IF: 5.066) 27. A. Pareek, P. Paik and P.H. Borse, Characterization of Nano-Titania Modified CdS /Polysulfide Electrolyte Interface by

Utilizing Mott Schottky and Electrochemical Impedance Spectroscopy, Electroanalysis 2014, 26, 2403 – 2407. (IF: 2.872)

26. Alka Pareek, Rahul Purbia, Pradip Paik, · Neha Y. Hebalkar, · Hyun Gyu Kim, · Pramod H. Borse, Stabilizing effect in nano-titania functionalized CdS photoanode for sustained hydrogen generation, International Journal of Hydrogen

Energy, 2014, 2014, 39(9), 18 4170–4180. (IF: 3.313)

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25. Ramesh Manda, K. Santhosh Kumar, A. Chandar, Pradip Paik, Polyaniline Nanotubes with Rectangular-Hollow-Core and its Self-assembled Surface Decoration: high conductivity and dielectric properties, RSC Adv., 2014, 4, 12342-

12352. (IF: 3.289)

24. R. Manda, V. Dasari, P. Satayanarayana, N. V. Rasna, S. Dhara, P. Paik, Colloidal Suspension of Nanopolymers of

Conducting Polymers in nimetic Liquid Crystals and Their anisotropic Physical Properties, Applied Physics Letter,

2013, 103, 141910. (IF: 3.142) 23. Vijay Bhooshon Kumar, Aharon Gedanken, Pradip Paik, Triangular core shell ZnO@SiO2 nanoparticles,

ChemPhysChem, 2013, 14(14)3215-3220. (IF: 3.138)

22. Satarupa Pattanayak, Amiya Priyam and Pradip Paik, Facile tuning of plasmon bands in hollow silver nanoshells

using mild reductant and mild stabilizer, Dalton Trans., 2013,42, 10597-10607. (IF: 4.177)

21. K. Santhosh Kumar, Vijay Bhooshan Kumar, and Pradip Paik, Recent Advancement in Functional Core-

Shell Nanoparticles of Polymers: Synthesis, Physical Properties and Applications in Medical Biotechnology

(review Article), Journal of Nanoparticles. 2013, Vol (2013)1-24 pages, Article ID 672059,

(http://dx.doi.org/10.1155/2013/672059). (IF: )

20. Pradip Paik, Yitzhak Mastai, Iwan Kityk, Piort Rakus, Aharon Gedanken, Synthesis of amino acid block-copolymer imprinted chiral mesoporous silica and its acoustically-induced optical Kerr effects, Journal of Solid State Chemistry,

2012, 192, 127-131. (IF: 2.133)

19. P. Suresh Kumar, Pradip Paik, D. Mangalaraj, Aharon Gedanken, D. Nataraj, Biodegradability study and

pH Influence on growth and orientation of ZnO nanorods via aqueous solution Process, Applied Surface

Science, 2012, 258, 6765–6771. (IF: )

18. Pradip Paik, Yong Zhang, Synthesis of Hollow and Mesoporous Polycaprolactone Nanocapsules, Nanoscale, 2011, 3,

2215-2219. (IF: 7.760)

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17. Pradip Paik, Aharon Gedanken and Yitzhak Mastai, Chiral-mesoporous-polypyrrole Nanoparticles: Its Chiral Recognition Abilities and Use in Enantioselective Separation, Journal of Materials Chemistry, 2010, 20, 4085-4093.

(IF: 6.626)

16. Pradip Paik, Aharon Gedanken and Yitzhak Mastai, Chiral Separation Abilities: Aspartic Acid Block Copolymer-

imprinted Mesoporous Silica, Microporous and Mesoporous Materials, 2010, 129, 82-89. (IF: 3.349)

15. Pradip Paik, Aharon Gedanken and Yitzhak Mastai, Enantioselective Separation Using Chiral Mesoporous Spherical Silica Prepared by Templating of Chiral Block Copolymers, ACS Applied Materials & Interfaces, 2009, 1(8), 1834-

1842. (IF: 7.145) 14. Pradip Paik and Kamal K. Kar, 'Polypropylene Nanosphere: Particle Size and Crystal Structure, International Journal

of Plastics Technology, 2009, 13(1), 68-82. (IF: )

13. Pradip Paik and Kamal K. Kar, Thermal Degradation Kinetics and Estimation of Lifetime of Polyethylene Particles:

Effects of Particle Size, Materials Chemistry and Physics, 2009, 113, 953–961. (IF: 2.101)

12. Pradip Paik and Kamal K. Kar, Surface Roughness and Morphology of Polypropylene Nanospheres: Effects of Particles

Size, Surface Engineering, 2008, 24(5), 341-349. (IF: )

11. Pradip Paik and Kamal K. Kar, Kinetics of Thermal Degradation and Estimation of Lifetime for Polypropylene Particles:

Effects of Particle Size, Polymer Degradation and Stability, 2008, 93, 24-35. (IF: 3.553)

10. Pradip Paik and Kamal K Kar, High Molecular Weight Polyethylene Nanospheres: Synthesis Physical and Mechanical

Properties, Journal of Nanoscience and Nanotechnology, 2008, 8, 3123-3135. (IF: 1.6)

9. Pradip Paik, Kamal K. Kar, Dinesh Deva and Ashutosh Sharma, Measurement of Mechanical Properties of Polymer

Nanospheres by Atomic Force Microscopy: Effects of Particle Size, Micro & Nano Letters, 2007, 2(3), 72-77. (IF: 1.5)

8. Pradip Paik and Kamal K. Kar, High Molecular Weight Polypropylene Nanospheres: Synthesis and Characterization,

Journal of Applied Polymer Science, 2007, 105(3), 1133-1143. (IF:1.6)

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7. Pradip Paik and Kamal K. Kar. Physical and mechanical properties of high molecular weight polystyrene nanoparticles.

ANTEC - Society of Plastics Engineers, 2010, 68, 1724-1728. (IF: )

6. Pradip Paik and Kamal K. Kar. ‘High Molecular Weight (MW) Nano Sized Polyethylene (PE): Effect of Particle Size,

Macro-Micro-Nano,’ ANTEC - Society of Plastics Engineers, 2007, 65th, 543-547 (in USA). (IF: )

5. Pradip Paik and Kamal K. Kar. ‘Glass Transition Temperature of High Molecular Weight Polystyrene: Effect of Particle

Size, Bulk to Micron to Nano,’ NSTI Nanotech, 2006, 1, 483-486 (in USA). (IF: )

4. Kamal K. Kar; Pradip Pradip; Suresrao, A. S. and Otaigbe, Joshua U. ‘Scanning Electron microscopy, Spectroscopy and Viscoelastic Studies of Nano Low Density Polyethylene,’ ANTEC - Society of Plastics Engineers, 2004, 62 (2),

2505-2509, (in USA). (IF: ) 3. Kamal K. Kar; Pradip Pradip Kumar, Rakesh; and Otaigbe, Joshua U. ‘Synthesis and Characterization of Nano-

polystyrene: Effect of Temperature, Shear Rate and Solvents,’ ANTEC - Society of Plastics Engineers, 2004, 62 (2),

2500-2504, (in USA). (IF: ) 2. Kamal K. Kar; Pradip Pradip; Otaigbe and Joshua U. ‘Characterization of Structure and Viscoelastic Properties of

