Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College...
-
Upload
shayla-chum -
Category
Documents
-
view
229 -
download
0
Transcript of Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College...
![Page 1: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/1.jpg)
Anaesthesia for intracranial SOL, including vascular surgeries
Dr. Megha Aggarwal
University College of Medical Sciences & GTB Hospital, Delhi
![Page 2: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/2.jpg)
Outline
Introduction to SOLClassification
Presentation
Management strategies
Neuroanaesthetic goals
Hemodynamic concerns
Conduct of anaesthesiaPre anaesthetic assessment
Monitoring
Induction, maintenance and emergence
Post-operative concerns
![Page 3: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/3.jpg)
Classification of SOLCONGENITAL Dermoid, epidermoid, teratoma.
TRAUMATIC Subdural & extradural haematoma
INFLAMMATORY Abscess, tuberculoma, syphilitic gumma,fungal granulomas.
PARASITIC Cysticercosis, hydratid cyst, amebic abscess, Schistosoma
NEOPLASMS Meningionas, gliomas, choroid pappilomas , metastasis
VASCULAR Aneurysms, A-V malformations
![Page 4: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/4.jpg)
Neoplasms
![Page 5: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/5.jpg)
1. Meningioma- 90% supratentorial
5-6th decade
benign
Highly vascular with large feeding vessels
2. Gliomas - most common 1 intracranial tumors⁰
slow growing astrocytomas to malignant glioblastomas
seizures, focal deficits, ↑ ICP as per tumour type
Common SOLs
![Page 6: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/6.jpg)
3. Tumors of ventricular system
Choroid plexus papillomas, ependymomas,
Obstructive hydrocephalus, midbrain compression
4. Metastatic
Most common intracranial tumors
Multiple
5. Intracerebral abscess
Frontal sinus, middle ear, blood born, foreign body
Meningitis , ↑ ICP
Common SOLs (cont …)
![Page 7: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/7.jpg)
ANATOMICAL REGION CLINICAL SIGNS
Supratentorial (forebrain) Seizures
Headache
Motor/ sensory deficits
Infratentorial (brainstem)
(RAS, CN, Cardiac & resp centres)
- CN deficit (3-12)- ocular palsy, dysphagia,
laryngeal dysfunction (chronic aspiration).
- Arrhythmias/ respiratory irregularities
Sleep abnormality
Infratentorial (cerebellum) Ataxia
Tremors
Vestibular signs
Hydrocephalus
Infratentorial (vestibular system) Head tilt
Postural deficit
Nystagmus
How do they present ?
![Page 8: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/8.jpg)
Herniation / midline shift
HTN ,
Tachy/ brady
arrythmias,
3 & 6th CN palsy (I/L
pupil dilation + no light
reflex),
C/L hemiplegia/ paresis,
Coma ,
Resp arrest
![Page 9: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/9.jpg)
Treatment
![Page 10: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/10.jpg)
Goals of anaesthesia
1. Preserve both injured & uninjured cerebral territories by global maintenance of cerebral homeostasis.
2. Maintain normocarbia, normotension, normoxia, euthermia, euglycemia.
3. Avoid secondary brain insults
4. Optimizing operative conditions to facilitate resection
![Page 11: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/11.jpg)
Depending on type (vascularity) and location (supra/
infratentorial) of tumor
Anaesthetic implications
Supratentorial
ICP management
Monitoring brain function
Massive intraoperative hemorrhage
Seizures
Air embolism (if venous sinuses
traversed)
Infratentorial
Air embolism
Care during vital
structure handling
Positioning
Higher mortality
![Page 12: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/12.jpg)
Secondary insults
INTRACRANIAL SYSTEMICIncreased intracranial pressure Hypercapnia/hypoxemia
Epilepsy Hypo-/hypertension
Vasospasm Hypo-/hyperglycemia
Herniation: falx, tentorium, foramen magnum, craniotomy
Low cardiac output
Midline shift: tearing of cerebral vessels
Hypo-osmolality
Shivering/pyrexia
![Page 13: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/13.jpg)
AVM/ aneurysm/ head injuries/ tumors
Disruption of cerebral autoregulation
BP fluctuation poorly tolerated
↑BP – Vasogenic edema, ↑ tumor / aneurysm size, aneurysmal rupture↓ BP – Ischemia/ infarction
WHY CONTROL BP ?
