CHAPTER 10 MOLECULAR GENETICS NUCLEIC ACIDS to PROTEINS: STRUCTURE REPLICATION PROTEIN SYNTHESIS.
AP Biology DNA Structure & Replication. Nucleic Acid Structure.
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Transcript of AP Biology DNA Structure & Replication. Nucleic Acid Structure.
AP Biology
DNA Structure & Replication
Nucleic Acid Structure
Complimentary Base Pairing
S Phase of Cell Cycle
ThetaReplication
in Prokaryotes
Origin ofreplication
Replication fork
Termination of replication
Linear Replication in Eukaryotes
.
The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen bonding with its specific partner, A with T and G with C.
.
The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen bonding with its specific partner, A with T and G with C.
The first step in replication is separation of the two DNA strands.
Semi Conservative process of DNA Replication
The parent molecule has two complementary strands of DNA. Each base is paired by hydrogen bonding with its specific partner, A with T and G with C.
The first step in replication is separation of the two DNA strands.
Each parental strand now serves as a template that determines the order of nucleotides along a new, complementary strand.
Origins and Replication bubbles
DNA Replication
DNA Replication by adding Nucleosides on the 3’ end
New strand
5 end
Phosphate Base
Sugar
Template strand
3 end 5 end 3 end
5 end
3 end
5 end
3 end
Nucleosidetriphosphate
DNA polymerase
Pyrophosphate
5 Carbon Sugar Important Parts(It could be DNA or RNA)
Helicase is the GREEN “blob”
RNA Primer(Remember, RNA is temporary)
.
New strand
5 end
Phosphate Base
Sugar
Template strand
3 end 5 end 3 end
5 end
3 end
5 end
3 end
Nucleosidetriphosphate
DNA polymerase
Pyrophosphate
Nucleotide Excision Repair
Telomere Removal at the
Chromosome Ends
End of parentalDNA strands
5
3
Lagging strand 5
3
Last fragment
RNA primer
Leading strandLagging strand
Previous fragment
Primer removed butcannot be replacedwith DNA becauseno 3 end available
for DNA polymerase5
3
Removal of primers andreplacement with DNAwhere a 3 end is available
Second roundof replication
5
3
5
3Further roundsof replication
New leading strand
New leading strand
Shorter and shorterdaughter molecules
Apoptosis in the hand