Polypropylene Nanopolymer,’ ANTEC - Society of Plastics Engineers, 2004, 62 (2), 2495-2499, (in USA). (IF: ) 1. Kamal K. Kar; Pradip Pradip and Otaigbe, Joshua U. ‘Synthesis and Characterization of Nanopolymer: High Density

Polyethylene,’ ANTEC - Society of Plastics Engineers, 2004, 62 (2), 2490-2494. (IF: )

Conferences and Proceedings:

58. Monica Pandey, Ganta Rajesh, S. Chennakesavulu, Aramati BM Reddy,Pradip Paik, Mixed Metal Oxide nanoparticles for antibacterial studies, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

57. Koushi Kumar, Vasudevarao Penugurti, Gila Levi, Yitzhak Mastai, Bramanandam Manavathi, Pradip Paik, Hierarchical Self-Assembled Zinc phosphate nanostructure in presence of Cowpea Mosaic Virus: in vitro cell cycle, proliferation and prospective for tissue regeneration, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

56. Himadri Medhi, Sumbul Afroz, Somedutta Maity, Nooruddin Khan Pradip Paik, Nanostructured mesoporous

ZnO material for the enrichment of immunological response, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

55. Debasrita Bharatiya, Pradip Paik The Synthesis and Study of AB, BC and ABC Types of Bio-Compatible Amio-Acids Based Block Copolymers for Biomedical Applications, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

54. Anil Kumar Yamala,Vinod Nadella, Yitzhak Mastai, Hridayesh Prakash, , Pradip Paik, NAPA-HPN’s nanocapsules: sustained delivery of immunomodulatory drugs and adjuvant properties, NanoSciTech 2017, 9-10 Nov. 2017, Punjab University, (INVITED TALK)

53. Anil Kumar Yamala,Vinod Nadella, Hridayesh Prakash, , Pradip Paik NAPA-HPN’s nanocapsules for sustained delivery of immunomodulatory drugs and its adjuvant properties, BioQuest-2017, UOH, 12-13 Oct, 2017(Poster)

52. Paik, Pradip, Paper Presented: Invited Talk: Hollow Polymer Nanocapsules for siRNA silencing and Cancer therapy, conf-ICFM-IITKgp (12-14/12/2016

51. Paik , Pradip “NO” delivery through crossed-linked polymer capsules, LP Prasad Eye Institute, DBT-MRC WORKSHOP, together with University of Bradford and LV-Prasad, (Feb -2017)

50. Pradip Paik, Functional Porous-Hollow-Polymeric Micro and Nanocapsules and their Formulations for Nanomedicine, NSMF, NIT Durgapur, February 22-24, 2016

49. Chander Amgoth, Pradip Paik*, Amino Acid Based Porous Polymer Capsules for Drug delivery Cancer Diagnostics and Treatment, NanoSciTech 2016/Panjab University/18-20Feb 2016

48. Himadri Medhi, S. Chalapareddy, M. K. Bhattacharyya, P. Paik*, Mesoporous polymer capsules for preventing activity of Malaria P. falciparum, NanoSciTech 2016/Panjab University/18-20Feb 2016

47. Koushi Kumar U. and Pradip Paik*, Cow pea mosaic virus mediated SiO2 capsules in Drug delivery and cancer therapy,

NanoSciTech 2016/Panjab University/18-20Feb 2016

46. Pradip Paik, Idiosyncratic Porous-Hollow-Polymeric Nanocapsules and Nanoformulations for DNA, siRNA Silencing and Cancer Therapy, NanoSciTech 2016/Panjab University/18-20Feb 2016

45. K Santhosh Kumar and Pradip Paik, “High Dielectric Constant Silica Nanoparticles” International conference on Materials Science and Technology (ICMTECH-2016), 1st-4th March, 2016, University of Delhi, Delhi, India.

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44. K Santhosh Kumar and Pradip Paik, “Defects and Functional Groups Yield High Dielectric Constant in Graphene Oxide” International Union of Materials Research Societies- International conference on Electronic Materials (IUMRS-ICEM 2016), 4th -8th July, 2016, Suntec, Singapore.

43. K Santhosh Kumar and Pradip Paik, “Graphene Oxide with a High Dielectric Constant: Contribution of Functional Groups and Defects” National Conference on Advances in Materials Processing and Characterization, 4th-6th January, 2016, NIT Warangal, Telangana, India.

42. K Santhosh Kumar and Pradip Paik, “High Dielectric Constant Silica Nanoparticles” International conference on Materials Science and Technology (ICMTECH-2016), 1st-4th March, 2016, University of Delhi, Delhi, India.

41. K Santhosh Kumar and Pradip Paik, “Defects and Functional Groups Yield High Dielectric Constant in Graphene Oxide” International Union of Materials Research Societies- International conference on Electronic Materials (IUMRS-ICEM 2016), 4th -8th July, 2016, Suntec, Singapore.

40. Koushi Kumar U and Pradip Paik, Hollow-porous SiO2 Nanocapsules using CPMV: Nanoformulation in Drug delivery and cancer therapy, ICANN2015 IITG (03-12-2015)

39. Pradip Paik* K. Santhosh Kumar, Synthesis and dielectric properties of Rectangular Hallow Core Polyaniline Nanotubes, ICANN2015 IITG (03-12-2015).

38. K. Santhosh Kumar and Pradip Paik, Synthesis of Graphene Oxide with a High Dielectric Constant: Contribution of Functional Groups and Defects, ICANN2015 IITG (03-12-2015)

37. Himadri Medhi, S. Chalapareddy, M. K. Bhattacharyya, P. Paik, Mesoporous polymer capsules for suppressing the activity of Malaria P. falciparum, ICANN2015 IITG(03-12-2015)

36. Chander Amgoth, Pradip Paik, Nanoporous Polymer Capsules as Potential Drug Carrier for Cancer Diagnostics and Treatment, Proceedings of the India International Science Festival- Young Scientists’ Meet Department of Science and Technology, Government of India –Dec 4-8, 2015

35. Pradip Paik, Functional Nano porous Materials, AMEEA 2015, (National Conference on Advanced Materials for Energy and Environmental Applications), 18th 20th March 25, 2015, Bharatiar University, Quambatore

34. Paper name: Electrochemical characterization of Ag loaded nano-titania modified CdS /polysulphide electrolyte interface, Best oral presentation award (first) (Ms. Alka Pareek, Ph.D. scholar ), International Conference on Environment and Energy (ICEE-2014), December 15th -17th 2014, JNTU, Hyderabad, (Authors name: Alka Pareek, Dr. Pradip Paik, Dr. P.H. Borse).

33. Vijay. Bhooshan Kumar, Koushi Kumar, Aharon Gedanken and Pradip Paik, Self-Assembled Spherical and Mesoporous Dandelion Capsules of ZnO: formation of {(ZnO)n

+δ-(DOX)m} and {(ZnO)nδ+-(DNA)m} for drug and gene delivery, Polymeric

Biomaterials, Bioengineering and Biodiagonestices, October 27th -30th , 2014, IIT Delhi. 32. Vijay Bhooshan Kumar, Koushi Kumar1, Yitzhak Mastai2, Aharon Gedanken2, Pradip Paik1 SiOZO-plex: Complex of

Mesoporous Nanoparticles of SiO2-ZnO with DNA for therapeutic applications, NANO 2014, Moscow, Lomonosov

Moscow State University, Russia on July 13 – 18, 2014.

