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![Page 1: Bi-Ventricular Cardiac Assist Device - Research | School of …research.vuse.vanderbilt.edu/srdesign/199… · PPT file · Web view · 2007-09-21Compressional Assist Device Erika](https://reader031.fdocuments.net/reader031/viewer/2022030508/5ab7d5d77f8b9ad5338c0cf9/html5/thumbnails/1.jpg)
Minimally InvasiveCompressional Assist Device
Erika Brown, Caryl Brzymialkiewicz, and Mark Carlson
Advisor: Dr. Drew Gaffney, M.D.Professor of Medicine, VUMC
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Project Definition
To design a cardiac assist device, implantablewith minimally invasive surgery that aids inpumping, and in the case of a hypertrophic
heart, also improves function over time.
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Cardiac Indications
• Systolic Ejection Fraction= Stroke volume _
End Diastolic Volume• Hypertrophic heart
(e.g. Chagas disease)– sarcomeres expand and
lose contraction efficiency
– self-perpetuating positive feedback system Frank-Starling Curve
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What is currently available?
OPTIONS• Extracorporeal assist
devices• Heart transplants• Total Artificial Hearts• Ventricular Assist Devices • Batista’s wedge
resectioning surgery• Various drug treatments (ie
- digitalis)
PROBLEMS• Invasiveness
– Cost– Mortality– Discomfort
• Length of use• Aid in pumping or
healing, but not both• Recipient limitations
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Project Overview
• Brainstorming until end of January• Research until mid-February• In vitro model design and testing through
mid-March• Evaluation of in vitro results and adaptation
into a prototype clinical design by end of the semester
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What have we done so far?
• Web page is up and running• Patent search• Located pertinent cardiology and
instrumentation resources• Began in depth review of current technologies• Brainstormed wants and needs, possible
design options, potential problems
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What are we currently doing?
• Continuing review of current technologies/devices
• Biomaterials research• Re-evaluating our problem and looking for
alternative solutions• Trying to set up viewing of cardiac surgery
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Current questions...
• How much pressure should be applied to help the heart pump effectively?
• What is the most effective triggering mechanism?• Quantitatively, how much pressure is needed over
what length of time to help heal a hypertrophic heart?
• What are the anatomical constraints in implanting a device sub-xyphoidally?
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What will we do next?
• Make a evaluation matrix of potential solutions
• Focus brainstorms on best solution and develop concepts for in vitro model
• Specify design parameters • Develop tests for in vitro model • Research Batista’s wedge resection surgery
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Resources
• Sherwood, L. (1997) Human Physiology: From Cells to Systems, 3rd Ed. Wadsworth Publishing Co.: Belmont, CA.
• Quall, S.J., ed. (1993) Cardiac Mechanical Assistance Beyond Balloon Pumping. Mosby Year-Book, Inc.: St. Louis, MO.