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ONCOGEcircNESE
SAacuteBADO ndash 140320150800 h CARCINOGEcircNESE
A oncogecircnese ou carcinogecircnese eacute um fenocircmeno complexo multifaacutesico e dependente
de fenocircmenos geneacutetico e epigeneacuteticos que levam ao surgimento de ceacutelulas imortalizadas com crescimento autocircnomo com capacidade
de invasatildeo e metaacutestases
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull ANCORAGEMbull CEacuteLULAS MIGRADORASbull MECbull VASOSbull SIMETRIAbull PERIODICIDADEbull DIFUSAtildeO DE FCbull CEacuteL TRONCO bull CEacuteL SUPRESSORA
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR
(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
A oncogecircnese ou carcinogecircnese eacute um fenocircmeno complexo multifaacutesico e dependente
de fenocircmenos geneacutetico e epigeneacuteticos que levam ao surgimento de ceacutelulas imortalizadas com crescimento autocircnomo com capacidade
de invasatildeo e metaacutestases
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull ANCORAGEMbull CEacuteLULAS MIGRADORASbull MECbull VASOSbull SIMETRIAbull PERIODICIDADEbull DIFUSAtildeO DE FCbull CEacuteL TRONCO bull CEacuteL SUPRESSORA
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR
(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull ANCORAGEMbull CEacuteLULAS MIGRADORASbull MECbull VASOSbull SIMETRIAbull PERIODICIDADEbull DIFUSAtildeO DE FCbull CEacuteL TRONCO bull CEacuteL SUPRESSORA
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR
(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull POR ALTERACcedilOtildeES DO DNA (MUTACcedilOtildeES)bull POR ALTERAR MECANISMOS DE CONTROLE DA EXPRESSAtildeO GEcircNICA
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR
(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
MECANISMOS DE FORMACcedilAtildeO E DESENVOLVIMENTO DE NEOPLASIAS
bull AUTONOMIA PROLIFERATIVAbull EVASAtildeO DE SINAIS INIBIDORES DE MITOSEbull EVASAtildeO DE APOPTOSEbull EVASAtildeO DE SENESCEcircNCIA REPLICATIVAbull AUTONOMIA DE SOBREVIVEcircNCIAbull INSTABILIDADE GENOcircMICAbull EVASAtildeO DO SISTEMA IMUNEbull INVASAtildeO E CARAacuteTER SUBSTITUTIVObull METAacuteSTASE
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR
(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull DA PROLIFERACcedilAtildeO CELULARbull DA DIFERENCIACcedilAtildeO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR
(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull ESTIMULAM A PROLIFERACcedilAtildeO CELULAR
(ONCOGENES)bull FAT DE CRESCIMENTObull RECEPTORES PARA FCbull MOL TRANDUTORASbull MOL DO CICLO CELULAR
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
bull ALTERACcedilOtildeES NA EXPRESSAtildeO DE GENES REGULADORESbull GENES SUPRESSORES DE TUMORbull REGULAM APOPTOSEbull REPARO DO DNAbull METILACcedilAtildeO E DESACETILACcedilAtildeO DA CROMATINA
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
SUPRESSAtildeO DE CRESCIMENTO
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
ETAPAS DA CARCINOGEcircNESE
bull Iniciaccedilatildeo (induccedilatildeo de alteraccedilotildees geneacuteticas -transformaccedilatildeo)
bull Promoccedilatildeo ( amplificaccedilatildeo do clone transformado)
bull Progressatildeo (crescimento e metaacutestases)
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
VIAS DA CARCINOGEcircNESE
bull SUCESSAtildeO DE MUTACcedilOtildeES EM ONCOGENES E GENES SUPRESSORES DE TUMOR
bull DEFEITOS NO SISTEMA DE REPARO DO DNA
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
TRANSDUTORES DE SINAIS
EFEITOS
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
CARCINOGEcircNESE VIRAL (RETROVIacuteRUS)
PELA INS DE ONCOGENES VIRAIS
ATIVACcedilAtildeO DE PROTO-ONC AO INS DNA
PROTEINAS ANOcircMALAS
TRANSATIVACcedilAtildeO DE ONCOGENES (INDIRETA)
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
HTLV-1
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
CARCINOGEcircNESE VIRAL (VIacuteRUS DNA)
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
CARCINOGEcircNESE QUIacuteMICA
bull HIDROCARBONETOS PC ndash FUMObull AFLATOXINA (MUT P53)
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
CARCINOGEcircNESE POR RADIACcedilOtildeES
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
SUPRESSAtildeO DE CRESCIMENTO
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
PT LIGADORAS DE GTP
20 DOS CA HUMANOS
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
CARCINOGEcircNESE POR RADIACcedilAtildeO UV
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
CERATOSE ACTIacuteNICA
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
SIacuteNDROMES HEREDITAacuteRIAS ASSOCIADAS A TUMORES
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
POacuteLIPOS ADENOMATOSOS
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
IMPORTAcircNCIA DO ESTROMA NA IMORTALIDADE DAS CEacuteLULAS NEOPLAacuteSICAS
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]
Cancer Res 2015 Mar 175(5)792-797 Epub 2015 Feb 13
Fearful Symmetry Subversion of Asymmetric Division in Cancer
Development and Progression
Bajaj J1 Zimdahl B1 Reya T2Author information
AbstractAsymmetric division is an evolutionarily conserved process that generates daughter cells with different fates through the unequal partitioning of fate determinants
While asymmetric division is critically important in generating diversity during development its dysregulation can also promoteoncogenesis In particular signals that
shift the normal balance of symmetric and asymmetric division can lead to a differentiation arrest and trigger cancer progression Here we discuss the studies that
have provided increasing support for this idea Beginning with original work carried out in Drosophila we trace more recent work in mammalian systems that suggest
that the subversion of asymmetric division can contribute significantly to the development and progression of both hematologic malignancies and solid cancers
Cancer Res 75(5) 792-7 copy2015 AACR
copy2015 American Association for Cancer Research
PMID
25681272
[PubMed - as supplied by publisher]