31. Koushi Kumay, Pradip Paik,Virus Templated Mesoporous Hollow Biosilica Nanocapsules for Drug Delivery, Polymeric Biomaterials, Bioengineering and Biodiagonestices, October 27th -30th , 2014, IIT Delhi

30. Chandar A, Koushi Kumay, Pradip Paik, Block Copolymer Based Micro & Nano Capsules as a Potential Carrier for Drug Delivery, Polymeric Biomaterials, Bioengineering and Biodiagonestices, October 27th -30th , 2014, IIT Delhi

29. Vijay Bhooshan Kumar, Koushi Kumar, Yitzhak Mastai, Aharon Gedanken, Pradip Paik, Mesoporous SiOZO-plex: Mechanistic approach, Complex of Nanoparticles of SiO2-ZnO with DNA for Therapeutic Applications, 26th European Conference on Biomaterials, University of Liverpool, Liverpool, 31st August – 3rd September 2014

28. A.Pareek, N. Y. Hebalkar, P. Paik and P.H. Borse, Characterization of nano-titania modified CdS /polysulphide electrolyte interface by utilizing electrochemical impedance spectroscopy, 11th ISEAC-DM-2014, -Feb 2014

27. Himadri Medhi*, Chandar A, Koushi Kumar, Pradip Paik, Porous Surface Functionalized Polymers Nanocapsules for Drug Delivery, IU-MRS, Dec 16-22, 2013, IISC Bangalore.

26. RAJALAXMI MAHARANA, V.V.BHANU PRASAD,M.MANIVEL RAJA, PRADIP PAIK,SUBIR ROY, Ageing effect of ferromagnetic Ni nanoparticles embedded in AlPO4 matrix calcined at high temperatures, IU-MRS, Dec 16-22, 2013, IISC Bangalore.

25. Chander Amgoth, Koushi Kumar, Himadri Medhi, Pradip Paik, Amino Acid based Surfactant Free Porous Block-

copolymer Micro and Nanocarriers for Drug Delivery, IU-MRS, Dec 16-22, 2013, IISC Bangalore

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24. Pradip Paik, Vijay Bhooshan Kumar, Aharon Gedanken, Synthesis of Triangular core shell ZnO@SiO2 nanoparticles

and its spectroscopic confinement, IU-MRS, Dec 16-22, 2013, IISC Bangalore.

23. Vijay Bhooshan Kumar, Koushi Kumar, Yitzhak Mastai, Aharon Gedanken, Pradip Paik, SiOZO-plex for Gene Delivery,

IU-MRS, Dec 16-22, 2013, IISC Bangalore.

22. Alka Pareek, Pradip Paik, P. H. Borse, Stability improvement of CdS photoanode by control over adsorbed titania

nanoparticles phase, IU-MRS, Dec 16-22, 2013, IISC Bangalore.

21. Chander Amgoth, Koushi Kumar, Himadri Medhi, Pradip Paik, Surfactant Free Porous Block-copolymer Based Micro and Nanocarriers for Drug Delivery, International Conference on Advanced Polymeric Materials (ICAPM 2013), Mahatmagandgi University, Kottayam.

20. Himadri Medhi, Chandar A, Koushi Kumar, Pradip Paik, Surface Functionalized Porous Polymer Nanocapsules for Drug Delivery Applications, International Conference on Advanced Polymeric Materials (ICAPM 2013), Mahatmagandgi University, Kottayam.

19. Pradip Paik, Designing of Functional Polymeric Nanocapsules for Drugs and Gene Delivery, International Conference on Advanced Polymeric Materials (ICAPM 2013), October 2013, Mahatmagandgi university, Kottayam.

18. Pradip Paik, Designing of Polymer Nanocapsules for Drugs and Gene Delivery, Meditech'13, 08th March, 2013, MEDITECH, Department of Biomedical Engineering, University College of Engineering, Osmania University.

17. Satarupa Pattanayak, Pradip Paik, Amiya Priyam, Gamma-radiation assisted synthesis of hollow gold nanoshells with tunable plasmon bands, DAE-BRNS- 4th INTERdISCIPLINARY SYMPOSIUM, December 11-15, 2012 Venue: Bhabha Atomic Research Center, Mumbai.

16. Pradip Paik*, Imprinting Mesopores in Nano Materials, NEMPIQI (National Conference, Hyderabad, October 19-20,

2012).

15. Vijay Bhooshan Kumar, M K Arunasree, Pradip Paik, ZnO-Silica nanocapsules with mesopores and Encapsulation of

Small Molecules for Delivery Applications, ANM 2012, IIT Madras, October, 17-19th 2012.

14. Md. Quasim, Pradip Paik, Dibakar Das, et al. Synthesis and antifungal activity against Candida albicans of Ag

nanopartilces embedded mesoporous SiO2 nanosphere, 9th International Conference on Nanosciences &

Nanotechnologies (NN12) 3-6 July 2012, Thessaloniki, Greece.

12. Md. Quasim, Pradip Paik, Dibakar Das, et al. Tuning of Silica Nanoparticles with porous network structure through

modified Stober Method: Drug delivery applications, 9th International Conference on Nanosciences & Nanotechnologies

(NN12) 3-6 July 2012, Thessaloniki, Greece.

12. Vijay Bhooshan Kumar, Madhavi Annamanedi and Kalle M, Aruna sree, Pradip Paik, A new way to Synthesis of Mesoporous Silica - Zinc oxide (SiO2-ZnO) nanocapsules and their use in Biomedical Application, EMRS - 2012 spring meeting, 14-18th May, 2012, France.

11. Pradip Paik, Novel Polymer Nanocapsules @hollow-core and mesoporous-shell for Nucleic Acid Delivery, ICONSEAT-2012, Jan-20-23rd, 2012, Hyderabad.

10. Imprinting Chirality in Mesoporous Nanomaterials and its Use for Enantiomeric Separation (Invited Lecture), International Conference on Nanomaterials and Nanotechnology, Delhi, India, 18-21 Dec, 2011

9. Chiral Mesoporous Silica: Chiral Sensing and Resolution, 65th Annual Technical Meeting of The Indian Institute of Metals, 13-16th November, 2011, Hyderabad, India.

8. Pradip Paik, Muthu Kumaran, Yong Zhang, Polycaprolactone Nanocapsules with Hollow-core@Mesoporous-shell and

its use in Gene Delivery, International Symposium: NANOPOROUS MATERIALS – VI, Alberta, Canada, August 21 to

24, 2011. 7. Pradip Paik, Yitzhak Mastai and Aharon Gedanken, Imprinting Chirality in Mesoporous Polypyrrole: Enantioselective

Separation, International Symposium: NANOPOROUS MATERIALS – VI, Alberta, Canada, and August 21 to 24, 2011.

6. Pradip Paik, Yitzhak Mastai and Aharon Gedanken. ‘Novel Synthesis of Chiral Mesoporous Silica Spheres by Chiral Block Copolymers for Enantioselective Separation, BINA Internal Conference, 29-30th June, 2009, Israel.

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5. Pradip Paik and Kamal K. Kar. Polypropylene Nanospheres: Effects of Particle Size on Physical and Mechanical Properties, Student Conference, September 23, 2008, Bar-Ilan University, Israel.

4. Pradip Paik and Kamal K. Kar. ‘Polyethylene Nanospheres: Understanding its Properties,’ International and INCOM-6 Conference, 12-14th Dec 2007, pp. 4-11 (IIT Kanpur, India).

