Bile Juice

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Transcript of Bile Juice

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Bile is a thick digestive fluid, that is released by the liver

and stored in the gallbladder.

Bile is secreted upon eating into the duodenum.

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Color:

dark green to yellowish brown fluid

Volume:0.5 - l.0 L/day (depending on body size )

pH : 7.8-8.2

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 Water (85%),

Biliary Solids (3 g%)

bile salts (1.8 g%), such as cholic, chenodeoxycholic,

deoxycholic, and lithocholic acid.

Mucus

Bile pigments (0.1 g%) e.g bilirubin glucuronid.

phospholipids (0.8 - 0.9g%).

Cholesterol (0.2 - 0.3 g%)

inorganic salts (0.7 g%) ,such as Na +, K +, HCO3-,Cl- 

NO digestive enzymes

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Bile is an emulsifier, it helps to break down fats into

fatty acids, which can be taken into the body by the

digestive tract.

Bile juice reduces acidity of chyme.

Bile salts also act as bactericides ,it kills the germs andbacteria which are present in food. 

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Cholelithiasis The movement of cholesterol from the liver into the bile

must be accompanied by the simultaneous secretion of 

phospholipid and bile salts.

If this dual process is disrupted and more cholesterolenters the bile than it can be solubilized ,so cholesterol

may precipitate in the gallbladder, initiating the occurrence

of cholesterol gallstone disease- cholelithiasis .

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Gross malabsorption of bileacids from the intestine Obstruction of the biliary tract 

Severe hepatic dysfunction,leading to decreased synthesis of 

bile salts, or other abnormalitiesin bile production

Increased biliary cholesterol

excretion.

Cholelithiasis is caused by a 

decrease of bile acids in thebile, which may result from: 

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 Jaundice It refers to the yellow color of skin, nailbeds, and sclerae

(whites of the eyes) caused by deposition of bilirubin. 

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Newborn infants, particularly if premature, often accumulatebilirubin, because the activity of hepatic bilirubin glucuronyl

transferase is low at birth—it reaches adult levels in about four

 weeks.

Elevated bilirubin,in excess of the binding capacity of albumin,

can diffuse into the basal ganglia and cause toxic

encephalopathy (kernicterus).

Newborns with significantly elevated bilirubin levels are treated

 with blue fluorescent light which converts bilirubin to more

polar and, hence, water-soluble isomers.

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http://www.healthcentral.com/diet-exercise/h/bile-juice.html 

Berne, RM and Levy, MN (2004), Physiology, 5th ed., St.

Louis, Mosby Yearbook 

Champe, Pamela C. , Harvey, Richard A. , and Ferrier, Denise

R. (2008), Lippincott’s Illustrated Reviews:Biochemistry , 4th 

ed. , Baltimore, Lippincott Williams & Wilkins

http://health.wikinut.com/img/18072lt_cc74sq5u/Jaundice-

Types