An overview of probiotics and their role in cancer …profdoc.um.ac.ir/articles/a/1044005.pdf127 An...

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127 An overview of probiotics and their role in cancer management Farzaneh Bonyadi 1 , Amir Tukmechi 2 , Hadi Mohebalian 3 1 MSc, Department of Biology, School of Sciences, Urmia University, Urmia, Iran 2 Assistant Professor, Department of Pathobiology and Quality Control, Artemia and Aquatic Animals Research Institute, Urmia University, Urmia, Iran 3 Assistant Professor, Department of Immunology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran (Received January 8, 2014; Accepted April 20, 2014) Abstract Probiotics are alive microorganisms which have useful effects on health of host by balancing its intestinal micro flora. Nowadays, probiotics are known as a factor for prevention of infectious diseases and cancer. Anti cancer properties of probiotics exert with the detoxification of materials that cause genetic damages. The present study aimed to systematically review on studies in checking positive effects of probiotics on health and their association with cancer. Related articles were searched in English at ACM, IEEE, Springer, Science Direct, Google Scholar, clinical trials and systematic review literatures that have assessed effects of probiotics at prevention and treatment of cancer, enrolled in this study. There was a wide variation among studies in imaging parameters, type of used probiotics, host type and test conditions. The results implied that probiotic bacteria and yeasts can eliminate toxicity of carcinogens and induce cancer cell death in vitro. In addition, consumption of probiotics caused reduced cancer risk, stimulation of immune system and struggle to carcinogens. Despite acceptable evidence about their anti-cancer properties, studies in humans are still limited. Therefore, there is a need to plan for detailed clinical studies on human in such a way obtained information can be used to treat. Keywords: Probiotics, cancer, immune system, treatment J Mazand Univ Med Sci 2014; 24(112): 128-40 (Persian).

Transcript of An overview of probiotics and their role in cancer …profdoc.um.ac.ir/articles/a/1044005.pdf127 An...

Page 1: An overview of probiotics and their role in cancer …profdoc.um.ac.ir/articles/a/1044005.pdf127 An overview of probiotics and their role in cancer management Farzaneh Bonyadi 1, Amir

127

An overview of probiotics and their role in cancer management

Farzaneh Bonyadi1,

Amir Tukmechi2,

Hadi Mohebalian3

1 MSc, Department of Biology, School of Sciences, Urmia University, Urmia, Iran

2 Assistant Professor, Department of Pathobiology and Quality Control, Artemia and Aquatic Animals Research Institute, Urmia University, Urmia, Iran

3 Assistant Professor, Department of Immunology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran

(Received January 8, 2014; Accepted April 20, 2014)

Abstract

Probiotics are alive microorganisms which have useful effects on health of host by balancing its intestinal

micro flora. Nowadays, probiotics are known as a factor for prevention of infectious diseases and cancer. Anti cancer

properties of probiotics exert with the detoxification of materials that cause genetic damages. The present study

aimed to systematically review on studies in checking positive effects of probiotics on health and their association

with cancer. Related articles were searched in English at ACM, IEEE, Springer, Science Direct, Google Scholar,

clinical trials and systematic review literatures that have assessed effects of probiotics at prevention and treatment of

cancer, enrolled in this study. There was a wide variation among studies in imaging parameters, type of used

probiotics, host type and test conditions. The results implied that probiotic bacteria and yeasts can eliminate toxicity

of carcinogens and induce cancer cell death in vitro. In addition, consumption of probiotics caused reduced cancer

risk, stimulation of immune system and struggle to carcinogens. Despite acceptable evidence about their anti-cancer

properties, studies in humans are still limited. Therefore, there is a need to plan for detailed clinical studies on human

in such a way obtained information can be used to treat.

Keywords: Probiotics, cancer, immune system, treatment J Mazand Univ Med Sci 2014; 24(112): 128-40 (Persian).

Page 2: An overview of probiotics and their role in cancer …profdoc.um.ac.ir/articles/a/1044005.pdf127 An overview of probiotics and their role in cancer management Farzaneh Bonyadi 1, Amir

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