3. Pradip Paik and Kamal K. Kar. 'Synthesis and Characterization of High Molecular Weight Nano Sized Polyethylene: effects of Particle size,' Macro-Micro-Nano'. ISAMPE National Conference on Composites INCCOM-5. November 24-25, 2006, pp. 573-582 (Hyderabad, India).

2. Rakesh Kumar, Pradip Paik, Kamal K. Kar and Jos hua U. Otaigbe, 'New Synthesis of Spherical and High Percentage Nano Polystyrene Polymer,” APT-04 2004, pp. 442-448, (Cochin, India).

1. Pradip Paik, Kamal K. Kar and Joshua U. Otaigbe, “Synthesis and Characterization of Nano Polyethylene: Influence of Temperature and Shear Rate,” APT-04 2004, pp. 841-846, (Cochin).

Abstracts for Conferences:

3. Pradip Paik, Kamal K. Kar, Dinesh Deva and Ashutosh Sharma, Measurement of elastic modulus in nanoscale region polymer film using afm: hemispherical w-tip fabricated by focused ion beam, Advance Nano Materials Conference (ANM -2006), IIT Bombay, India, 8-10 Jan, 2007.

2. Pradip Paik, Aharon Gedanken and Yitzhak Mastai, Chiral-mesoporous-polypyrrol Nanoparticles: Enantioselective Separation, ICANN 2009, Dec 9-11, 2009, IIT Guwahati, India.

1. Pradip Paik, Nanotechnology, Resolution of Chiral Molecules and the Block Copolymers, SEB Enzyme and Biocatalysis, April 25-29, 2010, Dalian, China.

Poster in Conference:

27. Monica Pandey, Ganta Rajesh, S. Chennakesavulu, Aramati BM Reddy,Pradip Paik, Mixed Metal Oxide nanoparticles for antibacterial studies, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

26. Koushi Kumar, Vasudevarao Penugurti, Gila Levi, Yitzhak Mastai, Bramanandam Manavathi, Pradip Paik, Hierarchical Self-Assembled Zinc phosphate nanostructure in presence of Cowpea Mosaic Virus: in vitro cell cycle, proliferation and prospective for tissue regeneration, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

25. Himadri Medhi, Sumbul Afroz, Somedutta Maity, Nooruddin Khan Pradip Paik, Nanostructured mesoporous ZnO material for the enrichment of immunological response, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

24. Debasrita Bharatiya, Pradip Paik The Synthesis and Study of AB, BC and ABC Types of Bio-Compatible Amio-Acids Based Block Copolymers for Biomedical Applications, NanoSciTech 2017, 9-10 Nov. 2017, (Poster)

23. Anil Kumar Yamala,Vinod Nadella, Hridayesh Prakash, , Pradip Paik NAPA-HPN’s nanocapsules for sustained delivery of immunomodulatory drugs and its adjuvant properties, BioQuest-2017, UOH, 12-13 Oct, 2017(Poster)

22. Chander Amgoth, Pradip Paik*, Amino Acid Based Porous Polymer Capsules for Drug delivery Cancer Diagnostics and Treatment, NanoSciTech 2016/Panjab University/18-20Feb 2016

21. Himadri Medhi, S. Chalapareddy, M. K. Bhattacharyya, P. Paik*, Mesoporous polymer capsules for preventing activity of Malaria P. falciparum, NanoSciTech 2016/Panjab University/18-20Feb 2016

20. Koushi Kumar U. and Pradip Paik*, Cow pea mosaic virus mediated SiO2 capsules in Drug delivery and cancer therapy,

NanoSciTech 2016/Panjab University/18-20Feb 2016.

19. K Santhosh Kumar and Pradip Paik, “Graphene Oxide with a High Dielectric Constant: Contribution of Functional Groups and Defects” National Conference on Advances in Materials Processing and Characterization, 4th-6th January, 2016, NIT Warangal, Telangana, India.

18. Koushi Kumar U and Pradip Paik, Hollow-porous SiO2 Nanocapsules using CPMV: Nanoformulation in Drug delivery and cancer therapy, ICANN2015 IITG(03-12-2015)

15. Himadri Medhi, S. Chalapareddy, M. K. Bhattacharyya, P. Paik, Mesoporous polymer capsules for suppressing the activity of Malaria P. falciparum, ICANN2015 IITG(03-12-2015)

14. Koushi Kumay, Pradip Paik,Virus Templated Mesoporous Hollow Biosilica Nanocapsules for Drug Delivery, Polymeric Biomaterials, Bioengineering and Biodiagonestices, October 27th -30th , 2014, IIT Delhi

13. Chandar A, Koushi Kumay, Pradip Paik, Block Copolymer Based Micro & Nano Capsules as a Potential Carrier for Drug Delivery, Polymeric Biomaterials, Bioengineering and Biodiagonestices, October 27th -30th , 2014, IIT Delhi

15

12. Ramesh Manda, V. Dasari, P. Sathyanarayana, M.V. Rasna, Pradip Paik, Surajit Dhara Enhancement of Physical Properties of Nematic Liquid Crystals by Doping Conducting Polymer Nanofibers, Frontier in Physics (FIP-2013) Conducted in University of Hyderabad, Hyderabad, India, September 20-22

11. Ramesh Manda, Pradip Paik V. Dasari, P. Sathyanarayana, M. V. Rasna, and Surajit Dhara, Conducting Polyaniline based Nematic Liquid Crystal Nanocomposite for LCN Switch, 20th National Conference on Liquid Crystal (NCLC-2013) conducted in Manipal Institute of Technology, Manipal, Karnataka, India. December 16 – 18th, 2013

10. Himadri Medhi*, Chandar A, Koushi Kumar, Pradip Paik, Porous Surface Functionalized Polymers Nanocapsules for Drug Delivery, IU-MRS, Dec 16-22, 2013, IISC Bangalore.

9. RAJALAXMI MAHARANA, V.V.BHANU PRASAD, M.MANIVEL RAJA, PRADIP PAIK, SUBIR ROY, Ageing effect of ferromagnetic Ni nanoparticles embedded in AlPO4 matrix calcined at high temperatures, IU-MRS, Dec 16-22, 2013, IISC Bangalore.

8. Chander Amgoth, Koushi Kumar, Himadri Medhi, Pradip Paik, Amino Acid based Surfactant Free Porous Block-

copolymer Micro and Nanocarriers for Drug Delivery, IU-MRS, Dec 16-22, 2013, IISC Bangalore

7. Chander Amgoth, Pradip Paik, Porous Block-copolymer Micro and Nanocapsules for Drug and Gene Delivery,

2nd Annual Meeting of Society of Biological Chemists, India, International conference on genomes: Mechanism

and function, 2nd - 5th December, 2013, Hyderabad

3. R. Manda, V. Dasari, P. Sathayanarayana, N. V. Rasna, P. Paik, S. Dhara, Conducting Polyaniline based Nematic Liquid Crystal Nanocomposite for Magnetically Steered LCN Switch, International Conference on Advanced Polymeric Materials (ICAPM 2013).

5. Himadri Medhi, Chandar A, Koushi Kumar, Pradip Paik, Surface Functionalized Porous Polymer Nanocapsules for Drug Delivery Applications, International Conference on Advanced Polymeric Materials (ICAPM 2013).

