BDNF Pathway

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BDNF SHC SOS GRB2 PI3K P P P BAD P P Ca 2+ Ca 2+ IP3 P P BCLXL BCL2 I P 3 R PKC Pathway Cell Adhesion and Migration Cell Survival Synaptic Plasticity and Neurogenesis CREB CREB Gene Expression DAG Akt 14-3-3 Raf1 MEK1/2 ERK1/2 RSK PLCγ BAD TRKB Ras Ca 2+ GAB1 BDNF Pathway

description

BDNF. TRKB. GRB2. GAB1. PI3K. MEK1/2. Raf1. Akt. RSK. BAD. BCLXL. P. P. P. P. P. P. P. I P 3 R. 14-3-3. ERK1/2. SHC. SOS. BAD. Ca 2+. Ca 2+. Ca 2+. CREB. CREB. BCL2. Ras. BDNF Pathway. PLC γ. DAG. PKC Pathway. IP3. Cell Adhesion and Migration. Cell Survival. - PowerPoint PPT Presentation

Transcript of BDNF Pathway

Page 1: BDNF Pathway

BDNF

SHC SOS

GRB2

PI3K

P

P

P

BADP

P

Ca2+

Ca2+

IP3

PP

BCLXLBCL2

IP3R

PKC Pathway

Cell Adhesionand Migration

CellSurvival

Synaptic Plasticity andNeurogenesis

CREBCREB

Gene Expression

DAG

Akt

14-3-3

Raf1

MEK1/2

ERK1/2

RSK

PLCγ

BAD

TR

KB

Ras

Ca2+

GAB1

BDNF Pathway