![Page 14: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/14.jpg)
Stimuli for BP fluctuation
1. Laryngoscopy
2. Intubation
3. Positioning
4. Suction
5. Skeletal fixation of
head
Preventive measures
1. Deep plane of anesthesia
2. Additional dose of iv
anesthetic agent
3. Adequate muscle
relaxation
4. Lignocaine (1.5 mg/kg)
5. Esmolol (0.5 – 1 mg/kg)
![Page 15: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/15.jpg)
INVESTIGATIONS
EXAMINATION
HISTORY
Preoperative assessment
Assessment & documentation
![Page 16: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/16.jpg)
Preoperative assessment1. Level of consciousness
2. Seizures - ↑ CMRO2 , ↑ ICP
3. ↑ ICP – headache, vomiting, without nausea, blurred vision, ocular palsy (CN 6)
4. Hydration – fluid intake, NPO status, diuretics, SIADH
5. Medications – steroids, antiepileptic drugs, aspirin/ clopidogrel, diuretics, mannitol
6. CN palsies- dysphagia, laryngeal dysfunction
7. Associate systemic illness- Cardiac – HTN (hypotensive anaesthesia) Respiratory Renal – intraoperative mannitol and diuretics, SIADH, DI
HISTORY
![Page 17: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/17.jpg)
Preoperative assessment1. Mental status, level of consciousness (GCS)
2. Hydration status
3. Systemic examination
a) CNS ↑ICP – papilloedema, cushing response (↑BP, ↓HR), sutural
diastasis, bulging fontanels.
Focal signs (CN palsies) - Dysphagia, strabismus, focal seizures, speech deficit, motor & sensory examination.
Midline shift - I/L Pupillary dilatation and absent light reflex (3rd CN)
EXAMINATION
![Page 18: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/18.jpg)
Preoperative assessment
b) Respiratory- effect of positioning, resp. pattern, neurogenic pulm. edema
c) CVS – Cushing reflex, HTN (resets limits of cerebral autoregulation), BP (cerebral perfusion)
d) GI -↑ Aspiration (steroids, ↑ ICP , low GCS, emergency)
e) Renal - ↓fluid intake, diuretics, mannitol, SIADH, DI
f) Paraneoplastic syndromes
EXAMINATION
![Page 19: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/19.jpg)
Preoperative assessment
1. Complete blood count – Hb, TLC, Platelet count
2. RBS – hyperglycemia – cerebral edema , ↑ischemic brain injury
3. KFT – urea, Na, K
4. Coagulation profile
5. ECG – ischemic changes, arrhythmias
6. CXR
INVESTIGATION
![Page 20: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/20.jpg)
7. CT/ MRI – tumor assessment
Location – silent/ eloquent area
Size – degree of compromise of intracranial dynamics
including auto regulation.
Ventricular distortion / CSF obstruction
Midline shift
Perilesional edema - makes tumor functionally bigger
Contrast enhancement - degree of BBB disruption
Proximity to venous sinuses - blood loss
Preoperative assessment INVESTIGATION
![Page 21: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/21.jpg)
ASA physical status ????
Nature of surgery
High incidence of systemic involvement – CN
palsies, motor/ sensory involvement
Higher comorbidities
Poor surgical outcome
![Page 22: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/22.jpg)
Premedication1. Sedation -Risk assessment, individualised
- often avoided
2. Others - Continue anticonvulsants, antihypertensives,
steroids till morning of surgery
- mannitol, furosemide
Sedation - hypoventilation (hypercapnia, hypoxia, airway obst )
Sedation - ↓stress→↓ICP→↓ vasogenic edema
![Page 23: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/23.jpg)
Vascular access1. Intravascular
a) 2 large bore i.v cannulas
b) CVP -VAE (diagnostic + therapeutic )
- vasoactive drugs
2. Arterial canulation
a) NIBP (anticipated blood loss)
b) ABG
c) Hypotensive anaesthesia
![Page 24: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/24.jpg)
Monitoring
1. ECG, HR – myocardial ischemia, arrhythmias
2. SpO2
3. ETCO2
4. NIBP/ IBP – at level of operative field
5. NMT – on non hemiplegic limb
6. Temperature
7. CVP
8. Urine output
9. Precordial doppler, TEE, ETN2
10. ICP – currently rarely used, except in neurotraumatology
UMN lesion ↑ Ach receptor density
Resistance to NDMR
![Page 25: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/25.jpg)
Induction GOALS – Normotension, Normocarbia, Normoxia
Preoxygenation
P/M – opioid (fentanyl 1-2 μg/kg , morphine 0.1 mg/kg)
I/W – Thiopentone (3-5 mg/kg) Propofol (1.5 – 2.5 mg/kg)
Myorelaxation – Sch (transient ↑ ICP) Use intermediate acting relaxants Atracurium – histamine release ( cerebral vasodilatation) Vecuronium, Rocuronium – commonly used
Only after adequate muscle relaxation achieved, perform quick + gentle laryngoscopy
Intubation – armoured ETT Tape on opposite side of surgery Bandaging may ↓cerebral venous return
Controlled ventilation
Lignocaine , Esmolol, 2nd dose of i.v induction agent
60-90 sec earlier
![Page 26: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/26.jpg)
Positioning GOAL- Slow and gentle positioning with 15- 20 ⁰
head up tilt to aid cerebral venous drainage
Verify cautiously – 1. All potential pressure points padded
2. Eyes protected & padded
3. Peripheral pulses palpable
4. Nerve compression absent
5. Ventilation adequate ( PEEP, ETT position)
ETT – Kinking in post. Oropharynx
Advancement / extubation
Neck – Extreme rotation / flexion may cause ↑ ICP,
quadriparesis, tongue swelling
Head pins – Adequate plane of anaesthesia
Local infiltration / bolus opioid (fentanyl)
![Page 27: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/27.jpg)
Dural opening in presence of high ICP –
- sudden decompression & transcalvarial herniation
- herniated tissue cannot be interposed back
- permanent neural damage
ICP to be brought within normal limits before opening the dura.