4. Surfactant Free Porous Block-copolymer Based Micro and Nanocarriers for Drug Delivery, International Conference on Advanced Polymeric Materials (ICAPM 2013).

3. Pradip Paik, Yitzhak Mastai and Aharon Gedanken, Imprinting Chirality in Mesoporous Polypyrrole: Enantioselective Separation, International Symposium: NANOPOROUS MATERIALS – VI, Alberta, Canada, August 21 to 24, 2011.

2. Vijay Bhooshan Kumar, M K Arunasree, Pradip Paik, ZnO-Silica nanocapsules with mesopores and Encapsulation of Small Molecules for Delivery Applications, ANM 2012, IIT, Madras, Chennai, India, October 17th – 19th, 2012.

1. Pradip Paik, Aharon Gedanken and Yitzhak Mastai, Chiral-mesoporous-polypyrrol: Its uses for Enantioselective Separation, 75th Israel Chemical Society, 25-26th January, 2010, Tel Aviv, Israel.

Invited/ Plenary Talk Talks:

37. Anil Kumar Yamala,Vinod Nadella, Yitzhak Mastai, Hridayesh Prakash, , Pradip Paik, NAPA-HPN’s nanocapsules: sustained delivery of immunomodulatory drugs and adjuvant properties, NanoSciTech 2017, 9-10 Nov. 2017, Punjab University, (INVITED TALK)

36. Engineered Mesoporous and Hollow Polymers Nanocapsules for Drug Delivery, Oral-invited talk/ UCL-USA/AFM 2017(August (14-17)2017

35. Engineering Nanocapsules and Nanobiopolymers for Nanomedicines, (Short term course on Development and Formulation of Nanoparticles Organized by School of Engineering Sciences and Technology under the aegis of UGC-HRDC, University of Hyderabad, From 20/3/2017 – 25/3/2017)

34. Measuring Mechanical Properties of Polymer Nanoparticle/Single Molecular Chains by Force-Mode-Microscopy, Short Term Course in Nanotech (20-26-03(2017), Academic Staff college, UOH

33. Sono-chemical Root for Nanotechnology, Short Term Course in Nanotech(20-26-03(2017), Academic Staff college, UOH

32. Sonochemical synthesis root of nanoparticles for various application, (Short term course on Development and Formulation of Nanoparticles Organized by School of Engineering Sciences and Technology under the aegis of UGC-HRDC, University of Hyderabad, From 20/3/2017 – 25/3/2017)

32. “NO” delivery through crossed-linked polymer capsules, DBT-MRC WORKSHOP, together with University of Bradford and LV-Prasad, (Jan 15-17-2016)

31. Invited talk: Hollow Polymer Nanocapsules for siRNA silencing and Cancer therapy, ICFM-IITKgp (12-14/12/2016)

16

30. Invited Talk (20-24 June 2016): Novel Meso-Porous and Hollow-Polymer Nanocapsules for Drug and gene Delivery and for Cancer Therapy, Seoul, South Korea, (CC3DMR 2016).

29. Guest speaker/Invited Talk (14/15-03-2016)): Mesoporous nanocapsules for targets and drug, gene delivery and therapeutic applications (in Exploring new targets and drug delivery systems using smart materials to minimize antibiotic resistance), “UK-India Centre for Advanced Technology for Minimizing Indiscriminate Use of Antibiotics,” from DBT, India and MRC, UK.; organized by L V Prasad Eye Institute, Hyderabad.

28. Invited Talk (22-02-2016): Functional Porous-Hollow-Polymeric Micro and Nanocapsules and their Formulations for Nanomedicine, NSMF 2016, NIT Durgapore.

27. Invited Talk (18-02-2016): Idiosyncratic Porous-Hollow-Polymeric Nanocapsules and Nanoformulations for DNA, siRNA Silencing and Cancer Therapy, NanoSciTech 2016/Panjab University, Chandigarh.

26. Invited Talk (16-11-2015): Thermal Analysis of Materials, UGC – Human Resource Development Centre as a Resource

Person and address the participants of the Refresher Course in Experimental Physics commencing on October 29, 2015 and concluded on November 18, 2015.

25. Invited Talk (16-11-2015): AFM- Principle & its Applications, UGC – Human Resource Development Centre as a Resource Person and address the participants of the Refresher Course in Experimental Physics commencing on October 29, 2015 and concluded on November 18, 2015.

24. Invited Talk: Polymer Nanoparticles for Nanomedicine, Formulation development of Nanoparticles-Application to Pharma Industry, 20-08-2015, UGC- Human Resource Development Centre, JNTU Hyderabad

23. Invited Talk: Functional Nano porous Materials, AMEEA 2015, (National Conference on Advanced Materials for Energy and Environmental Applications), 18th 20th March 25, 2015, Bharatier University, Coambatore

22. Invited Talk: Novel Sustained Drugs and Gene Delivery Tools, Bioinspired Devices (An emerging trend in Science)” on 17th & 18th January, 2014, Francis College for Women, Hyderabad

22. Invited Talk (resource Person): Nanomedicine, and Drug and gene Delivery (Interaction short term course, on Bionanotechnology, sponsored UGC), Date: 22-27/09/2014

21. Invited Talk: Functional Nanocapsules: A Sustained Drugs and Gene Delivery Tools, JNTU Polovendula January, 2014, Bioinspired Devices (An emerging trend in Science)” on 17th & 18th­ January, 2014

20. Invited Talk: Sustained Drugs and Gene Delivery: Needs to Incorporation of Functional Properties in Mesoporous Nanocapsules, ICONBMS-(8-10 Jan)-2014

19. Invited Talk: Needs of Incorporation of Functional Properties in Mesoporous Nanocapsules for Sustained Drugs and Gene Delivery, 82nd Annual Meeting of Society of Biological Chemists, India, International conference on genomes: Mechanism and function, 2nd - 5th December, 2013, School of Life Science, UoH.

18. Invited Talk: Designing Criteria of Nanomaterials and Nanocapsules for Drug and Gene Delivery Application. AP Science Congress 2013, UoH, Nov. 14-16th, 2013

17. Invited Talk: Nano-structured Functional Polymeric materials, International Conference on Advances in Material Science, ICAMS 2013-OCt-23-24 2013-Kerala, Mahatmagandhi University, Kottayam

16. Invited Talk: Designing of Functional Polymeric Nanocapsules for Drugs and Gene Delivery, International Conference on Advanced Polymeric Materials, (ICAPM 2013), 11-13th October 2013, Mahatmagandhi University, Kottayam.

