One dose = immediate immunityDISEASE DESCRIPTION: The cause of neonatal calf diarrhea/scours is complex, but K99+ E. coli, coronavirus and rotavirus have been found to be 3 of its most common causative agents. Diarrhea/scours has been shown to make an animal more susceptible to secondary enteric and respiratory diseases.

MODE OF ACTION: Antibodies allow for passive immunity as they rapidly bind and neutralize targeted pathogens in the GI tract. When delivered prior to gut closure, antibodies are also absorbed into the bloodstream. Antibody products are compatible with colostrum, do not require vaccine induced system stress or lag time. The antibody levels for each of the active ingredients in First DeFense tri-shielD (E. coli, coronavirus and rotavirus) are measured and guaranteed to meet levels proven effective in controlled animal trials.

SAFETY AND EFFICACY: In newborn/neonatal calves First DeFense

tri-shielD is a one-time preventative treatment against K99+ E. coli, coronavirus and rotavirus diarrhea/scour causing pathogens. No allergic or other adverse reactions were observed.

Beyond Vaccination is forward-thinking.Be a Calf Hero. GoFirst DeFense tri-shielD aids in the reduction of mortality

and morbidity from scours caused by K99+ E. coli and coronavirus while also reducing the severity and duration of scours caused by rotavirus.

K99+ E. coliRotavirus Coronavirus

Those daring enough to go Beyond Vaccination are our heroes – calf heroes, to be exact.

We salute them, and all thatthey do for calves.

Join the revolution. firstdefensecalfhealth.com | 800.466.8235 | NASDAQ: ICCC Rotavirus Coronavirus K99+ E. coli

™

90%Approval Trials Showed:

SURVIVAL RATE SURVIVAL RATE100%

In an E. coli Challenge In a Coronavirus Challenge

and treatment was reduced by 65%1

and treatment was reduced by 76%1

Dare to break traditionFirst DeFense tri-shielD is the only product that can go Beyond Vaccination to provide immediate and lasting immunity to newborn calves for:

7 REASONS TO BREAK FROM TRADITION

Vaccination has been the traditional way to protect calves from scours.But, First DeFense tri-shielD breaks tradition, providing a better way. • Gel tube is administered to the calf orally,

eliminating the need for dam and calf-level scours vaccinations.

• One dose provides immediate immunity, no need to stimulate an immune response or follow-up with annual boosters.

• Guaranteed antibody levels in every dose – all calves are equally protected.

• Can be administered with colostrum, without the delay some calf-level vaccines require.

• Delivery is targeted to liveborn and valued calves, maximizing return on investment.

• No dam-level vaccine means less stress on the dam, increasing her response rate to critical vaccines, clearing room in her vaccination schedule.

3 vs. 2 Anti-Pathogens

Targeted vs. Wasted Investment

Easy vs. Complicated Delivery

Immediate vs. Delayed

2 Bristol, L. Duhamel, G. Zinckgraf, J. Crabb, J. Nydam, D. “Passive Antibodies Derived from Virus Like Particles for Reduction of Rotavirus Diarrhea.” Publication submitted.

Guaranteed vs. Variable

Progressive vs. Traditional

Comfortable vs. Stressed Calves & Cows

1 Combs, K. Bringe, A. Lopez, J. Crabb, J. Ruch, F. “Protection of Neonatal Calves Against K99-E. coli and Coronavirus Using a Colostrum-Derived Immunoglobulin Preparation.” Agri-Practice. May 1993.

Rotavirus

Coronavirus

K99+ E. coli

First DeFense tri-shielDis a USDA-approved veterinary biologic.

the way rotavirus isspread from calf-to-calf

2WITH 75%

REDUCTION IN DURATION OF SCOURS2

REDUCTION INSEVERITY

2

1.8 DAYREDUCED PATHOGEN SHEDDING

In a Rotavirus Challenge

56%REDUCTION INSCOURS BREAKS