Methods – head elevation, mannitol, furosemide, CSF drainage
Optimization of ICP
![Page 28: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/28.jpg)
Mannitol (20%)
Hyperosmolar agent
Dose : 0.5 – 2 mg/kg i.v. (0.5-1 mg/kg over 15 min just before
opening dura)
Action reaches peak at 20-30 min.
Advantages : Draws water from brain (↓ brain bulk)
↓ Hct (↑CBF , O2 delivery)
Disadvantages: 1.If given fast, it transiently ↑ blood vol. &
may cause CHF , pulmonary edema
2. Hypokalemia
3. Worsen C. edema if BBB disrupted
Optimize ICP (cont…)
![Page 29: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/29.jpg)
Optimize ICP (cont…)
Furosemide
Loop diuretic (Na K 2Cl channel blocker)
Dose : 0.5 – 1 mg/kg i.v.
use : sole agent to ↓ ICP
adjunct to mannitol
Mannitol draws fluid out of brain & lasix discards it through kidneys
![Page 30: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/30.jpg)
Optimize ICP (cont…) CSF drainage
1. Lumbar subarachnoid drainage system
2. Ventriculostomy drain (EVD)
(connected by tubing to a CSF collection device which can be elevated or lowered)
CSF drainage (↑ICP, aneurysm / ENT surgeries) ICP measurement
CSF drainage – Slow– bolus ≤ 20-30 ml
Complications – hematoma formation– infection– if abrupt ↓ICP – aneurysmal rupture
![Page 31: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/31.jpg)
MaintenanceGOAL- Maintain cerebral homeostasis + Aid “slack” brain.TARGET – Anaesthetic agent , Fluid therapy, Neuroprotection strategies.
ANAESTHETIC AGENT
VOLATILE ANAESTHETIC
I.V. ANAESTHETIC
PROS 1. Easy, 2. Extensively available
1. Intact CBF – CMRO2 coupling
2. ↓brain bulk3. Propofol blunts N2O
cerebrostimulation
CONS 1. CBF – CMRO2 uncoupling
2. ↑ICP
1. Short acting
RECOMMENDATION 1. Use in short, uncomplicated surgeries
2. At < 1.5 MAC3. Avoid combination
with N2O
1. Use in cases with high risk of ↑ICP/ brain bulk
![Page 32: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/32.jpg)
Maintenance (cont…)
FLUID THERAPY
Principle – BBB is selectively permeable
Water crosses freely, most ions (Na+) don't.
If BBB disrupted (ischemia, head injury, tumors) – hyperosmolar agents may
↑brain water instead of drawing water out.
![Page 33: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/33.jpg)
RECOMMENDATIONS (FLUID RESTRICTION)
1. FLUID LOSS – Do not replace fasting / III space losses
2. BLOOD LOSS – Assessment difficult (drapes + continuous irrigation)
3. SERUM OSMOLARITY –
Maintain at 305- 320 mosm/L
Give NS (309 mosm/L)
Avoid RL (272 mosm/L)
Use them alternately
Avoid glucose containing solutions (5%D , DNS)
Mannitol (0.5 – 2 mg/kg)
Furosemide (0.5 - 1mg/kg)
Maintenance (cont…)
![Page 34: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/34.jpg)
NEUROPROTECTION
a) PaO2
b) PaCO2
c) BP (sympatholysis,
antihypertensives)
d) Glucose ( <170 mg/dL )
e) Temperature ( controlled
hypothermia 32-34 C)⁰
f) Analgesia
g) Adequate depth of anaesthesia
Maintenance (cont…)
OTHERS
a) Seizure prophylaxis/ control
b) Steroids
c) Nimodipine (SAH)
d) Barbiturates
e) Magnesium (experimental)
![Page 35: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/35.jpg)
The chemical brain retractor concept
Mild hyperosmolality
Adequate head-up positioning
Lumbar cerebrospinal fluid drainage
Intravenous anesthetic agent (propofol)
Avoidance of brain retractors
Venous drainage: jugular veins free
Maintenance (cont…)
![Page 36: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/36.jpg)
Emergence Most important but often neglected
“ A well planned procedure is often rewarded by a fully awake patient who is appropriately responding to verbal commands and neurological examination.”