15. Invited Talk: Nano-structured Functional Polymeric materials for Sensing and Drug delivery, National Conference on National Seminar on “Nanotechnology’s Invisible threat: Small Science, Big Consequences” from 26th - 27th September, 2013, MGNIRSA Hyderabad

14. Invited Talk: Polymer Nanoparticles/Nanopolymers and Composites, (As Recourse person for Refresher Course) August 2013, JNTU, Hyderabad

13. Invited Talk: Designing of Polymer Nanocapsules for Drugs and Gene Delivery, 8-3-2013, Meditech-2013, Osmaniya University, Hyderabad

12. Invited Talk: Functional Polymer Nanoparticle/Nanopolymers, QIP course, 18th Feb, 2013, IIT Kanpur

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11. Invited Talk: Functional Polymer Nanoparticle/Nanopolymers, 26th Feb, 2013, JNTU Hyderabad (invited Talk, UGC Refresher course),

10. Invited Talk: Imprinting Mesopores in Nano Materials, NEMPIQI (National Conference, Hyderabad, October 19-20,

2012)

9. Invited Talk: Nanomaterials for Biomedical Applications, National Conference, Emerging Trends in Biotechnology NCETB-2012, 7-8/8/2012, JNTUA College of Engineering, Pulivendula, AP, India

8. Invited Talk: Functional porous polymers and inorganic nanomaterials for Drug/Gene Delivery and Sensor Applications, IIT Kanpur, Dec, 2011

7. Invited Talk: Functional Nanomaterials, IIT Hyderabad, Dec 2011

6. Invited Talk: Imprinting Chirality in Mesoporous Nanomaterials and its Use for Enantiomeric Separation, International Conference on Nanomaterials and Nanotechnology, Delhi, India, 18-21 Dec, 2011

5. Invited Talk: Functionalized Mesoporous and Nanoporous Nanoparticles and its Application as Sensor, NIT Rourkela, 17th March, 2010

4. Invited Talk: 'Imprinting Chirality in Mesoporous Structures and its Application in Chiral Resolution', ECOLE Polytechnique, Lausanne, Switzerland, 21st Jan, 2010

3. Invited Talk: 'High Molecular Weight Nanopolymers: Effects of Particle Size on its Properties', ECOLE Polytechnique, Lausanne, Switzerland, 21st Jan, 2010

2. Invited Talk: ‘Polyethylene Nanospheres: Effects of particle size on Physical and Mechanical Properties’, 95th Indian Science Congress, Vishakshapatnm, India, 4th January, 2008.

1. Invited Talk: 'Nanomaterials: Synthesis, Characterization and Uses', Dept. of Chemical Technology, University of Calcutta, India, 21st November, 2007,

Other Seminar Presentations:

26. Chiral Mesoporous Silica: Chiral Sensing and Resolution, 65th Annual Technical Meeting of The Indian Institute of Metals, 13-16th November, 2011, Hyderabad, India.

25. Imprinting Chirality in Mesoporous Polypyrrole: Enantioselective Separation, International Symposium: NANOPOROUS MATERIALS – VI, Alberta, Canada, August 24th, 2011

24. Polycaprolactone Nanocapsules with Hollow-core@Mesoporous-shell and its use in Gene Delivery, International Symposium: NANOPOROUS MATERIALS – VI, Alberta, Canada, August 24th, 2011

23. Functional Nano and Mesoporous Materials and its Applications, University of Hyderabad, 21st October, 2010. 22. Nano and Mesoporous Materials and its Applications as Sensor, University of Hyderabad, 6st October, 2010

21. Functionalized Nanoparticles and Fibers and Its use as Sensor, IIT Guwahati, 11th March, 2010

20. 'Template Synthesis of Chiral Mesoporous Silica by Templating Chiral Block-co-polymer of Polyethylene Oxide and

Aspartic Acid and its Application for Enantioselective Separation,’ BIU Student Nanoconference, 3rd August, 2009, Israel.

19. ‘Novel Synthesis of Chiral Mesoporous Silica Spheres by Chiral Block Copolymers for Enantioselective Separation, BINA

Internal Conference, 29-30th June, 2009, Israel.

18. 'Synthesis and characterization of nanopolymers: polyethylene, polypropylene and polystyrene', Ph.D. defense, 8th Dec,

2008.

17. Polypropylene Nanospheres: Effects of Particle Size on Physical and Mechanical Properties, Bar-Ilan University, Israel, September 23, 2008.

16. Formation of Chiral Mesopores in Conducting Polymers, Bar-Ilan University, Israel, August 17, 2008.

15. Nano Polypropylene: Effects of Particle Size on Physical and Mechanical properties, Bar-Ilan University, Israel, April 14, 2008.

14. ‘Polyethylene Nanospheres: Effects of Particle Size on Physical and Mechanical Properties,’ International and INCCOM-6 conference, IIT Kanpur, 12-14th December, 2007.

13. 'Nanopolymers: Synthesis and Characterizations', (Open Seminar), 12th November, 2007, ACMS, IIT Kanpur.

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12. ‘High Molecular Weight Polyethylene Nanospheres: Effects of particle size on Physical and Mechanical Properties,’ (ISCA-Young Scientist Programme), Andhra University, Vishakshapatnm, India, 13th October, 2007.

11. ‘High Molecular Weight Polyethylene Nanospheres: Effects of particle size on Physical and Mechanical Properties,’ (Graduate Seminar), August 2007, Advance Centre for Materials Science, IIT Kanpur.

10. “Synthesis and Characterization of Polyethylene Nanosphere”, INCCOM-5, November, 2006, Hyderabad, India.

9. ‘Thermal analysis of materials,’ in Quality Improvement Programme (QIP), 10th November, 2006 at IIT Kanpur.

8. Dynamic mechanical analysis (DMA): Basics and beyond,’ (Graduate Seminar), August 2006, Advance Centre for Materials Science, IIT Kanpur.

7. AFM–Principle and application,’ (Graduate Seminar), April 2006, Advance Centre for Materials Science, IIT Kanpur.

6. Thermal analysis of materials and finite size effect of polymer particles on glass transition temperature,’ (Graduate Seminar), November 2005, Advance Centre for Materials Science, IIT Kanpur.

5. Electroconductive polymer particles preparation and characterization of PANI and PEDOT,’ July-2003, Advance Centre for Materials Science, IIT Kanpur.

4. Preparation and characterization of polymers particles: high density polyethylene, Polypropylene and polystyrene,’ February 2003, Advance Centre for Materials Science, IITK

3. Polymers particles, August 2002, Advance Centre for Materials Science, IIT Kanpur.

2. ‘BaZrO2 gate dielectric: correlation between materials constants,’ February 2002, Advance Centre for Materials Science, IIT Kanpur.

1. ‘Hydraulic binder and their application,’ Lecture hall, Dept. of Chemical Technology, University of Calcutta, December, 2000.

Membership:

1. Indian Science Congress Association (Life Member)

2. Institute of Nanotechnology (IoN), UK (associate member)

3. Society of Biological Chemistry (Life Member)

4. The Society for Polymer Science, India (Life Member)

5. The Society for Biomaterials and Artificial Organ-India (Life Member)

Professional Activates: Potential Reviewer of the Scientific Journals

Nanoscale, RSC Advances, ChemComm., Chemical Communication, Journal of Materials Chemistry, ChemCrysChem,

Nanotechnology, Green Chemistry, ASC Materials & Interface, Nano Research, Chemistry: (A European Journal), Central

European Journal of Chemistry, Journal of Nanoparticle Research, Water Science and Technology, CLEAN-Soil- Air-Water,

Journal of Environmental Engineering, Korean Journal of Chemical Engineering, Canadian Journal of Chemical Engineering,

Bulletin of Materials Science, etc.

Place: IIT(BHU), Varanasi

Date: Jan, 2018

(PRADIP PAIK)

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Important works from Research group and their research highlights:

1. Poly N-acryloyl-(L-phenyl alanine methyl ester) hollow nanocapsules facilitate sustained delivery of

immunomodulatory drugs and exhibit adjuvant properties, Nanoscale, 2017,9, 14006-14014

Polymeric hollow nanocapsules have attracted significant research interest as novel drug carriers and their

preparation is of particular concern for their feasibility to encapsulate a broad range of drug molecules. This

work presents for the first time the synthesis and development of a novel poly-N-acryloyl L-phenylalanine

methyl ester hollow core nanocapsules (NAPA-HPN’s) of Avg. size ca. 100-150 nm prepared by mini-

emulsion technique. NAPA-HPN’s are biocompatible and capable of encapsulating sodium nitroprusside

(SNP) at a rate of ~1.3 µM per mg of capsules. These NAPA-HPN’s + SNP nano-formulations while

maintaining homeostasis of macrophages which carries and facilitate the action of various drug molecules

used against the various disease. These NAPA-HPN’s also facilitated the prolonged release of the low level

of Nitric oxide (NO) and enhanced metabolic activities of pro-inflammatory macrophages which are

important for the action of various drugs in body fluids. NAPA-HPN’s mediated skewing of naïve

macrophages toward M1 phenotype potentially demonstrated its adjuvant action on the innate immune

system. These results potentially suggested that NAPA-HPN’scan serve both as a carrier of the drugs as

well as an adjuvant for the immune system. Thus, these nanocapsules could be used for the effective

management of various infectious or tumor diseases where immune-stimulation is paramount for treatment.

Keywords: pNAPA nanocapsules, nitric oxide delivery, immunomodulator, adjuvant action, Nanomedicine.

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2. ZnO nanocapsules for the induction of enhanced antigen-specific immunological responses, Nanoscale, 2017 (Accepted, August, 2017), 10.1039/C7NR03697C

The application of nanotechnology in vaccinology have fuelled rapid advancement towards design and development

of nanovaccines. Nanoparticles have been found to enhance the vaccine efficacy through spatiotemporal

orchestration of antigen delivery to secondary lymphoid organs and antigen-presentation by Antigen Presenting Cells

(APCs) synchronized with stimulation of innate and adaptive immune responses. Metal based nanoparticles (MNPs)

have been extensively engineered for generation of nanovaccines owing to their intrinsic adjuvant- like properties

and immunomodulatory functions. Furthermore, mesoporous nanocapsules of late have attracted researchers due to

their precise size and exclusive capacity to encapsulate a wide range of biomolecules and their sustained release at

the targeted sites. Herein, we have designed a novel mesoporous ZnO nanocapsule (mZnO) having size ~ 12nm with

average pore diameter of 2.5nm, using surfactant-free sonochemical method and investigated its immunomodulatory

properties by using Ova loaded mZnO nanocapsules[mZnO(Ova)] in a mice model. Our finding exemplifies that

mZnO(Ova) administration steered enhanced expansion of antigen-specific T-cells and induction of IFN-γ producing

effector CD4+ and CD8+ T-cells. Also, antigen-specific IgG levels were enriched in both serum and lymph nodes

of mZnO(Ova) immunized mice. Further, we noticed a substantial increase in serum IgG2a or IgG2b levels and IFN-

γ secretion in Ova restimulated splenocytes from mZnO(Ova) immunized mice, indicating that mZnO(Ova) skew

Th1 type immune response. Overall, the uniqueness of mZnO nanocapsules in term of defined particle to pore

numbers ratio (maximum of three cavities per particle), allows to load antigens efficiently. Given these features in

combination with its immunomodulatory characteristics reinforces that mZnO could be used as an effective antigen-

adjuvant platform for the development of novel nano-based vaccines against multiple disease.

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3. Bio-inspired synthesis of Hierarchical Self-Assembled Zinc phosphate nanostructure in presence of Cowpea Mosaic Virus: in vitro cell cycle, proliferation and prospective for tissue regeneration, Biomedical Materials 2017 Aug 8. doi: 10.1088/1748-605X/aa84e9.

Self-assembly is an important auto-organization process used in designing structural biomaterials

which have potential capabilities in healing tissues after traumatic injuries. Notwithstanding, various

materials with healing ability after injuries are available, substantial need still exists for developing new

material to endorse the healing ability. To address this issue, we have developed a hierarchical 3-

dimensional (3D) self-assembled zinc phosphate (Zn3(PO4)2) in presence of cowpea mosaic virus (CPMV).

Zn3(PO4)2 nanoparticles are self-assembled into nanosheets with a high degree of isotropy and then self-

organized into 3D structure having functionality that enhanced surface interactions with biological entities.

The self-assembly structure has been formed through the auto organization of the nanoparticles of size ~50

nm in the influences of CPMV. The cellular response of self-assembled Zn3(PO4)2 and cell-particle

adhesion behavior have been investigated through in vitro studies using modeled osteoblast-like MG63

cells. Self-assembled Zn3(PO4)2 resulted up to 310% cell proliferation with the MG63 cells within 7 days of

incubation. A 15% higher in proliferation was obtained compared to the commercially available

hydroxyapatite (HAp). Immunofluorescent analysis of MG63 cells after co-culturing with self-assembled

Zn3(PO4)2 confirmed the healthy cytoskeleton organization and dense proliferation of MG63 cells. Further,

Zn3(PO4)2 exhibited ~28% of cell-cycle progression in S phase, which is higher in value compared to the

commercially available HAp. Overall, these results demonstrates the multiple functions of hierarchical self-

assembled Zn3(PO4)2 to the regeneration of bone tissues without defects and with increasing the cellular

network formation, and directed us for its use in bone tissue engineering.

Keywords: Self-assembly nanoparticles; zinc phosphate; bio-synthesis; cowpea mosaic virus; cell

proliferation; tissue engineering.

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4. Designing idiosyncratic hmPCL-siRNA Nanoformulated Capsules for Silencing and Cancer Therapy, Nanomedicine: Nanotechnology, Biology, and Medicine 2016, 12(3)579-588. (IF: 6.692)

In this work, we have designed a siRNA-nanoformulation with mesoporous polycaprolactone (hmPCL) for silencing and cancer therapy. Average hollow core size of hmPCL nanocapsules used for nanoformulation is ~180 nm with shell thickness of 10-20 nm and mesopore size of ~5-10 nm in diameter. Idiosyncratic capsules are biocompatible which has been confirmed with normal lymphocyte, K562 leukaemia cancer cells and on HepG2/EGFP cancer cells. In 1 mg of hmPCL capsules up to 400 ng of siRNA can be loaded. This nanoformulation is enable to tune the dose dependent delivery up to ~93.25% (373 ng) siRNA during therapy. hmPCL-siRNA nanoformulation mediated siRNA transfection on HepG2 cancer cells has been investigated and exhibited 32% silencing activity within 24 hrs of post transfection. Obtained results directed us that the hmPCL-siRNA nanoformulation could be an efficient tool in siRNA mediated therapy for knocking down of the infected cells. KEYWORDS. Hollow-mesoporous-PCL nanocapsules, Nanoformulation, siRNA silencing, cancer

therapy.