Due to pain and shivering, associated with
• ↑ catecholamine release
• ↑ O2 Consumption ( X 5 times)
AIMS
To maintain intra + extracranial homeostasis
(MAP- CPP- CBF- ICP- CMRO2 - PaO2 - PaCO2- temp)
Avoid intracranial bleed ( coughing, ventilator fight)
![Page 37: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/37.jpg)
Emergence (cont…)
EARLY AWAKENING LATE AWAKENING
1. Early neurological examination & reintervention
2. Less ↑BP/ catecholamine burst
3. ↓ cost of postop care
1. Less risk of ↓O2,↑CO2
associated with anaesthesia hangover
2. Better respiratory & hemodynamic control
RECOMMENDATION – Early awakening is recommended unless contraindicated.
![Page 38: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/38.jpg)
Checklist for early extubation
1. Good preop GCS (>8)
2. CVS stability + normothermia + normoxia
3. Limited brain surgery, no major brain laceration
4. No extensive post fossa manipulation ( CN 9 – 12)
5. No major AVM removal
Emergence (cont…)
![Page 39: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/39.jpg)
Indication of late extubation
1. Low GCS
2. Inadequate airway control
3. Intraop catastrophe
4. Brain edema/ deranged cerebral homeostasis
(long duration/ extensive/ repeat surgery)
5. Surgery around vital areas
Emergence (cont…)
![Page 40: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/40.jpg)
Immediate postoperative concerns
1. Failure to awaken
Nonanaesthetic causes – seizures, cerebral edema,
intracranial hematoma, pneumocephalus, vsl occlusion,
metabolic/ electrolyte disturbance, herniation.
Anaesthesia hangover – opioid, volatile anaesthetic,
muscle relaxant.
![Page 41: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/41.jpg)
Immediate postoperative concerns (cont….)
2. Post operative care
a) Head end elevation (15-30⁰)
b) Adequate ventilation & oxygenation
c) Monitoring of neurological function
d) Check for serum electrolytes and osmolarity (mannitol, frusemide
to continue)
e) Seizure prophylaxis (phenytoin / fosphenytoin)
f) Seizure treatment (thiopentone 50-100 mg, midazolam 2-4 mg ,
lorazepam 2 mg)
![Page 42: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/42.jpg)
Immediate postoperative concerns (cont….)
g) SIADH
Hyponatremia, S. hyposmolarity, high U. osmolarity
T/T restrict free water intake
h) DI
After pituitary surgery
Hyponatremia, S. hyposmolarity, low U. osmolarity
T/T ↑ water intake, vasopressin , desmopressin
i) Tension pneumocephalus
Skull X ray / CT
T/T opening the dura
![Page 43: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/43.jpg)
Concerns for posterior fossa surgery
1. Presentation
Cranial nerve palsies (IX, X) may impair gag reflex-
aspiration
Hydrocephalus
Cerebellar dysfunction
Edema in floor of fourth ventricle- damage to resp. centers
2. Cardiovascular instability
Bradycardia and hypertension – due to V nerve stimulation
(resolve with cessation of stimulus)
Bradycardia, asystole/ hypotension- due to IX/X nerve
stimulation
![Page 44: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/44.jpg)
3. Sitting positionAdvantages
– Better surgical exposure– Improved venous/CSF drainage– Low bleeding– Improved access to airway, chest
Disadvantages– VAE– CVS instability
Concerns for posterior fossa surgery
![Page 45: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/45.jpg)
1. Trans-sphenoidal resection through nasal/ labial incision
2. Endocrine manifestations- normo/hypo/ hyperpituitarism
3. ICP is not a concern due to small size of tumor
4. Uncontrolled bleeding is rare
5. Throat pack to prevent blood from accumulating in stomach /
aspiration
6. Nasal breathing obscured by postoperative nasal packs.
Concerns for pituitary surgery
![Page 46: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/46.jpg)
1. Miller’s anaesthesia.Ronald D Miller. 7th ed.
2. Stoelting's Anesthesia and Co-Existing Disease, 5th ed.
3. Handbook of neuroanaesthesia. James E Cottrell. 4th
ed.
4. Clinical anaesthesia procedures of massachusettes
general hospital. 7th ed.
5. Morgan’s clinical anaesthesiology.4th ed.
References
![Page 47: Anaesthesia for intracranial SOL, including vascular surgeries Dr. Megha Aggarwal University College of Medical Sciences & GTB Hospital, Delhi.](https://reader037.fdocuments.net/reader037/viewer/2022102718/56649c7f5503460f9493643d/html5/thumbnails/47.jpg)
THANK YOU