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5. Nanoporous capsules of block co-polymer of [(MeO-PEG-NH)-b-(L-GluA)]-PCL for control

release of anticancer drugs for therapeutic applications, Nanotechnology 27 (2016) 125101 (12pp). (IF:

3.573)

Herein, new nanoporous capsules of block co-polymers MeO-PEG-NH-(L-GluA)10 and polycaprolactone (PCL) have

been synthesized through surfactant free, cost effective self-assembled soft-templating approach for control release of

drugs and for therapeutic applications. Nanoporous polymer capsules designed are biocompatible and are capable of

encapsulating anticancer drugs (e.g., doxorubicin hydrochloride (DOX) and imatinib mesylate (ITM)) with a high

extent (~279 ng/µg and ~480 ng/µg, respectively). We have developed nanoformulation of porous MeO-PEG-NH-

(L-GluA)10-PCL capsules with DOX and ITM. The porous polymer nanoformulations have been programmed in

terms of release of anticancer drugs with a desired dose to treat the leukemia (K562) and human carcinoma cells

(HepG2) in vitro and show promising IC50 values with a very high mortality of cancer cells (upto ~96.6%). Our

nanoformulation arrests the cell divisions due to “cellular scenescence” and kill the cancer cells specifically. Present

findings could be enriched the effectiveness of idiosyncratic nanoporous polymer capsules to use them in various

other nanomedicinal and biomedical applications such as for killing cancer cells, immune therapy and gene delivery.

Keywords: Polymer capsules, nanopores, nanomedicine, cancer therapy, DOX, ITM

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6. Copper Prussian blue analogue: Investigation into multifunctional activities for biomedical applications, Chem. Commun., 2015,51, 7325-7328.

We have designed and developed stable and biocompatible copper analogues of a Prussian blue (PB)

nanoparticle based drug delivery system containing doxorubicin that show selective quenching of fluorescence of

doxorubicin compared to PB analogues with other metals and inhibition of cancer cell proliferation, suggesting

future potential multifunctional applications in biomedical sciences.

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7. CPMV induced synthesis of Hollow-meso porous SiO2 Nanocapsules with excellent performance in Drug delivery, Dalton Trans., 2015,44, 4308-4317.

An idiosyncratic hollow porous-SiO2 nanocapsule has been synthesized at room temperature using unmodified

Cowpea mosaic Virus (CPMV) as a template, and without using any catalyst or surfactant during synthesis. The

average size of the capsules synthesized is ~200-250 nm with 60-100 nm hollow core these nanocapsules have been

characterized through high resolution transmission electron microscopy (HRTEM). Biocompatibility of the hollow

mesoporous SiO2 nanocapsules has been investigated with MTT assay using the RAW 264.7, HepG2 and Hek293

cell lines. Nanocapsules are loaded with fluorescent molecules (rhodamine 6G), doxorubicin (DOX) an anticancer

drug and chloroqunine diphosphate (CQDP) an antimalarial drug and their release were studied through UV-Vis

spectrometer. Development of surfactant free, bio-safe, hollow and porous SiO2 nanocapsules with CPMV has

provided a route of synthesis of porous nanocapsules towards drug loading and sustained delivery of drugs. The

synthesis method of hollow porous bio-SiO2 nanocapsules using CPMV is novel and straight forward, further

demonstrating the generality of the nano-formulated capsules that can be used for various drug deliveries based

therapeutic applications. To check the efficacy of our materials a non-cancerous cell lines Hek293 (human embryonic

kidney cells) and HepG2 (human carcinoma cells) cell lines are used and studied the cell viability of DOX loaded

hollow silica nanocapsules. Results show that our bio SiO2 nanocapsules synthesized with CPMV is an effective

cargo in nano formulating with DOX and the resultant nanoformulation is very promising in killing cancer specific

cells.

Keywords: Cowpea mosaic virus, Hollow silica nanocapsules, Dye/Drug delivery

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8. Facile Synthesis of Self-Assembled Spherical and Mesoporous Dandelion Capsules of ZnO: Efficient Carrier for DNA and Anti-cancer Drugs, J. Mater. Chem. B, 2014, 2, 3956-3964. This work presents a new facile strategy to fabricate self-assembled spherical and mesoporous submicron-sized

capsules, ‘dandelions’ of ZnO nanorods and nanoparticles. Self-assemble ‘dandelions’ capsules have been

synthesized from Zn(Ac)2 and Igepal CO-520. The mechanistic approach for the growth of self-assembled ZnO

capsules has been elucidated. Physical characteristics of the novel capsules responsible for biomedical applications

have been studied through XRD, Raman, UV-Vis-NIR, XPS and EPR. The mechanical stability of the capsules has

been characterized through the high energy ultrasound with time scale in 10% PBS buffer. The biocompatibility of

the capsules has been investigated with a cell based study using normal lymphocyte and K562 cancer cells through

MTT assay. The loading and release efficiency of the fluorescent molecules (Rhodanine 6G), anti-cancer drugs

(doxorubicin hydrochloride, DOX), and nucleic acid (DNA) have been investigated. All the results indicate the high

potential of self-assembled ZnO ‘dandelions’ capsules in relevant applications in medical biotechnology, such as for

sustained drug delivery with the formation of {(ZnO)nᵟ+-(DOX)m} complex and gene delivery with the formation of

{(ZnO)nδ+-(DNA)m complex formation. The fabrication of such type of self-assembled idiosyncratic capsules is very

simple, feasible, and cost effective, and demonstrate improved performances in drug and gene delivery applications.

Keywords: self-assembly, dandelion capsules, ZnO- mesopores, DNA, {(ZnO)nᵟ+-(DOX)m}

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9. Silver nanoparticles embedded mesoporous SiO₂ nanosphere: an effective anticandidal agent against

Candida albicans 077. Nanotechnology. 2015 Jul 17; 26(28):285102. doi: 10.1088/0957-4484/26/28/285102.

Candida albicans is a diploid fungus that causes common infections such as denture stomatitis, thrush, urinary tract infections,

etc. Immunocompromised patients can become severely infected by this fungus. Development of an effective anticandidal agent

against this pathogenic fungus, therefore, will be very useful for practical application. In this work, Ag-embedded mesoporous

silica nanoparticles (mSiO2@AgNPs) have successfully been synthesized and their anticandidal activities against C. albicans

have been studied. The mSiO2@AgNPs nanoparticles (d ∼ 400 nm) were designed using pre-synthesized Ag nanoparticles and

tetraethyl orthosilicate (TEOS) as a precursor for SiO2 in the presence of cetyltrimethyl ammonium bromide (CTAB) as an

easily removable soft template. A simple, cost-effective, and environmentally friendly approach has been adopted to synthesize

silver (Ag) nanoparticles using silver nitrate and leaf extract of Azadirachta indica. The mesopores, with size-equivalent diameter

of the micelles (d = 4-6 nm), were generated on the SiO2 surface by calcination after removal of the CTAB template. The

morphology and surface structure of mSiO2@AgNPs were characterized through x-ray diffraction (XRD), Fourier-transform

infrared spectroscopy (FTIR), particle size analysis (PSA), atomic force microscopy (AFM), field emission scanning electron

microscopy (FESEM), Brunauer-Emmett-Teller (BET) and high-resolution transmission electron microscopy (HRTEM). The

HRTEM micrograph reveals the well-ordered mesoporous structure of the SiO2 sphere. The antifungal activities of

mSiO2@AgNPs on the C. albicans cell have been studied through microscopy and are seen to increase with increasing dose of

mSiO2@AgNPs, suggesting mSiO2@AgNPs to be a potential antifungal agent for C. albicans 077.

Keywords: Silver nanoparticles; Nanocomposite; Mesoporous silica; Structural property; Optical property; Antifungal activity

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Idiosyncratic hmPCL-siRNA Nanoformulated Capsules

for Silencing and Cancer Therapy

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